LOCUS MUSMHIAAU 868 bp mRNA linear ROD 27-APR-1993 DEFINITION Mouse MHC class II H2-IA-alpha gene (u haplotype), mRNA. ACCESSION K01926 VERSION K01926.1 KEYWORDS antigen; cell surface glycoprotein; class II gene; glycoprotein; histocompatibility antigen; integral membrane protein; major histocompatibility complex. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 868) AUTHORS Benoist,C.O., Mathis,D.J., Kanter,M.R., Williams,V.E. II and McDevitt,H.O. TITLE Regions of allelic hypervariability in the murine A alpha immune response gene JOURNAL Cell 34 (1), 169-177 (1983) PUBMED 6309407 COMMENT Original source text: Mouse B10.PL (u haplotype) spleen, cDNA to mRNA. The protein domains are as follows: first external protein domain (D1) at bases <1-246; second external protein domain (D2) at bases 247-528; connecting peptide, transmembrane region, and cytoplasmic tail (CP,TM,C) at bases 529-681. [1] also sequenced the IA-alpha genes from mice of d,b,f and q haplotypes. FEATURES Location/Qualifiers source 1..868 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" mRNA <1..>868 /product="IA-alpha mRNA" CDS <1..684 /note="MHC H2-IA-alpha" /codon_start=1 /protein_id="AAA39623.1" /translation="DHVGSYGIVVYQSPGDIGQYTFEFDGDELFYVDLDKKETIWMLP EFAQLRSFDPQGGLQNIATGKHNLGVLTKRSNSTPATNEAPQATVFPKSPVLLGQPNT LICFVDNIFPPVINITWLRNSKSVADGVYETSFFVNRDYSFHKLSYLTFIPSDDDIYD CKVEHWGLEEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSG GTSRHPGPL" BASE COUNT 192 a 230 c 213 g 233 t ORIGIN 53 bp upstream of HaeIII site, chromosome 17. 1 gaccatgtag gctcctatgg tatagttgta tatcagtctc ctggagacat tggccagtac 61 acatttgaat ttgatggtga tgagttgttc tatgtggact tggataagaa ggagactatc 121 tggatgcttc ctgagtttgc tcaactgaga agctttgacc cccaaggtgg actgcaaaac 181 atagctacag gaaaacacaa cttgggagtc ttgactaaga ggtcaaattc caccccagct 241 accaatgagg ctcctcaagc gactgtgttc cccaagtccc ctgtgctgct gggtcagccc 301 aacaccctca tctgctttgt ggacaacatc ttccctcctg tgatcaacat cacatggctc 361 agaaatagca agtcagtcgc agacggtgtt tatgagacca gcttcttcgt caaccgtgac 421 tattccttcc acaagctgtc ttatctcacc ttcatccctt ctgacgatga catttatgac 481 tgcaaggtgg aacactgggg cctggaggag ccggttctga aacactggga acctgagatt 541 ccagccccca tgtcagagct gacagagact gtggtctgtg ccctggggtt gtctgtgggc 601 cttgtgggca tcgtggtggg caccatcttc atcattcaag gcctgcgatc aggtggcacc 661 tccagacacc cagggccttt atgagtcaca ccctggaaag gaaggcgtgt gtccctcttc 721 atggaagaag tggtgtgctg ggtgacctgg cacagtgtgt tttctggacc aattcatggt 781 gttctttctc ttcttcaagt gacccccaac ttgcttttct cttggccctg aggctgtccc 841 tctcacagct cacacaccct tggaattc //