LOCUS AF082283 2810 bp mRNA linear HUM 11-MAY-1999 DEFINITION Homo sapiens CARD-containing apoptotic signaling protein (BCL10) mRNA, complete cds. ACCESSION AF082283 VERSION AF082283.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2810) AUTHORS Zhang,Q., Siebert,R., Yan,M., Hinzmann,B., Cui,X., Xue,L., Rakestraw,K.M., Naeve,C.W., Beckmann,G., Weisenburger,D.D., Sanger,W.G., Nowotny,H., Vesely,M., Callet-Bauchu,E., Salles,G., Dixit,V.M., Rosenthal,A., Schlegelberger,B. and Morris,S.W. TITLE Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) JOURNAL Nat. Genet. 22 (1), 63-68 (1999) PUBMED 10319863 REFERENCE 2 (bases 1 to 2810) AUTHORS Morris,S.W., Cui,X., Zhang,Q., Rakestraw,K. and Naeve,C. TITLE Direct Submission JOURNAL Submitted (04-AUG-1998) Experimental Oncology, St. Jude Children's Research Hospital, 332 N. Lauderdale Ave., Memphis, TN 38105, USA FEATURES Location/Qualifiers source 1..2810 /db_xref="H-InvDB:HIT000066514" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1p22" /tissue_type="spleen" gene 1..2810 /gene="BCL10" CDS 707..1408 /gene="BCL10" /note="B-cell CLL/lymphoma 10; similar to equine herpesvirus-2 ORF E10; overexpressed due to juxtaposition to the IgH enhancer in the t(1;14)(p22;q32) in MALT lymphomas; wild-type BCL10 gene promotes apoptotic cell death and induces NF-kappaB activation; a variety of mutations that inactivate the pro-apoptotic function of the gene, but in many cases leave NF-kappaB activation intact, occur in MALT lymphomas and other tumors of various types" /codon_start=1 /product="CARD-containing apoptotic signaling protein" /protein_id="AAC99767.1" /translation="MEPTAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK KILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDE VLKLRNIKLEHLKGLKCSSCEPFPDGATNNLSRSNSDESNFSEKLRASTVMYHPEGES STTPFFSTNSSLNLPVLEVGRTENTIFSSTTLPRPGDPGAPPLPPDLQLEEEGTCANS SEMFLPLRSRTVSRQ" BASE COUNT 768 a 627 c 551 g 864 t ORIGIN 1 tttttttttt ttttttgctt tcccgtttct taaacattgg cgttcccaag tttctccttg 61 gtcctcctgt catttttatc tactctcgta gcttcaaata ccatctagtt tatagtttat 121 ttagcatgtt gtccaagcca ccgtcttggg cccagggctc tacctgtagc ttttcatcca 181 cacttctcag gttgcttctt acacagcgcc atagtagtta aaatacggtc tggggatagt 241 cgtctcttca tcagtctccc ccgacgacct gcgcaggcgt ggcttgagga aacgcccgct 301 gtgggcggag ccacccgaaa ggctccggtc gggggcggga acaggatcgg cccgcgggct 361 ggcgtcgata ggctgccgca gagacagggc gggctctgct aagggacgcg cctcgccgtg 421 gggcggtgcc tgcgcctgag cctctacgag agggaaggaa cgctgctccg agctccgcgt 481 cgcgtcgcgt agattcgcgt cgccgtcgac ctcagaggcg gggccggaag cgctacggtt 541 tgacccccga gtccctctgt tcccgaaggg gcggccgtct ttctgccgac ccgctccgcc 601 tcctctcctt cttccccatt acccggaggc cgaagccccc agccagggcg gggcggcgca 661 gcccgagctc ccggacccgg aagaagcgcc atctcccgcc tccaccatgg agcccaccgc 721 accgtccctc accgaggagg acctcactga agtgaagaag gacgccttag aaaatttacg 781 tgtatacctg tgtgagaaaa tcatagctga gagacatttt gatcatctac gtgcaaaaaa 841 aatactcagt agagaagaca ctgaagaaat ttcttgtcga acatcaagta gaaaaagggc 901 tggaaaattg ttagactact tacaggaaaa cccaaaaggt ctggacaccc ttgttgaatc 961 tattcggcga gaaaaaacac agaacttcct gatacagaag attacagatg aagtgctgaa 1021 acttagaaat ataaaactag aacatctgaa aggactaaaa tgtagcagtt gtgaaccttt 1081 tccagatgga gccacgaaca acctctccag atcaaattca gatgagagta atttctctga 1141 aaaactgagg gcatccactg tcatgtacca tccagaagga gaatccagca cgacgccctt 1201 tttttctact aattcttctc tgaatttgcc tgttctagaa gtaggcagaa ctgaaaatac 1261 catcttctct tcaactacac ttcccagacc tggggaccca ggggctcctc ctttgccacc 1321 agatctacag ttagaagaag aaggaacttg tgcaaactct agtgagatgt ttcttccctt 1381 aagatcacgt actgtttcac gacaatgaca ctttattgcc ttttaatttt taatgatgac 1441 aaaaaatgtt ttaaagaata tgacttttta taaaatggct gtaatcattt gtttacattt 1501 gatgcatgtc ttttaaaatg caatgtaagc atactttgta aataggattt ttagaattaa 1561 aaaagcatac ttctaggata gctaactgta aatcatgttg atcatgtact ttttagtaat 1621 ttcttttttt cctttttaag gtctttcagt acttttttaa atattttcta ttttaagact 1681 gattttaata gggaatatat ctctatttga gaatagaccc ttactaggaa gaacgttttt 1741 tcctcagtgc atttgtgcta gaaattttca agagtctaat agtctttgcc agtcattcag 1801 cagcaaattt tcagcattaa gctgttcctg ttcagtaata aaaccggtca ctgatgggaa 1861 aactgccaat atagaaaaat aaaaatctct tttccactcc attgtcgtat aggcatgtaa 1921 acagcctctt tttgatactg gaggaacact tgatggagtg tgagccacct aagatctcgg 1981 tttgccaaaa ttcatttcta attaacctta ctaattatac tactttgtta ggattttcac 2041 attcttggct taatcatttt cattcctaaa gaaaaatatc ttggcctaaa cctcagttat 2101 tacatgtaat ttgatgaggt attttttcct tttttctttt tttttttttt gagacagtct 2161 tgctctatcg cccaggctgg agtgcagtgg cgcattctag gctcactgca acttctgcct 2221 cccatgctta cgtgatcctc tcacctcagc ctctcaagta atatagctga gactacaagt 2281 gtgtgccacc atgcctcact aatttttgta ttatttttgt agagacggtg ttttgccatg 2341 ttggccaggc tggtcttgaa ctcctggact caagcaacct acccagcgtg gcctcccaaa 2401 gtgctgggat tacagacacg agccacctca cctagcctga tgagattttt aaaaaatatt 2461 ttctctgtac ttttcattct cttttaatga ggaccaatgt acagttgaaa taactggaac 2521 aaattatttt tggtgtgtgt gacaattctg tttttaatgc tatttgaaca agtgggccat 2581 tagccagatt tgtctttttg ttgtaaaaca aaatttgact aattttacat gtttataaat 2641 cttatgctct cactgtttgt ttttatttaa attacaattt tatctgtttc ctgacattgt 2701 ctcctatata tttctattat taattgcaaa aacatagaaa tggaaatttt gctatcaaca 2761 ataaaatttt tttaaaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa //