LOCUS       AF216749                 909 bp    mRNA    linear   HUM 07-MAR-2001
DEFINITION  Homo sapiens B7-related protein-1 mRNA, complete cds.
ACCESSION   AF216749
VERSION     AF216749.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 909)
  AUTHORS   Yoshinaga,S.K., Zhang,M., Pistillo,J., Horan,T., Khare,S.D.,
            Miner,K., Sonnenberg,M., Boone,T., Brankow,D., Dai,T., Delaney,J.,
            Han,H., Hui,A., Kohno,T., Manoukian,R., Shih,G., Whoriskey,J.S. and
            Coccia,M.A.
  TITLE     Characterization of a new human B7-related protein: B7RP-1 is the
            ligand to the co-stimulatory protein ICOS
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 909)
  AUTHORS   Yoshinaga,S.K., Whoriskey,J.S. and Dai,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-DEC-1999) Molecular Biology, Amgen Inc., One Amgen
            Center Drive, Thousand Oaks, CA 91320, USA
FEATURES             Location/Qualifiers
     source          1..909
                     /db_xref="H-InvDB:HIT000074150"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_type="lymphocyte"
                     /tissue_type="peripheral blood"
     CDS             1..909
                     /function="T-cell co-stimulatory functions through ICOS"
                     /note="B7RP-1; similar to CD80 and CD86; does not interact
                     with CTLA-4 or CD28"
                     /codon_start=1
                     /product="B7-related protein-1"
                     /protein_id="AAK16241.1"
                     /translation="MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSR
                     FDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFN
                     VTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTS
                     INGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIE
                     NVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWV
                     CRDRCLQHSYAGAWAVSPETELTGHV"
BASE COUNT          205 a          257 c          266 g          181 t
ORIGIN      
        1 atgcggctgg gcagtcctgg actgctcttc ctgctcttca gcagccttcg agctgatact
       61 caggagaagg aagtcagagc gatggtaggc agcgacgtgg agctcagctg cgcttgccct
      121 gaaggaagcc gttttgattt aaatgatgtt tacgtatatt ggcaaaccag tgagtcgaaa
      181 accgtggtga cctaccacat cccacagaac agctccttgg aaaacgtgga cagccgctac
      241 cggaaccgag ccctgatgtc accggccggc atgctgcggg gcgacttctc cctgcgcttg
      301 ttcaacgtca ccccccagga cgagcagaag tttcactgcc tggtgttgag ccaatccctg
      361 ggattccagg aggttttgag cgttgaggtt acactgcatg tggcagcaaa cttcagcgtg
      421 cccgtcgtca gcgcccccca cagcccctcc caggatgagc tcaccttcac gtgtacatcc
      481 ataaacggct accccaggcc caacgtgtac tggatcaata agacggacaa cagcctgctg
      541 gaccaggctc tgcagaatga caccgtcttc ttgaacatgc ggggcttgta tgacgtggtc
      601 agcgtgctga ggatcgcacg gacccccagc gtgaacattg gctgctgcat agagaacgtg
      661 cttctgcagc agaacctgac tgtcggcagc cagacaggaa atgacatcgg agagagagac
      721 aagatcacag agaatccagt cagtaccggc gagaaaaacg cggccacgtg gagcatcctg
      781 gctgtcctgt gcctgcttgt ggtcgtggcg gtggccatag gctgggtgtg cagggaccga
      841 tgcctccaac acagctatgc aggtgcctgg gctgtgagtc cggagacaga gctcactggc
      901 cacgtttga
//