LOCUS       X07994                  6274 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Human mRNA for lactase-phlorizin hydrolase LPH (EC 3.2.1.23-62).
ACCESSION   X07994
VERSION     X07994.1
KEYWORDS    glycosylceramidase; hydrolase; phlorizin hydrolase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6274)
  AUTHORS   Mantei N.
  JOURNAL   Submitted (28-JUN-1988) to the INSDC. Mantei N., Swiss Federal
            Institute of Technology Zurich, Universitaetstrasse 16,
            ETH-Zentrum, CH-8092 Zurich, Switzerland.
REFERENCE   2
  AUTHORS   Mantei N., Villa M., Enzler T., Wacker H., Boll W., James P.,
            Hunziker W., Semenza G.
  TITLE     Complete primary structure of human and rabbit lactase-phlorizin
            hydrolase: implications for biosynthesis, membrane anchoring and
            evolution of the enzyme
  JOURNAL   EMBO J. 7(9), 2705-2713(1988).
   PUBMED   2460343
COMMENT     Data kindly reviewed (12-DEC-1988) by Mantei N.
FEATURES             Location/Qualifiers
     source          1..6274
                     /db_xref="H-InvDB:HIT000321293"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /dev_stage="adult"
                     /clone="pHLac-61, pHLac-5, pHLac-1"
                     /tissue_type="intestinal mucosa"
                     /db_xref="taxon:9606"
     CDS             12..5795
                     /note="LPH prepro-polypeptide (AA -19 to 1908)"
                     /db_xref="GOA:P09848"
                     /db_xref="H-InvDB:HIT000321293.15"
                     /db_xref="HGNC:HGNC:6530"
                     /db_xref="InterPro:IPR001360"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR018120"
                     /db_xref="InterPro:IPR033132"
                     /db_xref="UniProtKB/Swiss-Prot:P09848"
                     /protein_id="CAA30801.1"
                     /translation="MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLS
                     GLLGDQSSNFVAGDKDMYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGST
                     QNPDEKTVQCYRRLLKALKTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFH
                     SFGDLVGIWFTFSDLEEVIKELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLS
                     VVLRAEDIPELLLEPPISALAQDTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKV
                     FIFNLKLPDCPSTMKNPASLLFSLFEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSL
                     TGSLALQPDQQQDHETTDSSPASAYQRVWEAFANQSRAERDAFLQDTFPEGFLWGAST
                     GAFNVEGGWAEGGRGVSIWDPRRPLNTTEGQATLEVASDSYHKVASDVALLCGLRAQV
                     YKFSISWSRIFPMGHGSSPSLPGVAYYNKLIDRLQDAGIEPMATLFHWDLPQALQDHG
                     GWQNESVVDAFLDYAAFCFSTFGDRVKLWVTFHEPWVMSYAGYGTGQHPPGISDPGVA
                     SFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIVLNSDWAEPLSPERPEDLRASERFL
                     HFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPVAQLPEFTEAEKQLLKGSADFLG
                     LSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQTSSSWIRVVPWGIRRLLQFVS
                     LEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYINEVLKAIKEDSVDVRSYIA
                     RSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTSIIEKNGFLTKGAKRLL
                     PPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYHGTFRDDFLWGVSSS
                     AYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLDADLNMLRALKVK
                     AYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFHWDLPQALQDI
                     GGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFPPGVKDPGW
                     APYRIAHTVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDVEAADRM
                     LQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRATADVF
                     CLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWIKE
                     EYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
                     NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFP
                     EGFIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDL
                     VTLQNLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHW
                     DLPQTLQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTA
                     APGVSNRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSN
                     QEDVEAARRYVQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEK
                     RRINGTYDFFGFNHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTP
                     FGFRRILNWLKEEYNDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKV
                     DLRGYTVWSAMDNFEWATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPD
                     PATGPHACLHQPDAGPTISPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAF
                     LSYKYCKRSKQGKTQRSQQELSPVSSF"
     sig_peptide     12..68
                     /note="signal peptide (AA -19 to -1)"
     misc_feature    69..5792
                     /note="LPH propeptide (AA 1 to 1908)"
     mat_peptide     2616..5792
                     /note="put. mature LPH (AA 850 to 1908)"
     misc_feature    6250..6255
                     /note="polyA signal"
     polyA_site      6274..6274
                     /note="polyA site"
BASE COUNT         1536 a         1692 c         1582 g         1464 t
ORIGIN      
        1 gttcctagaa aatggagctg tcttggcatg tagtctttat tgccctgcta agtttttcat
       61 gctgggggtc agactgggag tctgatagaa atttcatttc caccgctggt cctctaacca
      121 atgacttgct gcacaacctg agtggtctcc tgggagacca gagttctaac tttgtagcag
      181 gggacaaaga catgtatgtt tgtcaccagc cactgcccac tttcctgcca gaatacttca
      241 gcagtctcca tgccagtcag atcacccatt ataaggtatt tctgtcatgg gcacagctcc
      301 tcccagcagg aagcacccag aatccagacg agaaaacagt gcagtgctac cggcgactcc
      361 tcaaggccct caagactgca cggcttcagc ccatggtcat cctgcaccac cagaccctcc
      421 ctgccagcac cctccggaga accgaagcct ttgctgacct cttcgccgac tatgccacat
      481 tcgccttcca ctccttcggg gacctagttg ggatctggtt caccttcagt gacttggagg
      541 aagtgatcaa ggagcttccc caccaggaat caagagcgtc acaactccag accctcagtg
      601 atgcccacag aaaagcctat gagatttacc acgaaagcta tgcttttcag ggcggaaaac
      661 tctctgttgt cctgcgagct gaagatatcc cggagctcct gctagaacca cccatatctg
      721 cgcttgccca ggacacggtc gatttcctct ctcttgattt gtcttatgaa tgccaaaatg
      781 aggcaagtct gcggcagaag ctgagtaaat tgcagaccat tgagccaaaa gtgaaagttt
      841 tcatcttcaa cctaaaactc ccagactgcc cctccaccat gaagaaccca gccagtctgc
      901 tcttcagcct ttttgaagcc ataaataaag accaagtgct caccattggg tttgatatta
      961 atgagtttct gagttgttca tcaagttcca agaaaagcat gtcttgttct ctgactggca
     1021 gcctggccct tcagcctgac cagcagcagg accacgagac cacggactcc tctcctgcct
     1081 ctgcctatca gagagtctgg gaagcatttg ccaatcagtc cagagcggaa agggatgcct
     1141 tcctgcagga tactttccct gaaggcttcc tctggggtgc ctccacagga gcctttaacg
     1201 tggaaggagg ctgggccgag ggtgggagag gggtgagcat ctgggatcca cgcaggcccc
     1261 tgaacaccac tgagggccaa gcgacgctgg aggtggccag cgacagttac cacaaggtag
     1321 cctctgacgt cgccctgctt tgcggcctcc gggctcaggt gtacaagttc tccatctcct
     1381 ggtcccggat cttccccatg gggcacggga gcagccccag cctcccaggc gttgcctact
     1441 acaacaagct gattgacagg ctacaggatg cgggcatcga gcccatggcc acgctgttcc
     1501 actgggacct gcctcaggcc ctgcaggatc atggtggatg gcagaatgag agcgtggtgg
     1561 atgccttcct ggactatgcg gccttctgct tctccacatt tggggaccgt gtgaagctgt
     1621 gggtgacctt ccatgagccg tgggtgatga gctacgcagg ctatggcacc ggccagcacc
     1681 ctcccggcat ctctgaccca ggagtggcct cttttaaggt ggctcacttg gtcctcaagg
     1741 ctcatgccag aacttggcac cactacaaca gccatcatcg cccacagcag caggggcacg
     1801 tgggcattgt gctgaactca gactgggcag aacccctgtc tccagagagg cctgaggacc
     1861 tgagagcctc tgagcgcttc ttgcacttca tgctgggctg gtttgcacac cccgtctttg
     1921 tggatggaga ctacccagcc accctgagga cccagatcca acagatgaac agacagtgct
     1981 cccatcctgt ggctcaactc cccgagttca cagaggcaga gaagcagctc ctgaaaggct
     2041 ctgctgattt tctgggtctg tcgcattaca cctcccgcct catcagcaac gccccacaaa
     2101 acacctgcat ccctagctat gataccattg gaggcttctc ccaacacgtg aaccatgtgt
     2161 ggccccagac ctcatcctct tggattcgtg tggtgccctg ggggataagg aggctgttgc
     2221 agtttgtatc cctggaatac acaagaggaa aagttccaat ataccttgcc gggaatggca
     2281 tgcccatagg ggaaagtgaa aatctctttg atgattcctt aagagtagac tacttcaatc
     2341 aatatatcaa tgaggtgctc aaggctatca aggaagactc tgtggatgtt cgttcctaca
     2401 ttgctcgttc cctcattgat ggcttcgaag gcccttctgg ttacagccag cggtttggcc
     2461 tgcaccacgt caacttcagc gacagcagca agtcaaggac tcccaggaaa tctgcctact
     2521 ttttcactag catcatagaa aagaacggtt tcctcaccaa gggggcaaaa agactgctac
     2581 cacctaatac agtaaacctc ccctccaaag tcagagcctt cacttttcca tctgaggtgc
     2641 cctccaaggc taaagtcgtt tgggaaaagt tctccagcca acccaagttc gaaagagatt
     2701 tgttctacca cgggacgttt cgggatgact ttctgtgggg cgtgtcctct tccgcttatc
     2761 agattgaagg cgcgtgggat gccgatggca aaggccccag catctgggat aactttaccc
     2821 acacaccagg gagcaatgtg aaagacaatg ccactggaga catcgcctgt gacagctatc
     2881 accagctgga tgccgatctg aatatgctcc gagctttgaa ggtgaaggcc taccgcttct
     2941 ctatctcctg gtctcggatt ttcccaactg ggagaaacag ctctatcaac agtcatgggg
     3001 ttgattatta caacaggctg atcaatggct tggtggcaag caacatcttt cccatggtga
     3061 cattgttcca ttgggacctg ccccaggccc tccaggatat cggaggctgg gagaatcctg
     3121 ccttgattga cttgtttgac agctacgcag acttttgttt ccagaccttt ggtgatagag
     3181 tcaagttttg gatgactttt aatgagccca tgtacctggc atggctaggt tatggctcag
     3241 gggaatttcc cccaggggtg aaggacccag gctgggcacc atataggata gcccacaccg
     3301 tcatcaaagc ccatgccaga gtctatcaca cgtacgatga gaaatacagg caggagcaga
     3361 agggggtcat ctcgctgagc ctcagtacac actgggcaga gcccaagtca ccaggggtcc
     3421 ccagagatgt ggaagccgct gaccgaatgc tgcagttctc cctgggctgg tttgctcacc
     3481 ccatttttag aaacggagac tatcctgaca ccatgaagtg gaaagtgggg aacaggagtg
     3541 aactgcagca cttagccacc tcccgcctgc caagcttcac tgaggaagag aagaggttca
     3601 tcagggcgac ggccgacgtc ttctgcctca acacgtacta ctccagaatc gtgcagcaca
     3661 aaacacccag gctaaaccca ccctcctacg aagacgacca ggagatggct gaggaggagg
     3721 acccttcgtg gccttccacg gcaatgaaca gagctgcgcc ctgggggacg cgaaggctgc
     3781 tgaactggat caaggaagag tatggtgaca tccccattta catcaccgaa aacggagtgg
     3841 ggctgaccaa tccgaacacg gaggatactg ataggatatt ttaccacaaa acctacatca
     3901 atgaggcttt gaaagcctac aggctcgatg gtatagacct tcgagggtat gtcgcctggt
     3961 ctctgatgga caactttgag tggctaaatg gctacacggt caagtttgga ctgtaccatg
     4021 ttgatttcaa caacacgaac aggcctcgca cagcaagagc ctccgccagg tactacacag
     4081 aggtcattac caacaacggc atgccactgg ccagggagga tgagtttctg tacggacggt
     4141 ttcctgaggg cttcatctgg agtgcagctt ctgctgcata tcagattgaa ggtgcgtgga
     4201 gagcagatgg caaaggactc agcatttggg acacgttttc tcacacacca ctgagggttg
     4261 agaacgatgc cattggagac gtggcctgtg acagttatca caagattgct gaggatctgg
     4321 tcaccctgca gaacctgggt gtgtcccact accgtttttc catctcctgg tctcgcatcc
     4381 tccctgatgg aaccaccagg tacatcaatg aagcgggcct gaactactac gtgaggctca
     4441 tcgatacact gctggccgcc agcatccagc cccaggtgac catttaccac tgggacctac
     4501 cacagacgct ccaagatgta ggaggctggg agaatgagac catcgtgcag cggtttaagg
     4561 agtatgcaga tgtgctcttc cagaggctgg gagacaaggt gaagttttgg atcacgttga
     4621 atgagccctt tgtcattgct taccagggct atggctacgg aacagcagct ccaggagtct
     4681 ccaataggcc tggcactgcc ccctacattg ttggccacaa tctaataaag gctcatgctg
     4741 aggcctggca tctgtacaac gatgtgtacc gcgccagtca aggtggcgtg atttccatca
     4801 ccatcagcag tgactgggct gaacccagag atccctctaa ccaggaggat gtggaggcag
     4861 ccaggagata tgttcagttc atgggaggct ggtttgcaca tcctattttc aagaatggag
     4921 attacaatga ggtgatgaag acgcggatcc gtgacaggag cttggctgca ggcctcaaca
     4981 agtctcggct gccagaattt acagagagtg agaagaggag gatcaacggc acctatgact
     5041 tttttgggtt caatcactac accactgtcc tcgcctacaa cctcaactat gccactgcca
     5101 tctcttcttt tgatgcagac agaggagttg cttccatcgc agatcgctcg tggccagact
     5161 ctggctcctt ctggctgaag atgacgcctt ttggcttcag gaggatcctg aactggttaa
     5221 aggaggaata caatgaccct ccaatttatg tcacagagaa tggagtgtcc cagcgggaag
     5281 aaacagacct caatgacact gcaaggatct actaccttcg gacttacatc aatgaggccc
     5341 tcaaagctgt gcaggacaag gtggaccttc gaggatacac agtttggagt gcgatggaca
     5401 attttgagtg ggccacaggc ttttcagaga gatttggtct gcattttgtg aactacagtg
     5461 acccttctct gccaaggatc cccaaagcat cagcgaagtt ctacgcctct gtggtccgat
     5521 gcaatggctt ccctgacccc gctacagggc ctcacgcttg tctccaccag ccagatgctg
     5581 gacccaccat cagccccgtg agacaggagg aggtgcagtt cctggggcta atgctcggca
     5641 ccacagaagc acagacagct ttgtacgttc tcttttctct tgtgcttctt ggagtctgtg
     5701 gcttggcatt tctgtcatac aagtactgca agcgctctaa gcaagggaaa acacaacgaa
     5761 gccaacagga attgagcccg gtgtcttcat tctgatgagt taccacctca agttctatga
     5821 agcaggccta gtttcttcat ctatctttac cggccaccaa acaccttagg gtcttagact
     5881 ctgctgatac tggacttctc cataaagtcc tgctgcaccg ttagagatga ctttaatctt
     5941 gaatgatttc gacttgctga gtaaaatgga aatatctcca tcttgctcca gtatcagagt
     6001 tcatttgggc atttgagaag caagtagctc ttgcggaaac gtgtagatac tggtctagtg
     6061 ggtctgtgaa ccacttaatt gaacttaaca gggctgtttt aagtttcaga gttgttaagg
     6121 gttgttaagg gagcaaaaac cgtaaaaatc cttcctataa gaagaaatca actccattgc
     6181 atagactgca atatcatctc ctgcccttct gcaagctctc cctagcttca catcttgtgt
     6241 tttccagaaa ataaaaacag aagactgtcc tttc
//