LOCUS Y17151 4948 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for multidrug resistance protein 3 (ABCC3).
ACCESSION Y17151
VERSION Y17151.2
KEYWORDS ABCC3 protein; MRP3 gene; multidrug resistance protein 3.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Koenig J., Rost D., Cui Y., Keppler D.
TITLE Characterization of the human multidrug resistance protein isoform
MRP3 localized to the basolateral hepatocyte membrane
JOURNAL Hepatology 29(4), 1156-1163(1999).
PUBMED 10094960
REFERENCE 2 (bases 1 to 4948)
AUTHORS Koenig J.
JOURNAL Submitted (21-APR-1998) to the INSDC. J. Koenig, DKFZ Heidelberg,
Abteilung Tumorbiochemie, Im Neuenheimer Feld, 280 D-69120
Heidelberg, FRG
FEATURES Location/Qualifiers
source 1..4948
/db_xref="H-InvDB:HIT000325980"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="liver"
/db_xref="taxon:9606"
CDS 43..4626
/gene="MRP3"
/product="multidrug resistance protein 3 (ABCC3)"
/db_xref="GOA:O15438"
/db_xref="H-InvDB:HIT000325980.12"
/db_xref="HGNC:HGNC:54"
/db_xref="InterPro:IPR003439"
/db_xref="InterPro:IPR003593"
/db_xref="InterPro:IPR005292"
/db_xref="InterPro:IPR011527"
/db_xref="InterPro:IPR017871"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036640"
/db_xref="UniProtKB/Swiss-Prot:O15438"
/protein_id="CAA76658.2"
/translation="MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPRIY
LWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPA
PVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAK
AEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRL
FFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAP
GKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSI
LIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRK
ALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGP
SVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEP
SFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAE
KAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG
YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLE
GKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEG
VLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE
DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDG
EGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL
AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAA
MAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVIL
MLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSP
IYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGN
CVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKE
YSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSG
TLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCL
ARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVL
VLDKGVVAEFDSPANLIAARGIFYGMARDAGLA"
BASE COUNT 1011 a 1453 c 1364 g 1120 t
ORIGIN
1 gtccgaccgc gctcgccttc cttgcagccg cgccccggcc ccatggacgc cctgtgcggt
61 tccggggagc tcggctccaa gttctgggac tccaacctgt ctgtgcacac agaaaacccg
121 gacctcactc cctgcttcca gaactccctg ctggcctggg tgccccgcat ctacctgtgg
181 gtcgccctgc cctgctactt gctctacctg cggcaccatt gtcgtggcta catcatcctc
241 tcccacctgt ccaagctcaa gatggtcctg ggtgtcctgc tgtggtgcgt ctcctgggcg
301 gacctttttt actccttcca tggcctggtc catggccggg cccctgcccc tgttttcttt
361 gtcaccccct tggtggtggg ggtcaccatg ctgctggcca ccctgctgat acagtatgag
421 cggctgcagg gcgtacagtc ttcgggggtc ctcattatct tctggttcct gtgtgtggtc
481 tgcgccatcg tcccattccg ctccaagatc cttttagcca aggcagaggg tgagatctca
541 gaccccttcc gcttcaccac cttctacatc cactttgccc tggtactctc tgccctcatc
601 ttggcctgct tcagggagaa acctccattt ttctccgcaa agaatgtcga ccctaacccc
661 taccctgaga ccagcgctgg ctttctctcc cgcctgtttt tctggtggtt cacaaagatg
721 gccatctatg gctaccggca tcccctggag gagaaggacc tctggtccct aaaggaagag
781 gacagatccc agatggtggt gcagcagctg ctggaggcat ggaggaagca ggaaaagcag
841 acggcacgac acaaggcttc agcagcacct gggaaaaatg cctccggcga ggacgaggtg
901 ctgctgggtg cccggcccag gccccggaag ccctccttcc tgaaggccct gctggccacc
961 ttcggctcca gcttcctcat cagtgcctgc ttcaagctta tccaggacct gctctccttc
1021 atcaatccac agctgctcag catcctgatc aggtttatct ccaaccccat ggccccctcc
1081 tggtggggct tcctggtggc tgggctgatg ttcctgtgct ccatgatgca gtcgctgatc
1141 ttacaacact attaccacta catctttgtg actggggtga agtttcgtac tgggatcatg
1201 ggtgtcatct acaggaaggc tctggttatc accaactcag tcaaacgtgc gtccactgtg
1261 ggggaaattg tcaacctcat gtcagtggat gcccagcgct tcatggacct tgcccccttc
1321 ctcaatctgc tgtggtcagc acccctgcag atcatcctgg cgatctactt cctctggcag
1381 aacctaggtc cctctgtcct ggctggagtc gctttcatgg tcttgctgat tccactcaac
1441 ggagctgtgg ccgtgaagat gcgcgccttc caggtaaagc aaatgaaatt gaaggactcg
1501 cgcatcaagc tgatgagtga gatcctgaac ggcatcaagg tgctgaagct gtacgcctgg
1561 gagcccagct tcctgaagca ggtggagggc atcaggcagg gtgagctcca gctgctgcgc
1621 acggcggcct acctccacac cacaaccacc ttcacctgga tgtgcagccc cttcctggtg
1681 accctgatca ccctctgggt gtacgtgtac gtggacccaa acaatgtgct ggacgccgag
1741 aaggcctttg tgtctgtgtc cttgtttaat atcttaagac ttcccctcaa catgctgccc
1801 cagttaatca gcaacctgac tcaggccagt gtgtctctga aacggatcca gcaattcctg
1861 agccaagagg aacttgaccc ccagagtgtg gaaagaaaga ccatctcccc aggctatgcc
1921 atcaccatac acagtggcac cttcacctgg gcccaggacc tgccccccac tctgcacagc
1981 ctagacatcc aggtcccgaa aggggcactg gtggccgtgg tggggcctgt gggctgtggg
2041 aagtcctccc tggtgtctgc cctgctggga gagatggaga agctagaagg caaagtgcac
2101 atgaagggct ccgtggccta tgtgccccag caggcatgga tccagaactg cactcttcag
2161 gaaaacgtgc ttttcggcaa agccctgaac cccaagcgct accagcagac tctggaggcc
2221 tgtgccttgc tagctgacct ggagatgctg cctggtgggg atcagacaga gattggagag
2281 aagggcatta acctgtctgg gggccagcgg cagcgggtca gtctggctcg agctgtttac
2341 agtgatgccg atattttctt gctggatgac ccactgtccg cggtggactc tcatgtggcc
2401 aagcacatct ttgaccacgt catcgggcca gaaggcgtgc tggcaggcaa gacgcgagtg
2461 ctggtgacgc acggcattag cttcctgccc cagacagact tcatcattgt gctagctgat
2521 ggacaggtgt ctgagatggg cccgtaccca gccctgctgc agcgcaacgg ctcctttgcc
2581 aactttctct gcaactatgc ccccgatgag gaccaagggc acctggagga cagctggacc
2641 gcgttggaag gtgcagagga taaggaggca ctgctgattg aagacacact cagcaaccac
2701 acggatctga cagacaatga tccagtcacc tatgtggtcc agaagcagtt tatgagacag
2761 ctgagtgccc tgtcctcaga tggggaggga cagggtcggc ctgtaccccg gaggcacctg
2821 ggtccatcag agaaggtgca ggtgacagag gcgaaggcag atggggcact gacccaggag
2881 gagaaagcag ccattggcac tgtggagctc agtgtgttct gggattatgc caaggccgtg
2941 gggctctgta ccacgctggc catctgtctc ctgtatgtgg gtcaaagtgc ggctgccatt
3001 ggagccaatg tgtggctcag tgcctggaca aatgatgcca tggcagacag tagacagaac
3061 aacacttccc tgaggctggg cgtctatgct gctttaggaa ttctgcaagg gttcttggtg
3121 atgctggcag ccatggccat ggcagcgggt ggcatccagg ctgcccgtgt gttgcaccag
3181 gcactgctgc acaacaagat acgctcgcca cagtccttct ttgacaccac accatcaggc
3241 cgcatcctga actgcttctc caaggacatc tatgtcgttg atgaggttct ggcccctgtc
3301 atcctcatgc tgctcaattc cttcttcaac gccatctcca ctcttgtggt catcatggcc
3361 agcacgccgc tcttcactgt ggtcatcctg cccctggctg tgctctacac cttagtgcag
3421 cgcttctatg cagccacatc acggcaactg aagcggctgg aatcagtcag ccgctcacct
3481 atctactccc acttttcgga gacagtgact ggtgccagtg tcatccgggc ctacaaccgc
3541 agccgggatt ttgagatcat cagtgatact aaggtggatg ccaaccagag aagctgctac
3601 ccctacatca tctccaaccg gtggctgagc atcggagtgg agttcgtggg gaactgcgtg
3661 gtgctctttg ctgcactatt tgccgtcatc gggaggagca gcctgaaccc ggggctggtg
3721 ggcctttctg tgtcctactc cttgcaggtg acatttgctc tgaactggat gatacgaatg
3781 atgtcagatt tggaatctaa catcgtggct gtggagaggg tcaaggagta ctccaagaca
3841 gagacagagg cgccctgggt ggtggaaggc agccgccctc ccgaaggttg gcccccacgt
3901 ggggaggtgg agttccggaa ttattctgtg cgctaccggc cgggcctaga cctggtgctg
3961 agagacctga gtctgcatgt gcacggtggc gagaaggtgg ggatcgtggg ccgcactggg
4021 gctggcaagt cttccatgac cctttgcctg ttccgcatcc tggaggcggc aaagggtgaa
4081 atccgcattg atggcctcaa tgtggcagac atcggcctcc atgacctgcg ctctcagctg
4141 accatcatcc cgcaggaccc catcctgttc tcggggaccc tgcgcatgaa cctggacccc
4201 ttcggcagct actcagagga ggacatttgg tgggctttgg agctgtccca cctgcacacg
4261 tttgtgagct cccagccggc aggcctggac ttccagtgct cagagggcgg ggagaatctc
4321 agcgtgggcc agaggcagct cgtgtgcctg gcccgagccc tgctccgcaa gagccgcatc
4381 ctggttttag acgaggccac agctgccatc gacctggaga ctgacaacct catccaggct
4441 accatccgca cccagtttga tacctgcact gtcctgacca tcgcacaccg gcttaacact
4501 atcatggact acaccagggt cctggtcctg gacaaaggag tagtagctga atttgattct
4561 ccagccaacc tcattgcagc tagaggcatc ttctacggga tggccagaga tgctggactt
4621 gcctaaaata tattcctgag atttcctcct ggcctttcct ggttttcatc aggaaggaaa
4681 tgacaccaaa tatgtccgca gaatggactt gatagcaaac actgggggca ccttaagatt
4741 ttgcacctgt aaagtgcctt acagggtaac tgtgctgaat gctttagatg aggaaatgat
4801 ccccaagtgg tgaatgacac gcctaaggtc acagctagtt tgagccagtt agactagtcc
4861 ccggtctccc gattcccaac tgagtgttat ttgcacactg cactgttttc aaataacgat
4921 tttatgaaat gaaaaaaaaa aaaaaaaa
//