LOCUS MUSMHIAAQ 834 bp mRNA linear ROD 27-APR-1993 DEFINITION Mouse MHC class II H2-IA-alpha gene (q haplotype), mRNA. ACCESSION K01925 VERSION K01925.1 KEYWORDS antigen; cell surface glycoprotein; class II gene; glycoprotein; histocompatibility antigen; integral membrane protein; major histocompatibility complex. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 834) AUTHORS Benoist,C.O., Mathis,D.J., Kanter,M.R., Williams,V.E. II and McDevitt,H.O. TITLE Regions of allelic hypervariability in the murine A alpha immune response gene JOURNAL Cell 34 (1), 169-177 (1983) PUBMED 6309407 COMMENT Original source text: Mouse B10.G (q haplotype) spleen, cDNA to mRNA. The protein domains are as follows: first external protein domain (D1) at bases <1-228; second external protein domain (D2) at bases 229-510; connecting peptide, transmembrane region, and cytoplasmic tail (CP,TM,C) at bases 511-663. [1] also sequenced the IA-alpha genes from mice of d,b,f and u haplotypes. FEATURES Location/Qualifiers source 1..834 /organism="Mus musculus" /mol_type="mRNA" /db_xref="taxon:10090" mRNA <1..>834 /product="IA-alpha mRNA" CDS <1..666 /note="MHC H2-IA-alpha" /codon_start=1 /protein_id="AAA39620.1" /translation="GIVVYQSPGDIGQYTHEFDGDEWFYVDLDKKETVWMLPEFGQLT SFDPQGGLQNIATGKHNLGGWTKRSNFTPATNEAPQATVFPKSPVLLGQPNTLICFVD NIFPPVINITWLRNSKSVTDGVYETSFLVNRDHSFHKLSYLTFIPSDDDIYDCKVEHW GLDEPVLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRPP GPL" BASE COUNT 193 a 224 c 202 g 215 t ORIGIN 35 bp upstream of HaeIII site, chromosome 17. 1 ggtatagttg tatatcagtc tcctggagac attggccagt atacacatga atttgatggt 61 gatgagtggt tctatgtgga cttggataag aaggagactg tctggatgct tcctgagttt 121 ggccaattga caagctttga cccccaaggt ggactacaaa acatagctac aggaaaacac 181 aacttgggag gctggactaa gaggtcaaat ttcaccccag ctaccaatga ggctcctcaa 241 gcaactgtgt tccccaagtc ccctgtgctg ctgggtcagc ccaataccct tatctgcttt 301 gtggacaaca tcttccctcc tgtgatcaac atcacatggc tcagaaatag caagtcagtc 361 acagacggcg tttatgagac cagcttcctt gtcaaccgtg accattcctt ccacaagctg 421 tcttatctca ccttcatccc ttctgacgat gacatttatg actgcaaggt ggaacactgg 481 ggcctggacg agccagttct gaaacactgg gaacctgaga tcccagcccc catgtcagag 541 ctgacagaga ctgtggtctg tgccctgggg ttgtctgtgg gccttgtggg catcgtggtg 601 ggaaccatct tcatcattca aggcctgcga tcaggtggca cctccagacc cccaggacct 661 ttatgagtca caccctggaa aggaaggcat gtgtccctct tcagggaaga agtggtgtgc 721 tgggtgacct ggaccaattc ttggtgttct ttctcatctt caagtaaccc ccaacttgct 781 tttccctttg ctccggaggc tgtccctctc acagctcaca cacccgtgga attc //