LOCUS X77196 1868 bp mRNA linear HUM 07-OCT-2008
DEFINITION H.sapiens mRNA for lysosome-associated membrane protein-2.
ACCESSION X77196
VERSION X77196.1
KEYWORDS lysosome associated; membrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Konecki D.S., Foetisch K., Schlotter M., Lichter-Konecki U.
TITLE Complete cDNA sequence of human lysosome-associated membrane
protein-2
JOURNAL Biochem. Biophys. Res. Commun. 205(1), 1-5(1994).
PUBMED 7999007
REFERENCE 2 (bases 1 to 1868)
AUTHORS Konecki D.S.
JOURNAL Submitted (22-JAN-1994) to the INSDC. D.S. Konecki, Deutsche
Krebsforschungszentrum, Im Neuenheimer Feld 280, Zimmer Nr 685b,
69120 Heidelberg, FRG
FEATURES Location/Qualifiers
source 1..1868
/db_xref="H-InvDB:HIT000323611"
/organism="Homo sapiens"
/chromosome="X"
/map="Xq24"
/isolate="patient D.S."
/mol_type="mRNA"
/clone_lib="lambda-1956"
/clone="122A2, 104A2, 122B2, B25, B1, 104C2, 122B1, B34,
B31, 122A1, B30, B28, B22, B24, B21, B4"
/cell_type="hepatocyte"
/tissue_type="liver"
/db_xref="taxon:9606"
mRNA join(1..201,202..320,321..534,535..693,694..878,879..1001,
1002..1065,1066..1230,1231..1868)
prim_transcript 1..1868
exon 1..201
/number=1
CDS join(138..201,202..320,321..534,535..693,694..878,
879..1001,1002..1065,1066..1230,1231..1370)
/product="lysosome-associated membrane protein-2"
/db_xref="GOA:P13473"
/db_xref="H-InvDB:HIT000323611.14"
/db_xref="HGNC:HGNC:6501"
/db_xref="InterPro:IPR002000"
/db_xref="InterPro:IPR018134"
/db_xref="PDB:2MOF"
/db_xref="PDB:2MOM"
/db_xref="UniProtKB/Swiss-Prot:P13473"
/protein_id="CAA54416.1"
/translation="MVCFRLFPVPGSGLVLVCLVLGAVRSYALELNLTDSENATCLYA
KWQMNFTVRYETTNKTYKTVTISDHGTVTYNGSICGDDQNGPKIAVQFGPGFSWIANF
TKAASTYSIDSVSFSYNTGDNTTFPDAEDKGILTVDELLAIRIPLNDLFRCNSLSTLE
KNDVVQHYWDVLVQAFVQNGTVSTNEFLCDKDKTSTVAPTIHTTVPSPTTTPTPKEKP
EAGTYSVNNGNDTCLLATMGLQLNITQDKVASVININPNTTHSTGSCRSHTALLRLNS
STIKYLDFVFAVKNENRFYLKEVNISMYLVNGSVFSIANNNLSYWDAPLGSSYMCNKE
QTVSVSGAFQINTFDLRVQPFNVTQGKYSTAQDCSADDDNFLVPIAVGAALAGVLILV
LLAYFIGLKHHHAGYEQF"
exon 202..320
/number=2
mat_peptide join(222..320,321..534,535..693,694..878,879..1001,
1002..1065,1066..1230,1231..1367)
/product="lysosome-associated membrane protein-2"
variation 294
/note="polymorphism (RsaI) and sequence difference C/T"
exon 321..534
/number=3
misc_difference 469
/note="sequence difference T/A, resulting amino acid
substitution I/N"
exon 535..693
/number=4
exon 694..878
/number=5
misc_difference 795
/note="sequence difference G/C, resulting amino acid
substitution A/P"
misc_difference 838..839
/note="sequence difference TG/GT, resulting amino acid
substitution L/R"
exon 879..1001
/number=6
exon 1002..1065
/number=7
variation 1064
/note="polymorphism (Nla IV) and sequence difference C/T"
exon 1066..1230
/number=8
exon 1231..1868
/number=9
regulatory 1520..1525
/regulatory_class="polyA_signal_sequence"
misc_difference 1623..1624
/note="sequence difference -/G"
misc_difference 1633..1634
/note="sequence difference -/G"
misc_difference 1652
/note="sequence difference T/-"
misc_difference 1658
/note="sequence difference T/-"
misc_difference 1662
/note="sequence difference C/-"
misc_difference 1672
/note="sequence difference G/-"
regulatory 1703..1708
/regulatory_class="polyA_signal_sequence"
regulatory 1735..1738
/regulatory_class="polyA_signal_sequence"
misc_difference 1768
/note="sequence difference T/-"
misc_difference 1773
/note="sequence difference G/C"
misc_difference 1821
/note="sequence difference C/G"
regulatory 1829..1834
/regulatory_class="polyA_signal_sequence"
BASE COUNT 530 a 398 c 368 g 572 t
ORIGIN
1 ccgattcctg gcttttgcaa ggctgtggtc ggtggtcatc agtgctcttg acccaggtcc
61 agcgagcctt ttccctggtg ttgcagctgt tgttgtaccg ccgccgtcgc cgccgtcgcc
121 gcctgctctg cggggtcatg gtgtgcttcc gcctcttccc ggttccgggc tcagggctcg
181 ttctggtctg cctagtcctg ggagctgtgc ggtcttatgc attggaactt aatttgacag
241 attcagaaaa tgccacttgc ctttatgcaa aatggcagat gaatttcaca gtacgctatg
301 aaactacaaa taaaacttat aaaactgtaa ccatttcaga ccatggcact gtgacatata
361 atggaagcat ttgtggggat gatcagaatg gtcccaaaat agcagtgcag ttcggacctg
421 gcttttcctg gattgcgaat tttaccaagg cagcatctac ttattcaatt gacagcgtct
481 cattttccta caacactggt gataacacaa catttcctga tgctgaagat aaaggaattc
541 ttactgttga tgaacttttg gccatcagaa ttccattgaa tgaccttttt agatgcaata
601 gtttatcaac tttggaaaag aatgatgttg tccaacacta ctgggatgtt cttgtacaag
661 cttttgtcca aaatggcaca gtgagcacaa atgagttcct gtgtgataaa gacaaaactt
721 caacagtggc acccaccata cacaccactg tgccatctcc tactacaaca cctactccaa
781 aggaaaaacc agaagctgga acctattcag ttaataatgg caatgatact tgtctgctgg
841 ctaccatggg gctgcagctg aacatcactc aggataaggt tgcttcagtt attaacatca
901 accccaatac aactcactcc acaggcagct gccgttctca cactgctcta cttagactca
961 atagcagcac cattaagtat ctagactttg tctttgctgt gaaaaatgaa aaccgatttt
1021 atctgaagga agtgaacatc agcatgtatt tggttaatgg ctccgttttc agcattgcaa
1081 ataacaatct cagctactgg gatgcccccc tgggaagttc ttatatgtgc aacaaagagc
1141 agactgtttc agtgtctgga gcatttcaga taaatacctt tgatctaagg gttcagcctt
1201 tcaatgtgac acaaggaaag tattctacag ctcaagactg cagtgcagat gacgacaact
1261 tccttgtgcc catagcggtg ggagctgcct tggcaggagt acttattcta gtgttgctgg
1321 cttattttat tggtctcaag caccatcatg ctggatatga gcaattttag aatctgcaac
1381 ctgattgatt atataaaaat acatgcaaat aacaagattt tcttacctct cagttgttga
1441 aacactttgc ttcttaaaat tgatatgttg aaactttaat tcttttatca atcccagcat
1501 tttgagatca gtctttatta ataaaacctg ttctctttaa tcagcttaaa atccaaagtg
1561 tcatatttac tggtcctgga gacaaacttg ttcaaaagaa catcaacgtg caatgtttta
1621 aggtctatct taagaagccc tggccaaatt ttgatcctaa ccttgaagta tgccttgaac
1681 ttattaacat ggccattata agaataaaat atgtagttgt gtcttaatgg aattaataaa
1741 tgtcatttca ctactggtgt tctgttttca atgtataagg actatagtga tttaaactca
1801 tcaatgtgcc tttgcataaa gttgattaaa taaatattga tgtggtataa atgcccatca
1861 gatatgct
//