LOCUS EU334168 1679 bp mRNA linear HUM 13-JAN-2008 DEFINITION Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 transcript variant 3 (PFKFB2) mRNA, complete cds, alternatively spliced. ACCESSION EU334168 VERSION EU334168.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1679) AUTHORS Minchenko,O.H., Opentanova,I.L., Ogura,T., Minchenko,D.O., Komisarenko,S.V., Caro,J. and Esumi,H. TITLE Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines JOURNAL Acta Biochim. Pol. 52 (4), 881-888 (2005) PUBMED 16025159 REFERENCE 2 (bases 1 to 1679) AUTHORS Minchenko,O.H., Ochiai,A., Opentanova,I.L., Ogura,T., Minchenko,D.O., Caro,J., Komisarenko,S.V. and Esumi,H. TITLE Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4 in the human breast and colon malignant tumors JOURNAL Biochimie 87 (11), 1005-1010 (2005) PUBMED 15925437 REFERENCE 3 (bases 1 to 1679) AUTHORS Minchenko,D.O., Moenner,M., Minchenko,O.H., Tsuchihara,K., Kanehara,S., Bikfalvi,A. and Esumi,H. TITLE Direct Submission JOURNAL Submitted (08-DEC-2007) Molecular Biology, Palladin Institute of Biochemistry, 9 Leontovycha, Kyiv 01601, Ukraine FEATURES Location/Qualifiers source 1..1679 /db_xref="H-InvDB:HIT000484836" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1q31" /cell_line="U87" /cell_type="glioma" gene 1..1679 /gene="PFKFB2" CDS 227..1645 /gene="PFKFB2" /EC_number="3.1.3.46" /note="alternatively spliced; involved in the synthesis and degradation of fructose-2,6-bisphosphate in the heart, liver, and muscle; functions as a homodimer; contains an insert between exon 2 and 3 relative to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2" /codon_start=1 /product="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 transcript variant 3" /protein_id="ABY59650.1" /translation="MTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVY RREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRE RRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKR IECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRT IYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQ TAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQ DLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTP VAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYS VGSRPLKPLSPLRAQDMQEGAD" BASE COUNT 459 a 408 c 428 g 384 t ORIGIN 1 gacatctgaa gagctgccat gtctggggca tcttcctcag aacagaacaa caacagctat 61 gaaaccaaaa ccccaaatct tcgaatgtca gagaagaaat gttacgaagt cttgctctgt 121 cgcccaggct ggagtgcagt gacgggatca tggctcactg caaccttgaa ctcctgagct 181 caagcaatcc tcctgagtag ctgggactat agcatgggcc tcctacatga ccaactcccc 241 gactctgatc gttatgattg gtttgccagc ccggggtaaa acctacgtgt ccaagaaact 301 aacacgctac ctcaactgga ttggagtccc caccaaagtg tttaatcttg gggtgtatcg 361 gcgtgaagca gtcaagtcct ataagtccta cgacttcttt cggcatgaca atgaggaggc 421 catgaagatc cgcaaacagt gtgctctggt ggcgctggaa gatgttaagg cgtatctcac 481 tgaggagaat ggtcagattg cggtgtttga tgccaccaat acaacccggg agaggaggga 541 catgattttg aactttgctg aacagaattc cttcaaggta ttctttgtgg aatccgtctg 601 tgatgatcct gatgtcattg ctgccaatat tctggaggtt aaggtatcaa gccctgacta 661 tcctgaaagg aacagagaga acgtgatgga ggacttcctg aagagaattg aatgctacaa 721 agttacctac cgacctcttg acccagacaa ctatgacaag gatctttctt tcatcaaggt 781 gataaacgtg ggccagcgat ttttagtcaa cagagtccag gactacatcc agagcaagat 841 agtctactac ctcatgaata tccacgtcca gcctcgcacc atttaccttt gccggcatgg 901 agaaagcgag ttcaatctct tggggaagat tgggggtgac tctggcctct cggtgcgggg 961 aaagcagttt gcccaagctc taaggaaatt tctggaggaa caggaaataa cagacctcaa 1021 agtgtggaca agccagttga agaggaccat acagactgct gaatctctcg gggtgcccta 1081 tgagcagtgg aagattctga atgagattga tgctggtgtg tgtgaagaga tgacctatgc 1141 agagattgag aaacggtacc cagaagagtt tgcacttcga gatcaagaga agtatctgta 1201 tcgatatcct ggtggggagt cataccagga cctggtgcag cggctggagc ctgtcatcat 1261 ggagctggaa cgtcagggca atgtcctcgt catctcccac caggctgtca tgcgctgcct 1321 cctggcctac ttcttggata agggcgcaga tgagctacca tacttgagat gccctctcca 1381 taccatcttc aaacttactc ctgtggccta tgggtgcaaa gtggaaacaa ttaaacttaa 1441 cgtggaggct gtgaacacgc accgtgacaa gccaactaac aacttcccca agaaccaaac 1501 ccctgtaagg atgagaagga acagctttac gcctctgtcc agttcgaata caataaggcg 1561 tccaagaaat tacagtgttg ggagccggcc cctcaagccc ctcagccctc tccgtgccca 1621 ggacatgcaa gaaggggccg actagccgaa gacccaagtc agcattccgg tggtgtaac //