LOCUS AY069961 885 bp mRNA linear HUM 13-AUG-2004 DEFINITION Homo sapiens lymphocyte effector toxicity activation ligand (LETAL) mRNA, complete cds. ACCESSION AY069961 VERSION AY069961.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 885) AUTHORS Conejo-Garcia,J.R., Benencia,F., Courreges,M.C., Khang,E., Zhang,L., Mohamed-Hadley,A., Vinocur,J.M., Buckanovich,R.J., Thompson,C.B., Levine,B. and Coukos,G. TITLE Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells JOURNAL Cancer Biol. Ther. 2 (4), 446-451 (2003) PUBMED 14508119 REFERENCE 2 (bases 1 to 885) AUTHORS Conejo-Garcia,J.R., Benencia,F., Courreges,M.C., Gimotty,P.A., Khang,E., Buckanovich,R.J., Frauwirth,K.A., Zhang,L., Katsaros,D., Thompson,C.B., Levine,B. and Coukos,G. TITLE Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells JOURNAL Cancer Res. 64 (6), 2175-2182 (2004) PUBMED 15026360 REFERENCE 3 (bases 1 to 885) AUTHORS Conejo-Garcia,J.-R., Zhang,L., Kang,E., Mohamed,A., Regnani,G., Benencia,F., Courrages,C., Vinacour,J. and Coukos,G. TITLE Direct Submission JOURNAL Submitted (12-DEC-2001) Center for Research on Reproduction & Women's Health, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6142, USA FEATURES Location/Qualifiers source 1..885 /db_xref="H-InvDB:HIT000084156" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6q25" /tissue_type="ovarian carcinoma" gene 1..885 /gene="LETAL" CDS 61..852 /gene="LETAL" /note="NKG2D-ligand" /codon_start=1 /product="lymphocyte effector toxicity activation ligand" /protein_id="AAL58090.1" /translation="MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSR PGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLR MLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVI NHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHW SSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS" BASE COUNT 230 a 204 c 226 g 225 t ORIGIN 1 accataccag tgagggtgaa tgtgtacacg cccagcttcc tgcctgttac tctccacagt 61 atgcgaagaa tatccctgac ttctagccct gtgcgccttc ttttgtttct gctgttgcta 121 ctaatagcct tggagatcat ggttggtggt cactctcttt gcttcaactt cactataaaa 181 tcattgtcca gacctggaca gccctggtgt gaagcgcagg tcttcttgaa taaaaatctt 241 ttccttcagt acaacagtga caacaacatg gtcaaacctc tgggcctcct ggggaagaag 301 gtatatgcca ccagcacttg gggagaattg acccaaacgc tgggagaagt ggggcgagac 361 ctcaggatgc tcctttgtga catcaaaccc cagataaaga ccagtgatcc ttccactctg 421 caagtcgaga tgttttgtca acgtgaagca gaacggtgca ctggtgcatc ctggcagttc 481 gccaccaatg gagagaaatc cctcctcttt gacgcaatga acatgacctg gacagtaatt 541 aatcatgaag ccagtaagat caaggagaca tggaagaaag acagagggct ggaaaagtat 601 ttcaggaagc tctcaaaggg agactgcgat cactggctca gggaattctt agggcactgg 661 gaggcaatgc cagaaccgac agtgtcacca gtaaatgctt cagatatcca ctggtcttct 721 tctagtctac cagatagatg gatcatcctg ggggcattca tcctgttagt tttaatggga 781 attgttctca tctgtgtctg gtggcaaaat ggtgagtggc aggctggtct ctggcccttg 841 aggacgtctt agtctggtaa ggactcaaga gaggtgaatc atggg //