LOCUS X98093 4465 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for DNA polymerase gamma, mitochondrial protein.
ACCESSION X98093
VERSION X98093.1
KEYWORDS DNA polymerase gamma catalytic subunit; MDP1 gene; mitochondria.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Lecrenier N.L., Van der Bruggen P., Foury F.
TITLE Mitochondrial DNA polymerases from yeast to man: a new family of
polymerases
JOURNAL Gene 185(1), 147-152(1997).
PUBMED 9034326
REFERENCE 2 (bases 1 to 4465)
AUTHORS Lecrenier N.L.
JOURNAL Submitted (21-MAY-1996) to the INSDC. N.L. Lecrenier, Universite
Catholique de Louvain, Unite de Biochimie Physiologique, Place
Croix du Sud 2/20, 1348 Louvain-la-Neuve, BELGIUM
FEATURES Location/Qualifiers
source 1..4465
/db_xref="H-InvDB:HIT000325036"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="Melanoma cDNA Library"
/db_xref="taxon:9606"
CDS 283..4002
/gene="MDP1"
/product="DNA polymerase gamma"
/note="catalytic subunit"
/db_xref="GOA:P54098"
/db_xref="H-InvDB:HIT000325036.15"
/db_xref="HGNC:HGNC:9179"
/db_xref="InterPro:IPR001098"
/db_xref="InterPro:IPR002297"
/db_xref="InterPro:IPR012337"
/db_xref="InterPro:IPR019760"
/db_xref="InterPro:IPR041336"
/db_xref="PDB:3IKM"
/db_xref="PDB:4ZTU"
/db_xref="PDB:4ZTZ"
/db_xref="PDB:5C51"
/db_xref="PDB:5C52"
/db_xref="PDB:5C53"
/db_xref="UniProtKB/Swiss-Prot:P54098"
/protein_id="CAA66719.1"
/translation="MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQ
QQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRR
SVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQA
QLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPS
AWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRA
HIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQR
KARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDL
MQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQG
TYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPA
TASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHL
PGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLV
PGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLT
DNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYN
DVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMI
SFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVE
PTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCT
AFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHR
LTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQR
ETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAV
QEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDR
YRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPT
GMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP"
BASE COUNT 1002 a 1256 c 1378 g 829 t
ORIGIN
1 gcggaccggc cgggtggagg ccacacgcta ccccgaggct gcgtaggccg cgcgaagggg
61 gacgccgtgc cgtgggcctg gggtcggggg agcagcagac cgggaagcac cgtgaggacc
121 gaggatttgg ggtggaaggc aggcatggtc aaacccattt cactgacagg agagcagaga
181 caggacgtgt ctctctccac gtcttccagc cagtaaaaga agccaagctg gagcccaaag
241 ccaggtgttc tgactcccag cgtgggggtc cctgcaccaa ccatgagccg cctgctctgg
301 aggaaggtgg ccggcgccac cgtcgggcca gggccggttc cagctccggg gcgctgggtc
361 tccagctccg tccccgcgtc cgaccccagc gacgggcagc ggcggcggca gcagcagcag
421 cagcagcagc agcagcagca acagcagcct cagcagccgc aagtgctatc ctcggagggc
481 gggcagctgc ggcacaaccc attggacatc cagatgctct cgagagggct gcacgagcaa
541 atcttcgggc aaggagggga gatgcctggc gaggccgcgg tgcgccgcag cgtcgagcac
601 ctgcagaagc acgggctctg ggggcagcca gccgtgccct tgcccgacgt ggagctgcgc
661 ctgccgcccc tctacgggga caacctggac cagcacttcc gcctcctggc ccagaagcag
721 agcctgccct acctggaggc ggccaacttg ctgttgcagg cccagctgcc cccgaagccc
781 ccggcttggg cctgggcgga gggctggacc cggtacggcc ccgaggggga ggccgtaccc
841 gtggccatcc ccgaggagcg ggccctggtg ttcgacgtgg aggtctgctt ggcagaggga
901 acttgcccca cattggcggt ggccatatcc ccctcggcct ggtattcctg gtgcagccag
961 cggctggtgg aagagcgtta ctcttggacc agccagctgt cgccggctga cctcatcccc
1021 ctggaggtcc ctactggtgc cagcagcccc acccagagag actggcagga gcagttagtg
1081 gtggggcaca atgtttcctt tgaccgagct catatcaggg agcagtacct gatccagggt
1141 tcccgcatgc gtttcctgga caccatgagc atgcacatgg ccatctcagg gctaagcagc
1201 ttccagcgca gtctgtggat agcagccaag cagggcaaac acaaggtcca gccccccaca
1261 aagcaaggcc agaagtccca gaggaaagcc agaagaggcc cagcgatctc atcctgggac
1321 tggctggaca tcagcagtgt caacagtctg gcagaggtgc acagacttta tgtagggggg
1381 cctcccttag agaaggagcc tcgagaactg tttgtgaagg gcaccatgaa ggacattcgt
1441 gagaacttcc aggacctgat gcagtactgt gcccaggacg tgtgggccac ccatgaggtt
1501 ttccagcagc agctaccgct cttcttggag aggtgtcccc acccagtgac tctggccggc
1561 atgctggaga tgggtgtctc ctacctgcct gtcaaccaga actgggagcg ttacctggca
1621 gaggcacagg gcacttatga ggagctccag cgggagatga agaagtcgtt gatggatctg
1681 gccaatgatg cctgccagct gctctcagga gagaggtaca aagaagaccc ctggctctgg
1741 gacctggagt gggacctgca agaatttaag cagaagaaag ctaagaaggt gaagaaggaa
1801 ccagccacag ccagcaagtt gcccatcgag ggggctgggg cccctggtga tcccatggat
1861 caggaagacc tcggcccctg cagtgaggag gaggagtttc aacaagatgt catggcccgc
1921 gcctgcttgc agaagctgaa ggggaccaca gagctcctgc ccaagcggcc ccagcacctt
1981 cctggacacc ctggatggta ccggaagctc tgcccccggc tagacgaccc tgcatggacc
2041 ccgggcccca gcctcctcag cctgcagatg cgggtcacac ctaaactcat ggcacttacc
2101 tgggatggct tccctctgca ctactcagag cgtcatggct ggggctactt ggtgcctggg
2161 cggcgggaca acctggccaa gctgccgaca ggtaccaccc tggagtcagc tggggtggtc
2221 tgcccctaca gagccatcga gtccctgtac aggaagcact gtctcgaaca ggggaagcag
2281 cagctgatgc cccaggaggc cggcctggcg gaggagttcc tgctcactga caatagtgcc
2341 atatggcaaa cggtagaaga actggattac ttagaagtgg aggctgaggc caagatggag
2401 aacttgcgag ctgcagtgcc aggtcaaccc ctagctctga ctgcccgtgg tggccccaag
2461 gacacccagc ccagctatca ccatggcaat ggaccttaca acgacgtgga catccctggc
2521 tgctggtttt tcaagctgcc tcacaaggat ggtaatagct gtaatgtggg aagccccttt
2581 gccaaggact tcctgcccaa gatggaggat ggcaccctgc aggctggccc aggaggtgcc
2641 agtgggcccc gtgctctgga aatcaacaaa atgatttctt tctggaggaa cgcccataaa
2701 cgtatcagct cccagatggt ggtgtggctg cccaggtcag ctctgccccg tgctgtgatc
2761 aggcaccccg actatgatga ggaaggcctc tatggggcca tcctgcccca agtggtgact
2821 gccggcacca tcactcgccg ggctgtggag cccacatggc tcaccgccag caatgcccgg
2881 cctgaccgag taggcagtga gttgaaagcc atggtgcagg ccccacctgg ctacaccctt
2941 gtgggtgctg atgtggactc ccaagagctg tggattgcag ctgtgcttgg agacgcccac
3001 tttgccggca tgcatggctg cacagccttt gggtggatga cactgcaggg caggaagagc
3061 aggggcactg atctacacag taagacagcc actactgtgg gcatcagccg tgagcatgcc
3121 aaaatcttca actacggccg catctatggt gctgggcagc cctttgctga gcgcttacta
3181 atgcagttta accaccggct cacacagcag gaggcagctg agaaggccca gcagatgtac
3241 gctgccacca agggcctccg ctggtatcgg ctgtcggatg agggcgagtg gctggtgagg
3301 gagttgaacc tcccagtgga caggactgag ggtggctgga tttccctgca ggatctgcgc
3361 aaggtccaga gagaaactgc aaggaagtca cagtggaaga agtgggaggt ggttgctgaa
3421 cgggcatgga aggggggcac agagtcagaa atgttcaata agcttgagag cattgctacg
3481 tctgacatac cacgtacccc ggtgctgggc tgctgcatca gccgagccct ggagccctcg
3541 gctgtccagg aagagtttat gaccagccgt gtgaattggg tggtacagag ctctgctgtt
3601 gactacttac acctcatgct tgtggccatg aagtggctgt ttgaagagtt tgccatagat
3661 gggcgcttct gcatcagcat ccatgacgag gttcgctacc tggtgcggga ggaggaccgc
3721 taccgcgctg ccctggcctt gcagatcacc aacctcttga ccaggtgcat gtttgcctac
3781 aagctgggtc tgaatgactt gccccagtca gtcgcctttt tcagtgcagt cgatattgac
3841 cggtgcctca ggaaggaagt gaccatggat tgtaaaaccc cttccaaccc aactgggatg
3901 gaaaggagat acgggattcc ccagggtgaa gcgctggata tttaccagat aattgaactc
3961 accaaaggct ccttggaaaa acgaagccag cctggaccat agcactgcct ggaggctctg
4021 tatttgctcc cgtggagctt catcggggtg gtgcaggctc ccaaactcag gctttcagct
4081 gtgctttttg caaaagggct tgcctaaggc cagccatttt tcagtagcag gacctgccaa
4141 gaagattcct tctaactgaa ggtgcagttg aattcagtgg gttcagaacc aagatgccaa
4201 catcggtgtg gactacagga caaggggcat tgttgcttgt tgggtaaaaa tgaagcagaa
4261 gccccaaagt tcacattaac tcaggcattt catttatttt ttccttttct tcttggctgg
4321 ttctttgttc tgtcccccat gctctgatgc agtgccctag aaggggaaag aattaatgct
4381 ctaacgtgat aaacctgctc caaggcagtg gaaataaaaa gaaggaaaaa aaagaaaaaa
4441 aaaaaaaaaa aaaaaaaaaa aaaat
//