LOCUS       X91906                  3173 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens voltage-gated chloride ion channel CLCN5.
ACCESSION   X91906
VERSION     X91906.1
KEYWORDS    CLCN5 gene; voltage-gated chloride channel.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Fisher,S.E., van,Bakel,I., Lloyd,S.E., Pearce,S.H.S., Thakker,R.V.
            and  Craig,I.W.
  TITLE     Cloning and characterization of CLCN5, the human kidney chloride
            channel gene implicated in Dent disease (an X-linked hereditary
            nephrolithiasis)
  JOURNAL   Genomics 29(3), 598-606(1995).
   PUBMED   8575751
REFERENCE   2  (bases 1 to 3173)
  AUTHORS   Craig,I.W.
  JOURNAL   Submitted (30-AUG-1995) to the INSDC. I.W. Craig, University of
            Oxford, Genetics Laboratory, Dept.of Biochemistry, South Parks
            Road, Oxford OX1 3QU, UK
REFERENCE   3
  AUTHORS   Lloyd,S.E., Pearce,S.H.S., Fisher,S.E., Steinmeyer,K.,
            Schwappach,B., Scheinman,S.J., Harding,B., Bolino,A., Devoto,M.,
            Goodyer,P., Rigden,S.P.A., Wrong,O., Jentsch,T.J., Craig,I.W. and 
            Thakker,R.V.
  TITLE     A common molecular basis for three inherited kidney stone diseases
  JOURNAL   Nature 379(6564), 445-449(1996).
   PUBMED   8559248
COMMENT     Related sequences X81836 and Z56277
FEATURES             Location/Qualifiers
     source          1..3173
                     /db_xref="H-InvDB:HIT000324475"
                     /organism="Homo sapiens"
                     /chromosome="X"
                     /map="p11.22"
                     /mol_type="mRNA"
                     /clone_lib="Clontech adult renal tissue library"
                     /clone="RL.3, RL.6, RL.7, RL.8"
                     /tissue_type="kidney"
                     /db_xref="taxon:9606"
     CDS             292..2532
                     /gene="CLCN5"
                     /product="voltage-gated chloride ion channel"
                     /db_xref="GOA:P51795"
                     /db_xref="H-InvDB:HIT000324475.14"
                     /db_xref="HGNC:HGNC:2023"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR001807"
                     /db_xref="InterPro:IPR002247"
                     /db_xref="InterPro:IPR014743"
                     /db_xref="PDB:2J9L"
                     /db_xref="PDB:2JA3"
                     /db_xref="UniProtKB/Swiss-Prot:P51795"
                     /protein_id="CAA63000.1"
                     /translation="MDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKEST
                     WALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCC
                     WNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKV
                     FAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVA
                     CCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLK
                     TLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGA
                     LFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDC
                     GLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKI
                     PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAA
                     ACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNG
                     YPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVV
                     SRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNI
                     LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDP
                     DSILFN"
BASE COUNT          811 a          682 c          732 g          948 t
ORIGIN
        1 tgatgtgata tggctgcaag tgcctttgac ccttttgtct cccttccata aactgaaata
       61 cctaagctgc tccaacctcc tttttgtctt ttgtttcata aatcctttcc cattgcacat
      121 caactcctgt ctctctttgt actgtcactc tcatctgttg ctttccattc acactgcctt
      181 tagccactca tcattttgtg cctacaccac agaaacctct gaatgtaatg gatgttccta
      241 ccagaggaca agtcgtacaa tggtggagga ataggttctt caaataggat catggacttc
      301 ttggaggagc caatccctgg tgtagggacc tatgatgatt tcaatacaat tgattgggtg
      361 agagagaagt ctcgagaccg ggataggcac cgagagatta ccaataaaag caaagagtca
      421 acatgggcct taattcacag tgtgagtgat gctttttccg gctggttgtt gatgctcctt
      481 attgggcttt tatcaggttc gttagctggt ttgatagaca tctctgctca ttggatgaca
      541 gacttaaaag aaggtatatg cacaggggga ttctggttta accatgaaca ttgttgctgg
      601 aactctgagc atgtcacctt tgaagagaga gacaaatgtc cagagtggaa tagttggtcc
      661 cagcttatca tcagcacaga tgagggagcc tttgcctaca tagtcaatta tttcatgtac
      721 gtcctctggg ctctcctatt tgccttcctt gccgtatctc ttgtcaaggt gtttgcgcct
      781 tatgcctgtg gctctggaat ccctgagata aaaactatct tgagtggttt cattattagg
      841 ggctatttgg gtaagtggac tctggttatc aaaaccatca ccttggtgct ggcagtgtcg
      901 tctggcttga gcctgggcaa agagggccct ctagtgcacg tggcttgctg ctgtgggaac
      961 atcctgtgcc actgcttcaa caaatacagg aagaatgaag ccaagcgcag agaggtcttg
     1021 tcggctgcag cagcagctgg tgtatctgta gcctttggag cacctatagg tggagtatta
     1081 ttcagccttg aagaggtcag ctactatttt cccctcaaaa cattgtggcg ttcattcttt
     1141 gctgccttgg tggcagcatt cactctacgc tccatcaatc catttgggaa cagccgcctg
     1201 gtactatttt atgtggagtt tcacacccca tggcatctct ttgagctcgt gccattcatt
     1261 ctgctgggca tatttggtgg tctgtgggga gcactgttta tccgcacaaa cattgcctgg
     1321 tgtcggaagc gaaagaccac ccagttgggc aagtatcctg ttatagaggt actcgtcgtg
     1381 acagccatca ctgccatcct ggctttcccc aatgaataca ctcggatgag cacaagtgag
     1441 ctcatttctg agctgtttaa tgactgtggc cttctggact cctccaagct ctgtgattat
     1501 gagaaccgtt tcaacacaag caaagggggt gaactgcctg acagaccggc tggcgtggga
     1561 gtctacagtg caatgtggca gctggcttta acactcatac tgaaaattgt cattactata
     1621 ttcacctttg gcatgaagat cccttctggc ctctttatcc ctagcatggc tgttggtgct
     1681 atagcaggtc gacttctagg agtaggaatg gaacagctgg cttattacca ccaggaatgg
     1741 accgtcttca atagctggtg tagtcaggga gctgattgca tcacccccgg cctttatgca
     1801 atggttgggg ctgcagcctg cttaggtggg gtgactcgga tgactgtttc tcttgttgtc
     1861 ataatgtttg aactgactgg tggcttagaa tacatcgtgc ctctgatggc tgcagccatg
     1921 acaagcaagt gggtggcaga tgctcttggg cgggagggca tctatgatgc ccacatccgt
     1981 ctcaatggat acccctttct tgaagccaaa gaagagtttg ctcataagac cctggcaatg
     2041 gatgtgatga aaccccggag aaatgatcct ttgttgactg tccttactca ggacagtatg
     2101 actgtggaag atgtagagac cataatcagt gaaaccactt acagtggctt cccagtggtg
     2161 gtatcccggg agtcccaaag acttgtgggc tttgtcctcc gaagagatct cattatttca
     2221 attgaaaatg ctcgaaagaa acaggatggg gttgttagca cttccatcat ttatttcacg
     2281 gagcattctc ctccattgcc accatacact ccacccactc taaagcttcg gaacatcctc
     2341 gatctcagcc ccttcactgt gactgacctt acacccatgg agatcgtagt ggatattttc
     2401 cgaaagctgg gactgcggca gtgcctggtt acacacaacg ggcgattgct tggaatcatt
     2461 accaaaaagg atgtgttaaa gcatatagca cagatggcga accaagatcc tgattccatt
     2521 ctcttcaact agaatcatag agttctggat gtaaagcggg aaggacatta cagaccatgg
     2581 atatgttgtt taacggtacc caaaacacat tttccatatt tggatggtga agtcacatta
     2641 gtgtgttgtc tctttcctac aagttaacca gttgcactac ataatctctg gaaattaatt
     2701 ttctctttag gagaaattat agttaggctt ccatgatgtt acattaggaa gatatcatga
     2761 aagaataaat aagattgcta tggtttaatt atatttgctt tttaaaagat ttttttaact
     2821 taaaaagtag ttagccaata tgcaatcact gaaaactatg caagagaaat tccaaccgtc
     2881 ctgacctata acctgtagga aaccgacgaa aaagtcactc ttttgggatc taactgttgt
     2941 tactggaaga cgaaggtaaa ctaaggggct ttgcttttca aaccagagaa aggaaagcca
     3001 gaaggaaaag agtaatggta ttttctagac tgtgaagatt cagttcaaat gttatccttg
     3061 ttcctgttac aatatttagc attattagtt tgttatgtgt gtatgtttat gttaatttta
     3121 atttctgatt ataagacaat gctgctttgg ttaatctctt ctaaaggaat tta
//