LOCUS       AH011568                6107 bp    DNA     linear   HUM 10-JUN-2016
DEFINITION  Homo sapiens chromosome 2 inducible costimulator (ICOS) gene,
            complete cds.
ACCESSION   AH011568 AF488346 AF488347
VERSION     AH011568.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6107)
  AUTHORS   Haaning Andersen,A.D., Lange,M. and Lillevang,S.T.
  TITLE     Allelic variation of the inducible costimulator (ICOS) gene:
            detection of polymorphisms, analysis of the promoter region, and
            extended haplotype estimation
  JOURNAL   Tissue Antigens 61 (4), 276-285 (2003)
   PUBMED   12753665
REFERENCE   2  (bases 1 to 6107)
  AUTHORS   Haaning Andersen,A.D., Lange,M. and Lillevang,S.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-FEB-2002) Dept. of Clinical Immunology, Odense
            University Hospital, Sdr. Boulevard 29, Odense, DK 5000, Denmark
COMMENT     On or before Jun 10, 2016 this sequence version replaced
            AF488346.1, AF488347.1, AH011568.1.
FEATURES             Location/Qualifiers
     source          1..6107
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33"
     gene            1..6107
                     /gene="ICOS"
     mRNA            join(1..125,391..726,1414..1520,2554..2638,4339..6107)
                     /gene="ICOS"
                     /product="inducible costimulator"
     exon            1..125
                     /gene="ICOS"
                     /number=1
     5'UTR           1..67
                     /gene="ICOS"
     CDS             join(68..125,391..726,1414..1520,2554..2638,4339..4352)
                     /gene="ICOS"
                     /codon_start=1
                     /product="inducible costimulator"
                     /protein_id="AAM00909.1"
                     /translation="MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKY
                     PDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHS
                     HANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCIL
                     ICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL"
     gap             224..323
                     /estimated_length=unknown
     exon            391..726
                     /gene="ICOS"
                     /number=2
     exon            1414..1520
                     /gene="ICOS"
                     /number=3
     variation       1526
                     /gene="ICOS"
                     /replace="t"
     variation       1646
                     /gene="ICOS"
                     /replace="g"
     variation       1874
                     /gene="ICOS"
                     /replace="g"
     variation       2297
                     /gene="ICOS"
                     /replace="g"
     variation       2326
                     /gene="ICOS"
                     /replace="t"
     exon            2554..2638
                     /gene="ICOS"
                     /number=4
     repeat_region   2703..2715
                     /gene="ICOS"
                     /note="polymorphic"
                     /rpt_unit_seq="t"
     variation       2735
                     /gene="ICOS"
                     /replace="t"
     variation       2981
                     /gene="ICOS"
                     /replace="t"
     variation       3491
                     /gene="ICOS"
                     /replace="a"
     variation       3535^3536
                     /gene="ICOS"
                     /replace="g"
     variation       3719
                     /gene="ICOS"
                     /replace="t"
     repeat_region   4211..4232
                     /gene="ICOS"
                     /note="polymorphic"
                     /rpt_type=tandem
                     /rpt_unit_seq="gt"
     variation       4313
                     /gene="ICOS"
                     /replace="t"
     exon            4339..6107
                     /gene="ICOS"
                     /number=5
     variation       4349
                     /gene="ICOS"
                     /replace="g"
     3'UTR           4353..6107
                     /gene="ICOS"
     variation       4354
                     /gene="ICOS"
                     /replace="c"
     variation       5211
                     /gene="ICOS"
                     /replace="t"
     variation       5316
                     /gene="ICOS"
                     /replace="c"
     variation       5376
                     /gene="ICOS"
                     /replace="t"
     variation       5614
                     /gene="ICOS"
                     /replace="g"
     variation       5759
                     /gene="ICOS"
                     /replace="a"
BASE COUNT         1801 a         1077 c         1239 g         1890 t
ORIGIN      
        1 cgagagcctg aattcactgt cagctttgaa cactgaacgc gaggactgtt aactgtttct
       61 ggcaaacatg aagtcaggcc tctggtattt ctttctcttc tgcttgcgca ttaaagtttt
      121 aacaggtaag tggtgtattg aatatttctt attaagttat aattcaagta aacattaaga
      181 aaaagcaaag gtagaaaaat tacgcaccca aaagacagtg gttnnnnnnn nnnnnnnnnn
      241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      301 nnnnnnnnnn nnnnnnnnnn nnnaaaatat aattattagg gcaacattat aaaatgtcac
      361 ttttgctttg ttttctttct ttttatgcag gagaaatcaa tggttctgcc aattatgaga
      421 tgtttatatt tcacaacgga ggtgtacaaa ttttatgcaa atatcctgac attgtccagc
      481 aatttaaaat gcagttgctg aaaggggggc aaatactctg cgatctcact aagacaaaag
      541 gaagtggaaa cacagtgtcc attaagagtc tgaaattctg ccattctcag ttatccaaca
      601 acagtgtctc tttttttcta tacaacttgg accattctca tgccaactat tacttctgca
      661 acctatcaat ttttgatcct cctcctttta aagtaactct tacaggagga tatttgcata
      721 tttatggtaa gacattgctt tcatcttcca aacttaagag tatatatatg ttttgacaac
      781 ttttctcact aataaaatca attagacaaa taaatatctt ttgtgttgga gttcacttag
      841 atgcagttga tggtaatcat ttataatgaa gatatacagg tgatgattta ctattaatca
      901 taattagtat tattcagcaa tatgcaatgt aatcccatag actgctaagt cagaaataga
      961 tcatattgcc ttttaaacac atatgctatt aaaaatcagg aaaaacatta agacaaatac
     1021 ttaaacttat ggcttaataa tgggtattat ctctattcac ctaagattta aggtttggtt
     1081 ttgcactgtg tttgtggaat gaagtatgat gattgaaaat catagtttta taacattact
     1141 tttactatta cctcttttat aaaaatatag gcagaaaagc cctttctatt aaccacattt
     1201 gtaaatacat tatatgcata atcttttaag ttttagttcc tggatccttg ccataatact
     1261 gagatgatgt tagtctaata acttgcccac ttactggatt tcatgactat aataaagaaa
     1321 agcttcattt gattaaatag ctcttttaaa tttggtaaga gaacttgtgg ttcagcagaa
     1381 tttttcatta acataccttt ttttccaatc cagaatcaca actttgttgc cagctgaagt
     1441 tctggttacc cataggatgt gcagcctttg ttgtagtctg cattttggga tgcatactta
     1501 tttgttggct tacaaaaaag gtaagcgatt tctatctttc cttgtatctg ctttacagat
     1561 gcacatcagt gattatttcc tcatcaaaag tacacatggc tcttgtcaga gtaatttgac
     1621 caacagggag acaattcctt ccccccaaga catacctact aattaaacta atcacttgga
     1681 acagaaattt atgtatttgt tttatagccc acacattcca aagaggactt gacttgatgg
     1741 cttacagaga gttacattat tattattatt gttcaaacta gatgaggaaa ttgaggtcaa
     1801 gagaagacta aaggtcagga ggaaggttaa aacatcaaaa tagatgactc tgatttttaa
     1861 aaaattatta tgcatgggct gcgaatttga atccaaggtt cctgagaggc agggcagaga
     1921 tgaaacaatt agttataagt tttgcttagc tggtaagtta aaaacagtca gcaagaaagc
     1981 cttctaaggt gtcaattgta gctgagaagg aaattgacaa cttttttaca tggtaggtta
     2041 ttagactcct tgcttttaaa gaaaaccact gaggagctat ttagaaagat aaacaacaat
     2101 gacaacaaca aaaatctccc tgtgctgggg gatattcttt ttggtctctt gcattacagg
     2161 ttctcaatca aagaactgac accactctgc atattacgcg agtatgctag tactcaagta
     2221 tatccacagt gtggtcattg gccagtgtat atctgtggga gagtggaatt tggaaagaga
     2281 cataaagaag gaagagaatg agatagcgcc catggtctaa gtctgctggg aaagaaacaa
     2341 taaaggcaaa aacgaggaag aaagttcagt agaaagctct ttttatgtaa agcccttttc
     2401 atattgtttt tctacttagc ctaaagccag gaacctaagt cacattatca tgtttttgtc
     2461 acataccact tcaacaaaga atagaaaaca gtcaaaaaac aaagagatgg agaagaaaag
     2521 atgaccaagc atgtttctgg ctttttcttt cagaagtatt catccagtgt gcacgaccct
     2581 aacggtgaat acatgttcat gagagcagtg aacacagcca aaaaatctag actcacaggt
     2641 atgactccat ttgggggttt gggaagggaa gaggtttctt cacagtaagc ctggaatgtt
     2701 aatttttttt tttttaattt taaaggaaag gaaaacatct ccaaggccta attctagaat
     2761 tttctgtgaa aatctggatt tctcactttt aactagattt atattttctg cagtatattg
     2821 aaaacaaaca agcaataggt ttgtaagcca ctattgaaac taaacacaca aacagctcat
     2881 aaaccaccat agtatcaagg caattttccc attgatgttt caaaagttgg gatgattcta
     2941 agtgtttttt gttgaagggt tcattcagtc attcaatgag cgtttattga gcatcagtta
     3001 agtgtgagtt actgagtgag gcactctggg gaatttggac agatatatgc taattttgga
     3061 ctgagattag gaagagagat ctgtgctggt actgctagag ggaagaagga gaaattgatg
     3121 aagatatctg gttattttga ggtaaagagt gtgcaagttt agagaacttg gatggcttta
     3181 gaagtctcag taacatggaa atttgacctt ttctgttaag agtcagaaaa ctgaaagttg
     3241 ccaagtttga ggagcaccca gaaagtttga agcttccatt gtggaaaatt catgtcttat
     3301 gcccttgagg ttcgaatgat gtgcgatgtg taatgagaca gaagccactg catttttcca
     3361 cccctcagtg gctacagatt atctaaaggg gacacacata gcttgcgttg tcatggaatt
     3421 atagcatggg atgggagcta aaaaggatcc ttgagttcac atttcatgtt ttagatgaca
     3481 gaaattgatg ctcaaagtgt tcagtgactc ttttggttcc ctagacagtt aatacctagc
     3541 tttgacactt gcaaagagct tatgtttcat tactttgctg tttaaaaaat atatgatctc
     3601 tcaatctctt tgcttaatgt gttctggctg tttggatccc cacaagcaga acctgacata
     3661 aggacttggg tgcaagtagt ttatttggga ggtgatccca ggaagaaggg gtgagggggc
     3721 agggagagtg agacagccaa caaggagaag caaatgaagg gcgcattatt atcaaggtct
     3781 cagctccagg ccacagaggc ctgacttcat tggacctctg agaagtgtac agatgcctcc
     3841 cagaatcatt ctcttgaagg atggcaacca ctggctccat cctcactgat ttggggttgc
     3901 ctgcggaggg cattagcttt ccctcatctc tgagctgtgc ctctacttgg gatgagccta
     3961 cttgggatga gtcttcagag aaagtctgga ggcagaaaag cagtgaaatg cagtggggct
     4021 gttgtgctag aacagtcagc ccatgcagcg ctttctgccc cagcagcagc tgcaatcaga
     4081 ggtggacagt ttcaaagtga tgagtttaga taatgtctgt tataggagtc gagagctaaa
     4141 cttctctgga aatggggaac tggtgctggg tgttgaagca taaagatgag tttgcatggt
     4201 gtgtgtgtga gtgtgtgtgt gtgtgtgtgt gcacgtgtgt gtttgtgtgt atgaaaggca
     4261 atggagaggg gaaagcttct tgtagggaac tggcacatgg agagcattta gagaatttat
     4321 gctgaatttt tgttacagat gtgaccctat aatatggaac tctggcaccc aggcatgaag
     4381 cacgttggcc agttttcctc aacttgaagt gcaagattct cttatttccg ggaccacgga
     4441 gagtctgact taactacata catcttctgc tggtgttttg ttcaatctgg aagaatgact
     4501 gtatcagtca atggggattt taacagactg ccttggtact gccgagtcct ctcaaaacaa
     4561 acaccctctt gcaaccagct ttggagaaag cccagctcct gtgtgctcac tgggagtgga
     4621 atccctgtct ccacatctgc tcctagcagt gcatcagcca gtaaaacaaa cacatttaca
     4681 agaaaaatgt tttaaagatg ccaggggtac tgaatctgca aagcaaatga gcagccaagg
     4741 accagcatct gtccgcattt cactatcata ctacctcttc tttctgtagg gatgagaatt
     4801 cctcttttaa tcagtcaagg gagatgcttc aaagctggag ctattttatt tctgagatgt
     4861 tgatgtgaac tgtacattag tacatactca gtactctcct tcaattgctg aaccccagtt
     4921 gaccatttta ccaagacttt agatgctttc ttgtgccctc aattttcttt ttaaaaatac
     4981 ttctacatga ctgcttgaca gcccaacagc cactctcaat agagagctat gtcttacatt
     5041 ctttcctctg ctgctcaata gttttatata tctatgcata catatataca cacatatgta
     5101 tataaaattc ataatgaata tatttgccta tattctccct acaagaatat ttttgctcca
     5161 gaaagacatg ttcttttctc aaattcagtt aaaatggttt actttgttca agttagtggt
     5221 aggaaacatt gcccggaatt gaaagcaaat ttattttatt atcctatttt ctaccattat
     5281 ctatgttttc atggtgctat taattacaag tttagttctt tttgtagatc atattaaaat
     5341 tgcaaacaaa atcatcttta atgggccagc attctcatgg ggtagagcag aatattcatt
     5401 tagcctgaaa gctgcagtta ctataggttg ctgtcagact atacccatgg tgcctctggg
     5461 cttgacaggt caaaatggtc cccatcagcc tggagcagcc ctccagacct gggtggaatt
     5521 ccagggttga gagactcccc tgagccagag gccactaggt attcttgctc ccagaggctg
     5581 aagtcaccct gggaatcaca gtggtctacc tgcattcata attccaggat ctgtgaagag
     5641 cacatatgtg tcagggcaca attccctctc ataaaaacca cacagcctgg aaattggccc
     5701 tggcccttca agatagcctt ctttagaata tgatttggct agaaagattc ttaaatatgt
     5761 ggaatatgat tattcttagc tggaatattt tctctacttc ctgtctgcat gcccaaggct
     5821 tctgaagcag ccaatgtcga tgcaacaaca tttgtaactt taggtaaact gggattatgt
     5881 tgtagtttaa cattttgtaa ctgtgtgctt atagtttaca agtgagaccc gatatgtcat
     5941 tatgcatact tatattatct taagcatgtg taatgctgga tgtgtacagt acagtactga
     6001 acttgtaatt tgaatctagt atggtgttct gttttcagct gacttggaca acctgactgg
     6061 ctttgcacag gtgttccctg agttgtttgc aggtttctgt gtgtggg
//