LOCUS       X63575                  4535 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  H.sapiens mRNA for plasma membrane calcium ATPase.
ACCESSION   X63575 S37350
VERSION     X63575.1
KEYWORDS    ATPase; calcium-transporting ATPase; hPMCA2 gene; plasma membrane
            calcium ATPase; transmembrane protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Strehler E.E.
  JOURNAL   Submitted (20-DEC-1991) to the INSDC. E.E. Strehler, Lab of
            Biochemistry III, Swiss Federal Institute of Technology,
            ETH-Zentrum, CH 8092, SWITZERLAND
  REMARK    revised by [3]
REFERENCE   2  (bases 1 to 4535)
  AUTHORS   Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E.
  TITLE     Microdiversity of human-plasma-membrane calcium-pump isoform 2
            generated by alternative RNA splicing in the N-terminal coding
            region
  JOURNAL   Eur. J. Biochem. 205(1), 333-340(1992).
   PUBMED   1313367
REFERENCE   3  (bases 1 to 4535)
  AUTHORS   Strehler E.E.
  JOURNAL   Submitted (11-JUN-1997) to the INSDC. E.E. Strehler, Dept. of
            Biochem. and Molec. Biol., Mayo Clinic/Foundatin, Rochester, MN
            55905, USA
COMMENT     Related sequences L00620 and L20977
FEATURES             Location/Qualifiers
     source          1..4535
                     /db_xref="H-InvDB:HIT000322606"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /clone_lib="hTera2D in lambda gt10, hbrain in lambda gt11"
                     /clone="lambda t10.1, RACE-b, hbPCR6.3"
                     /cell_line="hTera2D"
                     /cell_type="teratocarcinoma /skeletal muscle/brain"
                     /tissue_type="undefined/skeletal muscle /brain"
                     /db_xref="taxon:9606"
     5'UTR           1..70
     CDS             71..3802
                     /gene="hPMCA2"
                     /product="plasma membrane calcium ATPase"
                     /db_xref="GOA:Q01814"
                     /db_xref="H-InvDB:HIT000322606.14"
                     /db_xref="HGNC:HGNC:815"
                     /db_xref="InterPro:IPR001757"
                     /db_xref="InterPro:IPR004014"
                     /db_xref="InterPro:IPR006068"
                     /db_xref="InterPro:IPR006408"
                     /db_xref="InterPro:IPR008250"
                     /db_xref="InterPro:IPR018303"
                     /db_xref="InterPro:IPR022141"
                     /db_xref="InterPro:IPR023214"
                     /db_xref="InterPro:IPR023298"
                     /db_xref="InterPro:IPR023299"
                     /db_xref="InterPro:IPR030320"
                     /db_xref="UniProtKB/Swiss-Prot:Q01814"
                     /protein_id="CAA45131.1"
                     /translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
                     KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEA
                     LQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLS
                     VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY
                     GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAV
                     GVNSQTGIIFTLLGAGGEEEEKKDKKGVKKGDGLQLPAADGAAASNAADSANASLVNG
                     KMQDGNVDASQSKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTK
                     LAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYVQYFVKFFIIGVTV
                     LVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNR
                     MTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVG
                     NKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYS
                     KGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSS
                     PEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA
                     IAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHT
                     LVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD
                     NFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVN
                     LIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFV
                     GEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNP
                     IFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSR
                     LKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVKA
                     FRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNSSPPS
                     SLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
     3'UTR           3803..4511
     regulatory      4489..4494
                     /regulatory_class="polyA_signal_sequence"
     polyA_site      4511
     misc_feature    4529..4535
                     /note="EcoRI linker"
BASE COUNT         1100 a         1290 c         1261 g          884 t
ORIGIN      
        1 agccatcacc cggcagcctc ttgtccagcg ctgacccttg ggcccagccc gagcaaggac
       61 cgcagcaaac atgggtgaca tgaccaacag cgacttttac tccaaaaacc aaagaaatga
      121 gtcgagccat gggggcgagt tcgggtgcac aatggaggag ctccgctccc tcatggagct
      181 gcggggcact gaggctgtgg tcaagatcaa ggagacttat ggggacaccg aagccatctg
      241 ccggcgcctc aaaacctcac ctgttgaagg tttgccgggc accgctccag acctggaaaa
      301 gagaaagcaa atttttgggc aaaactttat acctccaaag aagccaaaaa ccttcctgca
      361 gctcgtgtgg gaggcgctgc aggacgtgac gctcatcatc ctggagattg ccgccatcat
      421 ctccctgggg ctgtccttct accacccgcc cggcgagggc aacgaaggat gtgcgacggc
      481 ccagggtggg gcagaggatg aaggagaggc agaggcaggt tggatcgagg gggccgccat
      541 tctcctctca gttatctgtg tggtcctggt cacggccttc aatgactgga gcaaagagaa
      601 acagttccgg ggcctgcaga gccgcatcga gcaggaacag aaatttaccg tggtccgggc
      661 tggccaggtg gtgcagatcc ctgtggctga gatcgtggtt ggggacatag cccaggtcaa
      721 atatggtgac ctcctccctg ccgacggcct cttcatccag ggcaatgacc tcaagattga
      781 tgaaagctcc ctaactggag agtctgacca ggtgcgcaag tccgtggaca aggaccccat
      841 gctgctgtca ggaacccacg tgatggaggg ctcaggacgg atgttggtga ctgctgtggg
      901 tgtgaactct cagactggca tcatctttac cctcctgggg gctggtggtg aagaggaaga
      961 gaagaaagac aaaaaaggtg tgaagaaggg ggatggcctt cagctaccag cagcagacgg
     1021 tgcggcagct tcaaacgctg cagatagtgc gaatgccagc ctagtcaatg gtaaaatgca
     1081 ggatggcaat gtggacgcca gccagagcaa agccaaacaa caggacgggg cagccgccat
     1141 ggagatgcag cccctcaaga gtgccgaggg cggcgacgct gacgacagga agaaggccag
     1201 catgcacaag aaggagaagt ccgtgctgca gggcaagctc accaagctgg ctgtgcagat
     1261 cgggaaggcg ggcttggtga tgtcagccat cacggtgatc atcctggtgc tctacttcac
     1321 tgtggacacc ttcgtggtca acaagaagcc gtggctgcct gagtgcacgc ccgtctacgt
     1381 gcagtacttt gtcaagttct tcatcattgg cgtgacggtg ctggtggtcg ccgtgcccga
     1441 ggggctccct ctggccgtca ccatctcgtt ggcctattcg gtgaagaaaa tgatgaagga
     1501 caacaacctg gtacgccacc tggatgcctg tgagaccatg ggcaatgcca cagccatctg
     1561 ctcagacaag acaggcacgc tgaccaccaa tcgcatgaca gtggtacagg cctatgtcgg
     1621 cgacgtccac tataaagaga tccccgaccc cagctccatc aacaccaaga ccatggagct
     1681 gctgatcaat gccatcgcca tcaacagcgc ctacaccacc aagattctgc ccccagagaa
     1741 ggagggcgcc ctgcctcggc aggtgggcaa caagacggag tgcggcctgc tgggcttcgt
     1801 gctggacctg aagcaggact acgagcccgt gcgcagccag atgccagagg agaagttgta
     1861 caaagtgtac accttcaact ccgtgcgcaa gtccatgagc actgtcatca agctgcccga
     1921 cgagagcttc cgcatgtaca gcaagggggc ttctgagatc gtgctcaaga agtgctgcaa
     1981 aatcctcaat ggggcgggag agcctcgtgt cttccggccc cgcgaccggg acgagatggt
     2041 aaagaaggtg attgagccca tggcttgcga tgggctccgc actatctgcg tggcctaccg
     2101 cgacttcccc agcagcccgg agccggactg ggacaatgag aatgacatcc tcaacgaact
     2161 cacctgcatc tgcgtggtgg gcatcgagga cccggtgcgg ccagaggtcc cagaagccat
     2221 ccgcaagtgc cagcgggcag gcatcacggt ccgcatggtc actggcgaca atatcaacac
     2281 ggctcgggcc atcgccatca agtgtggcat catccatcct ggggaggact ttctgtgcct
     2341 cgagggcaag gagttcaaca ggaggatccg caacgagaag ggggagattg agcaggagcg
     2401 aattgacaag atctggccaa agctgcgggt gctggctcgc tcctccccaa cggacaagca
     2461 taccctggtt aaaggcatca tcgacagcac acacactgag cagcggcagg tggtggccgt
     2521 gacgggggac gggaccaacg acgggcctgc actcaagaag gccgacgtgg gcttcgccat
     2581 gggcatcgca ggcactgacg tggccaagga ggcctcagac atcatcctga cagacgacaa
     2641 tttcagcagc atcgtcaagg cagtgatgtg gggccgcaac gtctatgaca gcatctccaa
     2701 attcttgcag ttccagctca ccgtcaacgt ggtggccgtg attgtggcct tcacaggcgc
     2761 ctgcatcacg caggactccc ctctgaaggc cgtgcagatg ctctgggtga acctcatcat
     2821 ggacacgttt gcctcgctgg cactggccac tgagccgccc acggagaccc tgctgctgag
     2881 gaagccgtac ggccgcaaca agccgctcat ctccaggacc atgatgaaga acatcctggg
     2941 ccatgctgtc taccagcttg ccctcatctt caccctgctc tttgttggcg agaagatgtt
     3001 ccagatcgac agcgggagga acgcgcccct gcattcgcca ccctcagaac attacaccat
     3061 catcttcaac accttcgtca tgatgcagct cttcaacgag atcaacgccc gcaagatcca
     3121 cggcgagcgc aatgtctttg acggcatctt ccggaacccc atcttctgca ccatcgtgct
     3181 gggcaccttt gccatccaga tagtgatcgt gcagtttgga gggaagccat tcagctgctc
     3241 tccactgcag ctggaccagt ggatgtggtg catattcatt gggttaggag agctcgtttg
     3301 gggccaggtc atcgccacca tcccgaccag cagactcaag ttcctcaagg aggcaggcag
     3361 gctcacacag aaggaggaga tcccggagga ggagctcaac gaggacgtgg aggagatcga
     3421 ccacgcggag cgggagctgc ggcggggcca gatcctgtgg ttccgaggcc tgaatcggat
     3481 ccagacacag atccgcgtcg tgaaggcgtt ccgtagctct ctctatgaag gtttagaaaa
     3541 gcctgaatct cgaacctcca tccataactt catggctcat cctgaattcc ggatcgaaga
     3601 ttcccagccc cacatccccc tcattgatga caccgacctg gaagaagatg ccgcgctcaa
     3661 gcagaactcg agcccgccgt catccctcaa caagaacaac agcgccatcg acagtgggat
     3721 caacctgacg accgacacaa gcaaatcagc tacctcttca agtccaggga gccccatcca
     3781 cagcctggag acgtcgcttt agctgaggac cctctcgcct gcccgcccgc cctcatggac
     3841 cccgctgcca cccgctttcc gggcacccat ccatccaggc acccaactca cccaagcagc
     3901 aacgagcaac aatcggaaac caaatactgg agagaaaacc aacgtttcca cccacagacc
     3961 ctttctctgg ctgcgatgct gtttgaactc tttttcactt caaggcaagg ggcgggatct
     4021 ccactggggg cttacgggag tgagcggttt tccaaaacaa gcccttcctg gctcccaccc
     4081 agacatggac cagccatgca cccgcccagc caccacgtcc ccgcatgaat gtactgtcac
     4141 atttcaatcc tcccttgttt ggtttttggg ggttggggag gggtttttgt ttgtttgttt
     4201 gttttcttag gcgggaactg caaacagact cttttctgag actatttatc caatccactg
     4261 gtctgtgagt ttttgaaaat gcttgcacag catggtctca gttgtataga ttaatttaat
     4321 aactttttga aattgcagag cttaactcgc ctagtagatt tgcaccaatg gaaccgaaga
     4381 acttcataga cactcacaag gttatatcca tttctttgta tctatatcaa cgtatacttt
     4441 tccgagactg tatacgtcca tatagatagg tagatatata tatatatata taaatatata
     4501 tacatggata taaaaaaaaa aaaaaaaagg aattc
//