LOCUS       AF233516                1553 bp    mRNA    linear   HUM 04-OCT-2000
DEFINITION  Homo sapiens PD-1-ligand precursor, mRNA, complete cds.
ACCESSION   AF233516
VERSION     AF233516.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
            Nishimura,H., Fitz,L.J., Malenkovich,N., Okazaki,T., Byrne,M.C.,
            Horton,H.F., Fouser,L., Carter,L., Ling,V., Bowman,M.R.,
            Carreno,B.M., Collins,M., Wood,C.R. and Honjo,T.
  TITLE     Engagement of the PD-1 immunoinhibitory receptor by a novel B7
            family member leads to negative regulation of lymphocyte activation
  JOURNAL   J. Exp. Med. 192 (7), 1027-1034 (2000)
   PUBMED   11015443
REFERENCE   2  (bases 1 to 1553)
  AUTHORS   Freeman,G.J., Long,A.J., Iwai,Y., Bourque,K., Chernova,T.,
            Nishimura,H., Fitz,L., Malenkovich,N., Okazaki,T., Byrne,M.,
            Horton,H., Fouser,L., Carter,L., Carreno,B., Collins,M., Wood,C.R.
            and Honjo,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-FEB-2000) Adult Oncology, Dana-Farber Cancer
            Institute, 44 Binney St., Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..1553
                     /db_xref="H-InvDB:HIT000074686"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="placenta"
     CDS             53..925
                     /codon_start=1
                     /product="PD-1-ligand precursor"
                     /protein_id="AAG18508.1"
                     /translation="MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPV
                     EKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQIT
                     DVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGY
                     PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEE
                     NHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQD
                     TNSKKQSDTHLEET"
     sig_peptide     53..106
     mat_peptide     107..922
                     /product="PD-1-ligand"
BASE COUNT          467 a          312 c          384 g          390 t
ORIGIN      
        1 cgaggctccg caccagccgc gcttctgtcc gcctgcaggg cattccagaa agatgaggat
       61 atttgctgtc tttatattca tgacctactg gcatttgctg aacgcattta ctgtcacggt
      121 tcccaaggac ctatatgtgg tagagtatgg tagcaatatg acaattgaat gcaaattccc
      181 agtagaaaaa caattagacc tggctgcact aattgtctat tgggaaatgg aggataagaa
      241 cattattcaa tttgtgcatg gagaggaaga cctgaaggtt cagcatagta gctacagaca
      301 gagggcccgg ctgttgaagg accagctctc cctgggaaat gctgcacttc agatcacaga
      361 tgtgaaattg caggatgcag gggtgtaccg ctgcatgatc agctatggtg gtgccgacta
      421 caagcgaatt actgtgaaag tcaatgcccc atacaacaaa atcaaccaaa gaattttggt
      481 tgtggatcca gtcacctctg aacatgaact gacatgtcag gctgagggct accccaaggc
      541 cgaagtcatc tggacaagca gtgaccatca agtcctgagt ggtaagacca ccaccaccaa
      601 ttccaagaga gaggagaagc ttttcaatgt gaccagcaca ctgagaatca acacaacaac
      661 taatgagatt ttctactgca cttttaggag attagatcct gaggaaaacc atacagctga
      721 attggtcatc ccagaactac ctctggcaca tcctccaaat gaaaggactc acttggtaat
      781 tctgggagcc atcttattat gccttggtgt agcactgaca ttcatcttcc gtttaagaaa
      841 agggagaatg atggatgtga aaaaatgtgg catccaagat acaaactcaa agaagcaaag
      901 tgatacacat ttggaggaga cgtaatccag cattggaact tctgatcttc aagcagggat
      961 tctcaacctg tggtttaggg gttcatcggg gctgagcgtg acaagaggaa ggaatgggcc
     1021 cgtgggatgc aggcaatgtg ggacttaaaa ggcccaagca ctgaaaatgg aacctggcga
     1081 aagcagagga ggagaatgaa gaaagatgga gtcaaacagg gagcctggag ggagaccttg
     1141 atactttcaa atgcctgagg ggctcatcga cgcctgtgac agggagaaag gatacttctg
     1201 aacaaggagc ctccaagcaa atcatccatt gctcatccta ggaagacggg ttgagaatcc
     1261 ctaatttgag ggtcagttcc tgcagaagtg ccctttgcct ccactcaatg cctcaatttg
     1321 ttttctgcat gactgagagt ctcagtgttg gaacgggaca gtatttatgt atgagttttt
     1381 cctatttatt ttgagtctgt gaggtcttct tgtcatgtga gtgtggttgt gaatgatttc
     1441 ttttgaagat atattgtagt agatgttaca attttgtcgc caaactaaac ttgctgctta
     1501 atgatttgct cacatctagt aaaacatgga gtatttgtaa aaaaaaaaaa aaa
//