LOCUS       X70508                   450 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for insulinoma pre-proinsulin.
ACCESSION   X70508
VERSION     X70508.1
KEYWORDS    preproinsulin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 450)
  AUTHORS   Chekhranova,M.K., Shubalova,E.I., Kutin,A.M., Betnev,V.Y.,
            Valentsova,A.B., Il'ina,E.N. and  Pankov,Y.A.
  TITLE     Cloning, primary structure determination and expression of
            preproinsulin cDNA from human insulinoma in Escherichia coli
  JOURNAL   Mol. Biol. (Mosk.) 26(3), 596-600(1992).
   PUBMED   1406615
FEATURES             Location/Qualifiers
     source          1..450
                     /db_xref="H-InvDB:HIT000323103"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="Human insulinoma cDNA library"
                     /clone="pUEX1Ins12"
                     /db_xref="taxon:9606"
     sig_peptide     45..80
     CDS             45..377
                     /product="pre-proinsulin"
                     /db_xref="GOA:P01308"
                     /db_xref="H-InvDB:HIT000323103.12"
                     /db_xref="HGNC:HGNC:6081"
                     /db_xref="InterPro:IPR004825"
                     /db_xref="InterPro:IPR016179"
                     /db_xref="InterPro:IPR022352"
                     /db_xref="InterPro:IPR022353"
                     /db_xref="PDB:1A7F"
                     /db_xref="PDB:1AI0"
                     /db_xref="PDB:1AIY"
                     /db_xref="PDB:1B9E"
                     /db_xref="PDB:1BEN"
                     /db_xref="PDB:1EFE"
                     /db_xref="PDB:1EV3"
                     /db_xref="PDB:1EV6"
                     /db_xref="PDB:1EVR"
                     /db_xref="PDB:1FU2"
                     /db_xref="PDB:1FUB"
                     /db_xref="PDB:1G7A"
                     /db_xref="PDB:1G7B"
                     /db_xref="PDB:1GUJ"
                     /db_xref="PDB:1HIQ"
                     /db_xref="PDB:1HIS"
                     /db_xref="PDB:1HIT"
                     /db_xref="PDB:1HLS"
                     /db_xref="PDB:1HTV"
                     /db_xref="PDB:1HUI"
                     /db_xref="PDB:1IOG"
                     /db_xref="PDB:1IOH"
                     /db_xref="PDB:1J73"
                     /db_xref="PDB:1JCA"
                     /db_xref="PDB:1JCO"
                     /db_xref="PDB:1JK8"
                     /db_xref="PDB:1K3M"
                     /db_xref="PDB:1KMF"
                     /db_xref="PDB:1LKQ"
                     /db_xref="PDB:1LPH"
                     /db_xref="PDB:1MHI"
                     /db_xref="PDB:1MHJ"
                     /db_xref="PDB:1MSO"
                     /db_xref="PDB:1OS3"
                     /db_xref="PDB:1OS4"
                     /db_xref="PDB:1Q4V"
                     /db_xref="PDB:1QIY"
                     /db_xref="PDB:1QIZ"
                     /db_xref="PDB:1QJ0"
                     /db_xref="PDB:1RWE"
                     /db_xref="PDB:1SF1"
                     /db_xref="PDB:1SJT"
                     /db_xref="PDB:1SJU"
                     /db_xref="PDB:1T0C"
                     /db_xref="PDB:1T1K"
                     /db_xref="PDB:1T1P"
                     /db_xref="PDB:1T1Q"
                     /db_xref="PDB:1TRZ"
                     /db_xref="PDB:1TYL"
                     /db_xref="PDB:1TYM"
                     /db_xref="PDB:1UZ9"
                     /db_xref="PDB:1VKT"
                     /db_xref="PDB:1W8P"
                     /db_xref="PDB:1XDA"
                     /db_xref="PDB:1XGL"
                     /db_xref="PDB:1XW7"
                     /db_xref="PDB:1ZEG"
                     /db_xref="PDB:1ZEH"
                     /db_xref="PDB:1ZNJ"
                     /db_xref="PDB:2AIY"
                     /db_xref="PDB:2C8Q"
                     /db_xref="PDB:2C8R"
                     /db_xref="PDB:2CEU"
                     /db_xref="PDB:2G54"
                     /db_xref="PDB:2G56"
                     /db_xref="PDB:2H67"
                     /db_xref="PDB:2HH4"
                     /db_xref="PDB:2HHO"
                     /db_xref="PDB:2HIU"
                     /db_xref="PDB:2JMN"
                     /db_xref="PDB:2JUM"
                     /db_xref="PDB:2JUU"
                     /db_xref="PDB:2JUV"
                     /db_xref="PDB:2JV1"
                     /db_xref="PDB:2JZQ"
                     /db_xref="PDB:2K91"
                     /db_xref="PDB:2K9R"
                     /db_xref="PDB:2KJJ"
                     /db_xref="PDB:2KJU"
                     /db_xref="PDB:2KQP"
                     /db_xref="PDB:2KQQ"
                     /db_xref="PDB:2KXK"
                     /db_xref="PDB:2L1Y"
                     /db_xref="PDB:2L1Z"
                     /db_xref="PDB:2LGB"
                     /db_xref="PDB:2LWZ"
                     /db_xref="PDB:2M1D"
                     /db_xref="PDB:2M1E"
                     /db_xref="PDB:2M2M"
                     /db_xref="PDB:2M2N"
                     /db_xref="PDB:2M2O"
                     /db_xref="PDB:2M2P"
                     /db_xref="PDB:2OLY"
                     /db_xref="PDB:2OLZ"
                     /db_xref="PDB:2OM0"
                     /db_xref="PDB:2OM1"
                     /db_xref="PDB:2OMG"
                     /db_xref="PDB:2OMH"
                     /db_xref="PDB:2OMI"
                     /db_xref="PDB:2QIU"
                     /db_xref="PDB:2R34"
                     /db_xref="PDB:2R35"
                     /db_xref="PDB:2R36"
                     /db_xref="PDB:2RN5"
                     /db_xref="PDB:2VJZ"
                     /db_xref="PDB:2VK0"
                     /db_xref="PDB:2W44"
                     /db_xref="PDB:2WBY"
                     /db_xref="PDB:2WC0"
                     /db_xref="PDB:2WRU"
                     /db_xref="PDB:2WRV"
                     /db_xref="PDB:2WRW"
                     /db_xref="PDB:2WRX"
                     /db_xref="PDB:2WS0"
                     /db_xref="PDB:2WS1"
                     /db_xref="PDB:2WS4"
                     /db_xref="PDB:2WS6"
                     /db_xref="PDB:2WS7"
                     /db_xref="PDB:3AIY"
                     /db_xref="PDB:3BRR"
                     /db_xref="PDB:3BXQ"
                     /db_xref="PDB:3E7Y"
                     /db_xref="PDB:3E7Z"
                     /db_xref="PDB:3EXX"
                     /db_xref="PDB:3FQ9"
                     /db_xref="PDB:3HYD"
                     /db_xref="PDB:3I3Z"
                     /db_xref="PDB:3I40"
                     /db_xref="PDB:3ILG"
                     /db_xref="PDB:3INC"
                     /db_xref="PDB:3IR0"
                     /db_xref="PDB:3JSD"
                     /db_xref="PDB:3KQ6"
                     /db_xref="PDB:3P2X"
                     /db_xref="PDB:3P33"
                     /db_xref="PDB:3Q6E"
                     /db_xref="PDB:3ROV"
                     /db_xref="PDB:3TT8"
                     /db_xref="PDB:3U4N"
                     /db_xref="PDB:3UTQ"
                     /db_xref="PDB:3UTS"
                     /db_xref="PDB:3UTT"
                     /db_xref="PDB:3V19"
                     /db_xref="PDB:3V1G"
                     /db_xref="PDB:3W11"
                     /db_xref="PDB:3W12"
                     /db_xref="PDB:3W13"
                     /db_xref="PDB:3W7Y"
                     /db_xref="PDB:3W7Z"
                     /db_xref="PDB:3W80"
                     /db_xref="PDB:3ZI3"
                     /db_xref="PDB:3ZQR"
                     /db_xref="PDB:3ZS2"
                     /db_xref="PDB:3ZU1"
                     /db_xref="PDB:4AIY"
                     /db_xref="PDB:4AJX"
                     /db_xref="PDB:4AJZ"
                     /db_xref="PDB:4AK0"
                     /db_xref="PDB:4AKJ"
                     /db_xref="PDB:4EFX"
                     /db_xref="PDB:4EWW"
                     /db_xref="PDB:4EWX"
                     /db_xref="PDB:4EWZ"
                     /db_xref="PDB:4EX0"
                     /db_xref="PDB:4EX1"
                     /db_xref="PDB:4EXX"
                     /db_xref="PDB:4EY1"
                     /db_xref="PDB:4EY9"
                     /db_xref="PDB:4EYD"
                     /db_xref="PDB:4EYN"
                     /db_xref="PDB:4EYP"
                     /db_xref="PDB:4F0N"
                     /db_xref="PDB:4F0O"
                     /db_xref="PDB:4F1A"
                     /db_xref="PDB:4F1B"
                     /db_xref="PDB:4F1C"
                     /db_xref="PDB:4F1D"
                     /db_xref="PDB:4F1F"
                     /db_xref="PDB:4F1G"
                     /db_xref="PDB:4F4T"
                     /db_xref="PDB:4F4V"
                     /db_xref="PDB:4F51"
                     /db_xref="PDB:4F8F"
                     /db_xref="PDB:4FG3"
                     /db_xref="PDB:4FKA"
                     /db_xref="PDB:4GBC"
                     /db_xref="PDB:4GBI"
                     /db_xref="PDB:4GBK"
                     /db_xref="PDB:4GBL"
                     /db_xref="PDB:4GBN"
                     /db_xref="PDB:4IUZ"
                     /db_xref="PDB:4IYD"
                     /db_xref="PDB:4IYF"
                     /db_xref="PDB:5AIY"
                     /db_xref="UniProtKB/Swiss-Prot:P01308"
                     /protein_id="CAA49913.1"
                     /translation="MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCG
                     ERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSL
                     YQLENYCN"
     mat_peptide     80..374
                     /product="pre-proinsulin"
BASE COUNT           86 a          152 c          136 g           76 t
ORIGIN
        1 gctgcatcag aagaggccat caagcacatc actgtccttc tgccatggcc ctgtggatgc
       61 gcctcctgcc cctgctggcg ctgctggccc tctggggacc tgacccagcc gcagcctttg
      121 tgaaccaaca cctgtgcggc tcacacctgg tggaagctct ctacctagtg tgcggggaac
      181 gaggcttctt ctacacaccc aagacccgcc gggaggcaga ggacctgcag gtggggcagg
      241 tggagctggg cgggggccct ggtgcaggca gcctgcagcc cttggccctg gaggggtccc
      301 tgcagaagcg tggcattgtg gaacaatgct gtaccagcat ctgctccctc taccagctgg
      361 agaactactg caactagacg cagcccgcag gcagcccccc acccgccgcc tcctgcaccg
      421 agagagatgg aataaagccc ttgaaccagc
//