LOCUS X57110 3090 bp mRNA linear HUM 12-DEC-1992
DEFINITION Human mRNA for c-cbl proto-oncogene.
ACCESSION X57110
VERSION X57110.1
KEYWORDS cbl oncogene; nuclear protein; oncogene cellular.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3090)
AUTHORS Langdon W.Y.
JOURNAL Submitted (02-JAN-1991) to the INSDC. W.Y. Langdon, INSTITUTE OF
MEDICAL & VETERINARY SCIENE, IMVS, DIVISION OF HUMAN IMMUNOLOGY,
BOX 14 RUNDEL MALL POST OFFICE, ADELAIDE SA 5000, AUSTRALIA
REFERENCE 2
AUTHORS Langdon W.Y.
JOURNAL Submitted (01-JAN-1991) to the INSDC. Langdon W.Y., Institute of
Medical und Veterinary, Sciene, IMVS, Division of Human Immunology,
Box 14 Rundel Mall Post Office, Adelaide SA 5000, Australia.
REFERENCE 3
AUTHORS Blake T.S., Shapiro M., Morse III M.C., Langdon W.Y.
TITLE The sequences of the human and mouse c-cbl proto-oncogenes show
v-cbl was generated by a large truncation encompassing a
proline-rich domain and a leucine zipper-like motif
JOURNAL Oncogene 6(4), 653-657(1991).
PUBMED 2030914
REFERENCE 4 (bases 1 to 3090)
AUTHORS Blake T.J., Langdon W.Y.
TITLE A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma
cells results in a truncated protein
JOURNAL Oncogene 7(4), 757-762(1992).
PUBMED 1565471
FEATURES Location/Qualifiers
source 1..3090
/db_xref="H-InvDB:HIT000322065"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA 1..3090
/gene="c-cbl"
/experiment="experimental evidence, no additional details
recorded"
CDS 149..2869
/gene="c-cbl"
/note="c-cbl protein"
/db_xref="GOA:P22681"
/db_xref="H-InvDB:HIT000322065.13"
/db_xref="HGNC:HGNC:1541"
/db_xref="InterPro:IPR001841"
/db_xref="InterPro:IPR003153"
/db_xref="InterPro:IPR009060"
/db_xref="InterPro:IPR011992"
/db_xref="InterPro:IPR013083"
/db_xref="InterPro:IPR014741"
/db_xref="InterPro:IPR014742"
/db_xref="InterPro:IPR015940"
/db_xref="InterPro:IPR017907"
/db_xref="InterPro:IPR024159"
/db_xref="InterPro:IPR024162"
/db_xref="InterPro:IPR036537"
/db_xref="InterPro:IPR036860"
/db_xref="InterPro:IPR039520"
/db_xref="PDB:1B47"
/db_xref="PDB:1FBV"
/db_xref="PDB:1YVH"
/db_xref="PDB:2CBL"
/db_xref="PDB:2JUJ"
/db_xref="PDB:2K4D"
/db_xref="PDB:2OO9"
/db_xref="PDB:2Y1M"
/db_xref="PDB:2Y1N"
/db_xref="PDB:3BUM"
/db_xref="PDB:3BUN"
/db_xref="PDB:3BUO"
/db_xref="PDB:3BUW"
/db_xref="PDB:3BUX"
/db_xref="PDB:3OB1"
/db_xref="PDB:3OB2"
/db_xref="PDB:3PLF"
/db_xref="PDB:4A49"
/db_xref="PDB:4A4B"
/db_xref="PDB:4A4C"
/db_xref="PDB:4GPL"
/db_xref="PDB:5HKW"
/db_xref="PDB:5HKX"
/db_xref="PDB:5HKY"
/db_xref="PDB:5HKZ"
/db_xref="PDB:5HL0"
/db_xref="PDB:5J3X"
/db_xref="PDB:5O76"
/db_xref="UniProtKB/Swiss-Prot:P22681"
/protein_id="CAA40393.1"
/translation="MAGNVKKSSGAGGGTGSGGSGSGGLIGLMKDAFQPHHHHHHHLS
PHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRY
EGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSH
MLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSG
LEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDE
VKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFRE
GFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVK
IEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGA
PSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVC
VPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLP
CTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSL
PSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLP
VPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQ
APSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASS
SFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQ
LSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT"
BASE COUNT 757 a 840 c 764 g 729 t
ORIGIN
1 gaattccggg cccggatagc cggcggcggc ggcggcggcg gcggcggcgg cggccgggag
61 aggcccctcc ttcacgccct gcttctctcc ctcgctcgca gtcgagccga gccggcggac
121 ccgcctgggc tccgaccctg cccaggccat ggccggcaac gtgaagaaga gctctggggc
181 cgggggcggc acgggctccg ggggctcggg ttcgggtggc ctgattgggc tcatgaagga
241 cgccttccag ccgcaccacc accaccacca ccacctcagc ccccacccgc cggggacggt
301 ggacaagaag atggtggaga agtgctggaa gctcatggac aaggtggtgc ggttgtgtca
361 gaacccaaag ctggcgctaa agaatagccc accttatatc ttagacctgc taccagatac
421 ctaccagcat ctccgtacta tcttgtcaag atatgagggg aagatggaga cacttggaga
481 aaatgagtat tttagggtgt ttatggagaa tttgatgaag aaaactaagc aaaccataag
541 cctcttcaag gagggaaaag aaagaatgta tgaggagaat tctcagccta ggcgaaacct
601 aaccaaactg tccctcatct tcagccacat gctggcagaa ctaaaaggaa tctttccaag
661 tggactcttt cagggagaca catttcggat tactaaagca gatgctgcgg aattttggag
721 aaaagctttt ggggaaaaga caatagtccc ttggaagagc tttcgacagg ctctacatga
781 agtgcatccc atcagttctg ggctggaggc catggctctg aaatccacta ttgatctgac
841 ctgcaatgat tatatttcgg tttttgaatt tgacatcttt acccgactct ttcagccctg
901 gtcctctttg ctcaggaatt ggaacagcct tgctgtaact catcctggct acatggcttt
961 tttgacgtat gacgaagtga aagctcggct ccagaaattc attcacaaac ctggcagtta
1021 tatcttccgg ctgagctgta ctcgtctggg tcagtgggct attgggtatg ttactgctga
1081 tgggaacatt ctccagacaa tccctcacaa taaacctctc ttccaagcac tgattgatgg
1141 cttcagggaa ggcttctatt tgtttcctga tggacgaaat cagaatcctg atctgactgg
1201 cttatgtgaa ccaactcccc aagaccatat caaagtgacc caggaacaat atgaattata
1261 ctgtgagatg ggctccacat tccaactatg taaaatatgt gctgaaaatg ataaggatgt
1321 aaagattgag ccctgtggac acctcatgtg cacatcctgt cttacatcct ggcaggaatc
1381 agaaggtcag ggctgtcctt tctgccgatg tgaaattaaa ggtactgaac ccatcgtggt
1441 agatccgttt gatcctagag ggagtggcag cctgttgagg caaggagcag agggagctcc
1501 ctccccaaat tatgatgatg atgatgatga acgagctgat gatactctct tcatgatgaa
1561 ggaattggct ggtgccaagg tggaacggcc gccttctcca ttctccatgg ccccacaagc
1621 ttcccttccc ccggtgccac cacgacttga ccttctgccg cagcgagtat gtgttccctc
1681 aagtgcttct gctcttggaa ctgcttctaa ggctgcttct ggctcccttc ataaagacaa
1741 accattgcca gtacctccca cacttcgaga tcttccacca ccaccgcctc cagaccggcc
1801 atattctgtt ggagcagaat cccgacctca aagacgcccc ttgccttgta caccaggcga
1861 ctgtccctcc agagacaaac tgccccctgt cccctctagc cgccttggag actcatggct
1921 gccccggcca atccccaaag taccagtatc tgccccaagt tccagtgatc cctggacagg
1981 aagagaatta accaaccggc actcacttcc attttcattg ccctcacaaa tggagcccag
2041 accagatgtg cctaggctcg gaagcacgtt cagtctggat acctccatga gtatgaatag
2101 cagcccatta gtaggtccag agtgtgacca ccccaaaatc aaaccttcct catctgccaa
2161 tgccatttat tctctggctg ccagacctct tcctgtgcca aaactgccac ctggggagca
2221 atgtgagggt gaagaggaca cagagtacat gactccctct tccaggcctc tacggccttt
2281 ggatacatcc cagagttcac gagcatgtga ttgcgaccag cagattgata gctgtacgta
2341 tgaagcaatg tataatattc agtcccaggc gccatctatc accgagagca gcacctttgg
2401 tgaagggaat ttggccgcag cccatgccaa cactggtccc gaggagtcag aaaatgagga
2461 tgatgggtat gatgtcccaa agccacctgt gccggccgtg ctggcccgcc gaactctctc
2521 agatatctct aatgccagct cctcctttgg ctggttgtct ctggatggtg atcctacaac
2581 aaatgtcact gaaggttccc aagttcccga gaggcctcca aaaccattcc cgcggagaat
2641 caactctgaa cggaaagctg gcagctgtca gcaaggtagt ggtcctgccg cctctgctgc
2701 caccgcctca cctcagctct ccagtgagat cgagaacctc atgagtcagg ggtactccta
2761 ccaggacatc cagaaagctt tggtcattgc ccagaacaac atcgagatgg ccaaaaacat
2821 cctccgggaa tttgtttcca tttcttctcc tgcccatgta gctacctagc acaccatctc
2881 cctgctgcag gtttagagga ccagtgagtt gggagttatt actcaagtgg cacctagaag
2941 ggcaggagtt cctttggtga cttcacagtg aagtcttgcc ctctctgtgg gatatcacat
3001 cagtggttcc aagatttcaa agtggtgaaa tgaaaatgga gcagctagta tgttttatta
3061 ttttatgggt cttgagtgca tttgaaggtg
//