LOCUS       Z11584                  7217 bp    mRNA    linear   HUM 18-APR-2005
DEFINITION  H.sapiens mRNA for NuMA protein.
ACCESSION   Z11584
VERSION     Z11584.1
KEYWORDS    NuMA protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7217)
  AUTHORS   Compton,D.A., Szilak,I. and  Cleveland,D.W.
  TITLE     Primary structure of NuMA, an intranuclear protein that defines a
            novel pathway for segregation of proteins at mitosis
  JOURNAL   J. Cell Biol. 116(6), 1395-1408(1992).
   PUBMED   1541636
REFERENCE   2  (bases 1 to 7217)
  AUTHORS   Cleveland,D.W.
  JOURNAL   Submitted (17-JAN-1992) to the INSDC. Don W. Cleveland Ph.D.,
            Biological Chemistry, Johns Hopkins, University School of Medicine,
            725 N. Wolfe St., Baltimore, Maryland, 21205, USA
FEATURES             Location/Qualifiers
     source          1..7217
                     /db_xref="H-InvDB:HIT000326366"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     5'UTR           1..258
     CDS             259..6564
                     /product="NuMA protein"
                     /db_xref="GOA:Q14980"
                     /db_xref="H-InvDB:HIT000326366.12"
                     /db_xref="HGNC:HGNC:8059"
                     /db_xref="InterPro:IPR026650"
                     /db_xref="PDB:3RO2"
                     /db_xref="UniProtKB/Swiss-Prot:Q14980"
                     /protein_id="CAA77670.1"
                     /translation="MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIH
                     GTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTMLL
                     LYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPSTC
                     SSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRR
                     LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPK
                     ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL
                     QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE
                     HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL
                     LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT
                     TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ
                     LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL
                     QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS
                     EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK
                     AETRSLVEQHKRERKELEEERAGRKGLEARLLQLGEAHQAETEVLRRELAEAMAAQHT
                     AESECEQLVKEVAAWRDGYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKV
                     AGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK
                     EVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER
                     EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL
                     EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVK
                     QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL
                     ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK
                     AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS
                     QKLEESCACCRQRQPATVPELQNAALLCGRRCRASGREAEKQRVASENLRQELTSQAE
                     RAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE
                     KRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ
                     LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV
                     QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSDQASK
                     VQQQKLKAVQAQGGESQQEAQRFQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK
                     KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRS
                     LEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK
                     LPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFL
                     DSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQS
                     LARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQL
                     DDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQP
                     IQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEA
                     QKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSP
                     RIATTTASAATAAAIGATPRAKGKAKH"
     3'UTR           6562..7217
     polyA_signal    7202..7207
BASE COUNT         1793 a         2012 c         2274 g         1138 t
ORIGIN
        1 gcccacgaag aggtacgatt ccggagaatc gcgaggcaga gcgggagcgc gcagccaggt
       61 ggaaactaat tctaagccag actgctggag atcaccctgt tctagtgtgt ggaggcttcc
      121 accaggagtc tggagtgcaa tggcacgatc tcggctcact gcaacctcca cctcccaggt
      181 tcaagcgatt ctcctgcctc agcctcccaa gtagctggga ttacaggcgc attggagtga
      241 ctgtctggca tcaccaagat gacactccac gccacccggg gggctgcact cctctcttgg
      301 gtgaacagtc tacacgtggc tgaccctgtg gaggctgtgc tgcagctcca ggactgcagc
      361 atcttcatca agatcattga cagaatccat ggcactgaag agggacagca aatcttgaag
      421 cagccggtgt cagagagact ggactttgtg tgcagttttc tgcagaaaaa tcgaaaacat
      481 ccctcttccc cagaatgcct ggtatctgca cagaaggtgc tagagggatc agagctggaa
      541 ctggcgaaga tgaccatgct gctcttatac cactctacca tgagctccaa aagtcccagg
      601 gactgggaac agtttgaata taaaattcag gctgagttgg ctgtcattct taaatttgtg
      661 ctggaccatg aggacgggct aaaccttaat gaggacctag agaacttcct acagaaagct
      721 cctgtgcctt ctacctgttc tagcacattc cctgaagagc tctccccacc tagccaccag
      781 gccaagaggg agattcgctt cctagagcta cagaaggttg cctcctcttc cagtgggaac
      841 aactttctct caggttctcc agcttctccc atgggtgata tcctgcagac cccacagttc
      901 cagatgagac ggctgaagaa gcagcttgct gatgagagaa gtaataggga tgagctggag
      961 ctggagctag ctgagaaccg caagctcctc accgagaagg atgcacagat agccatgatg
     1021 cagcagcgca ttgaccgcct agccctgctg aatgagaagc aggcggccag cccactggag
     1081 cccaaggagc ttgaggagct gcgtgacaag aatgagagcc ttaccatgcg gctgcatgaa
     1141 accctgaagc agtgccagga cctgaagaca gagaagagcc agatggatcg caaaatcaac
     1201 cagctttcgg aggagaatgg agacctttcc tttaagctgc gggagtttgc cagtcatctg
     1261 cagcagctac aggatgccct caatgagctg acggaggagc acagcaaggc cactcaggag
     1321 tggctagaga agcaggccca gctggagaag gagctcagcg cagccctgca ggacaagaaa
     1381 tgccttgaag agaagaacga aatccttcag ggaaaacttt cacagctgga agaacacttg
     1441 tcccagctgc aggataaccc accccaggag aagggcgagg tgctgggtga tgtcttgcag
     1501 ctggaaacct tgaagcaaga ggcagccact cttgctgcaa acaacacaca gctccaagcc
     1561 agggtagaga tgctggagac tgagcgaggc cagcaggaag ccaagctgct tgctgagcgg
     1621 ggccacttcg aagaagaaaa gcagcagctg tctagcctga tcactgacct gcagagctcc
     1681 atctccaacc tcagccaggc caaggaagag ctggagcagg cctcccaggc tcatggggcc
     1741 cggttgactg cccaggtggc ctctctgacc tctgagctca ccacactcaa tgccaccatc
     1801 cagcaacagg atcaagaact ggctggcctg aagcagcagg ccaaagagaa gcaggcccag
     1861 ctagcacaga ccctccaaca gcaagaacag gcctcccagg gcctccgcca ccaggtggag
     1921 cagctaagca gtagcctgaa gcagaaggag cagcagttga aggaggtagc ggagaagcag
     1981 gaggcaacta ggcaggacca tgcccagcaa ctggccactg ctgcagagga gcgagaggcc
     2041 tccttaaggg agcgggatgc ggctctcaag cagctggagg cactggagaa ggagaaggct
     2101 gccaagctgg agattctgca gcagcaactt caggtggcta atgaagcccg ggacagtgcc
     2161 cagacctcag tgacacaggc ccagcgggag aaggcagagc tgagccggaa ggtggaggaa
     2221 ctccaggcct gtgttgagac agcccgccag gaacagcatg aggcccaggc ccaggttgca
     2281 gagctagagt tgcagctgcg gtctgagcag caaaaagcaa ctgagaaaga aagggtggcc
     2341 caggagaagg accagctcca ggagcagctc caggccctca aagagtcctt gaaggtcacc
     2401 aagggcagcc ttgaagagga gaagcgcagg gctgcagatg ccctggaaga gcagcagcgt
     2461 tgtatctctg agctgaaggc agagacccga agcctggtgg agcagcataa gcgggaacga
     2521 aaggagctgg aagaagagag ggctgggcgc aaggggctgg aggctcgatt actgcagctt
     2581 ggggaggccc atcaggctga gactgaagtc ctgcggcggg agctggcaga ggccatggct
     2641 gcccagcaca cagctgagag tgagtgtgag cagctcgtca aagaagtagc tgcctggcgt
     2701 gacgggtatg aggatagcca gcaagaggag gcacagtatg gcgccatgtt ccaggaacag
     2761 ctgatgactt tgaaggagga atgtgagaag gcccgccagg agctgcagga ggcaaaggag
     2821 aaggtggcag gcatagaatc ccacagcgag ctccagataa gccggcagca gaacaaacta
     2881 gctgagctcc atgccaacct ggccagagca ctccagcagg tccaagagaa ggaagtcagg
     2941 gcccagaagc ttgcagatga cctctccact ctgcaggaaa agatggctgc caccagcaaa
     3001 gaggtggccc gcttggagac cttggtgcgc aaggcaggtg agcagcagga aacagcctcc
     3061 cgggagttag tcaaggagcc tgcgagggca ggagacagac agcccgagtg gctggaagag
     3121 caacagggac gccagttctg cagcacacag gcagcgctgc aggctatgga gcgggaggca
     3181 gagcagatgg gcaatgagct ggaacggctg cgggccgcgc tgatggagag ccaggggcag
     3241 cagcaggagg agcgtgggca gcaggaaagg gaggtggcgc ggctgaccca ggagcggggc
     3301 cgtgcccagg ctgaccttgc cctggagaag gcggccagag cagagcttga gatgcggctg
     3361 cagaacgccc tcaacgagca gcgtgtggag ttcgctaccc tgcaagaggc actggctcat
     3421 gccctgacgg aaaaggaagg caaggaccag gagttggcca agcttcgtgg tctggaggca
     3481 gcccagataa aagagctgga ggaacttcgg caaaccgtga agcaactgaa ggaacagctg
     3541 gctaagaaag aaaaggagca cgcatctggc tcaggagccc aatctgaggc tgctggcagg
     3601 acagagccaa caggccccaa gctggaagca ctgcgggcag aggtgagcaa gctggaacag
     3661 caatgccaga agcagcagga gcaggctgac agcctggaac gcagcctcga ggctgagcgg
     3721 gcctcccggg ctgagcggga cagtgctctg gagactctgc agggccagtt agaggagaag
     3781 gcccaggagc tagggcacag tcagagtgcc ttagcctcgg cccaacggga gttggctgcc
     3841 ttccgcacca aggtacaaga ccacagcaag gctgaagatg agtggaaggc ccaggtggcc
     3901 cggggccggc aagaggctga gaggaaaaat agcctcatca gcagcttgga ggaggaggtg
     3961 tccatcctga atcgccaggt cctggagaag gagggggaga gcaaggagtt gaagcggctg
     4021 gtgatggccg agtcagagaa gagccagaag ctggaggaga gctgcgcctg ctgcaggcag
     4081 agacagccag caacagtgcc agagctgcag aacgcagctc tgctctgcgg gaggaggtgc
     4141 agagcctccg ggagggaggc tgagaaacag cgggtggctt cagagaacct gcggcaggag
     4201 ctgacctcac aggctgagcg tgcggaggag ctgggccaag aattgaaggc gtggcaggag
     4261 aagttcttcc agaaagagca ggccctctcc accctgcagc tcgagcacac cagcacacag
     4321 gccctggtga gtgagctgct gccagctaag cacctctgcc agcagctgca ggccgagcag
     4381 gccgctgccg agaaacgcca ccgtgaggag ctggagcaga gcaagcaggc cgctggggga
     4441 ctgcgggcag agctgctgcg ggcccagcgg gagcttgggg agctgattcc tctgcggcag
     4501 aaggtggcag agcaggagcg aacagctcag cagctgcggg cagagaaggc cagctatgca
     4561 gagcagctga gcatgctgaa gaaggcgcat ggcctgctgg cagaggagaa ccgggggctg
     4621 ggtgagcggg ccaaccttgg ccggcagttt ctggaagtgg agttggacca ggcccgggaa
     4681 aagtatgtcc aagagttggc agccgtacgt gctgatgctg agacccgtct ggctgaggtg
     4741 cagcgagaag cacagagcac tgcccgggag ctggaggtga tgactgccaa gtatgagggt
     4801 gccaaggtca aggtcctgga ggagaggcag cggttccagg aagagaggca gaaactcact
     4861 gcccaggtgg aagaactgag taagaaactg gctgactctg accaagccag caaggtgcag
     4921 cagcagaagc tgaaggctgt ccaggctcag ggaggcgaga gccagcagga ggcccagcgc
     4981 ttccaggccc agctgaatga actgcaagcc cagttgagcc agaaggagca ggcagctgag
     5041 cactataagc tgcagatgga gaaagccaaa acacattatg atgccaagaa gcagcagaac
     5101 caagagctgc aggagcagct gcggagcctg gagcagctgc agaaggaaaa caaagagctg
     5161 cgagctgaag ctgaacggct gggccatgag ctacagcagg ctgggctgaa gaccaaggag
     5221 gctgaacaga cctgccgcca ccttactgcc caggtgcgca gcctggaggc acaggttgcc
     5281 catgcagacc agcagcttcg agacctgggc aaattccagg tggcaactga tgctttaaag
     5341 agccgtgagc cccaggctaa gccccagctg gacttgagta ttgacagcct ggatctgagc
     5401 tgcgaggagg ggaccccact cagtatcacc agcaagctgc ctcgtaccca gccagacggc
     5461 accagcgtcc ctggagaacc agcctcacct atctcccagc gcctgccccc caaggtagaa
     5521 tccctggaga gtctctactt cactcccatc cctgctcgga gtcaggcccc cctggagagc
     5581 agcctggact ccctgggaga cgtcttcctg gactcgggtc gtaagacccg ctccgctcgt
     5641 cggcgcacca cgcagatcat caacatcacc atgaccaaga agctagatgt ggaagagcca
     5701 gacagcgcca actcatcgtt ctacagcacg cggtctgctc ctgcttccca ggctagcctg
     5761 cgagccacct cctctactca gtctctagct cgcctgggtt ctcccgatta tggcaactca
     5821 gccctgctca gcttgcctgg ctaccgcccc accactcgca gttctgctcg tcgttcccag
     5881 gccggggtgt ccagtggggc ccctccagga aggaacagct tctacatggg cacttgccag
     5941 gatgagcctg agcagctgga tgactggaac cgcattgcag agctgcagca gcgcaatcga
     6001 gtgtgccccc cacatctgaa gacctgctat cccctggagt ccaggccttc cctgagcctg
     6061 ggcaccatca cagatgagga gatgaaaact ggagaccccc aagagaccct gcgccgagcc
     6121 agcatgcagc caatccagat agccgagggc actggcatca ccacccggca gcagcgcaaa
     6181 cgggtctccc tagagcccca ccagggccct ggaactcctg agtctaagaa ggccaccagc
     6241 tgtttcccac gccccatgac tccccgagac cgacatgaag ggcgcaaaca gagcactact
     6301 gaggcccaga agaaagcagc tccagcttct actaaacagg ctgaccggcg ccagtcgatg
     6361 gccttcagca tcctcaacac acccaagaag ctagggaaca gccttctgcg gcggggagcc
     6421 tcaaagaagg ccctgtccaa ggcttccccc aacactcgca gtggaacccg ccgttctccg
     6481 cgcattgcca ccaccacagc cagtgccgcc actgctgccg ccattggtgc cacccctcga
     6541 gccaagggca aggcaaagca ctaaagggcc agtaccagtg agtggcccca cctgtgtccc
     6601 cgatgctgcc gtcacctggt cctccgccta ctgtccctct cagtgccttc tctcagctcc
     6661 caggccaaca gtagccaaac ccctagagac agtgatgcct gcccgcaccc tggcctggcc
     6721 cctggtcctt cactggcgcc ttctcggagc tggcccaggg ggcctggagc atggacagtg
     6781 tgggcgctct ccctaccttg cctccttttt tcttaaagca aagtcacttc tccatcacaa
     6841 ccagatttga ggctggtttt gatggctggg tccttgggcc tggccagtct tcctcttagc
     6901 ctctggatct agaagggacc ataagaggag taggccctgg ttcctgctgt cctggtggct
     6961 gggccagcag gggccctcac tcttgaagtc caggactggg tctgacctgg tgggagcacc
     7021 tgccagagga tgctctttcc caggacggat gggccctgtg tctcaggagt ggggttgggg
     7081 gacagccttc agcagcagct cacaccctac cttccccaga cttgcactgg ggtgggattt
     7141 ggagtgatgg gaaggttttt aagggccggg gatggatctt ttctaaatgt tattacttgt
     7201 aaataaagtc tattttt
//