LOCUS X13916 14896 bp mRNA linear HUM 18-APR-1996 DEFINITION Human mRNA for LDL-receptor related protein. ACCESSION X13916 VERSION X13916.1 KEYWORDS calcium binding protein; cell surface protein; lipoprotein receptor; low density lipoprotein receptor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 14896) AUTHORS Herz J.J. JOURNAL Submitted (24-NOV-1988) to the INSDC. Herz J.J., EMBL, Meyerhofstrasse 1, 6900 Heidelberg, FRG. REFERENCE 2 AUTHORS Herz J.J., Hamann U., Rogne S., Myklebost O., Gausepohl H., Stanley K.K. TITLE Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor JOURNAL EMBO J. 7(13), 4119-4127(1988). PUBMED 3266596 REFERENCE 3 AUTHORS Myklebost O., Arheden K., Rogne S., Van Kessel G., Mandahl N., Herz J., Stanley K., Heim S., Mitelman F. TITLE The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14 JOURNAL Genomics 5(1), 65-69(1989). PUBMED 2548950 COMMENT Data kindly reviewed (16-MAY-1989) by Herz J. J. FEATURES Location/Qualifiers source 1..14896 /db_xref="H-InvDB:HIT000321395" /organism="Homo sapiens" /map="chromosome 12 q13-14" /mol_type="mRNA" /clone_lib="HL9" /clone="LRP 1-9" /tissue_type="liver" /db_xref="taxon:9606" CDS 467..14101 /product="LDL-receptor related precursor (AA -19 to 4525)" /db_xref="GOA:Q07954" /db_xref="H-InvDB:HIT000321395.14" /db_xref="HGNC:HGNC:6692" /db_xref="InterPro:IPR000033" /db_xref="InterPro:IPR000152" /db_xref="InterPro:IPR000742" /db_xref="InterPro:IPR001881" /db_xref="InterPro:IPR002172" /db_xref="InterPro:IPR009030" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013032" /db_xref="InterPro:IPR018097" /db_xref="InterPro:IPR023415" /db_xref="InterPro:IPR026823" /db_xref="InterPro:IPR032485" /db_xref="InterPro:IPR036055" /db_xref="PDB:1CR8" /db_xref="PDB:1D2L" /db_xref="PDB:1J8E" /db_xref="PDB:2FYJ" /db_xref="PDB:2FYL" /db_xref="PDB:2KNX" /db_xref="PDB:2KNY" /db_xref="UniProtKB/Swiss-Prot:Q07954" /protein_id="CAA32112.1" /translation="MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKG WRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGS DEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTC SQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQ VSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINIS LSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAM GKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIE VVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEY QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRS GFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDF HAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPK KTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERA WMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGP ELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQ QQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQP GEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLC DGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCA YPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPE HWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDC MDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACR PPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGI VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCR SLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLR TTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWP NGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWT DWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHL CLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFT VPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWV SRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISM ANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRS QLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQL DHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEG IRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRED VVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVH PEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTD KIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSV PLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAED GASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTS PGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTST ITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALS GANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHP FGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELS PCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI NFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSD EIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG VLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMS WTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCE GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNR QCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHD QSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINEC LSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGS YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYW CDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMD GSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHI FALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNH PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFW WKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC DIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRC IPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGS DEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSC ANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMD GSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPN RPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLS SSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFH TVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYI ADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLP PAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMK GENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQW PTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYG VTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLL SPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKC RCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCAN NSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEG SRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMM PECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAK GFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATL YMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA" sig_peptide 467..523 /note="put. signal peptide (-19 to -1)" mat_peptide 524..14098 /note="LDL-receptor related protein (AA 1-4525)" misc_feature 524..790 /note="LDL-receptor-like domain 1" misc_feature 3026..4012 /note="LDL-receptor-like domain 2" misc_feature 8036..9283 /note="LDL-receptor-like domain 3" misc_feature 10466..11794 /note="LDL-receptor-like domain 4" BASE COUNT 3192 a 4562 c 4395 g 2747 t ORIGIN 1 cagcggtgcg agctccaggc ccatgcactg aggaggcgga aacaagggga gcccccagag 61 ctccatcaag ccccctccaa aggctcccct acccggtcca cgccccccac cccccctccc 121 cgcctcctcc caattgtgca tttttgcagc cggaggcggc tccgagatgg ggctgtgagc 181 ttcgcccggg gagggggaaa gagcagcgag gagtgaagcg ggggggtggg gtgaagggtt 241 tggatttcgg ggcagggggc gcacccccgt cagcaggccc tccccaaggg gctcggaact 301 ctacctcttc acccacgccc ctggtgcgct ttgccgaagg aaagaataag aacagagaag 361 gaggaggggg aaaggaggaa aagggggacc ccccaactgg ggggggtgaa ggagagaagt 421 agcaggacca gaggggaagg ggctgctgct tgcatcagcc cacaccatgc tgaccccgcc 481 gttgctcctg ctgctgcccc tgctctcagc tctggtcgcg gcggctatcg acgcccctaa 541 gacttgcagc cccaagcagt ttgcctgcag agatcaaata acctgtatct caaagggctg 601 gcggtgcgac ggtgagaggg actgcccaga cggatctgac gaggcccctg agatttgtcc 661 acagagtaag gcccagcgat gccagccaaa cgagcataac tgcctgggta ctgagctgtg 721 tgttcccatg tcccgcctct gcaatggggt ccaggactgc atggacggct cagatgaggg 781 gccccactgc cgagagctcc aaggcaactg ctctcgcctg ggctgccagc accattgtgt 841 ccccacactc gatgggccca cctgctactg caacagcagc tttcagcttc aggcagatgg 901 caagacctgc aaagattttg atgagtgctc agtgtacggc acctgcagcc agctatgcac 961 caacacagac ggctccttca tatgtggctg tgttgaagga tacctcctgc agccggataa 1021 ccgctcctgc aaggccaaga acgagccagt agaccggccc cctgtgctgt tgatagccaa 1081 ctcccagaac atcttggcca cgtacctgag tggggcccag gtgtctacca tcacacctac 1141 gagcacgcgg cagaccacag ccatggactt cagctatgcc aacgagaccg tatgctgggt 1201 gcatgttggg gacagtgctg ctcagacgca gctcaagtgt gcccgcatgc ctggcctaaa 1261 gggcttcgtg gatgagcaca ccatcaacat ctccctcagt ctgcaccacg tggaacagat 1321 ggccatcgac tggctgacag gcaacttcta ctttgtggat gacatcgatg ataggatctt 1381 tgtctgcaac agaaatgggg acacatgtgt cacattgcta gacctggaac tctacaaccc 1441 caagggcatt gccctggacc ctgccatggg gaaggtgttt ttcactgact atgggcagat 1501 cccaaaggtg gaacgctgtg acatggatgg gcagaaccgc accaagctcg tcgacagcaa 1561 gattgtgttt cctcatggca tcacgctgga cctggtcagc cgccttgtct actgggcaga 1621 tgcctatctg gactatattg aagtggtgga ctatgagggc aagggccgcc agaccatcat 1681 ccagggcatc ctgattgagc acctgtacgg cctgactgtg tttgagaatt atctctatgc 1741 caccaactcg gacaatgcca atgcccagca gaagacgagt gtgatccgtg tgaaccgctt 1801 taacagcacc gagtaccagg ttgtcacccg ggtggacaag ggtggtgccc tccacatcta 1861 ccaccagagg cgtcagcccc gagtgaggag ccatgcctgt gaaaacgacc agtatgggaa 1921 gccgggtggc tgctctgaca tctgcctgct ggccaacagc cacaaggcgc ggacctgccg 1981 ctgccgttcc ggcttcagcc tgggcagtga cgggaagtca tgcaagaagc cggagcatga 2041 gctgttcctc gtgtatggca agggccggcc aggcatcatc cggggcatgg atatgggggc 2101 caaggtcccg gatgagcaca tgatccccat tgaaaacctc atgaaccccc gagccctgga 2161 cttccacgct gagaccggct tcatctactt tgccgacacc accagctacc tcattggccg 2221 ccagaagatt gatggcactg agcgggagac catcctgaag gacggcatcc acaatgtgga 2281 gggtgtggcc gtggactgga tgggagacaa tctgtactgg acggacgatg ggcccaaaaa 2341 gacaatcagc gtggccaggc tggagaaagc tgctcagacc cgcaagactt taatcgaggg 2401 caaaatgaca caccccaggg ctattgtggt ggatccactc aatgggtgga tgtactggac 2461 agactgggag gaggacccca aggacagtcg gcgtgggcgg ctggagaggg cgtggatgga 2521 tggctcacac cgagacatct ttgtcacctc caagacagtg ctttggccca atgggctaag 2581 cctggacatc ccggctgggc gcctctactg ggtggatgcc ttctacgacc gcatcgagac 2641 gatactgctc aatggcacag accggaagat tgtgtatgaa ggtcctgagc tgaaccacgc 2701 ctttggcctg tgtcaccatg gcaactacct cttctggact gagtatcgga gtggcagtgt 2761 ctaccgcttg gaacggggtg taggaggcgc accccccact gtgacccttc tgcgcagtga 2821 gcggcccccc atctttgaga tccgaatgta tgatgcccag cagcagcaag ttggcaccaa 2881 caaatgccgg gtgaacaatg gcggctgcag cagcctgtgc ttggccaccc ctgggagccg 2941 ccagtgcgcc tgtgctgagg accaggtgtt ggacgcagac ggcgtcactt gcttggcgaa 3001 cccatcctac gtgcctccac cccagtgcca gccaggcgag tttgcctgtg ccaacagccg 3061 ctgcatccag gagcgctgga agtgtgacgg agacaacgat tgcctggaca acagtgatga 3121 ggccccagcc ctctgccatc agcacacctg cccctcggac cgattcaagt gcgagaacaa 3181 ccggtgcatc cccaaccgct ggctctgcga cggggacaat gactgtggga acagtgaaga 3241 tgagtccaat gccacttgtt cagcccgcac ctgccccccc aaccagttct cctgtgccag 3301 tggccgctgc atccccatct cctggacgtg tgatctggat gacgactgtg gggaccgctc 3361 tgatgagtct gcttcgtgtg cctatcccac ctgcttcccc ctgactcagt ttacctgcaa 3421 caatggcaga tgtatcaaca tcaactggag atgcgacaat gacaatgact gtggggacaa 3481 cagtgacgaa gccggctgca gccactcctg ttctagcacc cagttcaagt gcaacagcgg 3541 gcgttgcatc cccgagcact ggacctgcga tggggacaat gactgcggag actacagtga 3601 tgagacacac gccaactgca ccaaccaggc cacgaggccc cctggtggct gccacactga 3661 tgagttccag tgccggctgg atggactatg catccccctg cggtggcgct gcgatgggga 3721 cactgactgc atggactcca gcgatgagaa gagctgtgag ggagtgaccc acgtctgcga 3781 tcccagtgtc aagtttggct gcaaggactc agctcggtgc atcagcaaag cgtgggtgtg 3841 tgatggcgac aatgactgtg aggataactc ggacgaggag aactgcgagt ccctggcctg 3901 caggccaccc tcgcaccctt gtgccaacaa cacctcagtc tgcctgcccc ctgacaagct 3961 gtgtgatggc aacgacgact gtggcgacgg ctcagatgag ggcgagctct gcgaccagtg 4021 ctctctgaat aacggtggct gcagccacaa ctgctcagtg gcacctggcg aaggcattgt 4081 gtgttcctgc cctctgggca tggagctggg gcccgacaac cacacctgcc agatccagag 4141 ctactgtgcc aagcatctca aatgcagcca aaagtgcgac cagaacaagt tcagcgtgaa 4201 gtgctcctgc tacgagggct gggtcctgga acctgacggc gagagctgcc gcagcctgga 4261 ccccttcaag ccgttcatca ttttctccaa ccgccatgaa atccggcgca tcgatcttca 4321 caaaggagac tacagcgtcc tggtgcccgg cctgcgcaac accatcgccc tggacttcca 4381 cctcagccag agcgccctct actggaccga cgtggtggag gacaagatct accgcgggaa 4441 gctgctggac aacggagccc tgactagttt cgaggtggtg attcagtatg gcctggccac 4501 acccgagggc ctggctgtag actggattgc aggcaacatc tactgggtgg agagtaacct 4561 ggatcagatc gaggtggcca agctggatgg gaccctccgg accaccctgc tggccggtga 4621 cattgagcac ccaagggcaa tcgcactgga tccccgggat gggatcctgt tttggacaga 4681 ctgggatgcc agcctgcccc gcattgaggc agcctccatg agtggggctg ggcgccgcac 4741 cgtgcaccgg gagaccggct ctgggggctg gcccaacggg ctcaccgtgg actacctgga 4801 gaagcgcatc ctttggattg acgccaggtc agatgccatt tactcagccc gttacgacgg 4861 ctctggccac atggaggtgc ttcggggaca cgagttcctg tcgcacccgt ttgcagtgac 4921 gctgtacggg ggggaggtct actggactga ctggcgaaca aacacactgg ctaaggccaa 4981 caagtggacc ggccacaatg tcaccgtggt acagaggacc aacacccagc cctttgacct 5041 gcaggtgtac cacccctccc gccagcccat ggctcccaat ccctgtgagg ccaatggggg 5101 ccagggcccc tgctcccacc tgtgtctcat caactacaac cggaccgtgt cctgcgcctg 5161 cccccacctc atgaagctcc acaaggacaa caccacctgc tatgagttta agaagttcct 5221 gctgtacgca cgtcagatgg agatccgagg tgtggacctg gatgctccct actacaacta 5281 catcatctcc ttcacggtgc ccgacatcga caacgtcaca gtgctagact acgatgcccg 5341 cgagcagcgt gtgtactggt ctgacgtgcg gacacaggcc atcaagcggg ccttcatcaa 5401 cggcacaggc gtggagacag tcgtctctgc agacttgcca aatgcccacg ggctggctgt 5461 ggactgggtc tcccgaaacc tgttctggac aagctatgac accaataaga agcagatcaa 5521 tgtggcccgg ctggatggct ccttcaagaa cgcagtggtg cagggcctgg agcagcccca 5581 tggccttgtc gtccaccctc tgcgtgggaa gctctactgg accgatggtg acaacatcag 5641 catggccaac atggatggca gcaatcgcac cctgctcttc agtggccaga agggccccgt 5701 gggcctggct attgacttcc ctgaaagcaa actctactgg atcagctccg ggaaccatac 5761 catcaaccgc tgcaacctgg atgggagtgg gctggaggtc atcgatgcca tgcggagcca 5821 gctgggcaag gccaccgccc tggccatcat gggggacaag ctgtggtggg ctgatcaggt 5881 gtcggaaaag atgggcacat gcagcaaggc tgacggctcg ggctccgtgg tccttcggaa 5941 cagcaccacc ctggtgatgc acatgaaggt ctatgacgag agcatccagc tggaccataa 6001 gggcaccaac ccctgcagtg tcaacaacgg tgactgctcc cagctctgcc tgcccacgtc 6061 agagacgacc cgctcctgca tgtgcacagc cggctatagc ctccggagtg gccagcaggc 6121 ctgcgagggc gtaggttcct ttctcctgta ctctgtgcat gagggaatca ggggaattcc 6181 cctggatccc aatgacaagt cagatgccct ggtcccagtg tccgggacct cgctggctgt 6241 cggcatcgac ttccacgctg aaaatgacac catctactgg gtggacatgg gcctgagcac 6301 gatcagccgg gccaagcggg accagacgtg gcgtgaagac gtggtgacca atggcattgg 6361 ccgtgtggag ggcattgcag tggactggat cgcaggcaac atctactgga cagaccaggg 6421 ctttgatgtc atcgaggtcg cccggctcaa tggctccttc cgctacgtgg tgatctccca 6481 gggtctagac aagccccggg ccatcaccgt ccacccggag aaagggtact tgttctggac 6541 tgagtggggt cagtatccgc gtattgagcg gtctcggcta gatggcacgg agcgtgtggt 6601 gctggtcaac gtcagcatca gctggcccaa cggcatctca gtggactacc aggatgggaa 6661 gctgtactgg tgcgatgcac ggacagacaa gattgaacgg atcgacctgg agacaggtga 6721 gaaccgcgag gtggttctgt ccagcaacaa catggacatg ttttcagtgt ctgtgtttga 6781 ggatttcatc tactggagtg acaggactca tgccaacggc tctatcaagc gcgggagcaa 6841 agacaatgcc acagactccg tgcccctgcg aaccggcatc ggcgtccagc ttaaagacat 6901 caaagtcttc aaccgggacc ggcagaaagg caccaacgtg tgcgcggtgg ccaatggcgg 6961 gtgccagcag ctgtgcctgt accggggccg tgggcagcgg gcctgcgcct gtgcccacgg 7021 gatgctggct gaagacggag catcgtgccg cgagtatgcc ggctacctgc tctactcaga 7081 gcgcaccatt ctcaagagta tccacctgtc ggatgagcgc aacctcaatg cgcccgtgca 7141 gcccttcgag gaccctgagc acatgaagaa cgtcatcgcc ctggcctttg actaccgggc 7201 aggcacctct ccgggcaccc ccaatcgcat cttcttcagc gacatccact ttgggaacat 7261 ccaacagatc aacgacgatg gctccaggag gatcaccatt gtggaaaacg tgggctccgt 7321 ggaaggcctg gcctatcacc gtggctggga cactctctat tggacaagct acacgacatc 7381 caccatcacg cgccacacag tggaccagac ccgcccaggg gccttcgagc gtgagaccgt 7441 catcactatg tctggagatg accacccacg ggccttcgtt ttggacgagt gccagaacct 7501 catgttctgg accaactgga atgagcagca tcccagcatc atgcgggcgg cgctctcggg 7561 agccaatgtc ctgaccctta tcgagaagga catccgtacc cccaatggcc tggccatcga 7621 ccaccgtgcc gagaagctct acttctctga cgccaccctg gacaagatcg agcggtgcga 7681 gtatgacggc tcccaccgct atgtgatcct aaagtcagag cctgtccacc ccttcgggct 7741 ggccgtgtat ggggagcaca ttttctggac tgactgggtg cggcgggcag tgcagcgggc 7801 caacaagcac gtgggcagca acatgaagct gctgcgcgtg gacatccccc agcagcccat 7861 gggcatcatc gccgtggcca acgacaccaa cagctgtgaa ctctctccat gccgaatcaa 7921 caacggtggc tgccaggacc tgtgtctgct cactcaccag ggccatgtca actgctcatg 7981 ccgagggggc cgaatcctcc aggatgacct cacctgccga gcggtgaatt cctcttgccg 8041 agcacaagat gagtttgagt gtgccaatgg cgagtgcatc aacttcagcc tgacctgcga 8101 cggcgtcccc cactgcaagg acaagtccga tgagaagcca tcctactgca actcccgccg 8161 ctgcaagaag actttccggc agtgcagcaa tgggcgctgt gtgtccaaca tgctgtggtg 8221 caacggggcc gacgactgtg gggatggctc tgacgagatc ccttgcaaca agacagcctg 8281 tggtgtgggc gagttccgct gccgggacgg gacctgcatc gggaactcca gccgctgcaa 8341 ccagtttgtg gattgtgagg acgcctcaga tgagatgaac tgcagtgcca ccgactgcag 8401 cagctacttc cgcctgggcg tgaagggcgt gctcttccag ccctgcgagc ggacctcact 8461 ctgctacgca cccagctggg tgtgtgatgg cgccaatgac tgtggggact acagtgatga 8521 gcgcgactgc ccaggtgtga aacgccccag atgccctctg aattacttcg cctgccctag 8581 tgggcgctgc atccccatga gctggacgtg tgacaaagag gatgactgtg aacatggcga 8641 ggacgagacc cactgcaaca agttctgctc agaggcccag tttgagtgcc agaaccatcg 8701 ctgcatctcc aagcagtggc tgtgtgacgg cagcgatgac tgtggggatg gctcagacga 8761 ggctgctcac tgtgaaggca agacgtgcgg cccctcctcc ttctcctgcc ctggcaccca 8821 cgtgtgcgtc cccgagcgct ggctctgtga cggtgacaaa gactgtgctg atggtgcaga 8881 cgagagcatc gcagctggtt gcttgtacaa cagcacttgt gacgaccgtg agttcatgtg 8941 ccagaaccgc cagtgcatcc ccaagcactt cgtgtgtgac cacgaccgtg actgtgcaga 9001 tggctctgat gagtcccccg agtgtgagta cccgacctgc ggccccagtg agttccgctg 9061 tgccaatggg cgctgtctga gctcccgcca gtgggagtgt gatggcgaga atgactgcca 9121 cgaccagagt gacgaggctc ccaagaaccc acactgcacc agcccagagc acaagtgcaa 9181 tgcctcgtca cagttcctgt gcagcagtgg gcgctgtgtg gctgaggcac tgctctgcaa 9241 cggccaggat gactgtggcg acagctcgga cgagcgtggc tgccacatca atgagtgtct 9301 cagccgcaag ctcagtggct gcagccagga ctgtgaggac ctcaagatcg gcttcaagtg 9361 ccgctgtcgc cctggcttcc ggctgaagga tgacggccgg acgtgtgctg atgtggacga 9421 gtgcagcacc accttcccct gcagccagcg ctgcatcaac acccatggca gctataagtg 9481 tctgtgtgtg gagggctatg caccccgcgg cggcgacccc cacagctgca aggctgtgac 9541 tgacgaggaa ccgtttctga tcttcgccaa ccggtactac ctgcgcaagc tcaacctgga 9601 cgggtccaac tacacgttac ttaagcaggg cctgaacaac gccgttgcct tggattttga 9661 ctaccgagag cagatgatct actggacaga tgtgaccacc cagggcagca tgatccgaag 9721 gatgcacctt aacgggagca atgtgcaggt cctacaccgt acaggcctca gcaaccccga 9781 tgggctggct gtggactggg tgggtggcaa cctgtactgg tgcgacaaag gccgggacac 9841 catcgaggtg tccaagctca atggggccta tcggacggtg ctggtcagct ctggcctccg 9901 tgagcccagg gctctggtgg tggatgtgca gaatgggtac ctgtactgga cagactgggg 9961 tgaccattca ctgatcggcc gcatcggcat ggatgggtcc agccgcagcg tcatcgtgga 10021 caccaagatc acatggccca atggcctgac gctggactat gtcactgagc gcatctactg 10081 ggccgacgcc cgcgaggact acattgaatt tgccagcctg gatggctcca atcgccacgt 10141 tgtgctgagc caggacatcc cgcacatctt tgcactgacc ctgtttgagg actacgtcta 10201 ctggaccgac tgggaaacaa agtccattaa ccgagcccac aagaccacgg gcaccaacaa 10261 aacgctcctc atcagcacgc tgcaccggcc catggacctg catgtcttcc atgccctgcg 10321 ccagccagac gtgcccaatc acccctgcaa ggtcaacaat ggtggctgca gcaacctgtg 10381 cctgctgtcc cccgggggag ggcacaaatg tgcctgcccc accaacttct acctgggcag 10441 cgatgggcgc acctgtgtgt ccaactgcac ggctagccag tttgtatgca agaacgacaa 10501 gtgcatcccc ttctggtgga agtgtgacac cgaggacgac tgcggggacc actcagacga 10561 gcccccggac tgccctgagt tcaagtgccg gcccggacag ttccagtgct ccacaggtat 10621 ctgcacaaac cctgccttca tctgcgatgg cgacaatgac tgccaggaca acagtgacga 10681 ggccaactgt gacatccacg tctgcttgcc cagtcagttc aaatgcacca acaccaaccg 10741 ctgtattccc ggcatcttcc gctgcaatgg gcaggacaac tgcggagatg gggaggatga 10801 gagggactgc cccgaggtga cctgcgcccc caaccagttc cagtgctcca ttaccaaacg 10861 gtgcatcccc cgggtctggg tctgcgaccg ggacaatgac tgtgtggatg gcagtgatga 10921 gcccgccaac tgcacccaga tgacctgtgg tgtggacgag ttccgctgca aggattcggg 10981 ccgctgcatc ccagcgcgtt ggaagtgtga cggagaggat gactgtgggg atggctcgga 11041 tgagcccaag gaagagtgtg atgaacgcac ctgtgagcca taccagttcc gctgcaagaa 11101 caaccgctgc gtgcccggcc gctggcagtg cgactacgac aacgattgcg gtgacaactc 11161 cgatgaagag agctgcaccc ctcggccctg ctccgagagt gagttctcct gtgccaacgg 11221 ccgctgcatc gcggggcgct ggaaatgcga tggagaccac gactgcgcgg acggctcgga 11281 cgagaaagac tgcacccccc gctgtgacat ggaccagttc cagtgcaaga gcggccactg 11341 catccccctg cgctggcgct gtgacgcaga cgccgactgc atggacggca gcgacgagga 11401 ggcctgcggc actggcgtgc ggacctgccc cctggacgag ttccagtgca acaacacctt 11461 gtgcaagccg ctggcctgga agtgcgatgg cgaggatgac tgtggggaca actcagatga 11521 gaaccccgag gagtgtgccc ggttcgtgtg ccctcccaac cggcccttcc gttgcaagaa 11581 tgaccgcgtc tgtctgtgga tcgggcgcca atgcgatggc acggacaact gtggggatgg 11641 gactgatgaa gaggactgtg agccccccac agcccacacc acccactgca aagacaagaa 11701 ggagtttctg tgccggaacc agcgctgcct ctcctcctcc ctgcgctgca acatgttcga 11761 tgactgcggg gacggctctg acgaggagga ctgcagcatc gaccccaagc tgaccagctg 11821 cgccaccaat gccagcatct gtggggacga ggcacgctgc gtgcgcaccg agaaagcggc 11881 ctactgtgcc tgccgctcgg gcttccacac cgtgcccggc cagcccggat gccaagacat 11941 caacgagtgc ctgcgcttcg gcacctgctc ccagctctgc aacaacacca agggcggcca 12001 cctctgcagc tgcgctcgga acttcatgaa gacgcacaac acctgcaagg ccgaaggctc 12061 tgagtaccag gtcctgtaca tcgctgatga caatgagatc cgcagcctgt tccccggcca 12121 cccccattcg gcttacgagc aggcattcca gggtgacgag agtgtccgca ttgatgctat 12181 ggatgtccat gtcaaggctg gccgtgtcta ttggaccaac tggcacacgg gcaccatctc 12241 ctaccgcagc ctgccacctg ctgcgcctcc taccacttcc aaccgccacc ggcgacagat 12301 tgaccggggt gtcacccacc tcaacatttc agggctgaag atgcccagag gcatcgccat 12361 cgactgggtg gccggaaacg tgtactggac cgactcgggc cgagatgtga ttgaggtggc 12421 gcagatgaag ggcgagaacc gcaagacgct catctcgggc atgattgacg agccccacgc 12481 cattgtggtg gacccactga gggggaccat gtactggtca gactggggca accaccccaa 12541 gattgagacg gcagcgatgg atgggacgct tcgggagaca ctggtgcagg acaacattca 12601 gtggcccaca ggcctggccg tggattatca caatgagcgg ctgtactggg cagacgccaa 12661 gctttcagtc atcggcagca tccggctcaa tggcacggac cccattgtgg ctgctgacag 12721 caaacgaggc ctaagtcacc ccttcagcat cgacgtcttt gaggattaca tctatggtgt 12781 cacctacatc aataatcgtg tcttcaagat ccataagttt ggccacagcc ccttggtcaa 12841 cctgacaggg ggcctgagcc acgcctctga cgtggtcctt taccatcagc acaagcagcc 12901 cgaagtgacc aacccatgtg accgcaagaa atgcgagtgg ctctgcctgc tgagccccag 12961 tgggcctgtc tgcacctgtc ccaatgggaa gcggctggac aacggcacat gcgtgcctgt 13021 gccctctcca acgccccccc cagatgctcc ccggcctgga acctgtaacc tgcagtgctt 13081 caacggtggc agctgtttcc tcaatgcacg gaggcagccc aagtgccgct gccaaccccg 13141 ctacacgggt gacaagtgtg aactggacca gtgctgggag cactgtcgca atgggggcac 13201 ctgtgctgcc tccccctctg gcatgcccac gtgccggtgc cccacgggct tcacgggccc 13261 caaatgcacc cagcaggtgt gtgcgggcta ctgtgccaac aacagcacct gcactgtcaa 13321 ccagggcaac cagccccagt gccgatgcct acccggcttc ctgggcgacc gctgccagta 13381 ccggcagtgc tctggctact gtgagaactt tggcacatgc cagatggctg ctgatggctc 13441 ccgacaatgc cgctgcactg cctactttga gggatcgagg tgtgaggtga acaagtgcag 13501 ccgctgtctc gaaggggcct gtgtggtcaa caagcagagt ggggatgtca cctgcaactg 13561 cacggatggc cgggtggccc ccagctgtct gacctgcgtc ggccactgca gcaatggcgg 13621 ctcctgtacc atgaacagca aaatgatgcc tgagtgccag tgcccacccc acatgacagg 13681 gccccggtgt gaggagcacg tcttcagcca gcagcagcca ggacatatag cctccatcct 13741 aatccctctg ctgttgctgc tgctgctggt tctggtggcc ggagtggtat tctggtataa 13801 gcggcgagtc caaggggcta agggcttcca gcaccaacgg atgaccaacg gggccatgaa 13861 cgtggagatt ggaaacccca cctacaagat gtacgaaggc ggagagcctg atgatgtggg 13921 aggcctactg gacgctgact ttgccctgga ccctgacaag cccaccaact tcaccaaccc 13981 cgtgtatgcc acactctaca tggggggcca tggcagtcgc cactccctgg ccagcacgga 14041 cgagaagcga gaactcctgg gccggggccc tgaggacgag ataggggacc ccttggcata 14101 gggccctgcc ccgtcggact gcccccagaa agcctcctgc cccctgccgg tgaagtcctt 14161 cagtgagccc ctccccagcc agcccttccc tggccccgcc ggatgtataa atgtaaaaat 14221 gaaggaatta cattttatat gtgagcgagc aagccggcaa gcgagcacag tattatttct 14281 ccatcccctc cctgcctgct ccttggcacc cccatgctgc cttcagggag acaggcaggg 14341 agggcttggg gctgcacctc ctaccctccc accagaacgc accccactgg gagagctggt 14401 ggtgcagcct tcccctccct gtataagaca ctttgccaag gctctcccct ctcgccccat 14461 ccctgcttgc ccgctcccac agcttcctga gggctaattc tgggaaggga gagttctttg 14521 ctgcccctgt ctggaagacg tggctctggg tgaggtaggc gggaaaggat ggagtgtttt 14581 agttcttggg ggaggccacc ccaaacccca gccccaactc caggggcacc tatgagatgg 14641 ccatgctcaa cccccctccc agacaggccc tccctgtctc cagggccccc accgaggttc 14701 ccagggctgg agacttcctc tggtaaacat tcctccagcc tcccctcccc tggggacgcc 14761 aaggaggtgg gccacaccca ggaagggaaa gcgggcagcc ccgttttggg gacgtgaacg 14821 ttttaataat ttttgctgaa ttctttacaa ctaaataaca cagatattct tataaataaa 14881 attgtaaaaa aaaaaa //