LOCUS       AY069961                 885 bp    mRNA    linear   HUM 13-AUG-2004
DEFINITION  Homo sapiens lymphocyte effector toxicity activation ligand (LETAL)
            mRNA, complete cds.
ACCESSION   AY069961
VERSION     AY069961.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 885)
  AUTHORS   Conejo-Garcia,J.R., Benencia,F., Courreges,M.C., Khang,E.,
            Zhang,L., Mohamed-Hadley,A., Vinocur,J.M., Buckanovich,R.J.,
            Thompson,C.B., Levine,B. and Coukos,G.
  TITLE     Letal, A tumor-associated NKG2D immunoreceptor ligand, induces
            activation and expansion of effector immune cells
  JOURNAL   Cancer Biol. Ther. 2 (4), 446-451 (2003)
   PUBMED   14508119
REFERENCE   2  (bases 1 to 885)
  AUTHORS   Conejo-Garcia,J.R., Benencia,F., Courreges,M.C., Gimotty,P.A.,
            Khang,E., Buckanovich,R.J., Frauwirth,K.A., Zhang,L., Katsaros,D.,
            Thompson,C.B., Levine,B. and Coukos,G.
  TITLE     Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the
            survival and expansion of CD28- antitumor T cells
  JOURNAL   Cancer Res. 64 (6), 2175-2182 (2004)
   PUBMED   15026360
REFERENCE   3  (bases 1 to 885)
  AUTHORS   Conejo-Garcia,J.-R., Zhang,L., Kang,E., Mohamed,A., Regnani,G.,
            Benencia,F., Courrages,C., Vinacour,J. and Coukos,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-DEC-2001) Center for Research on Reproduction &
            Women's Health, University of Pennsylvania, 421 Curie Boulevard,
            Philadelphia, PA 19104-6142, USA
FEATURES             Location/Qualifiers
     source          1..885
                     /db_xref="H-InvDB:HIT000084156"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25"
                     /tissue_type="ovarian carcinoma"
     gene            1..885
                     /gene="LETAL"
     CDS             61..852
                     /gene="LETAL"
                     /note="NKG2D-ligand"
                     /codon_start=1
                     /product="lymphocyte effector toxicity activation ligand"
                     /protein_id="AAL58090.1"
                     /translation="MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSR
                     PGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLR
                     MLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVI
                     NHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHW
                     SSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS"
BASE COUNT          230 a          204 c          226 g          225 t
ORIGIN      
        1 accataccag tgagggtgaa tgtgtacacg cccagcttcc tgcctgttac tctccacagt
       61 atgcgaagaa tatccctgac ttctagccct gtgcgccttc ttttgtttct gctgttgcta
      121 ctaatagcct tggagatcat ggttggtggt cactctcttt gcttcaactt cactataaaa
      181 tcattgtcca gacctggaca gccctggtgt gaagcgcagg tcttcttgaa taaaaatctt
      241 ttccttcagt acaacagtga caacaacatg gtcaaacctc tgggcctcct ggggaagaag
      301 gtatatgcca ccagcacttg gggagaattg acccaaacgc tgggagaagt ggggcgagac
      361 ctcaggatgc tcctttgtga catcaaaccc cagataaaga ccagtgatcc ttccactctg
      421 caagtcgaga tgttttgtca acgtgaagca gaacggtgca ctggtgcatc ctggcagttc
      481 gccaccaatg gagagaaatc cctcctcttt gacgcaatga acatgacctg gacagtaatt
      541 aatcatgaag ccagtaagat caaggagaca tggaagaaag acagagggct ggaaaagtat
      601 ttcaggaagc tctcaaaggg agactgcgat cactggctca gggaattctt agggcactgg
      661 gaggcaatgc cagaaccgac agtgtcacca gtaaatgctt cagatatcca ctggtcttct
      721 tctagtctac cagatagatg gatcatcctg ggggcattca tcctgttagt tttaatggga
      781 attgttctca tctgtgtctg gtggcaaaat ggtgagtggc aggctggtct ctggcccttg
      841 aggacgtctt agtctggtaa ggactcaaga gaggtgaatc atggg
//