LOCUS       Y17151                  4948 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for multidrug resistance protein 3 (ABCC3).
ACCESSION   Y17151
VERSION     Y17151.2
KEYWORDS    ABCC3 protein; MRP3 gene; multidrug resistance protein 3.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Koenig J., Rost D., Cui Y., Keppler D.
  TITLE     Characterization of the human multidrug resistance protein isoform
            MRP3 localized to the basolateral hepatocyte membrane
  JOURNAL   Hepatology 29(4), 1156-1163(1999).
   PUBMED   10094960
REFERENCE   2  (bases 1 to 4948)
  AUTHORS   Koenig J.
  JOURNAL   Submitted (21-APR-1998) to the INSDC. J. Koenig, DKFZ Heidelberg,
            Abteilung Tumorbiochemie, Im Neuenheimer Feld, 280 D-69120
            Heidelberg, FRG
FEATURES             Location/Qualifiers
     source          1..4948
                     /db_xref="H-InvDB:HIT000325980"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /tissue_type="liver"
                     /db_xref="taxon:9606"
     CDS             43..4626
                     /gene="MRP3"
                     /product="multidrug resistance protein 3 (ABCC3)"
                     /db_xref="GOA:O15438"
                     /db_xref="H-InvDB:HIT000325980.12"
                     /db_xref="HGNC:HGNC:54"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR005292"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR030242"
                     /db_xref="UniProtKB/Swiss-Prot:O15438"
                     /protein_id="CAA76658.2"
                     /translation="MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPRIY
                     LWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPA
                     PVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAK
                     AEGEISDPFRFTTFYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRL
                     FFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAP
                     GKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSI
                     LIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRK
                     ALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGP
                     SVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEP
                     SFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAE
                     KAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG
                     YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLE
                     GKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGD
                     QTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEG
                     VLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE
                     DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDG
                     EGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL
                     AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAA
                     MAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVIL
                     MLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSP
                     IYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGN
                     CVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKE
                     YSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
                     IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSG
                     TLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCL
                     ARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVL
                     VLDKGVVAEFDSPANLIAARGIFYGMARDAGLA"
BASE COUNT         1011 a         1453 c         1364 g         1120 t
ORIGIN      
        1 gtccgaccgc gctcgccttc cttgcagccg cgccccggcc ccatggacgc cctgtgcggt
       61 tccggggagc tcggctccaa gttctgggac tccaacctgt ctgtgcacac agaaaacccg
      121 gacctcactc cctgcttcca gaactccctg ctggcctggg tgccccgcat ctacctgtgg
      181 gtcgccctgc cctgctactt gctctacctg cggcaccatt gtcgtggcta catcatcctc
      241 tcccacctgt ccaagctcaa gatggtcctg ggtgtcctgc tgtggtgcgt ctcctgggcg
      301 gacctttttt actccttcca tggcctggtc catggccggg cccctgcccc tgttttcttt
      361 gtcaccccct tggtggtggg ggtcaccatg ctgctggcca ccctgctgat acagtatgag
      421 cggctgcagg gcgtacagtc ttcgggggtc ctcattatct tctggttcct gtgtgtggtc
      481 tgcgccatcg tcccattccg ctccaagatc cttttagcca aggcagaggg tgagatctca
      541 gaccccttcc gcttcaccac cttctacatc cactttgccc tggtactctc tgccctcatc
      601 ttggcctgct tcagggagaa acctccattt ttctccgcaa agaatgtcga ccctaacccc
      661 taccctgaga ccagcgctgg ctttctctcc cgcctgtttt tctggtggtt cacaaagatg
      721 gccatctatg gctaccggca tcccctggag gagaaggacc tctggtccct aaaggaagag
      781 gacagatccc agatggtggt gcagcagctg ctggaggcat ggaggaagca ggaaaagcag
      841 acggcacgac acaaggcttc agcagcacct gggaaaaatg cctccggcga ggacgaggtg
      901 ctgctgggtg cccggcccag gccccggaag ccctccttcc tgaaggccct gctggccacc
      961 ttcggctcca gcttcctcat cagtgcctgc ttcaagctta tccaggacct gctctccttc
     1021 atcaatccac agctgctcag catcctgatc aggtttatct ccaaccccat ggccccctcc
     1081 tggtggggct tcctggtggc tgggctgatg ttcctgtgct ccatgatgca gtcgctgatc
     1141 ttacaacact attaccacta catctttgtg actggggtga agtttcgtac tgggatcatg
     1201 ggtgtcatct acaggaaggc tctggttatc accaactcag tcaaacgtgc gtccactgtg
     1261 ggggaaattg tcaacctcat gtcagtggat gcccagcgct tcatggacct tgcccccttc
     1321 ctcaatctgc tgtggtcagc acccctgcag atcatcctgg cgatctactt cctctggcag
     1381 aacctaggtc cctctgtcct ggctggagtc gctttcatgg tcttgctgat tccactcaac
     1441 ggagctgtgg ccgtgaagat gcgcgccttc caggtaaagc aaatgaaatt gaaggactcg
     1501 cgcatcaagc tgatgagtga gatcctgaac ggcatcaagg tgctgaagct gtacgcctgg
     1561 gagcccagct tcctgaagca ggtggagggc atcaggcagg gtgagctcca gctgctgcgc
     1621 acggcggcct acctccacac cacaaccacc ttcacctgga tgtgcagccc cttcctggtg
     1681 accctgatca ccctctgggt gtacgtgtac gtggacccaa acaatgtgct ggacgccgag
     1741 aaggcctttg tgtctgtgtc cttgtttaat atcttaagac ttcccctcaa catgctgccc
     1801 cagttaatca gcaacctgac tcaggccagt gtgtctctga aacggatcca gcaattcctg
     1861 agccaagagg aacttgaccc ccagagtgtg gaaagaaaga ccatctcccc aggctatgcc
     1921 atcaccatac acagtggcac cttcacctgg gcccaggacc tgccccccac tctgcacagc
     1981 ctagacatcc aggtcccgaa aggggcactg gtggccgtgg tggggcctgt gggctgtggg
     2041 aagtcctccc tggtgtctgc cctgctggga gagatggaga agctagaagg caaagtgcac
     2101 atgaagggct ccgtggccta tgtgccccag caggcatgga tccagaactg cactcttcag
     2161 gaaaacgtgc ttttcggcaa agccctgaac cccaagcgct accagcagac tctggaggcc
     2221 tgtgccttgc tagctgacct ggagatgctg cctggtgggg atcagacaga gattggagag
     2281 aagggcatta acctgtctgg gggccagcgg cagcgggtca gtctggctcg agctgtttac
     2341 agtgatgccg atattttctt gctggatgac ccactgtccg cggtggactc tcatgtggcc
     2401 aagcacatct ttgaccacgt catcgggcca gaaggcgtgc tggcaggcaa gacgcgagtg
     2461 ctggtgacgc acggcattag cttcctgccc cagacagact tcatcattgt gctagctgat
     2521 ggacaggtgt ctgagatggg cccgtaccca gccctgctgc agcgcaacgg ctcctttgcc
     2581 aactttctct gcaactatgc ccccgatgag gaccaagggc acctggagga cagctggacc
     2641 gcgttggaag gtgcagagga taaggaggca ctgctgattg aagacacact cagcaaccac
     2701 acggatctga cagacaatga tccagtcacc tatgtggtcc agaagcagtt tatgagacag
     2761 ctgagtgccc tgtcctcaga tggggaggga cagggtcggc ctgtaccccg gaggcacctg
     2821 ggtccatcag agaaggtgca ggtgacagag gcgaaggcag atggggcact gacccaggag
     2881 gagaaagcag ccattggcac tgtggagctc agtgtgttct gggattatgc caaggccgtg
     2941 gggctctgta ccacgctggc catctgtctc ctgtatgtgg gtcaaagtgc ggctgccatt
     3001 ggagccaatg tgtggctcag tgcctggaca aatgatgcca tggcagacag tagacagaac
     3061 aacacttccc tgaggctggg cgtctatgct gctttaggaa ttctgcaagg gttcttggtg
     3121 atgctggcag ccatggccat ggcagcgggt ggcatccagg ctgcccgtgt gttgcaccag
     3181 gcactgctgc acaacaagat acgctcgcca cagtccttct ttgacaccac accatcaggc
     3241 cgcatcctga actgcttctc caaggacatc tatgtcgttg atgaggttct ggcccctgtc
     3301 atcctcatgc tgctcaattc cttcttcaac gccatctcca ctcttgtggt catcatggcc
     3361 agcacgccgc tcttcactgt ggtcatcctg cccctggctg tgctctacac cttagtgcag
     3421 cgcttctatg cagccacatc acggcaactg aagcggctgg aatcagtcag ccgctcacct
     3481 atctactccc acttttcgga gacagtgact ggtgccagtg tcatccgggc ctacaaccgc
     3541 agccgggatt ttgagatcat cagtgatact aaggtggatg ccaaccagag aagctgctac
     3601 ccctacatca tctccaaccg gtggctgagc atcggagtgg agttcgtggg gaactgcgtg
     3661 gtgctctttg ctgcactatt tgccgtcatc gggaggagca gcctgaaccc ggggctggtg
     3721 ggcctttctg tgtcctactc cttgcaggtg acatttgctc tgaactggat gatacgaatg
     3781 atgtcagatt tggaatctaa catcgtggct gtggagaggg tcaaggagta ctccaagaca
     3841 gagacagagg cgccctgggt ggtggaaggc agccgccctc ccgaaggttg gcccccacgt
     3901 ggggaggtgg agttccggaa ttattctgtg cgctaccggc cgggcctaga cctggtgctg
     3961 agagacctga gtctgcatgt gcacggtggc gagaaggtgg ggatcgtggg ccgcactggg
     4021 gctggcaagt cttccatgac cctttgcctg ttccgcatcc tggaggcggc aaagggtgaa
     4081 atccgcattg atggcctcaa tgtggcagac atcggcctcc atgacctgcg ctctcagctg
     4141 accatcatcc cgcaggaccc catcctgttc tcggggaccc tgcgcatgaa cctggacccc
     4201 ttcggcagct actcagagga ggacatttgg tgggctttgg agctgtccca cctgcacacg
     4261 tttgtgagct cccagccggc aggcctggac ttccagtgct cagagggcgg ggagaatctc
     4321 agcgtgggcc agaggcagct cgtgtgcctg gcccgagccc tgctccgcaa gagccgcatc
     4381 ctggttttag acgaggccac agctgccatc gacctggaga ctgacaacct catccaggct
     4441 accatccgca cccagtttga tacctgcact gtcctgacca tcgcacaccg gcttaacact
     4501 atcatggact acaccagggt cctggtcctg gacaaaggag tagtagctga atttgattct
     4561 ccagccaacc tcattgcagc tagaggcatc ttctacggga tggccagaga tgctggactt
     4621 gcctaaaata tattcctgag atttcctcct ggcctttcct ggttttcatc aggaaggaaa
     4681 tgacaccaaa tatgtccgca gaatggactt gatagcaaac actgggggca ccttaagatt
     4741 ttgcacctgt aaagtgcctt acagggtaac tgtgctgaat gctttagatg aggaaatgat
     4801 ccccaagtgg tgaatgacac gcctaaggtc acagctagtt tgagccagtt agactagtcc
     4861 ccggtctccc gattcccaac tgagtgttat ttgcacactg cactgttttc aaataacgat
     4921 tttatgaaat gaaaaaaaaa aaaaaaaa
//