LOCUS AF142145 10640 bp DNA linear ROD 08-OCT-1999
DEFINITION Mus musculus cytotoxic T-lymphocyte associated molecule 4 (Ctla4)
gene, complete cds.
ACCESSION AF142145
VERSION AF142145.1
KEYWORDS .
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 10640)
AUTHORS Ling,V., Wu,P.W., Finnerty,H.F., Sharpe,A.H., Gray,G.S. and
Collins,M.
TITLE Complete sequence determination of the mouse and human CTLA4 gene
loci: cross-species DNA sequence similarity beyond exon borders
JOURNAL Genomics 60 (3), 341-355 (1999)
PUBMED 10493833
REFERENCE 2 (bases 1 to 10640)
AUTHORS Ling,V., Wu,P.W., Finnerty,H.F., Sharpe,A.H., Gray,G.S. and
Collins,M.
TITLE Direct Submission
JOURNAL Submitted (12-APR-1999) Immunology, Genetics Institute, 87
Cambridge Park Drive, Cambridge, MA 02140, USA
FEATURES Location/Qualifiers
source 1..10640
/organism="Mus musculus"
/mol_type="genomic DNA"
/strain="129/SvJ"
/db_xref="taxon:10090"
gene <1050..>6592
/gene="Ctla4"
mRNA join(<1050..1158,4302..4649,5098..5207,6488..>6592)
/gene="Ctla4"
/product="cytotoxic T-lymphocyte associated molecule 4"
CDS join(1050..1158,4302..4649,5098..5207,6488..6592)
/gene="Ctla4"
/note="CTLA4; CTLA-4; CD152"
/codon_start=1
/product="cytotoxic T-lymphocyte associated molecule 4"
/protein_id="AAF01489.1"
/translation="MACLGLRRYKAQLQLPSRTWPFVALLTLLFIPVFSEAIQVTQPS
VVLASSHGVASFPCEYSPSHNTDEVRVTVLRQTNDQMTEVCATTFTEKNTVGFLDYPF
CSGTFNESRVNLTIQGLRAVDTGLYLCKVELMYPPPYFVGMGNGTQIYVIDPEPCPDS
DFLLWILVAVSLGLFFYSFLVTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPY
FIPIN"
BASE COUNT 2936 a 2161 c 2292 g 3251 t
ORIGIN
1 gaattctggt aatatatatc cttagttttg gtggtgctgg gaattgaacc tcaggtctac
61 tgcatactag gcaagtattc taccactgag ctacatctat acctctgagc tgtgtcttca
121 ttgctgaggt atatgaacta cgtctctatc actgagctgt gcctccaagt tttaagtttc
181 tacctttgaa aatttttact atttttttta aaagcccatc ctcctgtgga ggttttaaat
241 gtcttttcat ttggattgac tttctctggg ccatccacaa ctttattttg ccgttgttac
301 agttttaaaa gcatctggtt tatttcccaa cggacaaaac cagaggcccc tttccctgtt
361 ttgtgtgtgt gtgtttgtgt gtgcatatgt gtgcatgcat gtgcatgtac aaatgtgtgt
421 gtgtctttca tttcttgtga ttttggcatt tttctctcag taaaatacta agtggagtta
481 ggcaaaaata aacccttttg tgtactgagg ggctcataga aggacacaat ttttcttggt
541 gccttccaaa gagaaattca gacatcagct ccaggactaa gagggatggc catgggacgc
601 taagtaagag tactggggga ttaaagatga ccagatgact ggataaagtt gggactggga
661 tttagggatt ccttgtacta cagaaattat actctccaag actccacgtc tccaggtcct
721 cagaggtgac tcgaagcttc agtttcaagt tgagtacatt ttccatccat ggatttgctt
781 gttttgttca gttttagttt gaatatttga ggtcgtcttt acgacgtaac agctaaaccc
841 acggcttcct ttctcgtaaa accaaaacaa aaaggctctc tgttcaggtg tcctgtgtgt
901 gcactacaca tatgtagcac gtaccttgga tcaaagctgt ctatataaag tccccgagtc
961 tgtgtgggtt caaacacatc tcaaggcttc tggatcctgt tgggttttac tctgctccct
1021 gaggacctca gcacatttgc cccccagcca tggcttgtct tggactccgg aggtacaaag
1081 ctcaactgca gctgccttct aggacttggc cttttgtagc cctgctcact cttcttttca
1141 tcccagtctt ctctgaaggt gagtggagac ttctggaaca tggaggtgga ggaggtgttt
1201 ttcctacatg ggtttcgttt tttttttttc tttcagaagc tgaggacagt gatttataga
1261 aatgccagaa gttaaagcca aaccctctac tttttggttt aacagcttcc tacagacaag
1321 ttccaagaag aatataggag gtctagcagt agcgaaggag ctgagactag ccacagcagc
1381 ttgctgggat ctcagctggg acttaaggaa ccatgagagt tccttaagtc ccatatgggg
1441 gagaacaagt tctttgtcac tgctagaaaa tcctgtaaag ttaagagatt taaggggggc
1501 atttgaaatc gtgagtacat ttgatcttga tatcacagta acattaaggt ttttctcctt
1561 acccccaatc ccacccccaa aacttaccta aattcaaata aataagaagt tttcctcatt
1621 cactttaaga ttttgagaca ctcttagttc tttaaattat cacacctaag gcttagggga
1681 catagcagaa gagggggcag aaagactatg agagccaaag gtacatagag tttactgaga
1741 gattgtgtct cttaggatgt caaatggtac acccataaag tctcaccaac acgactgcct
1801 aaacttgagc tgaataagga catgaataac aatagacata cccaagtgga tggggaaaga
1861 ccaagatgct tcagcactat agcaataact acaggaagcc aaggaatatg gagagtagga
1921 aattgccaag ggaaaagcac accagctgac tatccaataa catatggtca gccttcaaaa
1981 caaaaagcaa ataacatata gaatgggcag gtttcattaa gaatgactat aactatagtc
2041 tgtgcatatc acaacaaata atgaaaaggg gggccatgaa tttgaaagaa aagcaaggag
2101 gggtacatga gaaggtttgg aggagagaaa ggagaaataa tgtaattata ttaatctcaa
2161 agaatagaag aagtagtaag taaagggaaa ataaattagt taattatttt aaagatggaa
2221 tagttttaag tcgaaggaag aaagaaaggc aaagtgatag aaagacaaga aaaggggagg
2281 aaggaagaga gaagagagga aggaagaaag gaaggaagga aggaagggag gaagggaggg
2341 aaaaagaaag aagagagaag ggaggaggac aggaaggagg gagggaggga gggaggaagg
2401 gagaaaggga gaaaggaaga aaacaattat cagctttttg gcctaagagt ctttttatta
2461 ttttttttct tcataaaatc cttaattgtt tcattaacta tccatggatt tttaagtacg
2521 aatccctgtt ttttcagatg aaatagaaac ttttgaaagg ctaataccag gcttgttatg
2581 tgccttgaga tgtacatatc tactggaccc tgagcatctc tctctagatc ttttaaatta
2641 agaaatcaca tagtttgtgt gacactgatg cacaaatgat atttgataat ctaattttac
2701 taaataagtc atggacagtt tcttgtctga ataggccaca aaaactttaa tgtgggagag
2761 aacatttttt aaacactcta gtggggtttc catgagcaaa gggtgcttgc agaaagtctc
2821 tgatagtaga gatgaaggct aggcagacac ctgctgtttc acccgctaag ctgatggagt
2881 aaccatggca actgccacca tattgttctc ttttctgagg acagatgcta atcagtacag
2941 gtgctttcag aagagactag ggtatctata tagcctggtt tatggatagg agaggtggtc
3001 ttggaaacta agcctggggt agtattcaag attgcaatac actgaaaact aattattgtc
3061 ttgtttttac aatctatgtt agtaaactac caatgacatt gttcagttta agttttgggt
3121 gtaatcttca atactgaccg gaaaacatcc aggttagtta tgaaaaggca atatgacaga
3181 aagccacttt tgtgtgctga gagtacaacc cgagatcgtg tgtattctag gcaagcactc
3241 taccaccgac ctacatctcc agcccttctg cctgtggttc tttgtcttgt aaagcaatgt
3301 cttgttgttt agctgatgct ggccttgcac ttgctatgta gccttcatct gctggctgct
3361 aggactgcag atttgtacca ccaataccgg actgcaaacc cactaatttc taatgatgaa
3421 ggcatgtttg tatagagagc tggactcctt tcttctgtag tatacaggga ggaaagagaa
3481 aacaacaaaa acagcagcag cagcagcagc aacaacaaca acaacaaaaa ccccaaggac
3541 aaggaaagtg ttaagtgaag gaaagaaggg aggcagaaga ggtggcaggg aagcagggga
3601 agcccacaga agttaaagca gggttgtctc aacccagaga ggaaatgacc ctggtgccct
3661 cagctctgtg gcttccttga ctgatgtata caccactcta ccacagtgat gccaggaaaa
3721 gggtgaccaa tgcattgacc tgaggttcaa ctgctcctgg ttgacagagg tacgcttata
3781 aataagtagg taggaaaatt ttgaagctta ctttgagaga tgaggcaagg ttctgcacct
3841 caagctccag gaatgtctcg actgccattc actatgtttc ctgcgtgata tagttctatt
3901 atcaccaaag aaggcgctgt actgacatgt aggctacccc cttttcttac tgcaggggag
3961 aataaatgaa aggaagaatt atttgccaaa atgacacatt ttatgagagc cagatcttct
4021 ttttgctata ccagtattct ccttgccata gccaactgtc ttcaataaac tatcaataag
4081 gggatcttgg agagtgactg actacagctg aaagatggga agtggagtgc cagggtggat
4141 gggtggagag gcaaagggtg aagggagtga tgagtttgtt gaggggtgag cttgcaggag
4201 ttcatccaag atgaacctcc cctggcctca ggtgtggcct aatagttcaa accgtggatg
4261 atcatgagcc cactaagtgc cctttggact ttccatgtca gccatacagg tgacccaacc
4321 ttcagtggtg ttggctagca gccatggtgt cgccagcttt ccatgtgaat attcaccatc
4381 acacaacact gatgaggtcc gggtgactgt gctgcggcag acaaatgacc aaatgactga
4441 ggtctgtgcc acgacattca cagagaagaa tacagtgggc ttcctagatt accccttctg
4501 cagtggtacc tttaatgaaa gcagagtgaa cctcaccatc caaggactga gagctgttga
4561 cacgggactg tacctctgca aggtggaact catgtaccca ccgccatact ttgtgggcat
4621 gggcaacggg acgcagattt atgtcattgg tgagcaaagc cattccacta agaacaagtc
4681 tgttgcatta ttattgtctt tacaccagaa tagttttgtt ccttggtttg gagtccttca
4741 tagttaggtc tgtgatgcat agctaggaat tccctagtag atagtagtct tgcttatact
4801 gagaagttac ataaccatca ctctgattgc aatgaaacgc atttggggat gtgtttttta
4861 tactgcttgc tgatagtcta ggacacttgt tcttgaagtt tagtcttgtc cctttgatgg
4921 cactctggga aagtcatgta ttaaataagt agccagactt ccctatagtt taccaataca
4981 agttagggtt gactagcaaa acctggaacc tctaacttcc ttttactacc catgaggaac
5041 taggacccca caattggaaa ctctctcagg aggttgatgc ttcgtcttct gttgcagatc
5101 cagaaccatg cccggattct gacttcctcc tttggatcct tgtcgcagtt agcttggggt
5161 tgttttttta cagtttcctg gtcactgctg tttctttgag caagatggtg agtgtgatgt
5221 tgacgtttcc ccacagttaa tggggatact tttagttgta ccctactgac caattggtgt
5281 tgagttgaag caataaacaa ggagcaggaa ggatagggta aagaacacgc tagaacccca
5341 tgcacttgcc ttagaggttt cgggatgact aatactgtac gtgagcatgt ttgacagtga
5401 atgtttgtgt gcttctgagc agggtttcag tttgagtaac tgtttgaaca acatggagca
5461 gctgttttgg ttgtcactgt catggcaatg tccttaatcc taggacacac agcagtctct
5521 gggcaaccct ttctagttag aaccacctag atggattttt gtcctttacc aagcaccatc
5581 tcttggtccc tcttgtgtct tctttgttca aggcatagat acttgtagaa tacccatccc
5641 cattatctat gtacttactt accttgcctt gatgccctcc ctagctcagt gaatgaaagc
5701 ccttgttttt atttagtata ttggcagtga aaagagagaa gtgtagaatc aagtctccag
5761 tcagggttct gaacagtcct ccaccatgtc tgtgtaaggc tggctttcct tatcacaagc
5821 aatatccttt gaccccatct cttctcttct ttttcttact cttcctactc ctccattttc
5881 ctcatctctc tacctttgcc actttctgta tctctttctg catctatatt cacacacaca
5941 cacacacaca cacacacaca cacacacaca cacatacaca cacactttca cagaatcttt
6001 gttctgttgc tgtcttcctt ttttatctac cattaagcta ccacccaggc tggctgacta
6061 gacatccatt gttgaagtgt tgaggtgaca gagactggaa actaacacag acaaagaaaa
6121 agcactaaca aacataagag gaatggagat gcagaattca gcttcaaagc aggttatcag
6181 agccaccttc aaatatttca ggtgctttga ttaccacaga cacgatctag ccaactatct
6241 tgggcatttt ggttgttctt ggtgaagttg tctcaaagcc cctttctccc ttttgcagaa
6301 ttatttatct aaggtgaatt tgactagctc agttaagaaa atctcccaga gtttataatt
6361 ctgtatgtcg ttgtggatgt tttatttttg ctggggaggg acccgatatt tactgggtcc
6421 tattatgatt gcaattggct tctatattct ttgataataa ttgcctttta aaaaatgttt
6481 tttgcagcta aagaaaagaa gtcctcttac aacaggggtc tatgtgaaaa tgcccccaac
6541 agagccagaa tgtgaaaagc aatttcagcc ttattttatt cccatcaact gaaaggccgt
6601 ttatgaagaa gaaggagcat acttcagtct ctaaaagctg aggcaatttc aactttcctt
6661 ttctctccag ctatttttac ctgtttgtat attttaagga gagtatgcct ctctttaata
6721 gaaagctgga tgcaaaattc caattaagca tactacaatt taaagctaag gagcatgaac
6781 agagagctgg gatatttctg ttgtgtcaga accattttac taaaagcatc acttggaagc
6841 agcataagga tatagcatta tggtgtgggg tcaagggaac attagggaat ggcacagccc
6901 aaagaaagga agggggtgaa ggaagagatt atattgtaca catcttgtat ttacctgaga
6961 gatgtttatg acttaaataa tttttaaatt tttcatgctg ttattttctt taacaatgta
7021 taattacacg aaggtttaaa catttattca cagagctatg tgacatagcc agtggttcca
7081 aaggttgtag tgttccaaga tgtattttta agtaatattg tacatgggtg tttcatgtgc
7141 tgttgtgtat ttgctggtgg tttgaatata aacactatgt atcagtgtcg tcccacagtg
7201 ggtcctgggg aggtttggct ggggagctta ggacactaat ccatcaggtt ggactcgagg
7261 tcctgcacca actggcttgg aaactagatg aggctgtcac agggctcagt tgcataaacc
7321 gatggtgatg gagtgtaaac tgggtcttta cactcatttt attttttgtt tctgcttttg
7381 ttttcttcaa tgatttgcaa ggaaaccaaa agctggcagt gtttgtatga acctgacaga
7441 acactgtctt caaggaaatg cctcattcct gagaccagta ggtttgtttt tttaggaagt
7501 tccaatacta ggacccccta caagtactat ggctcctcga aaacacaaag ttaatgccac
7561 aggaagcagc agatggtagg atgggatgca caagagttcc tgaaaactaa cactgttagt
7621 gttttttttt taactcaata ttttccatga aaatgcaacc acatgtataa tatttttaat
7681 taaataaaag tttcttgtga ttgttttatg ggctgcccaa tttatcagct ttgtttttaa
7741 gtgtagtgtt tgtgtttggt tttgaaaaat gttttcaatt acgtgtgtct gtgtgtggat
7801 atgcacagat gtgtgtaggt gcccctgagg tgtgggatat ccctagagct ggagttacaa
7861 gtggttgtca gctgcctgat atcagtgctg ggaatccaac tcctgtcttc tgtaagagca
7921 gtgtgctccc ctaactcctg aaccagctct ccagcccctg catttgtttt ttatggattc
7981 attcagcact aagtagagcc ttttatgcta aaaatcctgg aaacaaactg gatcagtgaa
8041 aagaggaaaa gaatattcta tggatcagcc atgtaccagc cgttatctga agcccattcc
8101 tggaaagagt ctatcatgta ctcttaattt cttctttttg gataaaattc aggcacaacc
8161 atcctttaaa ctttacacgc agttctcttt atccagattc cccacttcct ctttcttacc
8221 cgcagtttca ctaactgatt actgttgcca taacagctcc cagggctgtt agatgttcct
8281 cccgtggctg ttttgattag tcttcattgt aaatggagag ttcccctgtg tcttagatat
8341 ggacgatttt acagacgtag aggaaacata tctactcttc tgtgttatta acaacactca
8401 agatttgggc caattcaagt ttctctgatt cttggttcac caaggtgtac cattagcctg
8461 attagtgtca cgtaaagttt ctcattcttg acctccacat cctgttattg tcatgtgcag
8521 cattctttgt gtggttggag accacctgtt actgaacacg ttggaacact tgccacagac
8581 gctggctcag ggccttgact ctctgtgctc tgactcagag gcttcggatg gcgaggctct
8641 ggaaatctcc cagaagctcc tagtgttttc tttctcatga tcacttaggt ggctttcttt
8701 acctatgtct ctctctgtgt gtctctgtct gtctgtccct gtctctccgt ctctctccct
8761 gtgtctttgt ctctttgtca gtatctctct ctctcccatt tgctcactct tgcacacaca
8821 cagctcccca aagtcctaac aaatgagaca gctactgtaa gcattccaga aaggcttgcc
8881 aagtaaaaac aaacagatgt ttccatacag ggttgtggtt attacctaaa acatgctggt
8941 ataacacggg aggctctgct tcctgctctc ttggtctttg gttgatatcc ttgatgaaat
9001 atgtaaatgt ctttcagctc caaatatctc taggcaaatt tcaacagtaa tatgtctcaa
9061 tggccaaagg accatggaca cataaaagct ttttctaaca gctatttcgt ttacctttag
9121 caatcagaaa gggacattgt cttgagacca gaagactggc cttatctttg tattccaacc
9181 catgtagctc tgggaacagg tctcaagaaa gcctaaatat tccatgtgtc taaatgaaac
9241 ctagtctatt atacacagga agccctgact ttcagacaca gatgtagatg acaggggagt
9301 gagacagaac tctcagggct gcagaattgg cttcatctcc ttaccaccca agcacatgcc
9361 tttattcatt ttttccagtt atgataacct catttctgct atttctattt ctctatcttt
9421 atctctaagt atatttattt aaaactcctg tttgtgtgtt ttcacatgca cacgtggtgt
9481 gtaagtccag tgtgtgtgtg gtgtgtacca cagtgtctat ggaggtcaga gaacagcctc
9541 aggtattgtc ccttaccttt cctccttttt gagacaggtc tttgttgtgt gacactgtgt
9601 gccaagtctc actgacccag gagactcccg tctcacagga acactgggaa tccaggatgg
9661 gttaccgcat ttagcctcac atggcgtcca gtggtccaaa cgactagtac ttgcgtagca
9721 aggctctgtc cattgagtca ttttcctagt cttctcctaa tatctcaacc cccatcctcg
9781 tgcttaagat tactggcact ttaagcccac acaaatcccc cttttctgtt tcacagccac
9841 ctttggtttc acctctaata gtttcaagta tgcctgaatt ttatgcctag cttgaatgaa
9901 gccctctagg gatcctcaca gctttaggca tactggagat gctctagcca aaggcctaaa
9961 gtgctgggga cctaggctct ctgggacttt gggagggata actgtcctct actaaaaagc
10021 tttctgtgtt ttattgagta gttcagtcta atctccattc ctctgataag aaaatctctg
10081 tatgagttaa ttcatcttgt cttaaacctt taagattctg gagtatgagt tcaatgccca
10141 ccacattcta catttgtgtc atgttctcaa tcattttatg ggaagaatac tctcaatttt
10201 atgatctcct tctccaattg ttaaagccga ctaaatttat ttgtactcca gcagagactc
10261 ttcaatggcc atattagaca catacctagt ttaagcttaa ctgggattgc atttgcaaaa
10321 tattgatgtc attatgctgt taacttacaa gtccaaggaa tcatgttggg agatcacaaa
10381 taaaagaggc aatgattctt gaagcgtagt tgccatggct acacttctct tttgagggtc
10441 atgtctcctt agagcccatg ctttattgcc tatatacttt cttctttctc agttcagatc
10501 aacttcctct atcctatctg tccagagcta tgccagtgta tggatgagag agaggagagg
10561 tttctctttc ttatatgctt acttggttat gactatgata gacattaata ggtaagttta
10621 ccacattctt tatggaattc
//