LOCUS X70340 4119 bp mRNA linear HUM 07-DEC-1993
DEFINITION H.sapiens mRNA for transforming growth factor alpha.
ACCESSION X70340
VERSION X70340.1
KEYWORDS transforming growth factor alpha.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1
AUTHORS Qian J.F., Feingold J., Stoll C., May E.
TITLE Transforming growth factor-alpha: characterization of the BamHI,
RsaI, and TaqI polymorphic regions
JOURNAL Am. J. Hum. Genet. 53(1), 168-175(1993).
PUBMED 8100397
REFERENCE 2 (bases 1 to 4119)
AUTHORS May E.
JOURNAL Submitted (04-FEB-1993) to the INSDC. E. May, Lab d'Oncologie
Moleculaire - IRSC-CNRS, 7 rue Guy Moquet, 94801 Villejuif Cedex,
FRANCE
REFERENCE 3
AUTHORS Qian J.F., Lazar-Wesley E., Breugnot C., May E.
TITLE Human transforming growth factor alpha: sequence analysis of the
4.5-kb and 1.6-kb mRNA species
JOURNAL Gene 132(2), 291-296(1993).
PUBMED 8224876
FEATURES Location/Qualifiers
source 1..4119
/db_xref="H-InvDB:HIT000323098"
/organism="Homo sapiens"
/chromosome="2"
/map="2p13"
/mol_type="mRNA"
/cell_line="SW613S c13"
/cell_type="carcinoma"
/tissue_type="colon"
/db_xref="taxon:9606"
CDS 32..514
/gene="TGFA"
/product="transforming growth factor alpha"
/db_xref="GOA:P01135"
/db_xref="H-InvDB:HIT000323098.15"
/db_xref="HGNC:HGNC:11765"
/db_xref="InterPro:IPR000742"
/db_xref="InterPro:IPR013032"
/db_xref="PDB:1GK5"
/db_xref="PDB:1MOX"
/db_xref="PDB:1YUF"
/db_xref="PDB:1YUG"
/db_xref="PDB:2TGF"
/db_xref="PDB:3E50"
/db_xref="PDB:3TGF"
/db_xref="PDB:4TGF"
/db_xref="PDB:5KN5"
/db_xref="UniProtKB/Swiss-Prot:P01135"
/protein_id="CAA49806.1"
/translation="MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHF
NDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITA
LVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
"
mat_peptide 149..298
/product="transforming growth factor alpha"
polyA_site 1333..1338
/note="1.6 kb species"
misc_feature 2796..2801
/note="BamHI polymorphic site"
polyA_site 4069..4074
/note="4.5 kb species"
BASE COUNT 1122 a 897 c 916 g 1184 t
ORIGIN
1 ctggagagcc tgctgcccgc ccgcccgtaa aatggtcccc tcggctggac agctcgccct
61 gttcgctctg ggtattgtgt tggctgcgtg ccaggccttg gagaacagca cgtccccgct
121 gagtgcagac ccgcccgtgg ctgcagcagt ggtgtcccat tttaatgact gcccagattc
181 ccacactcag ttctgcttcc atggaacctg caggtttttg gtgcaggagg acaagccagc
241 atgtgtctgc cattctgggt acgttggtgc acgctgtgag catgcggacc tcctggccgt
301 ggtggctgcc agccagaaga agcaggccat caccgccttg gtggtggtct ccatcgtggc
361 cctggctgtc cttatcatca catgtgtgct gatacactgc tgccaggtcc gaaaacactg
421 tgagtggtgc cgggccctca tctgccggca cgagaagccc agcgccctcc tgaagggaag
481 aaccgcttgc tgccactcag aaacagtggt ctgaagagcc cagaggagga gtttggccag
541 gtggactgtg gcagatcaat aaagaaaggc ttcttcagga cagcactgcc agagatgcct
601 gggtgtgcca cagaccttcc tacttggcct gtaatcacct gtgcagcctt ttgtgggcct
661 tcaaaactct gtcaagaact ccgtctgctt ggggttattc agtgtgacct agagaagaaa
721 tcagcggacc acgatttcaa gacttgttaa aaaagaactg caaagagacg gactcctgtt
781 cacctaggtg aggtgtgtgc agcagttggt gtctgagtcc acatgtgtgc agttgtcttc
841 tgccagccat ggattccagg ctatatattt ctttttaatg ggccacctcc ccacaacaga
901 attctgccca acacaggaga tttctatagt tattgttttc tgtcatttgc ctactgggga
961 agaaagtgaa ggaggggaaa ctgtttaata tcacatgaag accctagctt taagagaagc
1021 tgtatcctct aaccacgaga ctctcaacca gcccaacatc ttccatggac acatgacatt
1081 gaagaccatc ccaagctatc gccacccttg gagatgatgt cttatttatt agatggataa
1141 tggttttatt tttaatctct taagtcaatg taaaaagtat aaaacccctt cagacttcta
1201 cattaatgat gtatgtgttg ctgactgaaa agctatactg attagaaatg tctggcctct
1261 tcaagacagc taaggcttgg gaaaagtctt ccagggtgcg gagatggaac cagaggctgg
1321 gttactggta ggaataaagg taggggttca gaaatggtgc cattgaagcc acaaagccgg
1381 taaatgcctc aatacgttct gggagaaaac ttagcaaatc catcagcagg gatctgtccc
1441 ctctgttggg gagagaggaa gagtgtgtgt gtctacacag gataaaccca atacatattg
1501 tactgctcag tgattaaatg ggttcacttc ctcgtgagcc ctcggtaagt atgtttagaa
1561 atagaacatt agccacgagc cataggcatt tcaggccaaa tccatgaaag ggggaccagt
1621 catttatttt ccattttgtt gcttggttgg tttgttgctt tatttttaaa aggagaagtt
1681 taactttgct atttattttc gagcactagg aaaactattc cagtaatttt tttttcctca
1741 tttccattca ggatgccggc tttattaaca aaaactctaa caagtcacct ccactatgtg
1801 ggtcttcctt tcccctcaag agaaggagca attgttcccc tgacatctgg gtccatctga
1861 cccatggggc ctgcctgtga gaaacagtgg gtcccttcaa atacatagtg gatagctcat
1921 ccctaggaat tttcattaaa atttggaaac agagtaatga agaaataata tataaactcc
1981 ttatgtgagg aaatgctact aatatctgaa aagtgaaaga tttctatgta ttaactctta
2041 agtgcaccta gcttattaca tcgtgaaagg tacatttaaa atatgttaaa ttggcttgaa
2101 attttcagag aattttgtct tcccctaatt cttcttcctt ggtctggaag aacaatttct
2161 atgaattttc tctttatttt ttttttataa ttcagacaat tctatgaccc gtgtcttcat
2221 ttttggcact cttatttaac aatgccacac ctgaagcact tggatctgtt cagagctgac
2281 cccctagcaa cgtagttgac acagctccag gtttttaaat tactaaaata agttcaagtt
2341 tacatccctt gggccagata tgtgggttga ggcttgactg tagcatcctg cttagagacc
2401 aatcaatgga cactggtttt tagacctcta tcaatcagta gttagcatcc aagagacttt
2461 gcagaggcgt aggaatgagg ctggacagat ggcggaacga gaggttccct gcgaagactt
2521 gagatttagt gtctgtgaat gttctagttc ctaggtccag caagtcacac ctgccagtgc
2581 cctcatcctt atgcctgtaa cacacatgca gtgagaggcc tcacatatac gcctccctag
2641 aagtgccttc caagtcagtc ctttggaaac cagcaggtct gaaaaagagg ctgcatcaat
2701 gcaagcctgg ttggaccatt gtccatgcct caggatagaa cagcctggct tatttgggga
2761 tttttcttct agaaatcaaa tgactgataa gcattggctc cctctgccat ttaatggcaa
2821 tggtagtctt tggttagctg caaaaatact ccatttcaag ttaaaaatgc atcttctaat
2881 ccatctctgc aagctccctg tgtttccttg ccctttagaa aatgaattgt tcactacaat
2941 tagagaatca tttaacatcc tgacctggta agctgccaca cacctggcag tggggagcat
3001 cgctgtttcc aatggctcag gagacaatga aaagccccca tttaaaaaaa taacaaacat
3061 tttttaaaag gcctccaata ctcttatgga gcctggattt ttcccactgc tctacaggct
3121 gtgacttttt ttaagcatcc tgacaggaaa tgttttcttc tacatggaaa gatagacagc
3181 agccaaccct gatctggaag acagggcccc ggctggacac acgtggaacc aagccaggga
3241 tgggctggcc attgtgtccc cgcaggagag atgggcagaa tggccctaga gttcttttcc
3301 ctgagaaagg agaaaaagat gggattgcca ctcacccacc cacactggta agggaggaga
3361 atttgtgctt ctggagcttc tcaagggatt gtgttttgca ggtacagaaa actgcctgtt
3421 atcttcaagc caggttttcg agggcacatg ggtcaccagt tgctttttca gtcaatttgg
3481 ccgggatgga ctaatgaggc tctaacactg ctcaggagac ccctgccctc tagttggttc
3541 tgggctttga tctcttccaa cctgcccagt cacagaagga ggaatgactc aaatgcccaa
3601 aaccaagaac acattgcaga agtaagacaa acatgtatat ttttaaatgt tctaacataa
3661 gacctgttct ctctagccat tgatttacca ggctttctga aagatctagt ggttcacaca
3721 gagagagaga gagtactgaa aaagcaactc ctcttcttag tcttaataat ttactaaaat
3781 ggtcaacttt tcattatctt tattataata aacctgatgc ttttttttag aactccttac
3841 tctgatgtct gtatatgttg cactgaaaag gttaatattt aatgttttaa tttattttgt
3901 gtggtaagtt aattttgatt tctgtaatgt gttaatgtga ttagcagtta ttttccttaa
3961 tatctgaatt atacttaaag agtagtgagc aatataagac gcaattgtgt ttttcagtaa
4021 tgtgcattgt tattgagttg tactgtacct tatttggaag gatgaaggaa tgaacctttt
4081 tttcctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//