LOCUS AF141305 2187 bp mRNA linear HUM 25-SEP-2000
DEFINITION Homo sapiens serine protease Htra2 mRNA, alternatively spliced,
complete cds.
ACCESSION AF141305
VERSION AF141305.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2187)
AUTHORS Gray,C.W., Ward,R.V., Karran,E., Turconi,S., Rowles,A.,
Viglienghi,D., Southan,C., Barton,A., Fantom,K.G., West,A.,
Savopoulos,J., Hassan,N.J., Clinkenbeard,H., Hanning,C.,
Amegadzie,B., Davis,J.B., Dingwall,C., Livi,G.P. and Creasy,C.L.
TITLE Characterization of human HtrA2, a novel serine protease involved
in the mammalian cellular stress response
JOURNAL Eur. J. Biochem. 267 (18), 5699-5710 (2000)
PUBMED 10971580
REFERENCE 2 (bases 1 to 2187)
AUTHORS Creasy,C.L., Southan,C.D., Livi,G.P., Clinkenbeard,H., Browne,M.
and Eric Karran.
TITLE Direct Submission
JOURNAL Submitted (08-APR-1999) Comparative Genetics, SmithKline Beecham
Pharmaceuticals, Inc., 709 Swedeland Road, King of Prussia, PA
19406, USA
FEATURES Location/Qualifiers
source 1..2187
/db_xref="H-InvDB:HIT000071154"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p13"
/tissue_type="brain"
/dev_stage="fetus; adult"
CDS 603..1979
/note="alternatively spliced"
/codon_start=1
/product="serine protease Htra2"
/protein_id="AAF66596.1"
/translation="MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTS
DPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTR
SRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPA
VVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEA
VVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVS
SAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIP
SDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVL
IHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTL
YVTPEVTE"
BASE COUNT 424 a 635 c 700 g 428 t
ORIGIN
1 cgtggatccc gagaaagagg cgcaggacga ggaggcagaa cccgactggc gcgtagagca
61 gcagcacgag cagtaggaag cagtcacccg gaagcctggg ggcgagaggc gaagtggtca
121 ggcgccgaag gccgagagca cgcggggatc ggtctcttcc cgccgggtct cttaccggtg
181 cgagtcaaag agccgctccg gccccggccc tgagggaagc tccataactg ctgcttcagg
241 agcgcccggc cgtcgccgcc gccgccattt tcgcgcccgg ccgcaggggc tcttgggaag
301 gcggagtctt tgggcatccg cccggggtga ggggacccga agtcctgagg cgcgccggaa
361 gggctagcgg tcccagcata ccccgcggcc ccttgggccg tctcacaact cgcgtccggc
421 ggagaccaca attcccggca ttcgtggggc agggaggagt cggcctcccg gaatcctggt
481 cccggcgtgc acttctgaag gacttcaggt accggcgtgc cccgcgtcct actgtccgcc
541 tgctcgcgtc ctgggtgccg cctctgagta gggcgggcga ggaggcagcc aaggcggagc
601 tgatggctgc gccgagggcg gggcggggtg caggctggag ccttcgggca tggcgggctt
661 tggggggcat tcgctggggg aggagacccc gtttgacccc tgacctccgg gccctgctga
721 cgtcaggaac ttctgacccc cgggcccgag tgacttatgg gacccccagt ctctgggccc
781 ggttgtctgt tggggtcact gaaccccgag catgcctgac gtctgggacc ccgggtcccc
841 gggcacaact gactgcggtg accccagata ccaggacccg ggaggcctca gagaactctg
901 gaacccgttc gcgcgcgtgg ctggcggtgg cgctgggcgc tgggggggca gtgctgttgt
961 tgttgtgggg cgggggtcgg ggtcctccgg ccgtcctcgc cgccgtccct agcccgccgc
1021 ccgcttctcc ccggagtcag tacaacttca tcgcagatgt ggtggagaag acagcacctg
1081 ccgtggtcta tatcgagatc ctggaccggc accctttctt gggccgcgag gtccctatct
1141 cgaacggctc aggattcgtg gtggctgccg atgggctcat tgtcaccaac gcccatgtgg
1201 tggctgatcg gcgcagagtc cgtgtgagac tgctaagcgg cgacacgtat gaggccgtgg
1261 tcacagctgt ggatcccgtg gcagacatcg caacgctgag gattcagact aaggagcctc
1321 tccccacgct gcctctggga cgctcagctg atgtccggca aggggagttt gttgttgcca
1381 tgggaagtcc ctttgcactg cagaacacga tcacatccgg cattgttagc tctgctcagc
1441 gtccagccag agacctggga ctcccccaaa ccaatgtgga atacattcaa actgatgcag
1501 ctattgattt tggaaactct ggaggtcccc tggttaacct ggatggggag gtgattggag
1561 tgaacaccat gaaggtcaca gctggaatct cctttgccat cccttctgat cgtcttcgag
1621 agtttctgca tcgtggggaa aagaagaatt cctcctccgg aatcagtggg tcccagcggc
1681 gctacattgg ggtgatgatg ctgaccctga gtcccagcat ccttgctgaa ctacagcttc
1741 gagaaccaag ctttcccgat gttcagcatg gtgtactcat ccataaagtc atcctgggct
1801 cccctgcaca ccgggctggt ctgcggcctg gtgatgtgat tttggccatt ggggagcaga
1861 tggtacaaaa tgctgaagat gtttatgaag ctgttcgaac ccaatcccag ttggcagtgc
1921 agatccggcg gggacgagaa acactgacct tatatgtgac ccctgaggtc acagaatgaa
1981 tagatcacca agagtatgag gctcctgctc tgatttcctc cttgcctttc tggctgaggt
2041 tctgagggca ccgagacaga gggttaaatg aaccagtggg ggcaggtccc tccaaccacc
2101 agcactgact cctgggctct gaagaatcac agaaacactt tttatataaa ataaaattat
2161 acctagcaac ataaaaaaaa aaaaaaa
//