LOCUS AJ277832 2641 bp mRNA linear HUM 07-OCT-2008 DEFINITION Homo sapiens mRNA for inducible T-cell co-stimulator (ICOS gene). ACCESSION AJ277832 VERSION AJ277832.1 KEYWORDS ICOS gene; inducible T-cell co-stimulator. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2641) AUTHORS Hutloff A. JOURNAL Submitted (05-MAY-2000) to the INSDC. Hutloff A., Molecular Immunology, Robert Koch-Institut, Nordufer 20, Berlin, 13353, GERMANY. REFERENCE 2 AUTHORS Hutloff A., Dittrich A.M., Beier K.C., Eljaschewitsch B., Kraft R., Anagnostopoulos I., Kroczek R.A. TITLE ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 JOURNAL Nature 397(6716), 263-266(1999). PUBMED 9930702 REFERENCE 3 AUTHORS Beier K.C., Hutloff A., Dittrich A.M., Heuck C., Rauch A., Buechner K., Ludewig B., Ochs H.D., Mages H.W., Kroczek R.A. TITLE Induction, binding specificity and function of human ICOS JOURNAL Eur. J. Immunol. 30(12), 3707-3717(2000). PUBMED 11169414 FEATURES Location/Qualifiers source 1..2641 /db_xref="H-InvDB:HIT000246404" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="MOLT-4V" /cell_type="T-cell" /db_xref="taxon:9606" CDS 68..667 /gene="ICOS" /product="inducible T-cell co-stimulator" /function="immune response" /db_xref="GOA:Q9Y6W8" /db_xref="H-InvDB:HIT000246404.14" /db_xref="HGNC:HGNC:5351" /db_xref="InterPro:IPR013106" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR039943" /db_xref="UniProtKB/Swiss-Prot:Q9Y6W8" /citation=[2] /protein_id="CAC06612.1" /translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL" sig_peptide 68..124 /gene="ICOS" /citation=[2] mat_peptide 125..664 /gene="ICOS" /product="inducible T-cell co-stimulator" /citation=[2] BASE COUNT 743 a 556 c 516 g 826 t ORIGIN 1 cgagagcctg aattcactgt cagctttgaa cactgaacgc gaggactgtt aactgtttct 61 ggcaaacatg aagtcaggcc tctggtattt ctttctcttc tgcttgcgca ttaaagtttt 121 aacaggagaa atcaatggtt ctgccaatta tgagatgttt atatttcaca acggaggtgt 181 acaaatttta tgcaaatatc ctgacattgt ccagcaattt aaaatgcagt tgctgaaagg 241 ggggcaaata ctctgcgatc tcactaagac aaaaggaagt ggaaacacag tgtccattaa 301 gagtctgaaa ttctgccatt ctcagttatc caacaacagt gtctcttttt ttctatacaa 361 cttggaccat tctcatgcca actattactt ctgcaaccta tcaatttttg atcctcctcc 421 ttttaaagta actcttacag gaggatattt gcatatttat gaatcacaac tttgttgcca 481 gctgaagttc tggttaccca taggatgtgc agcctttgtt gtagtctgca ttttgggatg 541 catacttatt tgttggctta caaaaaagaa gtattcatcc agtgtgcacg accctaacgg 601 tgaatacatg ttcatgagag cagtgaacac agccaaaaaa tctagactca cagatgtgac 661 cctataatat ggaactctgg cacccaggca tgaagcacgt tggccagttt tcctcaactt 721 gaagtgcaag attctcttat ttccgggacc acggagagtc tgacttaact acatacatct 781 tctgctggtg ttttgttcaa tctggaagaa tgactgtatc agtcaatggg gattttaaca 841 gactgccttg gtactgccga gtcctctcaa aacaaacacc ctcttgcaac cagctttgga 901 gaaagcccag ctcctgtgtg ctcactggga gtggaatccc tgtctccaca tctgctccta 961 gcagtgcatc agccagtaaa acaaacacat ttacaagaaa aatgttttaa agatgccagg 1021 ggtactgaat ctgcaaagca aatgagcagc caaggaccag catctgtccg catttcacta 1081 tcatactacc tcttctttct gtagggatga gaattcctct tttaatcagt caagggagat 1141 gcttcaaagc tggagctatt ttatttctga gatgttgatg tgaactgtac attagtacat 1201 actcagtact ctccttcaat tgctgaaccc cagttgacca ttttaccaag actttagatg 1261 ctttcttgtg ccctcaattt tctttttaaa aatacttcta catgactgct tgacagccca 1321 acagccactc tcaatagaga gctatgtctt acattctttc ctctgctgct caatagtttt 1381 atatatctat gcatacatat atacacacat atgtatataa aattcataat gaatatattt 1441 gcctatattc tccctacaag aatatttttg ctccagaaag acatgttctt ttctcaaatt 1501 cagttaaaat ggtttacttt gttcaagtta gtggtaggaa acattgcccg gaattgaaag 1561 caaatttatt ttattatcct attttctacc attatctatg ttttcatggt gctattaatt 1621 acaagtttag ttctttttgt agatcatatt aaaattgcaa acaaaatcat ctttaatggg 1681 ccagcattct catggggtag agcagaatat tcatttagcc tgaaagctgc agttactata 1741 ggttgctgtc agactatacc catggtgcct ctgggcttga caggtcaaaa tggtccccat 1801 cagcctggag cagccctcca gacctgggtg gaattccagg gttgagagac tcccctgagc 1861 cagaggccac taggtattct tgctcccaga ggctgaagtc accctgggaa tcacagtggt 1921 ctacctgcat tcataattcc aggatctgtg aagagcacat atgtgtcagg gcacaattcc 1981 ctctcataaa aaccacacag cctggaaatt ggccctggcc cttcaagata gccttcttta 2041 gaatatgatt tggctagaaa gattcttaaa tatgtggaat atgattattc ttagctggaa 2101 tattttctct acttcctgtc tgcatgccca aggcttctga agcagccaat gtcgatgcaa 2161 caacatttgt aactttaggt aaactgggat tatgttgtag tttaacattt tgtaactgtg 2221 tgcttatagt ttacaagtga gacccgatat gtcattatgc atacttatat tatcttaagc 2281 atgtgtaatg ctggatgtgt acagtacagt actgaacttg taatttgaat ctagtatggt 2341 gttctgtttt cagctgactt ggacaacctg actggctttg cacaggtgtt ccctgagttg 2401 tttgcaggtt tctgtgtgtg gggtggggta tggggaggag aaccttcatg gtggcccacc 2461 tggcctggtt gtccaagctg tgcctcgaca catcctcatc cccagcatgg gacacctcaa 2521 gatgaataat aattcacaaa atttctgtga aatcaaatcc agttttaaga ggagccactt 2581 atcaaagaga ttttaacagt agtaagaagg caaagaataa acatttgata ttcagcaact 2641 g //