LOCUS X53586 5629 bp mRNA linear HUM 14-NOV-2006
DEFINITION Human mRNA for integrin alpha 6.
ACCESSION X53586
VERSION X53586.1
KEYWORDS integrin; integrin alpha 6 subunit; laminin receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5629)
AUTHORS Quaranta V.
JOURNAL Submitted (19-JUN-1990) to the INSDC. Quaranta V., Scripps Clinnic
and Research Foundation, Research Institute of Scripps Clinic,
Department of Immunnology, IMM-8, 10666 North Torrey Pines Road, La
Jolla, CA 92037, USA.
REFERENCE 2
AUTHORS Tamura R.N., Rozzo C., Starr L., Chambers J., Reichardt L.F.,
Cooper H.M., Quaranta V.
TITLE Epithelial integrin alpha 6 beta 4: complete primary structure of
alpha 6 and variant forms of beta 4
JOURNAL J. Cell Biol. 111(4), 1593-1604(1990).
PUBMED 1976638
COMMENT Subunit structure alpha(6)beta(4) = alpha(E)beta(4) = TSP180
Subunit structure alpha(6)beta(1) = VLA-6
FEATURES Location/Qualifiers
source 1..5629
/db_xref="H-InvDB:HIT000321841"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone_lib="ptZB FG-2/3, ptZB FG-4"
/clone="26.44, 26.1-7"
/cell_line="FG"
/cell_type="carcinoma"
/tissue_type="pancreas"
/db_xref="taxon:9606"
CDS 147..3368
/product="integrin alpha 6 (or alpha E) protein"
/db_xref="GOA:P23229"
/db_xref="H-InvDB:HIT000321841.14"
/db_xref="HGNC:HGNC:6142"
/db_xref="InterPro:IPR000413"
/db_xref="InterPro:IPR013517"
/db_xref="InterPro:IPR013519"
/db_xref="InterPro:IPR013649"
/db_xref="InterPro:IPR018184"
/db_xref="InterPro:IPR028994"
/db_xref="InterPro:IPR032695"
/db_xref="UniProtKB/Swiss-Prot:P23229"
/protein_id="CAA37655.1"
/translation="MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLF
GFSLAMHWQLQPEDKRLLLVGAPRGEALPLQRANRTGGLYSCDITARGPCTRIEFDND
ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQN
LRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVR
VEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITF
VSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIV
IGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGY
PDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTAN
PAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEET
LWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKE
GCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSP
SNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELG
NPFKRNSNVTFYLVLSTTEVTFDTPYLDINLKLETTSNQDNLAPITAKAKVVIELLLS
VSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWP
KEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRK
FSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLD
ILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLA
LLVFILWKCGFFKRNKKDHYDATYHKAEIHAQPSDKERLTSDA"
mRNA <147..>5495
sig_peptide 147..215
/note="integrin alpha 6 (or alpha E) protein signal"
mat_peptide 216..3365
/product="integrin alpha 6 (or alpha E) protein"
misc_feature 216..3179
/note="extracellular domain"
old_sequence 378..379
/replace="tt"
/citation=[1]
old_sequence 1113
/replace="a"
/citation=[1]
misc_feature 3180..3257
/note="transmembane domain"
misc_feature 3258..3367
/note="cytoplasmic domain"
regulatory 5489..5495
/note="putative"
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1666 a 1097 c 1284 g 1582 t
ORIGIN
1 gcgcgaccgt cccgggggtg gggccgggcg cagcggcgag aggaggcgaa ggtggctgcg
61 gtagcagcag cgcggcagcc tcggacccag cccggagcgc agggcggccg ctgcaggtcc
121 ccgctcccct ccccgtgcgt ccgcccatgg ccgccgccgg gcagctgtgc ttgctctacc
181 tgtcggcggg gctcctgtcc cggctcggcg cagccttcaa cttggacact cgggaggaca
241 acgtgatccg gaaatatgga gaccccggga gcctcttcgg cttctcgctg gccatgcact
301 ggcaactgca gcccgaggac aagcggctgt tgctcgtggg ggccccgcgc ggagaagcgc
361 ttccactgca gagagccaac agaacgggag ggctgtacag ctgcgacatc accgcccggg
421 ggccatgcac gcggatcgag tttgataacg atgctgaccc cacgtcagaa agcaaggaag
481 atcagtggat gggggtcacc gtccagagcc aaggtccagg gggcaaggtc gtgacatgtg
541 ctcaccgata tgaaaaaagg cagcatgtta atacgaagca ggaatcccga gacatctttg
601 ggcggtgtta tgtcctgagt cagaatctca ggattgaaga cgatatggat gggggagatt
661 ggagcttttg tgatgggcga ttgagaggcc atgagaaatt tggctcttgc cagcaaggtg
721 tagcagctac ttttactaaa gactttcatt acattgtatt tggagccccg ggtacttata
781 actggaaagg gattgttcgt gtagagcaaa agaataacac tttttttgac atgaacatct
841 ttgaagatgg gccttatgaa gttggtggag agactgagca tgatgaaagt ctcgttcctg
901 ttcctgctaa cagttactta ggtttttctt tggactcagg gaaaggtatt gtttctaaag
961 atgagatcac ttttgtatct ggtgctccca gagccaatca cagtggagcc gtggttttgc
1021 tgaagagaga catgaagtct gcacatctcc tccctgagca catattcgat ggagaaggtc
1081 tggcctcttc atttggctat gatgtggcgg tggtggacct caacaaggat gggtggcaag
1141 atatagttat tggagcccca cagtattttg atagagatgg agaagttgga ggtgcagtgt
1201 atgtctacat gaaccagcaa ggcagatgga ataatgtgaa gccaattcgt cttaatggaa
1261 ccaaagattc tatgtttggc attgcagtaa aaaatattgg agatattaat caagatggct
1321 acccagatat tgcagttgga gctccgtatg atgacttggg aaaggttttt atctatcatg
1381 gatctgcaaa tggaataaat accaaaccaa cacaggttct caagggtata tcaccttatt
1441 ttggatattc aattgctgga aacatggacc ttgatcgaaa ttcctaccct gatgttgctg
1501 ttggttccct ctcagattca gtaactattt tcagatcccg gcctgtgatt aatattcaga
1561 aaaccatcac agtaactcct aacagaattg acctccgcca gaaaacagcg tgtggggcgc
1621 ctagtgggat atgcctccag gttaaatcct gttttgaata tactgctaac cccgctggtt
1681 ataatccttc aatatcaatt gtgggcacac ttgaagctga aaaagaaaga agaaaatctg
1741 ggctatcctc aagagttcag tttcgaaacc aaggttctga gcccaaatat actcaagaac
1801 taactctgaa gaggcagaaa cagaaagtgt gcatggagga aaccctgtgg ctacaggata
1861 atatcagaga taaactgcgt cccattccca taactgcctc agtggagatc caagagccaa
1921 gctctcgtag gcgagtgaat tcacttccag aagttcttcc aattctgaat tcagatgaac
1981 ccaagacagc tcatattgat gttcacttct taaaagaggg atgtggagac gacaatgtat
2041 gtaacagcaa ccttaaacta gaatataaat tttgcacccg agaaggaaat caagacaaat
2101 tttcttattt accaattcaa aaaggtgtac cagaactagt tctaaaagat cagaaggata
2161 ttgctttaga aataacagtg acaaacagcc cttccaaccc aaggaatccc acaaaagatg
2221 gcgatgacgc ccatgaggct aaactgattg caacgtttcc agacacttta acctattctg
2281 catatagaga actgagggct ttccctgaga aacagttgag ttgtgttgcc aaccagaatg
2341 gctcgcaagc tgactgtgag ctcggaaatc cttttaaaag aaattcaaat gtcacttttt
2401 atttggtttt aagtacaact gaagtcacct ttgacacccc atatctggat attaatctga
2461 agttagaaac aacaagcaat caagataatt tggctccaat tacagctaaa gcaaaagtgg
2521 ttattgaact gcttttatcg gtctcgggag ttgctaaacc ttcccaggtg tattttggag
2581 gtacagttgt tggcgagcaa gctatgaaat ctgaagatga agtgggaagt ttaatagagt
2641 atgaattcag ggtaataaac ttaggtaaac ctcttacaaa cctcggcaca gcaaccttga
2701 acattcagtg gccaaaagaa attagcaatg ggaaatggtt gctttatttg gtgaaagtag
2761 aatccaaagg attggaaaag gtaacttgtg agccacaaaa ggagataaac tccctgaacc
2821 taacggagtc tcacaactca agaaagaaac gggaaattac tgaaaaacag atagatgata
2881 acagaaaatt ttctttattt gctgaaagaa aataccagac tcttaactgt agcgtgaacg
2941 tgaactgtgt gaacatcaga tgcccgctgc gggggctgga cagcaaggcg tctcttattt
3001 tgcgctcgag gttatggaac agcacatttc tagaggaata ttccaaactg aactacttgg
3061 acattctcat gcgagccttc attgatgtga ctgctgctgc cgaaaatatc aggctgccaa
3121 atgcaggcac tcaggttcga gtgactgtgt ttccctcaaa gactgtagct cagtattcgg
3181 gagtaccttg gtggatcatc ctagtggcta ttctcgctgg gatcttgatg cttgctttat
3241 tagtgtttat actatggaag tgtggtttct tcaagagaaa taagaaagat cattatgatg
3301 ccacatatca caaggctgag atccatgctc agccatctga taaagagagg cttacttctg
3361 atgcatagta ttgatctact tctgtaattg tgtggattct ttaaacgctc taggtacgat
3421 gacagtgttc cccgatacca tgctgtaagg atccggaaag aagagcgaga gatcaaagat
3481 gaaaagtata ttgataacct tgaaaaaaaa cagtggatca caaagtggaa cagaaatgaa
3541 agctactcat agcgggggcc taaaaaaaaa aaagcttcac agtacccaaa ctgctttttc
3601 caactcagaa attcaatttg gatttaaaag cctgctcaat ccctgaggac tgatttcaga
3661 gtgactacac acagtacgaa cctacagttt taactgtgga tattgttacg tagcctaagg
3721 ctcctgtttt gcacagccaa atttaaaact gttggaatgg atttttcttt aactgccgta
3781 atttaacttt ctgggttgcc tttgtttttg gcgtggctga cttacatcat gtgttgggga
3841 agggcctgcc cagttgcact caggtgacat cctccagata gtgtagctga ggaggcacct
3901 acactcacct gcactaacag agtggccgtc ctaacctcgg gcctgctgcg cagacgtcca
3961 tcacgttagc tgtcccacat cacaagacta tgccattggg gtagttgtgt ttcaacggaa
4021 agtgctgtct taaactaaat gtgcaataga aggtgatgtt gccatcctac cgtcttttcc
4081 tgtttcctag ctgtgtgaat acctgctcac gtcaaatgca tacaagtttc attctccctt
4141 tcactaaaaa cacacaggtg caacagactt gaatgctagt tatacttatt tgtatatggt
4201 atttattttt tcttttcttt acaaaccatt ttgttattga ctaacaggcc aaagagtctc
4261 cagtttaccc ttcaggttgg tttaatcaat cagaattaga attagagcat gggagggtca
4321 tcactatgac ctaaattatt tactgcaaaa agaaaatctt tataaatgta ccagagagag
4381 ttgttttaat aacttatcta taaactataa cctctccttc atgacagcct ccaccccaca
4441 acccaaaagg tttaagaaat agaattataa ctgtaaagat gtttatttca ggcattggat
4501 attttttact ttagaagcct gcataatgtt tctggattta catactgtaa cattcaggaa
4561 ttcttggaga agatgggttt attcactgaa ctctagtgcg gtttactcac tgctgcaaat
4621 actgtatatt caggacttga aagaaatggt gaatgcctat ggaactagtg gatccaaact
4681 gatccagtat aagactactg aatctgctac caaaacagtt aatcagtgag tcgagtgttc
4741 tattttttgt tttgtttcct cccctatctg tattcccaaa aattactttg gggctaattt
4801 aacaagaact ttaaattgtg ttttaattgt aaaaatggca gggggtggaa ttattactct
4861 atacattcaa cagagactga atagatatga aagctgattt tttttaatta ccatgcttca
4921 caatgttaag ttatatgggg agcaacagca aacaggtgct aatttgtttt ggatatagta
4981 taagcagtgt ctgtgttttg aaagaataga acacagtttg tagtgccact gttgttttgg
5041 ggggggcttt ttttcttttt ccggaaaatc cttaaacctt aagatactaa ggacgttgtt
5101 ttggttgtac ttggaattct tagtcacaaa atatattttg tttacaaaaa tttctgtaaa
5161 acaggttata acagtgttta aagtctcagt ttcttgcttg gggaacttgt gtccctaatg
5221 tgttagattg ctagattgct aaggagctga tacttgacag ttttttagac ctgtgttact
5281 aaaaaaaaga tgaatgtcgg aaaagggtgt tgggagggtg gtcaacaaag aaacaaagat
5341 gttatggtgt ttagacttat ggttgttaaa aatgtcatct caagtcaagt cactggtctg
5401 tttgcatttg atacattttt gtactaacta gcattgtaaa attatttcat gattagaaat
5461 tacctgtgga tatttgtata aaagtgtgaa ataaattttt tataaaagtg ttcattgttt
5521 cgtaacacag cattgtatat gtgaagcaaa ctctaaaatt ataaatgaca acctgaatta
5581 tctatttcat caaaaaaaaa aaaaaaaaaa actttatggg cacaactgg
//