LOCUS       BC113734                 978 bp    mRNA    linear   HUM 29-JUN-2006
DEFINITION  Homo sapiens CD274 molecule, mRNA (cDNA clone MGC:142294
            IMAGE:8322786), complete cds.
ACCESSION   BC113734
VERSION     BC113734.1
KEYWORDS    MGC.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 978)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   2  (bases 1 to 978)
  CONSRTM   NIH MGC Project
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2006) National Institutes of Health, Mammalian
            Gene Collection (MGC), Bethesda, MD 20892-2590, USA
  REMARK    NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT     Contact: MGC help desk
            Email: cgapbs-r@mail.nih.gov
            Tissue Procurement: Mike Brownstein, NIMH
            cDNA Library Preparation: British Columbia Cancer Research Center
            cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
            DNA Sequencing by: Genome Sequence Centre,
            BC Cancer Agency, Vancouver, BC, Canada
            info@bcgsc.bc.ca
            Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
            Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
            Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
            Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
            Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio, Ruth
            Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy Liao,
            Kim MacDonald,  Mike R. Mayo, Josh Moran, Diana Palmquist, JR
            Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,
            Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco Marra.
            
            Clone distribution: MGC clone distribution information can be found
            through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
            Series: IRCB Plate: 5 Row: p Column: 16.
FEATURES             Location/Qualifiers
     source          1..978
                     /db_xref="H-InvDB:HIT000387187"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="MGC:142294 IMAGE:8322786"
                     /tissue_type="Lung, PCR rescued clones"
                     /clone_lib="NIH_MGC_299"
                     /note="Vector: pCR4-TOPO with reversed insert; Clone
                     identification sequence tag: ACAATGTC"
     gene            1..978
                     /gene="CD274"
                     /gene_synonym="B7-H"
                     /gene_synonym="B7H1"
                     /gene_synonym="PD-L1"
                     /gene_synonym="PDCD1L1"
                     /gene_synonym="PDL1"
                     /db_xref="GeneID:29126"
                     /db_xref="HGNC:HGNC:17635"
                     /db_xref="MIM:605402"
     CDS             22..894
                     /gene="CD274"
                     /gene_synonym="B7-H"
                     /gene_synonym="B7H1"
                     /gene_synonym="PD-L1"
                     /gene_synonym="PDCD1L1"
                     /gene_synonym="PDL1"
                     /codon_start=1
                     /product="CD274 molecule"
                     /protein_id="AAI13735.1"
                     /db_xref="GeneID:29126"
                     /db_xref="HGNC:HGNC:17635"
                     /db_xref="MIM:605402"
                     /translation="MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPV
                     EKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQIT
                     DVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGY
                     PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEE
                     NHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQD
                     TNSKKQSDTHLEET"
BASE COUNT          304 a          204 c          235 g          235 t
ORIGIN      
        1 cctgcagggc attccagaaa gatgaggata tttgctgtct ttatattcat gacctactgg
       61 catttgctga acgcatttac tgtcacggtt cccaaggacc tatatgtggt agagtatggt
      121 agcaatatga caattgaatg caaattccca gtagaaaaac aattagacct ggctgcacta
      181 attgtctatt gggaaatgga ggataagaac attattcaat ttgtgcatgg agaggaagac
      241 ctgaaggttc agcatagtag ctacagacag agggcccggc tgttgaagga ccagctctcc
      301 ctgggaaatg ctgcacttca gatcacagat gtgaaattgc aggatgcagg ggtgtaccgc
      361 tgcatgatca gctatggtgg tgccgactac aagcgaatta ctgtgaaagt caatgcccca
      421 tacaacaaaa tcaaccaaag aattttggtt gtggatccag tcacctctga acatgaactg
      481 acatgtcagg ctgagggcta ccccaaggcc gaagtcatct ggacaagcag tgaccatcaa
      541 gtcctgagtg gtaagaccac caccaccaat tccaagagag aggagaagct tttcaatgtg
      601 accagcacac tgagaatcaa cacaacaact aatgagattt tctactgcac ttttaggaga
      661 ttagatcctg aggaaaacca tacagctgaa ttggtcatcc cagaactacc tctggcacat
      721 cctccaaatg aaaggactca cttggtaatt ctgggagcca tcttattatg ccttggtgta
      781 gcactgacat tcatcttccg tttaagaaaa gggagaatga tggatgtgaa aaaatgtggc
      841 atccaagata caaactcaaa gaagcaaagt gatacacatt tggaggagac gtaatccagc
      901 attggaactt ctgatcttca agcagggatt ctcaacctgt ggtttagggg ttcatcgggg
      961 ctgagcgtga caagagga
//