LOCUS STYHISOGD 4443 bp DNA linear BCT 15-NOV-2023
DEFINITION S.typhimurium his operon encoding ATP phosphoribosyl transferase
(hisG), histidinol dehydrogenase (hisD), histidinol phosphate
aminotransferase (hisC) complete cds, and imidazole-glycerol
phosphate dehydratase (hisB), 5' end.
ACCESSION J01804
VERSION J01804.1
KEYWORDS ATP phosphoribosyl transferase; attenuator; histidine operon;
histidinol dehydrogenase; histidinol-phosphate aminotransferase;
imidazole-glycerol phosphate dehydratase.
SOURCE Salmonella enterica subsp. enterica serovar Typhimurium (Salmonella
typhimurium)
ORGANISM Salmonella enterica subsp. enterica serovar Typhimurium
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Salmonella.
REFERENCE 1 (bases 649 to 943)
AUTHORS Barnes,W.M.
TITLE DNA sequence from the histidine operon control region: seven
histidine codons in a row
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 75 (9), 4281-4285 (1978)
PUBMED 360216
COMMENT Draft entry and computer-readable sequence for [1],[Unpublished
(1984) see COMMENT for author address.] kindly
provided by W.M. Barnes, 04-AUG-1989.
Department of Biological Chemistry, Washington University School of
Medicine, St. Louis, Missouri USA 63110.
FEATURES Location/Qualifiers
source 1..4443
/organism="Salmonella enterica subsp. enterica serovar
Typhimurium"
/mol_type="genomic DNA"
/strain="LT2"
/serovar="Typhimurium"
/sub_species="enterica"
/type_material="type strain of Salmonella enterica"
/db_xref="taxon:90371"
CDS 707..757
/note="leader peptide (with seven histidines)"
/codon_start=1
/transl_table=11
/protein_id="AAA88613.1"
/translation="MTRVQFKHHHHHHHPD"
variation 806..842
/note="a-35bp-c in wt; ac in hisO1242"
gene 904..1803
/gene="hisG"
CDS 904..1803
/gene="hisG"
/codon_start=1
/transl_table=11
/product="ATP phosphoribosyltransferase"
/protein_id="AAA88614.1"
/translation="MLDNTRLRIAIQKSGRLSDDSRELLARCGIKINLHTQRLIAMAE
NMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYLTLRRLDFG
GCRLSLATPVDEAWDGPAALDGKRIATSYPHLLKRYLDQKGVSFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMAQSKQELIDKLLTRIQ
GVIQARESKYIMMHAPSERLEEVIALLPGAERPTILPLAGEQQRVAMHMVSSETLFWE
TMEKLKALGASSILVLPIEKMME"
variation 1109
/gene="hisG"
/note="t in wt; c in hisG46 (Leu->Pro)"
variation 1194..1195
/gene="hisG"
/note="cc in wt; ccc in hisG6608"
variation 1522
/gene="hisG"
/note="c in wt; t in Ames test strain TA102 (->ochre)"
gene 1906..3210
/gene="hisD"
CDS 1906..3210
/gene="hisD"
/codon_start=1
/transl_table=11
/product="histidinol dehydrogenase"
/protein_id="AAA88615.1"
/translation="MSFNTLIDWNSCSPEQQRALLTRPAISASDSITRTVSDILDNVK
TRGDDALREYSAKFDKTEVTALRVTPEEIAAAGARLSDELKQAMTAAVKNIETFHSAQ
TLPPVDVETQPGVRCQQVTRPVSSVGLYIPGGSAPLFSTVLMLATPARIAGCQKVVLC
SPPPIADEILYAAQLCGVQEIFNVGGAQAIAALAFGSESVPKVDKIFGPGNAFVTEAK
RQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDAD
IARKVAEAVERQLAELPRADTARQALSASRLIVTKDLAQCVAISNQYGPEHLIIQTRN
ARDLVDAITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV
QELSKAGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA"
variation 1944..1946
/gene="hisD"
/note="ccc in wt; cc in hisD497"
variation 1944..1946
/gene="hisD"
/note="ccc in wt; cccc in hisD3749"
variation 2111..2114
/gene="hisD"
/note="cccc in wt; ccccc in hisD3018"
variation 2798..2800
/gene="hisD"
/note="ccc in wt; cc in hisD3052"
gene 3207..4286
/gene="hisC"
CDS 3207..4286
/gene="hisC"
/codon_start=1
/transl_table=11
/product="histidinol phosphate aminotransferase"
/protein_id="AAA88616.1"
/translation="MSTENTLSVADLARENVRNLVPYQSARRLGGNGDVWLNANEFPT
AVEFQLTQQTLNRYPECQPKAVIENYAQYAGVKPEQVLVSRGADEGIELVIRAFCEPG
KDAILYCPPTYGMYSVSAETIGVERRTVPALENWQLDLQGISDNLTAQKWCSFVAPII
LPDNLINPQDLRTLLELTRGKAIVVADEAYIEFCPQATLTGWLVEYPHLVILRTLSKA
FALAGLRCGFTLANEEVINLLLKVIAPYPLSTPVADIAAQALCPQGINAMRDRVAQTV
QERQYLVNALQQTACVEHVFDSETNYILARFTASSSVFKSLWDQGIILRDQNKQPSLS
GCLRITVGTRQENQRVIDALRAEPV"
gene 4283..4443
/gene="hisB"
CDS 4283..>4443
/gene="hisB"
/codon_start=1
/transl_table=11
/product="imidazole-glycerol phosphate dehydratase"
/protein_id="AAA88617.1"
/translation="MSQKYLFIDRDGTLISEPPSDFQVDRFDKLAFEPEVIPVLLKLQ
KAGFKLVMIT"
BASE COUNT 1017 a 1259 c 1216 g 951 t
ORIGIN
1 gaccatccgg cgcggttttt ccggcaaaga aacgtccggg atggcgccca ggcccgacca
61 accccgccag ccgcagaata tccactgacg tgcccggcag attatgcagc caatcttcca
121 gttccttcag ggtacgcccg ctggccgtga ccggattacg cggcgtattc tctttcacca
181 cgccttgcgc atcgccgtaa acagacgtcg aactggtaaa aataatacgc gggatacgat
241 aagccagcgc gctgtcgacc agctcctgca tcgcctgcag ataaaaatcc tctcccggac
301 cgctacggcg cgcgggcagt gttatcacca gcgcatcgac atccagcaga gcgtcaagat
361 cgtccgcctc acagaccaac tccggctcca gacgcagcgg atagctttca attccactca
421 tacgggccgc ttccaccccg tcaagggtgg ttttgctgcc ggtaacctgc cagcctctcg
481 ctgccagcga cattgccagc ggcatgccta accaacctaa accgacaatt gcgacctttt
541 tcatccattt tctcctgact ttaacgcctt atacataagg ctacgccagc ccgccgtgac
601 tgacaattca tactataaat gcgaaatgaa aaaagcgctt gctttaaggc gtaaaagtgg
661 tttaggttaa aaggtatcaa atgaataagc attcatcgga atttttatga cacgcgttca
721 atttaaacac caccatcatc accatcatcc tgactagtct ttcaggcgat gtgtgctgga
781 agacattcag atcttccagt ggtgcatgaa cgcatgagaa agcccccgga agatcatctt
841 ccgggggctt tttttttggc gcgcgataca gaccggttca gacaggataa agaggaacgc
901 agaatgttag acaacacccg cttacgcata gctattcaga aatcaggccg tttaagcgat
961 gattcacgag aattgctggc ccgctgcggc ataaaaatta atttacacac tcagcgcctg
1021 attgcgatgg cggaaaacat gccgattgat atcctgcgcg tgcgtgatga tgacattccg
1081 ggtctggtaa tggatggcgt ggtcgatctc ggtattatcg gcgaaaacgt gctggaagaa
1141 gagctactca accgccgcgc acagggcgaa gatccacgct atttaaccct gcgccgtctt
1201 gacttcggcg gctgccgttt atcgctggca acaccggttg acgaagcctg ggacggcccg
1261 gccgcgctgg acggtaaacg tatcgctacc tcatatccgc acctcctcaa acgctacctc
1321 gaccagaaag gcgtctcttt taaatcgtgt ctgttaaatg gttctgtcga agtcgcgccg
1381 cgcgcggggc tggccgacgc tatctgcgat ttggtctcta ccggcgcgac gcttgaagct
1441 aacggcctgc gtgaagtcga agttatctac cgctctaaag cctgtctgat tcagcgcgac
1501 ggtgagatgg cacagagcaa gcaagagctg atcgataaat tgctgacccg tattcagggc
1561 gtgattcagg cgcgcgaatc gaaatacatc atgatgcacg cgccaagtga acgcctggaa
1621 gaggttatcg ccctgctgcc aggcgccgaa aggccgacaa ttctgccgct ggcaggcgag
1681 caacagcgcg tggcgatgca catggtcagc agcgaaacgt tgttctggga aaccatggag
1741 aaactgaaag cgcttggcgc cagctcgatt ctggtactgc cgatcgagaa gatgatggag
1801 tgatctgacg cctgatggcg ctgcgcttat caggcctacg taatgcgttg atattttggg
1861 ttctgtaggc cggataaggc ggaaccctgt gatggagtaa agaccatgag cttcaatacc
1921 ctgattgact ggaacagctg tagccctgaa cagcagcgtg cgctgctgac gcgtccggcg
1981 atttccgcct ctgacagtat tacccggacg gtcagcgata ttctggataa tgtaaaaacg
2041 cgcggtgacg atgccctgcg tgaatacagc gctaaatttg ataaaacaga agtgacagcg
2101 ctacgcgtca cccctgaaga gatcgccgcc gccggcgcgc gtctgagcga cgaattaaaa
2161 caggcgatga ccgctgccgt caaaaatatt gaaacgttcc attccgcgca gacgctaccg
2221 cctgtagatg tggaaaccca gccaggcgtg cgttgccagc aggttacgcg tcccgtctcg
2281 tctgtcggtc tgtatattcc cggcggctcg gctccgctct tctcaacggt gctgatgctg
2341 gcgacgccgg cgcgcattgc gggatgccag aaggtggttc tgtgctcgcc gccgcccatc
2401 gctgatgaaa tcctctatgc ggcgcaactg tgtggcgtgc aggaaatctt taacgtcggc
2461 ggcgcgcagg cgattgccgc tctggccttc ggcagcgagt ccgtaccgaa agtggataaa
2521 atttttggcc ccggcaacgc ctttgtaacc gaagccaaac gtcaggtcag ccagcgtctc
2581 gacggcgcgg ctatcgatat gccagccggg ccgtctgaag tactggtgat cgcagacagc
2641 ggcgcaacac cggatttcgt cgcttctgac ctgctctccc aggctgagca cggcccggat
2701 tcccaggtga tcctgctgac gcctgatgct gacattgccc gcaaggtggc ggaggcggta
2761 gaacgtcaac tggcggaact gccgcgcgcg gacaccgccc ggcaggccct gagcgccagt
2821 cgtctgattg tgaccaaaga tttagcgcag tgcgtcgcca tctctaatca gtatgggccg
2881 gaacacttaa tcatccagac gcgcaatgcg cgcgatttgg tggatgcgat taccagcgca
2941 ggctcggtat ttctcggcga ctggtcgccg gaatccgccg gtgattacgc ttccggaacc
3001 aaccatgttt taccgaccta tggctatact gctacctgtt ccagccttgg gttagcggat
3061 ttccagaaac ggatgaccgt tcaggaactg tcgaaagcgg gcttttccgc tctggcatca
3121 accattgaaa cattggcggc ggcagaacgt ctgaccgccc ataaaaatgc cgtgaccctg
3181 cgcgtaaacg ccctcaagga gcaagcatga gcactgaaaa cactctcagc gtcgctgact
3241 tagcccgtga aaatgtccgc aacctggtac cgtatcagtc tgcccgccgt ctgggcggta
3301 acggcgatgt ctggctgaac gcgaatgaat tcccgacagc ggtggagttt cagctcaccc
3361 aacaaacgct taaccgctac ccggaatgcc agccaaaggc cgtgattgaa aactacgcgc
3421 aatatgctgg cgtaaagccg gagcaggtgc tggtcagccg cggcgcggat gaagggatcg
3481 agctggtgat ccgcgccttc tgtgaaccgg ggaaagacgc cattctctac tgtccgccca
3541 cttacggtat gtacagcgtc agcgccgaaa ccattggcgt agagcgccgg acggttcccg
3601 cgcttgaaaa ctggcagctg gatctacagg ggatttccga caacctgacg gcacaaaagt
3661 ggtgttcgtt tgtagcccca ataatcctac cggacaacct tatcaacccg caggatctgc
3721 gcacgctgct ggagttgaca cgcggtaaag cgatagtcgt cgccgacgaa gcttatattg
3781 agttttgccc gcaggccacg ctgacaggct ggctggttga atatcctcat ctggttatcc
3841 tgcgcacatt gtcgaaagct tttgcgctgg cgggtctgcg ctgcggcttt acactggcta
3901 atgaagaggt gatcaacctg ctgttaaaag tgatcgcccc ttatccgctt tctacgccag
3961 tggcggatat cgccgcccag gcgctgtgcc cgcagggaat aaacgcaatg cgcgatcgcg
4021 tggcgcagac agtgcaggaa cgtcagtatc tggtgaatgc cctgcaacag accgcctgcg
4081 tagaacacgt ctttgactct gaaaccaact atattctggc gcggtttacc gcctccagca
4141 gcgtgtttaa atccttatgg gatcagggca ttatcttacg cgatcagaat aaacaacctt
4201 ctttaagcgg ctgcctgcgg attacggtcg gcacccgcca ggaaaaccag cgcgtcattg
4261 acgccttacg tgcggagcca gtatgagtca gaagtatctt ttcatcgacc gggacggaac
4321 cttaatttcc gaaccgccga gcgattttca ggtagaccgc tttgataaac tggcctttga
4381 gccagaggtg attcccgtat tgctgaagct gcaaaaagcc ggttttaagc tggtgatgat
4441 cac
//