LOCUS AF233516 1553 bp mRNA linear HUM 04-OCT-2000 DEFINITION Homo sapiens PD-1-ligand precursor, mRNA, complete cds. ACCESSION AF233516 VERSION AF233516.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1553) AUTHORS Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T., Nishimura,H., Fitz,L.J., Malenkovich,N., Okazaki,T., Byrne,M.C., Horton,H.F., Fouser,L., Carter,L., Ling,V., Bowman,M.R., Carreno,B.M., Collins,M., Wood,C.R. and Honjo,T. TITLE Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation JOURNAL J. Exp. Med. 192 (7), 1027-1034 (2000) PUBMED 11015443 REFERENCE 2 (bases 1 to 1553) AUTHORS Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T., Nishimura,H., Fitz,L., Malenkovich,N., Okazaki,T., Byrne,M., Horton,H., Fouser,L., Carter,L., Carreno,B., Collins,M., Wood,C.R. and Honjo,T. TITLE Direct Submission JOURNAL Submitted (11-FEB-2000) Adult Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA FEATURES Location/Qualifiers source 1..1553 /db_xref="H-InvDB:HIT000074686" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="placenta" CDS 53..925 /codon_start=1 /product="PD-1-ligand precursor" /protein_id="AAG18508.1" /translation="MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPV EKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQIT DVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGY PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEE NHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQD TNSKKQSDTHLEET" sig_peptide 53..106 mat_peptide 107..922 /product="PD-1-ligand" BASE COUNT 467 a 312 c 384 g 390 t ORIGIN 1 cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa agatgaggat 61 atttgctgtc tttatattca tgacctactg gcatttgctg aacgcattta ctgtcacggt 121 tcccaaggac ctatatgtgg tagagtatgg tagcaatatg acaattgaat gcaaattccc 181 agtagaaaaa caattagacc tggctgcact aattgtctat tgggaaatgg aggataagaa 241 cattattcaa tttgtgcatg gagaggaaga cctgaaggtt cagcatagta gctacagaca 301 gagggcccgg ctgttgaagg accagctctc cctgggaaat gctgcacttc agatcacaga 361 tgtgaaattg caggatgcag gggtgtaccg ctgcatgatc agctatggtg gtgccgacta 421 caagcgaatt actgtgaaag tcaatgcccc atacaacaaa atcaaccaaa gaattttggt 481 tgtggatcca gtcacctctg aacatgaact gacatgtcag gctgagggct accccaaggc 541 cgaagtcatc tggacaagca gtgaccatca agtcctgagt ggtaagacca ccaccaccaa 601 ttccaagaga gaggagaagc ttttcaatgt gaccagcaca ctgagaatca acacaacaac 661 taatgagatt ttctactgca cttttaggag attagatcct gaggaaaacc atacagctga 721 attggtcatc ccagaactac ctctggcaca tcctccaaat gaaaggactc acttggtaat 781 tctgggagcc atcttattat gccttggtgt agcactgaca ttcatcttcc gtttaagaaa 841 agggagaatg atggatgtga aaaaatgtgg catccaagat acaaactcaa agaagcaaag 901 tgatacacat ttggaggaga cgtaatccag cattggaact tctgatcttc aagcagggat 961 tctcaacctg tggtttaggg gttcatcggg gctgagcgtg acaagaggaa ggaatgggcc 1021 cgtgggatgc aggcaatgtg ggacttaaaa ggcccaagca ctgaaaatgg aacctggcga 1081 aagcagagga ggagaatgaa gaaagatgga gtcaaacagg gagcctggag ggagaccttg 1141 atactttcaa atgcctgagg ggctcatcga cgcctgtgac agggagaaag gatacttctg 1201 aacaaggagc ctccaagcaa atcatccatt gctcatccta ggaagacggg ttgagaatcc 1261 ctaatttgag ggtcagttcc tgcagaagtg ccctttgcct ccactcaatg cctcaatttg 1321 ttttctgcat gactgagagt ctcagtgttg gaacgggaca gtatttatgt atgagttttt 1381 cctatttatt ttgagtctgt gaggtcttct tgtcatgtga gtgtggttgt gaatgatttc 1441 ttttgaagat atattgtagt agatgttaca attttgtcgc caaactaaac ttgctgctta 1501 atgatttgct cacatctagt aaaacatgga gtatttgtaa aaaaaaaaaa aaa //