LOCUS AF023450 6413 bp mRNA linear HUM 30-MAR-2001
DEFINITION Homo sapiens CHD2-52 Down syndrome cell adhesion molecule (DSCAM)
mRNA, complete cds.
ACCESSION AF023450
VERSION AF023450.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6413)
AUTHORS Yamakawa,K., Huot,Y.K., Haendelt,M.A., Hubert,R., Chen,X.N.,
Lyons,G.E. and Korenberg,J.R.
TITLE DSCAM: a novel member of the immunoglobulin superfamily maps in a
Down syndrome region and is involved in the development of the
nervous system
JOURNAL Hum. Mol. Genet. 7 (2), 227-237 (1998)
PUBMED 9426258
REFERENCE 2 (bases 1 to 6413)
AUTHORS Yamakawa,K., Huo,Y.-K., Haendel,M.A., Hubert,R., Chen,X.-N.,
Lyons,G.E. and Korenberg,J.R.
TITLE Direct Submission
JOURNAL Submitted (08-SEP-1997) Medical Genetics, Cedars-Sinai Research
Institute, 110 George Burns Road, Davis Building, Suite 2005, Los
Angeles, CA 90048-1869, USA
FEATURES Location/Qualifiers
source 1..6413
/db_xref="H-InvDB:HIT000062708"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="21 (trisomy 21)"
/map="21q22, between HMG14 and MX1"
/clone="CHD2-52"
/tissue_type="brain"
/dev_stage="14 weeks, fetal"
/note="derived from alternately-spliced mRNA"
gene 1..6413
/gene="DSCAM"
CDS 453..5168
/gene="DSCAM"
/note="member of immunoglobulin superfamily; involved in
nervous system development"
/codon_start=1
/product="Down syndrome cell adhesion molecule"
/protein_id="AAC17967.1"
/translation="MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLV
PCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYC
TAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSW
EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS
DPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT
GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS
CSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL
SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG
GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR
PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK
EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDL
PITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS
QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALN
GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTL
ATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV
REDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSP
ITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS
NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG
GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP
SYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTT
QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASM
VFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV
AVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM
KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQV
PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSY
RLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRL
NLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCN
SAGCAEKQAKEAARCKEFS"
BASE COUNT 1633 a 1779 c 1709 g 1292 t
ORIGIN
1 tgactgaggc cggagcacgg caaagatgag cctgcccgcc cgcctgctgc ctggatgcgg
61 agggtgaggg ctggcgcacg ggaggccgct ggctgcgcat tctgggcgcc gagtgcccgg
121 gatgagctca cgcccgcgtc tgcggctctc tccacctgcc gacctgccgg gggcccactg
181 agctgacggc gcacctgggc tccggccgca gcgtggggcg cggcgcccgg gagcaggtgt
241 gcaggagcgc agcgcgcggc gagcgcagcc ctcgctccgg agcccggccg cgccgcgtgc
301 ccgggcggct aggcagcggc ggcggcggcg gcgggcggcg ggcgggcggc ggcccccggg
361 caggtgccga gcggcgagcg gagccgggcc gggcggagcg cggggggcga ggccggcgcg
421 tcgctcgcgg gaggccgggg agcggcaggg gcatgtggat actggctctc tccttgttcc
481 agagcttcgc gaatgttttc agtgaagacc tacactccag cctctacttt gtcaatgcat
541 ctctgcaaga ggtagtgttt gccagcacca cggggactct ggtgccctgc cccgcagcag
601 gcatccctcc tgtgactctc agatggtacc tagccacggg cgaggagatc tacgatgtcc
661 ccgggatccg ccacgtccac cccaacggca ctctccaaat tttccccttc cctccttcaa
721 gcttcagtac cttaatccat gataatactt attattgcac agctgaaaat ccttcaggga
781 aaattagaag tcaggatgtc cacatcaagg ctgttttacg ggagccctat acagtccgtg
841 tggaggacca gaaaaccatg agaggcaatg ttgcggtctt caagtgcatt atcccctcct
901 cggtggaggc gtacatcact gtcgtctcat gggagaaaga cactgtttca cttgtctcag
961 gatctagatt tctcatcaca tccacgggag ccttgtatat taaagatgta cagaatgaag
1021 atggattgta taactaccgc tgcatcacgc ggcatcgata caccggagag acgaggcaga
1081 gcaacagcgc cagacttttt gtatcagacc cagcgaactc agccccatcc atactggatg
1141 ggtttgacca tcgcaaagcc atggctgggc agcgtgtgga gctgccttgc aaagcgctcg
1201 ggcaccctga gccagattac cgctggctga aggacaacat gcccctggaa ctttcaggga
1261 ggttccagaa gaccgtgacg gggctgctca ttgagaacat tcgcccctcg gactcaggca
1321 gctatgtttg tgaagtgtcc aacagatacg gaactgctaa ggtgataggc cgcctgtacg
1381 tgaaacagcc actgaaagcc accatcagtc ccaggaaggt taaaagcagc gtgggtagcc
1441 aagtttcctt gtcctgcagc gtgacaggaa ctgaggacca ggaactctcc tggtaccgca
1501 atggtgaaat cctcaaccct ggaaaaaatg tgaggatcac agggatcaac cacgaaaacc
1561 ttataatgga tcacatggtc aaaagtgacg ggggcgcata ccagtgcttt gtgcgcaagg
1621 acaagctgtc cgctcaagac tatgtgcagg tggtccttga agatggaact cccaaaatta
1681 tttctgcctt tagtgaaaag gtggtgagtc cagcagagcc ggtttccctt atgtgcaacg
1741 tgaagggaac acctttgccc acgatcacgt ggaccctgga cgatgacccg attctcaagg
1801 gtggcagtca ccgcatcagc cagatgatca cgtcggaggg gaacgtggtc agctacctga
1861 acatctccag ctcccaggtc cgggacgggg gagtctaccg ctgcactgcc aacaactcgg
1921 cgggagtcgt cctgtaccag gctcgaataa acgtaagagg gcctgcaagc attcgaccaa
1981 tgaaaaacat cacagcaata gcaggacggg acacatacat tcactgtcgt gtgattggct
2041 atccgtatta ctccattaaa tggtacaaga actctaacct gcttcctttc aaccaccgcc
2101 aagtggcatt tgagaacaat ggaactctta aactttcaga tgtgcaaaag gaagtggacg
2161 agggggagta cacgtgcaac gtgttggttc aaccacaact ctccaccagc cagagcgtcc
2221 acgtgaccgt gaaagttccg cctttcatac aaccctttga gtttccaaga ttctccattg
2281 ggcagcgggt cttcatcccc tgtgttgtgg tctcagggga cttacccatc acgatcacct
2341 ggcagaagga tggccggcca atccctggga gccttggggt gaccattgac aatattgact
2401 tcacgagctc cttgaggatt tccaatctct cgctcatgca caatgggaat tacacctgca
2461 tagcccggaa tgaggccgcc gctgtggagc accaaagcca gttgattgtc agagttcctc
2521 ccaagtttgt ggttcagcca cgggaccagg acgggattta tggcaaagca gtcatcctca
2581 attgttctgc tgagggttac cctgtaccta ccatcgtgtg gaaattctct aaaggtgctg
2641 gggttcccca gttccagcca attgccctaa atggccgaat ccaagttctc agcaatgggt
2701 cgttgctgat caagcatgtc gtggaggaag acagtggcta ctacctctgc aaggtcagca
2761 acgatgtggg cgcagacgtc agcaagtcca tgtacctcac ggttaaaatt cctgcgatga
2821 taacatccta tccaaatact accctggcca cgcaggggca gaaaaaggag atgagctgca
2881 cggcgcatgg tgagaagccc attatagtcc gctgggagaa ggaggaccga atcattaacc
2941 ctgagatggc ccgttatctt gtgtccacca aggaggtggg agaagaggtg atttctactc
3001 tgcagatttt gccaactgtg agagaagatt ctggtttctt ttcctgccat gctattaatt
3061 cttatgggga ggaccgtgga ataattcagc tcacagtgca agagccccca gaccctcccg
3121 aaattgagat caaagatgtc aaagcacgca caattacgct caggtggacc atggggtttg
3181 atggaaacag tcccatcaca ggctacgata ttgaatgcaa aaataaatca gactcctggg
3241 attctgctca gagaaccaaa gatgtttccc ctcagctgaa ctcggccacc atcattgata
3301 tccacccttc ctccacctac agcatccgca tgtacgccaa gaaccggatt ggcaagagcg
3361 agcccagcaa cgagctcacc atcacggcgg acgaggcagc tcctgatggt ccacctcagg
3421 aagttcacct ggagcctata tcatctcaga gcatcagggt cacatggaag gctcccaaga
3481 aacatttgca aaatgggatt atccgtggct accaaatagg ttaccgagag tacagcactg
3541 ggggtaactt ccaattcaac attatcagtg tcgacaccag cggggacagt gaggtttaca
3601 ccctggacaa cctgaataag ttcactcagt acggcctggt ggtgcaggcc tgtaaccggg
3661 ccggcacggg gccttcttct caggaaatca tcaccaccac tctcgaggat gtgcccagtt
3721 acccccccga aaatgtccaa gccatagcaa catcaccaga aagcatatca atatcctggt
3781 ccacactttc caaggaagcc ttgaatggaa ttctccaggg gttcagagtc atttactggg
3841 ccaacctcat ggacggagag ctgggtgaga ttaaaaacat caccaccaca cagccttcac
3901 tggagctgga cgggctggaa aagtacacca actacagcat ccaggtgctg gccttcaccc
3961 gcgcaggaga cggggtcagg agtgagcaga tcttcacccg gaccaaagag gatgttccag
4021 gtcctcccgc gggtgtgaag gcagcggcgg cctcagcctc catggtcttt gtgtcctggc
4081 ttccccctct caagctgaac ggcatcatcc gaaagtacac tgtattctgc tcccacccct
4141 atcccacagt gatcagcgag tttgaggcct ctcccgactc gttttcctac agaattccca
4201 acctgagtag gaatcgtcag tacagcgtct gggtggtggc tgttacttca gccggaagag
4261 gcaacagcag tgaaatcatc acagtcgagc cactagcaaa agctcctgca cgaatcctga
4321 ccttcagtgg gacagtgact actccatgga tgaaagacat tgtcttgcct tgtaaggctg
4381 ttggggaccc ttctcctgca gtcaaatgga tgaaagacag taacgggaca cccagtctag
4441 taacgattga tgggcggagg agcatcttta gcaacggaag cttcattatt cgcacggtga
4501 aagcagaaga ctccggctat tacagctgca ttgccaataa caactgggga tctgatgaaa
4561 ttattttaaa cttacaagta caagttccac cagatcagcc tcggcttaca gtctccaaga
4621 ccacgtcttc ctccatcacc ctttcttggc tccctggaga caacgggggc agctctatca
4681 gaggatacat actgcagtac tccgaggaca atagtgagca gtgggggagt tttccaatca
4741 gccccagcga acgttcctat cgcttggaaa atctcaaatg tgggacttgg tataagttca
4801 cactgacagc ccaaaatgga gtgggcccag ggcgcataag tgaaatcata gaagcaaaga
4861 ccttaggaaa agagccccag ttctcaaagg agcaggagct gtttgccagc atcaacacca
4921 cacgcgtgag gctgaacctc attggctgga atgatggcgg ctgccccatc acctccttca
4981 cactagagta caggcccttt gggaccacag tttggaccac agctcagagg acctctctct
5041 ccaagtccta catcctgtat gacctgcagg aagccacctg gtatgagctg cagatgcggg
5101 tgtgcaacag tgcgggctgc gcggagaagc aggctaaaga ggctgcgaga tgcaaagagt
5161 ttagctgaaa tgctcatgag taagaatacc cggacttcag atacgttaag caagcaacag
5221 cagaccctgc gaatgcacat cgacataccc agggctcagc ttttgattga agagagagac
5281 acgatggaga ccattgatga tcgctccacg gttctgttga cggatgctga ctttggagag
5341 gcagctaagc agaagtccct gacggtcact cacacggtcc attaccaatc ggtgtctcag
5401 gccactgggc ccttagtgga tgtttcagac gctcggccgg gaacgaatcc caccaccagg
5461 aggaatgcca aggctgggcc cacagcgaga aaccgctatg ccagccagtg gaccctcaac
5521 cgaccccacc ccaccatctc agcacacacc ctcaccacag actggaggct gccaacaccc
5581 agggctgcag gatcagtaga caaagagagc gacagttaca gcgtcagccc ctcgcaagac
5641 acagatcgag caagaagcag catggtctcc acagaaagtg cctcctccac ttacgaagaa
5701 ctggccaggg cctacgaaca cgccaagatg gaagagcaac tgaggcacgc caagttcacc
5761 atcacggagt gcttcatatc agacacgtca tcggagcagt tgacggcagg gacaaatgag
5821 tacacggaca gtctgacctc cagcacccct tccgaatcgg gaatctgcag gttcactgca
5881 tctcccccca aacctcagga tggaggaaga gtaatgaata tggcagttcc aaaggcaatc
5941 ggccaggtga cctcatacat ttgcctccat accttagaat ggactttttg ttaaaccgag
6001 gtggtccagg caccagcagg gacctgagct taggacaagc atgcttggaa cctcagaaaa
6061 gccggaccct gaagcgcccc acggtcctgg agcccatccc gatggaagcc gcctcctccg
6121 cctcctccac gagagaagga cagtcgtggc agccgggggc cgtggccaca ttacctcagc
6181 gggagggagc agagctggga caggcagcta aaatgagcag ctcccaagaa tcactgctcg
6241 actcccgggg ccatttgaaa ggaaacaatc cttacgcaaa atcttacacc ctggtataac
6301 agacagcatg actggacagc ggttgtaaat acaattcaaa caattcaatc aaagctacct
6361 tttttttacg gaattccaat atttataatt aaagaaaatt gccaaaatat att
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