LOCUS AH011568 6107 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens chromosome 2 inducible costimulator (ICOS) gene, complete cds. ACCESSION AH011568 AF488346 AF488347 VERSION AH011568.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6107) AUTHORS Haaning Andersen,A.D., Lange,M. and Lillevang,S.T. TITLE Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation JOURNAL Tissue Antigens 61 (4), 276-285 (2003) PUBMED 12753665 REFERENCE 2 (bases 1 to 6107) AUTHORS Haaning Andersen,A.D., Lange,M. and Lillevang,S.T. TITLE Direct Submission JOURNAL Submitted (27-FEB-2002) Dept. of Clinical Immunology, Odense University Hospital, Sdr. Boulevard 29, Odense, DK 5000, Denmark COMMENT On or before Jun 10, 2016 this sequence version replaced AF488346.1, AF488347.1, AH011568.1. FEATURES Location/Qualifiers source 1..6107 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="2" /map="2q33" gene 1..6107 /gene="ICOS" mRNA join(1..125,391..726,1414..1520,2554..2638,4339..6107) /gene="ICOS" /product="inducible costimulator" exon 1..125 /gene="ICOS" /number=1 5'UTR 1..67 /gene="ICOS" CDS join(68..125,391..726,1414..1520,2554..2638,4339..4352) /gene="ICOS" /codon_start=1 /product="inducible costimulator" /protein_id="AAM00909.1" /translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL" gap 224..323 /estimated_length=unknown exon 391..726 /gene="ICOS" /number=2 exon 1414..1520 /gene="ICOS" /number=3 variation 1526 /gene="ICOS" /replace="t" variation 1646 /gene="ICOS" /replace="g" variation 1874 /gene="ICOS" /replace="g" variation 2297 /gene="ICOS" /replace="g" variation 2326 /gene="ICOS" /replace="t" exon 2554..2638 /gene="ICOS" /number=4 repeat_region 2703..2715 /gene="ICOS" /note="polymorphic" /rpt_unit_seq="t" variation 2735 /gene="ICOS" /replace="t" variation 2981 /gene="ICOS" /replace="t" variation 3491 /gene="ICOS" /replace="a" variation 3535^3536 /gene="ICOS" /replace="g" variation 3719 /gene="ICOS" /replace="t" repeat_region 4211..4232 /gene="ICOS" /note="polymorphic" /rpt_type=tandem /rpt_unit_seq="gt" variation 4313 /gene="ICOS" /replace="t" exon 4339..6107 /gene="ICOS" /number=5 variation 4349 /gene="ICOS" /replace="g" 3'UTR 4353..6107 /gene="ICOS" variation 4354 /gene="ICOS" /replace="c" variation 5211 /gene="ICOS" /replace="t" variation 5316 /gene="ICOS" /replace="c" variation 5376 /gene="ICOS" /replace="t" variation 5614 /gene="ICOS" /replace="g" variation 5759 /gene="ICOS" /replace="a" BASE COUNT 1801 a 1077 c 1239 g 1890 t ORIGIN 1 cgagagcctg aattcactgt cagctttgaa cactgaacgc gaggactgtt aactgtttct 61 ggcaaacatg aagtcaggcc tctggtattt ctttctcttc tgcttgcgca ttaaagtttt 121 aacaggtaag tggtgtattg aatatttctt attaagttat aattcaagta aacattaaga 181 aaaagcaaag gtagaaaaat tacgcaccca aaagacagtg gttnnnnnnn nnnnnnnnnn 241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 301 nnnnnnnnnn nnnnnnnnnn nnnaaaatat aattattagg gcaacattat aaaatgtcac 361 ttttgctttg ttttctttct ttttatgcag gagaaatcaa tggttctgcc aattatgaga 421 tgtttatatt tcacaacgga ggtgtacaaa ttttatgcaa atatcctgac attgtccagc 481 aatttaaaat gcagttgctg aaaggggggc aaatactctg cgatctcact aagacaaaag 541 gaagtggaaa cacagtgtcc attaagagtc tgaaattctg ccattctcag ttatccaaca 601 acagtgtctc tttttttcta tacaacttgg accattctca tgccaactat tacttctgca 661 acctatcaat ttttgatcct cctcctttta aagtaactct tacaggagga tatttgcata 721 tttatggtaa gacattgctt tcatcttcca aacttaagag tatatatatg ttttgacaac 781 ttttctcact aataaaatca attagacaaa taaatatctt ttgtgttgga gttcacttag 841 atgcagttga tggtaatcat ttataatgaa gatatacagg tgatgattta ctattaatca 901 taattagtat tattcagcaa tatgcaatgt aatcccatag actgctaagt cagaaataga 961 tcatattgcc ttttaaacac atatgctatt aaaaatcagg aaaaacatta agacaaatac 1021 ttaaacttat ggcttaataa tgggtattat ctctattcac ctaagattta aggtttggtt 1081 ttgcactgtg tttgtggaat gaagtatgat gattgaaaat catagtttta taacattact 1141 tttactatta cctcttttat aaaaatatag gcagaaaagc cctttctatt aaccacattt 1201 gtaaatacat tatatgcata atcttttaag ttttagttcc tggatccttg ccataatact 1261 gagatgatgt tagtctaata acttgcccac ttactggatt tcatgactat aataaagaaa 1321 agcttcattt gattaaatag ctcttttaaa tttggtaaga gaacttgtgg ttcagcagaa 1381 tttttcatta acataccttt ttttccaatc cagaatcaca actttgttgc cagctgaagt 1441 tctggttacc cataggatgt gcagcctttg ttgtagtctg cattttggga tgcatactta 1501 tttgttggct tacaaaaaag gtaagcgatt tctatctttc cttgtatctg ctttacagat 1561 gcacatcagt gattatttcc tcatcaaaag tacacatggc tcttgtcaga gtaatttgac 1621 caacagggag acaattcctt ccccccaaga catacctact aattaaacta atcacttgga 1681 acagaaattt atgtatttgt tttatagccc acacattcca aagaggactt gacttgatgg 1741 cttacagaga gttacattat tattattatt gttcaaacta gatgaggaaa ttgaggtcaa 1801 gagaagacta aaggtcagga ggaaggttaa aacatcaaaa tagatgactc tgatttttaa 1861 aaaattatta tgcatgggct gcgaatttga atccaaggtt cctgagaggc agggcagaga 1921 tgaaacaatt agttataagt tttgcttagc tggtaagtta aaaacagtca gcaagaaagc 1981 cttctaaggt gtcaattgta gctgagaagg aaattgacaa cttttttaca tggtaggtta 2041 ttagactcct tgcttttaaa gaaaaccact gaggagctat ttagaaagat aaacaacaat 2101 gacaacaaca aaaatctccc tgtgctgggg gatattcttt ttggtctctt gcattacagg 2161 ttctcaatca aagaactgac accactctgc atattacgcg agtatgctag tactcaagta 2221 tatccacagt gtggtcattg gccagtgtat atctgtggga gagtggaatt tggaaagaga 2281 cataaagaag gaagagaatg agatagcgcc catggtctaa gtctgctggg aaagaaacaa 2341 taaaggcaaa aacgaggaag aaagttcagt agaaagctct ttttatgtaa agcccttttc 2401 atattgtttt tctacttagc ctaaagccag gaacctaagt cacattatca tgtttttgtc 2461 acataccact tcaacaaaga atagaaaaca gtcaaaaaac aaagagatgg agaagaaaag 2521 atgaccaagc atgtttctgg ctttttcttt cagaagtatt catccagtgt gcacgaccct 2581 aacggtgaat acatgttcat gagagcagtg aacacagcca aaaaatctag actcacaggt 2641 atgactccat ttgggggttt gggaagggaa gaggtttctt cacagtaagc ctggaatgtt 2701 aatttttttt tttttaattt taaaggaaag gaaaacatct ccaaggccta attctagaat 2761 tttctgtgaa aatctggatt tctcactttt aactagattt atattttctg cagtatattg 2821 aaaacaaaca agcaataggt ttgtaagcca ctattgaaac taaacacaca aacagctcat 2881 aaaccaccat agtatcaagg caattttccc attgatgttt caaaagttgg gatgattcta 2941 agtgtttttt gttgaagggt tcattcagtc attcaatgag cgtttattga gcatcagtta 3001 agtgtgagtt actgagtgag gcactctggg gaatttggac agatatatgc taattttgga 3061 ctgagattag gaagagagat ctgtgctggt actgctagag ggaagaagga gaaattgatg 3121 aagatatctg gttattttga ggtaaagagt gtgcaagttt agagaacttg gatggcttta 3181 gaagtctcag taacatggaa atttgacctt ttctgttaag agtcagaaaa ctgaaagttg 3241 ccaagtttga ggagcaccca gaaagtttga agcttccatt gtggaaaatt catgtcttat 3301 gcccttgagg ttcgaatgat gtgcgatgtg taatgagaca gaagccactg catttttcca 3361 cccctcagtg gctacagatt atctaaaggg gacacacata gcttgcgttg tcatggaatt 3421 atagcatggg atgggagcta aaaaggatcc ttgagttcac atttcatgtt ttagatgaca 3481 gaaattgatg ctcaaagtgt tcagtgactc ttttggttcc ctagacagtt aatacctagc 3541 tttgacactt gcaaagagct tatgtttcat tactttgctg tttaaaaaat atatgatctc 3601 tcaatctctt tgcttaatgt gttctggctg tttggatccc cacaagcaga acctgacata 3661 aggacttggg tgcaagtagt ttatttggga ggtgatccca ggaagaaggg gtgagggggc 3721 agggagagtg agacagccaa caaggagaag caaatgaagg gcgcattatt atcaaggtct 3781 cagctccagg ccacagaggc ctgacttcat tggacctctg agaagtgtac agatgcctcc 3841 cagaatcatt ctcttgaagg atggcaacca ctggctccat cctcactgat ttggggttgc 3901 ctgcggaggg cattagcttt ccctcatctc tgagctgtgc ctctacttgg gatgagccta 3961 cttgggatga gtcttcagag aaagtctgga ggcagaaaag cagtgaaatg cagtggggct 4021 gttgtgctag aacagtcagc ccatgcagcg ctttctgccc cagcagcagc tgcaatcaga 4081 ggtggacagt ttcaaagtga tgagtttaga taatgtctgt tataggagtc gagagctaaa 4141 cttctctgga aatggggaac tggtgctggg tgttgaagca taaagatgag tttgcatggt 4201 gtgtgtgtga gtgtgtgtgt gtgtgtgtgt gcacgtgtgt gtttgtgtgt atgaaaggca 4261 atggagaggg gaaagcttct tgtagggaac tggcacatgg agagcattta gagaatttat 4321 gctgaatttt tgttacagat gtgaccctat aatatggaac tctggcaccc aggcatgaag 4381 cacgttggcc agttttcctc aacttgaagt gcaagattct cttatttccg ggaccacgga 4441 gagtctgact taactacata catcttctgc tggtgttttg ttcaatctgg aagaatgact 4501 gtatcagtca atggggattt taacagactg ccttggtact gccgagtcct ctcaaaacaa 4561 acaccctctt gcaaccagct ttggagaaag cccagctcct gtgtgctcac tgggagtgga 4621 atccctgtct ccacatctgc tcctagcagt gcatcagcca gtaaaacaaa cacatttaca 4681 agaaaaatgt tttaaagatg ccaggggtac tgaatctgca aagcaaatga gcagccaagg 4741 accagcatct gtccgcattt cactatcata ctacctcttc tttctgtagg gatgagaatt 4801 cctcttttaa tcagtcaagg gagatgcttc aaagctggag ctattttatt tctgagatgt 4861 tgatgtgaac tgtacattag tacatactca gtactctcct tcaattgctg aaccccagtt 4921 gaccatttta ccaagacttt agatgctttc ttgtgccctc aattttcttt ttaaaaatac 4981 ttctacatga ctgcttgaca gcccaacagc cactctcaat agagagctat gtcttacatt 5041 ctttcctctg ctgctcaata gttttatata tctatgcata catatataca cacatatgta 5101 tataaaattc ataatgaata tatttgccta tattctccct acaagaatat ttttgctcca 5161 gaaagacatg ttcttttctc aaattcagtt aaaatggttt actttgttca agttagtggt 5221 aggaaacatt gcccggaatt gaaagcaaat ttattttatt atcctatttt ctaccattat 5281 ctatgttttc atggtgctat taattacaag tttagttctt tttgtagatc atattaaaat 5341 tgcaaacaaa atcatcttta atgggccagc attctcatgg ggtagagcag aatattcatt 5401 tagcctgaaa gctgcagtta ctataggttg ctgtcagact atacccatgg tgcctctggg 5461 cttgacaggt caaaatggtc cccatcagcc tggagcagcc ctccagacct gggtggaatt 5521 ccagggttga gagactcccc tgagccagag gccactaggt attcttgctc ccagaggctg 5581 aagtcaccct gggaatcaca gtggtctacc tgcattcata attccaggat ctgtgaagag 5641 cacatatgtg tcagggcaca attccctctc ataaaaacca cacagcctgg aaattggccc 5701 tggcccttca agatagcctt ctttagaata tgatttggct agaaagattc ttaaatatgt 5761 ggaatatgat tattcttagc tggaatattt tctctacttc ctgtctgcat gcccaaggct 5821 tctgaagcag ccaatgtcga tgcaacaaca tttgtaactt taggtaaact gggattatgt 5881 tgtagtttaa cattttgtaa ctgtgtgctt atagtttaca agtgagaccc gatatgtcat 5941 tatgcatact tatattatct taagcatgtg taatgctgga tgtgtacagt acagtactga 6001 acttgtaatt tgaatctagt atggtgttct gttttcagct gacttggaca acctgactgg 6061 ctttgcacag gtgttccctg agttgtttgc aggtttctgt gtgtggg //