LOCUS       AF023449                6110 bp    mRNA    linear   HUM 25-JUL-2016
DEFINITION  Homo sapiens CHD2-42 Down syndrome cell adhesion molecule (DSCAM)
            mRNA, partial cds.
ACCESSION   AF023449
VERSION     AF023449.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6110)
  AUTHORS   Yamakawa,K., Huot,Y.K., Haendelt,M.A., Hubert,R., Chen,X.N.,
            Lyons,G.E. and Korenberg,J.R.
  TITLE     DSCAM: a novel member of the immunoglobulin superfamily maps in a
            Down syndrome region and is involved in the development of the
            nervous system
  JOURNAL   Hum. Mol. Genet. 7 (2), 227-237 (1998)
   PUBMED   9426258
REFERENCE   2  (bases 1 to 6110)
  AUTHORS   Yamakawa,K., Huo,Y.-K., Haendel,M.A., Hubert,R., Chen,X.-N.,
            Lyons,G.E. and Korenberg,J.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-SEP-1997) Medical Genetics, Cedars-Sinai Research
            Institute, 110 George Burns Road, Davis Building, Suite 2005, Los
            Angeles, CA 90048-1869, USA
FEATURES             Location/Qualifiers
     source          1..6110
                     /db_xref="H-InvDB:HIT000062707"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21 (trisomy 21)"
                     /map="21q22, between HMG14 and MX1"
                     /clone="CHD2-42"
                     /tissue_type="brain"
                     /dev_stage="14 weeks, fetal"
                     /note="derived from alternately-spliced mRNA"
     gene            <1..6110
                     /gene="DSCAM"
     CDS             <1..5691
                     /gene="DSCAM"
                     /note="member of immunoglobulin superfamily; involved in
                     nervous system development"
                     /codon_start=1
                     /product="Down syndrome cell adhesion molecule"
                     /protein_id="AAC17966.1"
                     /translation="VFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRW
                     YLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDV
                     HIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFL
                     ITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFD
                     HRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGS
                     YVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWY
                     RNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGT
                     PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN
                     VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTY
                     IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQ
                     PQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIP
                     GSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQP
                     RDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK
                     HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAH
                     GEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINS
                     YGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDS
                     WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDG
                     PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSG
                     DSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSP
                     ESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN
                     YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI
                     IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII
                     TVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG
                     RRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTS
                     SSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFT
                     LTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITS
                     FTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL
                     NYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQR
                     LKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRS
                     TVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGP
                     TARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRAR
                     SSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTD
                     SLTSSTPSESGICRFTASPPKPQDGGRVMNMAVPKAIGQVTSYICLHTLEWTFC"
BASE COUNT         1621 a         1658 c         1548 g         1283 t
ORIGIN      
        1 gttttcagtg aagacctaca ctccagcctc tactttgtca atgcatctct gcaagaggta
       61 gtgtttgcca gcaccacggg gactctggtg ccctgccccg cagcaggcat ccctcctgtg
      121 actctcagat ggtacctagc cacgggcgag gagatctacg atgtccccgg gatccgccac
      181 gtccacccca acggcactct ccaaattttc cccttccctc cttcaagctt cagtacctta
      241 atccatgata atacttatta ttgcacagct gaaaatcctt cagggaaaat tagaagtcag
      301 gatgtccaca tcaaggctgt tttacgggag ccctatacag tccgtgtgga ggaccagaaa
      361 accatgagag gcaatgttgc ggtcttcaag tgcattatcc cctcctcggt ggaggcgtac
      421 atcactgtcg tctcatggga gaaagacact gtttcacttg tctcaggatc tagatttctc
      481 atcacatcca cgggagcctt gtatattaaa gatgtacaga atgaagatgg attgtataac
      541 taccgctgca tcacgcggca tcgatacacc ggagagacga ggcagagcaa cagcgccaga
      601 ctttttgtat cagacccagc gaactcagcc ccatccatac tggatgggtt tgaccatcgc
      661 aaagccatgg ctgggcagcg tgtggagctg ccttgcaaag cgctcgggca ccctgagcca
      721 gattaccgct ggctgaagga caacatgccc ctggaacttt cagggaggtt ccagaagacc
      781 gtgacggggc tgctcattga gaacattcgc ccctcggact caggcagcta tgtttgtgaa
      841 gtgtccaaca gatacggaac tgctaaggtg ataggccgcc tgtacgtgaa acagccactg
      901 aaagccacca tcagtcccag gaaggttaaa agcagcgtgg gtagccaagt ttccttgtcc
      961 tgcagcgtga caggaactga ggaccaggaa ctctcctggt accgcaatgg tgaaatcctc
     1021 aaccctggaa aaaatgtgag gatcacaggg atcaaccacg aaaaccttat aatggatcac
     1081 atggtcaaaa gtgacggggg cgcataccag tgctttgtgc gcaaggacaa gctgtccgct
     1141 caagactatg tgcaggtggt ccttgaagat ggaactccca aaattatttc tgcctttagt
     1201 gaaaaggtgg tgagtccagc agagccggtt tcccttatgt gcaacgtgaa gggaacacct
     1261 ttgcccacga tcacgtggac cctggacgat gacccgattc tcaagggtgg cagtcaccgc
     1321 atcagccaga tgatcacgtc ggaggggaac gtggtcagct acctgaacat ctccagctcc
     1381 caggtccggg acgggggagt ctaccgctgc actgccaaca actcggcggg agtcgtcctg
     1441 taccaggctc gaataaacgt aagagggcct gcaagcattc gaccaatgaa aaacatcaca
     1501 gcaatagcag gacgggacac atacattcac tgtcgtgtga ttggctatcc gtattactcc
     1561 attaaatggt acaagaactc taacctgctt cctttcaacc accgccaagt ggcatttgag
     1621 aacaatggaa ctcttaaact ttcagatgtg caaaaggaag tggacgaggg ggagtacacg
     1681 tgcaacgtgt tggttcaacc acaactctcc accagccaga gcgtccacgt gaccgtgaaa
     1741 gttccgcctt tcatacaacc ctttgagttt ccaagattct ccattgggca gcgggtcttc
     1801 atcccctgtg ttgtggtctc aggggactta cccatcacga tcacctggca gaaggatggc
     1861 cggccaatcc ctgggagcct tggggtgacc attgacaata ttgacttcac gagctccttg
     1921 aggatttcca atctctcgct catgcacaat gggaattaca cctgcatagc ccggaatgag
     1981 gccgccgctg tggagcacca aagccagttg attgtcagag ttcctcccaa gtttgtggtt
     2041 cagccacggg accaggacgg gatttatggc aaagcagtca tcctcaattg ttctgctgag
     2101 ggttaccctg tacctaccat cgtgtggaaa ttctctaaag gtgctggggt tccccagttc
     2161 cagccaattg ccctaaatgg ccgaatccaa gttctcagca atgggtcgtt gctgatcaag
     2221 catgtcgtgg aggaagacag tggctactac ctctgcaagg tcagcaacga tgtgggcgca
     2281 gacgtcagca agtccatgta cctcacggtt aaaattcctg cgatgataac atcctatcca
     2341 aatactaccc tggccacgca ggggcagaaa aaggagatga gctgcacggc gcatggtgag
     2401 aagcccatta tagtccgctg ggagaaggag gaccgaatca ttaaccctga gatggcccgt
     2461 tatcttgtgt ccaccaagga ggtgggagaa gaggtgattt ctactctgca gattttgcca
     2521 actgtgagag aagattctgg tttcttttcc tgccatgcta ttaattctta tggggaggac
     2581 cgtggaataa ttcagctcac agtgcaagag cccccagacc ctcccgaaat tgagatcaaa
     2641 gatgtcaaag cacgcacaat tacgctcagg tggaccatgg ggtttgatgg aaacagtccc
     2701 atcacaggct acgatattga atgcaaaaat aaatcagact cctgggattc tgctcagaga
     2761 accaaagatg tttcccctca gctgaactcg gccaccatca ttgatatcca cccttcctcc
     2821 acctacagca tccgcatgta cgccaagaac cggattggca agagcgagcc cagcaacgag
     2881 ctcaccatca cggcggacga ggcagctcct gatggtccac ctcaggaagt tcacctggag
     2941 cctatatcat ctcagagcat cagggtcaca tggaaggctc ccaagaaaca tttgcaaaat
     3001 gggattatcc gtggctacca aataggttac cgagagtaca gcactggggg taacttccaa
     3061 ttcaacatta tcagtgtcga caccagcggg gacagtgagg tttacaccct ggacaacctg
     3121 aataagttca ctcagtacgg cctggtggtg caggcctgta accgggccgg cacggggcct
     3181 tcttctcagg aaatcatcac caccactctc gaggatgtgc ccagttaccc ccccgaaaat
     3241 gtccaagcca tagcaacatc accagaaagc atatcaatat cctggtccac actttccaag
     3301 gaagccttga atggaattct ccaggggttc agagtcattt actgggccaa cctcatggac
     3361 ggagagctgg gtgagattaa aaacatcacc accacacagc cttcactgga gctggacggg
     3421 ctggaaaagt acaccaacta cagcatccag gtgctggcct tcacccgcgc aggagacggg
     3481 gtcaggagtg agcagatctt cacccggacc aaagaggatg ttccaggtcc tcccgcgggt
     3541 gtgaaggcag cggcggcctc agcctccatg gtctttgtgt cctggcttcc ccctctcaag
     3601 ctgaacggca tcatccgaaa gtacactgta ttctgctccc acccctatcc cacagtgatc
     3661 agcgagtttg aggcctctcc cgactcgttt tcctacagaa ttcccaacct gagtaggaat
     3721 cgtcagtaca gcgtctgggt ggtggctgtt acttcagccg gaagaggcaa cagcagtgaa
     3781 atcatcacag tcgagccact agcaaaagct cctgcacgaa tcctgacctt cagtgggaca
     3841 gtgactactc catggatgaa agacattgtc ttgccttgta aggctgttgg ggacccttct
     3901 cctgcagtca aatggatgaa agacagtaac gggacaccca gtctagtaac gattgatggg
     3961 cggaggagca tctttagcaa cggaagcttc attattcgca cggtgaaagc agaagactcc
     4021 ggctattaca gctgcattgc caataacaac tggggatctg atgaaattat tttaaactta
     4081 caagtacaag ttccaccaga tcagcctcgg cttacagtct ccaagaccac gtcttcctcc
     4141 atcacccttt cttggctccc tggagacaac gggggcagct ctatcagagg atacatactg
     4201 cagtactccg aggacaatag tgagcagtgg gggagttttc caatcagccc cagcgaacgt
     4261 tcctatcgct tggaaaatct caaatgtggg acttggtata agttcacact gacagcccaa
     4321 aatggagtgg gcccagggcg cataagtgaa atcatagaag caaagacctt aggaaaagag
     4381 ccccagttct caaaggagca ggagctgttt gccagcatca acaccacacg cgtgaggctg
     4441 aacctcattg gctggaatga tggcggctgc cccatcacct ccttcacact agagtacagg
     4501 ccctttggga ccacagtttg gaccacagct cagaggacct ctctctccaa gtcctacatc
     4561 ctgtatgacc tgcaggaagc cacctggtat gagctgcaga tgcgggtgtg caacagtgcg
     4621 ggctgcgcgg agaagcaggc caacttcgct acgctgaact acgatggcag tacaattcct
     4681 ccactcatta agtcagttgt ccaaaacgaa gaagggctga cgaccaacga ggggctcaag
     4741 atgctggtga ccatctcctg tatcctggtg ggggtcttgc tgctgtttgt gctcctgctg
     4801 gttgtgcgga ggaggcggcg ggagcagagg ctaaagaggc tgcgagatgc aaagagttta
     4861 gctgaaatgc tcatgagtaa gaatacccgg acttcagata cgttaagcaa gcaacagcag
     4921 accctgcgaa tgcacatcga catacccagg gctcagcttt tgattgaaga gagagacacg
     4981 atggagacca ttgatgatcg ctccacggtt ctgttgacgg atgctgactt tggagaggca
     5041 gctaagcaga agtccctgac ggtcactcac acggtccatt accaatcggt gtctcaggcc
     5101 actgggccct tagtggatgt ttcagacgct cggccgggaa cgaatcccac caccaggagg
     5161 aatgccaagg ctgggcccac agcgagaaac cgctatgcca gccagtggac cctcaaccga
     5221 ccccacccca ccatctcagc acacaccctc accacagact ggaggctgcc aacacccagg
     5281 gctgcaggat cagtagacaa agagagcgac agttacagcg tcagcccctc gcaagacaca
     5341 gatcgagcaa gaagcagcat ggtctccaca gaaagtgcct cctccactta cgaagaactg
     5401 gccagggcct acgaacacgc caagatggaa gagcaactga ggcacgccaa gttcaccatc
     5461 acggagtgct tcatatcaga cacgtcatcg gagcagttga cggcagggac aaatgagtac
     5521 acggacagtc tgacctccag caccccttcc gaatcgggaa tctgcaggtt cactgcatct
     5581 ccccccaaac ctcaggatgg aggaagagta atgaatatgg cagttccaaa ggcaatcggc
     5641 caggtgacct catacatttg cctccatacc ttagaatgga ctttttgtta aaccgaggtg
     5701 gtccaggcac cagcagggac ctgagcttag gacaagcatg cttggaacct cagaaaagcc
     5761 ggaccctgaa gcgccccacg gtcctggagc ccatcccgat ggaagccgcc tcctccgcct
     5821 cctccacgag agaaggacag tcgtggcagc cgggggccgt ggccacatta cctcagcggg
     5881 agggagcaga gctgggacag gcagctaaaa tgagcagctc ccaagaatca ctgctcgact
     5941 cccggggcca tttgaaagga aacaatcctt acgcaaaatc ttacaccctg gtataacaga
     6001 cagcatgact ggacagcggt tgtaaataca attcaaacaa ttcaatcaaa gctacctttt
     6061 ttttacggaa ttccaatatt tataattaaa gaaaattgcc aaaatatatt
//