LOCUS       X63692                  5434 bp    mRNA    linear   HUM 11-DEC-1996
DEFINITION  H.sapiens mRNA for DNA (cytosin-5)-methyltransferase.
ACCESSION   X63692
VERSION     X63692.1
KEYWORDS    DNA methyltransferase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Yen,R.
  JOURNAL   Submitted (31-JAN-1992) to the INSDC. R. Yen, The Oncology Center,
            The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
            21213, USA
  REMARK    Revised by [3]
REFERENCE   2  (bases 1 to 5194)
  AUTHORS   Yen,R.W.C., Vertino,P.M., Nelkin,B.D., Yu,J.J., Deiry,W.E.,
            Cumaraswamy,A., Lennon,G.G., Trask,B.J., Celano,P. and  Baylin,S.B.
  TITLE     Isolation and characterization of the cDNA encoding human DNA
            methyltransferase
  JOURNAL   Nucleic Acids Res. 20(9), 2287-2291(1992).
   PUBMED   1594447
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Yen,R.
  JOURNAL   Submitted (23-OCT-1996) to the INSDC. R. Yen, The Oncology Center,
            The Johns Hopkins Medical Inst, 424 N Bond Street, Baltimore MD
            21213, USA
REFERENCE   5  (bases 1 to 5434)
  AUTHORS   Bestor,T., Laudano,A., Mattaliano,R. and  Ingram,V.
  TITLE     Cloning and sequencing of mammalian DNA methyltransferase
  JOURNAL   J. Mol. Biol. 203(4), 971-983(1988).
   PUBMED   3210246
REFERENCE   6  (bases 1 to 5434)
  AUTHORS   Yoder,J.A., Yen,R.C., Vertino,P.M., Bestor,T.H. and  Baylin,S.B.
  TITLE     New 5' regions of the murine and human genes for DNA
            (cytosine-5)-methyltransferase
  JOURNAL   J Biol Chem 271(49), 31092-31097(1996).
   PUBMED   8940105
FEATURES             Location/Qualifiers
     source          1..5434
                     /db_xref="H-InvDB:HIT000322624"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="TT cells"
                     /cell_type="medullary thyroid carcinoma"
                     /db_xref="taxon:9606"
     CDS             238..5088
                     /product="DNA (cytosine-5-)-methyltransferase"
                     /EC_number="2.1.1.37"
                     /db_xref="GOA:P26358"
                     /db_xref="H-InvDB:HIT000322624.13"
                     /db_xref="HGNC:HGNC:2976"
                     /db_xref="InterPro:IPR001025"
                     /db_xref="InterPro:IPR001525"
                     /db_xref="InterPro:IPR002857"
                     /db_xref="InterPro:IPR010506"
                     /db_xref="InterPro:IPR017198"
                     /db_xref="InterPro:IPR018117"
                     /db_xref="InterPro:IPR022702"
                     /db_xref="PDB:3EPZ"
                     /db_xref="PDB:3PTA"
                     /db_xref="PDB:3SWR"
                     /db_xref="UniProtKB/Swiss-Prot:P26358"
                     /protein_id="CAA45219.1"
                     /translation="MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKE
                     KLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNRE
                     VNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRK
                     STRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLP
                     AEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDE
                     DGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTE
                     KKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDAN
                     ESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLE
                     GGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYI
                     SKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDE
                     AGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLV
                     YQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRS
                     KQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKT
                     DGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFC
                     AGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLE
                     GDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQL
                     EDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEH
                     YRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKS
                     TPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEA
                     YNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVFS
                     GCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETT
                     NSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRF
                     FLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAP
                     GEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVR
                     NGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDW
                     RDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNT
                     LIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRE
                     CARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASAKIKE
                     EEAAKD"
     polyA_signal    5388..5393
     polyA_site      5408
BASE COUNT         1418 a         1488 c         1511 g         1017 t
ORIGIN
        1 cgtccgcgtg gggggggtgt gtgcccgcct tgcgcatgcg tgttccctgg gcatggccgg
       61 ctccgttcca tccttctgca cagggtatcg cctctctccg tttggtacat cccctcctcc
      121 cccacgcccg gactggggtg gtagacgcgc ctccgctcat cgcccctccc catcggtttc
      181 cgcgcgaaaa gccggggcgc ctgcgctgcc gccgccgcgt ctgctgaagc ctccgagatg
      241 ccggcgcgta ccgccccagc ccgggtgccc acactggccg tcccggccat ctcgctgccc
      301 gacgatgtcc gcaggcggct caaagatttg gaaagagaca gcttaacaga aaaggaatgt
      361 gtgaaggaga aattgaatct cttgcacgaa tttctgcaaa cagaaataaa gaatcagtta
      421 tgtgacttgg aaaccaaatt acgtaaagaa gaattatccg aggagggcta cctggctaaa
      481 gtcaaatccc ttttaaataa agatttgtcc ttggagaacg gtgctcatgc ttacaaccgg
      541 gaagtgaatg gacgtctaga aaacgggaac caagcaagaa gtgaagcccg tagagtggga
      601 atggcagatg ccaacagccc ccccaaaccc ctttccaaac ctcgcacgcc caggaggagc
      661 aagtccgatg gagaggctaa gcctgaacct tcacctagcc ccaggattac aaggaaaagc
      721 accaggcaaa ccaccatcac atctcatttt gcaaagggcc ctgccaaacg gaaacctcag
      781 gaagagtctg aaagagccaa atcggatgag tccatcaagg aagaagacaa agaccaggat
      841 gagaagagac gtagagttac atccagagaa cgagttgcta gaccgcttcc tgcagaagaa
      901 cctgaaagag caaaatcagg aacgcgcact gaaaaggaag aagaaagaga tgaaaaagaa
      961 gaaaagagac tccgaagtca aaccaaagaa ccaacaccca aacagaaact gaaggaggag
     1021 ccggacagag aagccagggc aggcgtgcag gctgacgagg acgaagatgg agacgagaaa
     1081 gatgagaaga agcacagaag tcaacccaaa gatctagctg ccaaacggag gcccgaagaa
     1141 aaagaacctg aaaaagtaaa tccacagatt tctgatgaaa aagacgagga tgaaaaggag
     1201 gagaagagac gcaaaacgac ccccaaagaa ccaacggaga aaaaaatggc tcgcgccaaa
     1261 acagtcatga actccaagac ccaccctccc aagtgcattc agtgcgggca gtacctggac
     1321 gaccctgacc tcaaatatgg gcagcaccca ccagacgcgg tggatgagcc acagatgctg
     1381 acaaatgaga agctgtccat ctttgatgcc aacgagtctg gctttgagag ttatgaggcg
     1441 cttccccagc acaaactgac ctgcttcagt gtgtactgta agcacggtca cctgtgtccc
     1501 atcgacaccg gcctcatcga gaagaatatc gaactcttct tttctggttc agcaaaacca
     1561 atctatgatg atgacccgtc tcttgaaggt ggtgttaatg gcaaaaatct tggccccata
     1621 aatgaatggt ggatcactgg ctttgatgga ggtgaaaagg ccctcatcgg cttcagcacc
     1681 tcatttgccg aatacattct gatggatccc agtcccgagt atgcgcccat atttgggctg
     1741 atgcaggaga agatctacat cagcaagatt gtggtggagt tcctgcagag caattccgac
     1801 tcgacctatg aggacctgat caacaagatc gagaccacgg ttcctccttc tggcctcaac
     1861 ttgaaccgct tcacagagga ctccctcctg cgacacgcgc agtttgtggt ggagcaggtg
     1921 gagagttatg acgaggccgg ggacagtgat gagcagccca tcttcctgac gccctgcatg
     1981 cgggacctga tcaagctggc tggggtcacg ctgggacaga ggcgagccca ggcgaggcgg
     2041 cagaccatca ggcattctac cagggagaag gacaggggac ccacgaaagc caccaccacc
     2101 aagctggtct accagatctt cgatactttc ttcgcagagc aaattgaaaa ggatgacaga
     2161 gaagacaagg agaacgcctt taagcgccgg cgatgtggcg tctgtgaggt gtgtcagcag
     2221 cctgagtgtg ggaaatgtaa agcctgcaag gacatggtta aatttggtgg cagtggacgg
     2281 agcaagcagg cttgccaaga gcggaggtgt cccaatatgg ccatgaagga ggcagatgac
     2341 gatgaggaag tcgatgataa catcccagag atgccgtcac ccaaaaaaat gcaccagggg
     2401 aagaagaaga aacagaacaa gaatcgcatc tcttgggtcg gagaagccgt caagactgat
     2461 gggaagaaga gttactataa gaaggtgtgc attgatgcgg aaaccctgga agtgggggac
     2521 tgtgtctctg ttattccaga tgattcctca aaaccgctgt atctagcaag ggtcacggcg
     2581 ctgtgggagg acagcagcaa cgggcagatg tttcacgccc actggttctg cgctgggaca
     2641 gacacagtcc tcggggccac gtcggaccct ctggagctgt tcttggtgga tgaatgtgag
     2701 gacatgcagc tttcatatat ccacagcaaa gtgaaagtca tctacaaagc cccctccgaa
     2761 aactgggcca tggagggagg catggatccc gagtccctgc tggaggggga cgacgggaag
     2821 acctacttct accagctgtg gtatgatcaa gactacgcga gattcgagtc ccctccaaaa
     2881 acccagccaa cagaggacaa caagttcaaa ttctgtgtga gctgtgcccg tctggctgag
     2941 atgaggcaaa aagaaatccc cagggtcctg gagcagctcg aggacctgga tagccgggtc
     3001 ctctactact cagccaccaa gaacggcatc ctgtaccgag ttggtgatgg tgtgtacctg
     3061 ccccctgagg ccttcacgtt caacatcaag ctgtccagtc ccgtgaaacg cccacggaag
     3121 gagcccgtgg atgaggacct gtacccagag cactaccgga aatactccga ctacatcaaa
     3181 ggcagcaacc tggatgcccc tgagccctac cgaattggcc ggatcaaaga gatcttctgt
     3241 cccaagaaga gcaacggcag gcccaatgag actgacatca aaatccgggt caacaagttc
     3301 tacaggcctg agaacaccca caagtccact ccagcgagct accacgcaga catcaacctg
     3361 ctctactgga gcgacgagga ggccgtggtg gacttcaagg ctgtgcaggg ccgctgcacc
     3421 gtggagtatg gggaggacct gcccgagtgc gtccaggtgt actccatggg cggccccaac
     3481 cgcttctact tcctcgaggc ctataatgca aagagcaaaa gctttgaaga tcctcccaac
     3541 catgcccgta gccctggaaa caaagggaag ggcaagggaa aagggaaggg caagcccaag
     3601 tcccaagcct gtgagccgag cgagccagag atagagatca agctgcccaa gctgcggacc
     3661 ctggatgtgt tttctggctg cggggggttg tcggagggat tccaccaagc aggcatctct
     3721 gacacgctgt gggccatcga gatgtgggac cctgcggccc aggcgttccg gctgaacaac
     3781 cccggctcca cagtgttcac agaggactgc aacatcctgc tgaagctggt catggctggg
     3841 gagaccacca actcccgcgg ccagcggctg ccccagaagg gagacgtgga gatgctgtgc
     3901 ggcgggccgc cctgccaggg cttcagcggc atgaaccgct tcaattcgcg cacctactcc
     3961 aagttcaaaa actctctggt ggtttccttc ctcagctact gcgactacta ccggccccgg
     4021 ttcttcctcc tggagaatgt caggaacttt gtctccttca agcgctccat ggtcctgaag
     4081 ctcaccctcc gctgcctggt ccgcatgggc tatcagtgca ccttcggcgt gctgcaggcc
     4141 ggtcagtacg gcgtggccca gactaggagg cgggccatca tcctggccgc ggcccctgga
     4201 gagaagctcc ctctgttccc ggagccactg cacgtgtttg ctccccgggc ctgccagctg
     4261 agcgtggtgg tggatgacaa gaagtttgtg agcaacataa ccaggttgag ctcgggtcct
     4321 ttccggacca tcacggtgcg agacacgatg tccgacctgc cggaggtgcg gaatggagcc
     4381 tcggcactgg agatctccta caacggggag cctcagtcct ggttccagag gcagctccgg
     4441 ggcgcacagt accagcccat cctcagggac cacatctgta aggacatgag tgcattggtg
     4501 gctgcccgca tgcggcacat ccccttggcc ccagggtcag actggcgcga tctgcccaac
     4561 atcgaggtgc ggctctcaga cggcaccatg gccaggaagc tgcggtatac ccaccatgac
     4621 aggaagaacg gccgcagcag ctctggggcc ctccgtgggg tctgctcctg cgtggaagcc
     4681 ggcaaagcct gcgaccccgc agccaggcag ttcaacaccc tcatcccctg gtgcctgccc
     4741 cacaccggga accggcacaa ccactgggct ggcctctatg gaaggctcga gtgggacggc
     4801 ttcttcagca caaccgtcac caaccccgag cccatgggca agcagggccg cgtgctccac
     4861 ccagagcagc accgtgtggt gagcgtgcgg gagtgtgccc gctcccaggg cttccctgac
     4921 acctaccggc tcttcggcaa catcctggac aagcaccggc aggtgggcaa tgccgtgcca
     4981 ccgcccctgg ccaaagccat tggcttggag atcaagcttt gtatgttggc caaagcccga
     5041 gagagtgcct cagctaaaat aaaggaggag gaagctgcta aggactagtt ctgccctccc
     5101 gtcacccctg tttctggcac caggaatccc caacatgcac tgatgttgtg tttttaacat
     5161 gtcaatctgt ccgttcacat gtgtggtaca tggtgtttgt ggccttggct gacatgaagc
     5221 tgttgtgtga ggttcgctta tcaactaatg atttagtgat caaattgtgc agtactttgt
     5281 gcattctgga ttttaaaagt tttttattat gcattatatc aaatctacca ctgtatgagt
     5341 ggaaattaag actttatgta gtttttatat gttgtaatat ttcttcaaat aaatctctcc
     5401 tataaaccaa aaaaaaaaaa aaaaaaaaaa aaaa
//