LOCUS       EU334168                1679 bp    mRNA    linear   HUM 13-JAN-2008
DEFINITION  Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
            transcript variant 3 (PFKFB2) mRNA, complete cds, alternatively
            spliced.
ACCESSION   EU334168
VERSION     EU334168.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Minchenko,O.H., Opentanova,I.L., Ogura,T., Minchenko,D.O.,
            Komisarenko,S.V., Caro,J. and Esumi,H.
  TITLE     Expression and hypoxia-responsiveness of
            6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary
            gland malignant cell lines
  JOURNAL   Acta Biochim. Pol. 52 (4), 881-888 (2005)
   PUBMED   16025159
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Minchenko,O.H., Ochiai,A., Opentanova,I.L., Ogura,T.,
            Minchenko,D.O., Caro,J., Komisarenko,S.V. and Esumi,H.
  TITLE     Overexpression of
            6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human
            breast and colon malignant tumors
  JOURNAL   Biochimie 87 (11), 1005-1010 (2005)
   PUBMED   15925437
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Minchenko,D.O., Moenner,M., Minchenko,O.H., Tsuchihara,K.,
            Kanehara,S., Bikfalvi,A. and Esumi,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-2007) Molecular Biology, Palladin Institute of
            Biochemistry, 9 Leontovycha, Kyiv 01601, Ukraine
FEATURES             Location/Qualifiers
     source          1..1679
                     /db_xref="H-InvDB:HIT000484836"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31"
                     /cell_line="U87"
                     /cell_type="glioma"
     gene            1..1679
                     /gene="PFKFB2"
     CDS             227..1645
                     /gene="PFKFB2"
                     /EC_number="3.1.3.46"
                     /note="alternatively spliced; involved in the synthesis
                     and degradation of fructose-2,6-bisphosphate in the heart,
                     liver, and muscle; functions as a homodimer; contains an
                     insert between exon 2 and 3 relative to
                     6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2"
                     /codon_start=1
                     /product="6-phosphofructo-2-kinase/fructose-2,
                     6-bisphosphatase 2 transcript variant 3"
                     /protein_id="ABY59650.1"
                     /translation="MTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVY
                     RREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRE
                     RRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKR
                     IECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRT
                     IYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQ
                     TAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQ
                     DLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTP
                     VAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYS
                     VGSRPLKPLSPLRAQDMQEGAD"
BASE COUNT          459 a          408 c          428 g          384 t
ORIGIN      
        1 gacatctgaa gagctgccat gtctggggca tcttcctcag aacagaacaa caacagctat
       61 gaaaccaaaa ccccaaatct tcgaatgtca gagaagaaat gttacgaagt cttgctctgt
      121 cgcccaggct ggagtgcagt gacgggatca tggctcactg caaccttgaa ctcctgagct
      181 caagcaatcc tcctgagtag ctgggactat agcatgggcc tcctacatga ccaactcccc
      241 gactctgatc gttatgattg gtttgccagc ccggggtaaa acctacgtgt ccaagaaact
      301 aacacgctac ctcaactgga ttggagtccc caccaaagtg tttaatcttg gggtgtatcg
      361 gcgtgaagca gtcaagtcct ataagtccta cgacttcttt cggcatgaca atgaggaggc
      421 catgaagatc cgcaaacagt gtgctctggt ggcgctggaa gatgttaagg cgtatctcac
      481 tgaggagaat ggtcagattg cggtgtttga tgccaccaat acaacccggg agaggaggga
      541 catgattttg aactttgctg aacagaattc cttcaaggta ttctttgtgg aatccgtctg
      601 tgatgatcct gatgtcattg ctgccaatat tctggaggtt aaggtatcaa gccctgacta
      661 tcctgaaagg aacagagaga acgtgatgga ggacttcctg aagagaattg aatgctacaa
      721 agttacctac cgacctcttg acccagacaa ctatgacaag gatctttctt tcatcaaggt
      781 gataaacgtg ggccagcgat ttttagtcaa cagagtccag gactacatcc agagcaagat
      841 agtctactac ctcatgaata tccacgtcca gcctcgcacc atttaccttt gccggcatgg
      901 agaaagcgag ttcaatctct tggggaagat tgggggtgac tctggcctct cggtgcgggg
      961 aaagcagttt gcccaagctc taaggaaatt tctggaggaa caggaaataa cagacctcaa
     1021 agtgtggaca agccagttga agaggaccat acagactgct gaatctctcg gggtgcccta
     1081 tgagcagtgg aagattctga atgagattga tgctggtgtg tgtgaagaga tgacctatgc
     1141 agagattgag aaacggtacc cagaagagtt tgcacttcga gatcaagaga agtatctgta
     1201 tcgatatcct ggtggggagt cataccagga cctggtgcag cggctggagc ctgtcatcat
     1261 ggagctggaa cgtcagggca atgtcctcgt catctcccac caggctgtca tgcgctgcct
     1321 cctggcctac ttcttggata agggcgcaga tgagctacca tacttgagat gccctctcca
     1381 taccatcttc aaacttactc ctgtggccta tgggtgcaaa gtggaaacaa ttaaacttaa
     1441 cgtggaggct gtgaacacgc accgtgacaa gccaactaac aacttcccca agaaccaaac
     1501 ccctgtaagg atgagaagga acagctttac gcctctgtcc agttcgaata caataaggcg
     1561 tccaagaaat tacagtgttg ggagccggcc cctcaagccc ctcagccctc tccgtgccca
     1621 ggacatgcaa gaaggggccg actagccgaa gacccaagtc agcattccgg tggtgtaac
//