LOCUS       X98093                  4465 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens mRNA for DNA polymerase gamma, mitochondrial protein.
ACCESSION   X98093
VERSION     X98093.1
KEYWORDS    DNA polymerase gamma catalytic subunit; MDP1 gene; mitochondria.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Lecrenier N.L., Van der Bruggen P., Foury F.
  TITLE     Mitochondrial DNA polymerases from yeast to man: a new family of
            polymerases
  JOURNAL   Gene 185(1), 147-152(1997).
   PUBMED   9034326
REFERENCE   2  (bases 1 to 4465)
  AUTHORS   Lecrenier N.L.
  JOURNAL   Submitted (21-MAY-1996) to the INSDC. N.L. Lecrenier, Universite
            Catholique de Louvain, Unite de Biochimie Physiologique, Place
            Croix du Sud 2/20, 1348 Louvain-la-Neuve, BELGIUM
FEATURES             Location/Qualifiers
     source          1..4465
                     /db_xref="H-InvDB:HIT000325036"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="Melanoma cDNA Library"
                     /db_xref="taxon:9606"
     CDS             283..4002
                     /gene="MDP1"
                     /product="DNA polymerase gamma"
                     /note="catalytic subunit"
                     /db_xref="GOA:P54098"
                     /db_xref="H-InvDB:HIT000325036.15"
                     /db_xref="HGNC:HGNC:9179"
                     /db_xref="InterPro:IPR001098"
                     /db_xref="InterPro:IPR002297"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR019760"
                     /db_xref="PDB:3IKM"
                     /db_xref="PDB:4ZTU"
                     /db_xref="PDB:4ZTZ"
                     /db_xref="PDB:5C51"
                     /db_xref="PDB:5C52"
                     /db_xref="PDB:5C53"
                     /db_xref="UniProtKB/Swiss-Prot:P54098"
                     /protein_id="CAA66719.1"
                     /translation="MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQ
                     QQQQQQQQQQQPQQPQVLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRR
                     SVEHLQKHGLWGQPAVPLPDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQA
                     QLPPKPPAWAWAEGWTRYGPEGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPS
                     AWYSWCSQRLVEERYSWTSQLSPADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRA
                     HIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQR
                     KARRGPAISSWDWLDISSVNSLAEVHRLYVGGPPLEKEPRELFVKGTMKDIRENFQDL
                     MQYCAQDVWATHEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLAEAQG
                     TYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPA
                     TASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQDVMARACLQKLKGTTELLPKRPQHL
                     PGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLV
                     PGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLT
                     DNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALTARGGPKDTQPSYHHGNGPYN
                     DVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMI
                     SFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAILPQVVTAGTITRRAVE
                     PTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAAVLGDAHFAGMHGCT
                     AFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQPFAERLLMQFNHR
                     LTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWISLQDLRKVQR
                     ETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCISRALEPSAV
                     QEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDR
                     YRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTPSNPT
                     GMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP"
BASE COUNT         1002 a         1256 c         1378 g          829 t
ORIGIN      
        1 gcggaccggc cgggtggagg ccacacgcta ccccgaggct gcgtaggccg cgcgaagggg
       61 gacgccgtgc cgtgggcctg gggtcggggg agcagcagac cgggaagcac cgtgaggacc
      121 gaggatttgg ggtggaaggc aggcatggtc aaacccattt cactgacagg agagcagaga
      181 caggacgtgt ctctctccac gtcttccagc cagtaaaaga agccaagctg gagcccaaag
      241 ccaggtgttc tgactcccag cgtgggggtc cctgcaccaa ccatgagccg cctgctctgg
      301 aggaaggtgg ccggcgccac cgtcgggcca gggccggttc cagctccggg gcgctgggtc
      361 tccagctccg tccccgcgtc cgaccccagc gacgggcagc ggcggcggca gcagcagcag
      421 cagcagcagc agcagcagca acagcagcct cagcagccgc aagtgctatc ctcggagggc
      481 gggcagctgc ggcacaaccc attggacatc cagatgctct cgagagggct gcacgagcaa
      541 atcttcgggc aaggagggga gatgcctggc gaggccgcgg tgcgccgcag cgtcgagcac
      601 ctgcagaagc acgggctctg ggggcagcca gccgtgccct tgcccgacgt ggagctgcgc
      661 ctgccgcccc tctacgggga caacctggac cagcacttcc gcctcctggc ccagaagcag
      721 agcctgccct acctggaggc ggccaacttg ctgttgcagg cccagctgcc cccgaagccc
      781 ccggcttggg cctgggcgga gggctggacc cggtacggcc ccgaggggga ggccgtaccc
      841 gtggccatcc ccgaggagcg ggccctggtg ttcgacgtgg aggtctgctt ggcagaggga
      901 acttgcccca cattggcggt ggccatatcc ccctcggcct ggtattcctg gtgcagccag
      961 cggctggtgg aagagcgtta ctcttggacc agccagctgt cgccggctga cctcatcccc
     1021 ctggaggtcc ctactggtgc cagcagcccc acccagagag actggcagga gcagttagtg
     1081 gtggggcaca atgtttcctt tgaccgagct catatcaggg agcagtacct gatccagggt
     1141 tcccgcatgc gtttcctgga caccatgagc atgcacatgg ccatctcagg gctaagcagc
     1201 ttccagcgca gtctgtggat agcagccaag cagggcaaac acaaggtcca gccccccaca
     1261 aagcaaggcc agaagtccca gaggaaagcc agaagaggcc cagcgatctc atcctgggac
     1321 tggctggaca tcagcagtgt caacagtctg gcagaggtgc acagacttta tgtagggggg
     1381 cctcccttag agaaggagcc tcgagaactg tttgtgaagg gcaccatgaa ggacattcgt
     1441 gagaacttcc aggacctgat gcagtactgt gcccaggacg tgtgggccac ccatgaggtt
     1501 ttccagcagc agctaccgct cttcttggag aggtgtcccc acccagtgac tctggccggc
     1561 atgctggaga tgggtgtctc ctacctgcct gtcaaccaga actgggagcg ttacctggca
     1621 gaggcacagg gcacttatga ggagctccag cgggagatga agaagtcgtt gatggatctg
     1681 gccaatgatg cctgccagct gctctcagga gagaggtaca aagaagaccc ctggctctgg
     1741 gacctggagt gggacctgca agaatttaag cagaagaaag ctaagaaggt gaagaaggaa
     1801 ccagccacag ccagcaagtt gcccatcgag ggggctgggg cccctggtga tcccatggat
     1861 caggaagacc tcggcccctg cagtgaggag gaggagtttc aacaagatgt catggcccgc
     1921 gcctgcttgc agaagctgaa ggggaccaca gagctcctgc ccaagcggcc ccagcacctt
     1981 cctggacacc ctggatggta ccggaagctc tgcccccggc tagacgaccc tgcatggacc
     2041 ccgggcccca gcctcctcag cctgcagatg cgggtcacac ctaaactcat ggcacttacc
     2101 tgggatggct tccctctgca ctactcagag cgtcatggct ggggctactt ggtgcctggg
     2161 cggcgggaca acctggccaa gctgccgaca ggtaccaccc tggagtcagc tggggtggtc
     2221 tgcccctaca gagccatcga gtccctgtac aggaagcact gtctcgaaca ggggaagcag
     2281 cagctgatgc cccaggaggc cggcctggcg gaggagttcc tgctcactga caatagtgcc
     2341 atatggcaaa cggtagaaga actggattac ttagaagtgg aggctgaggc caagatggag
     2401 aacttgcgag ctgcagtgcc aggtcaaccc ctagctctga ctgcccgtgg tggccccaag
     2461 gacacccagc ccagctatca ccatggcaat ggaccttaca acgacgtgga catccctggc
     2521 tgctggtttt tcaagctgcc tcacaaggat ggtaatagct gtaatgtggg aagccccttt
     2581 gccaaggact tcctgcccaa gatggaggat ggcaccctgc aggctggccc aggaggtgcc
     2641 agtgggcccc gtgctctgga aatcaacaaa atgatttctt tctggaggaa cgcccataaa
     2701 cgtatcagct cccagatggt ggtgtggctg cccaggtcag ctctgccccg tgctgtgatc
     2761 aggcaccccg actatgatga ggaaggcctc tatggggcca tcctgcccca agtggtgact
     2821 gccggcacca tcactcgccg ggctgtggag cccacatggc tcaccgccag caatgcccgg
     2881 cctgaccgag taggcagtga gttgaaagcc atggtgcagg ccccacctgg ctacaccctt
     2941 gtgggtgctg atgtggactc ccaagagctg tggattgcag ctgtgcttgg agacgcccac
     3001 tttgccggca tgcatggctg cacagccttt gggtggatga cactgcaggg caggaagagc
     3061 aggggcactg atctacacag taagacagcc actactgtgg gcatcagccg tgagcatgcc
     3121 aaaatcttca actacggccg catctatggt gctgggcagc cctttgctga gcgcttacta
     3181 atgcagttta accaccggct cacacagcag gaggcagctg agaaggccca gcagatgtac
     3241 gctgccacca agggcctccg ctggtatcgg ctgtcggatg agggcgagtg gctggtgagg
     3301 gagttgaacc tcccagtgga caggactgag ggtggctgga tttccctgca ggatctgcgc
     3361 aaggtccaga gagaaactgc aaggaagtca cagtggaaga agtgggaggt ggttgctgaa
     3421 cgggcatgga aggggggcac agagtcagaa atgttcaata agcttgagag cattgctacg
     3481 tctgacatac cacgtacccc ggtgctgggc tgctgcatca gccgagccct ggagccctcg
     3541 gctgtccagg aagagtttat gaccagccgt gtgaattggg tggtacagag ctctgctgtt
     3601 gactacttac acctcatgct tgtggccatg aagtggctgt ttgaagagtt tgccatagat
     3661 gggcgcttct gcatcagcat ccatgacgag gttcgctacc tggtgcggga ggaggaccgc
     3721 taccgcgctg ccctggcctt gcagatcacc aacctcttga ccaggtgcat gtttgcctac
     3781 aagctgggtc tgaatgactt gccccagtca gtcgcctttt tcagtgcagt cgatattgac
     3841 cggtgcctca ggaaggaagt gaccatggat tgtaaaaccc cttccaaccc aactgggatg
     3901 gaaaggagat acgggattcc ccagggtgaa gcgctggata tttaccagat aattgaactc
     3961 accaaaggct ccttggaaaa acgaagccag cctggaccat agcactgcct ggaggctctg
     4021 tatttgctcc cgtggagctt catcggggtg gtgcaggctc ccaaactcag gctttcagct
     4081 gtgctttttg caaaagggct tgcctaaggc cagccatttt tcagtagcag gacctgccaa
     4141 gaagattcct tctaactgaa ggtgcagttg aattcagtgg gttcagaacc aagatgccaa
     4201 catcggtgtg gactacagga caaggggcat tgttgcttgt tgggtaaaaa tgaagcagaa
     4261 gccccaaagt tcacattaac tcaggcattt catttatttt ttccttttct tcttggctgg
     4321 ttctttgttc tgtcccccat gctctgatgc agtgccctag aaggggaaag aattaatgct
     4381 ctaacgtgat aaacctgctc caaggcagtg gaaataaaaa gaaggaaaaa aaagaaaaaa
     4441 aaaaaaaaaa aaaaaaaaaa aaaat
//