LOCUS X04828 1702 bp mRNA linear HUM 18-APR-2005
DEFINITION Human mRNA for G(i) protein alpha-subunit (adenylate cyclase
inhibiting GTP-binding protein).
ACCESSION X04828
VERSION X04828.1
KEYWORDS adenylate cyclase-inhibiting GTP-binding protein; G protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1702)
AUTHORS Didsbury J.R., Ho Y.S., Snyderman R.
TITLE Human Gi protein alpha-subunit: deduction of amino acid structure
from a cloned cDNA
JOURNAL FEBS Lett. 211(2), 160-164(1987).
PUBMED 3100330
COMMENT The poly(A) site was determined 38 bp 3' to the 3' terminus
of pJD43.
Four pot. GTP binding and hydrolysis sites are found at the
AA pos. 32-49, 200-206, 222-230 and 265-278.
Data kindly reviewed (24-APR-1987) by J. Didsbury
FEATURES Location/Qualifiers
source 1..1702
/db_xref="H-InvDB:HIT000321071"
/organism="Homo sapiens"
/mol_type="mRNA"
/clone="pJD43."
/cell_line="U937"
/db_xref="taxon:9606"
CDS 124..1191
/note="G protein alpha-subunit (AA 1-355)"
/db_xref="GOA:P04899"
/db_xref="H-InvDB:HIT000321071.14"
/db_xref="HGNC:HGNC:4385"
/db_xref="InterPro:IPR001019"
/db_xref="InterPro:IPR001408"
/db_xref="InterPro:IPR011025"
/db_xref="InterPro:IPR027417"
/db_xref="PDB:6D9H"
/db_xref="UniProtKB/Swiss-Prot:P04899"
/protein_id="CAA28512.1"
/translation="MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGES
GKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRAD
DARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDL
ERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEG
VTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFE
EKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQ
FVFDAVTDVIIKNNLKDCGLF"
BASE COUNT 375 a 504 c 506 g 317 t
ORIGIN
1 ccggcagtcc cgagtgcttc ccgcagaggg ctggtggtgg gagcggagtg gagtcgggcg
61 gggccgaagc cgggccgtgg gcgtagatgg gggccgggcg gcggcggagc ggcggaacgc
121 gggatgggct gcaccgtgag cgccgaggac aaggcggcgg ccgagcgctc taagatgatc
181 gacaagaacc tgcgggagga cggagagaag gcggcgcggg aggtgaagtt gctgctgttg
241 ggtgctgggg agtcagggaa gagcaccatc gtcaagcaga tgaagatcat ccacgaggat
301 ggctactccg aggaggaatg ccggcagtac cgggcggttg tctacagcaa caccatccag
361 tccatcatgg ccattgtcaa agccatggga aacctgcaga tcgactttgc cgacccctcc
421 agagcggacg acgccaggca gctatttgca ctgtcctgca ccgccgagga gcaaggcgtg
481 ctccctgatg acctgtccgg cgtcatccgg aggctctggg ctgaccatgg tgtgcaggcc
541 tgctttggcc gctcaaggga ataccagctc aacgactcag ctgcctacta cctgaacgac
601 ctggagcgta ttgcacagag tgactacatc cccacacagc aagatgtgct acggacccgc
661 gtaaagacca cggggatcgt ggagacacac ttcaccttca aggacctaca cttcaagatg
721 tttgatgtgg gtggtcagcg gtctgagcgg aagaagtgga tccactgctt tgagggcgtc
781 acagccatca tcttctgcgt agccttgagc gcctatgact tggtgctagc tgaggacgag
841 gagatgaacc gcatgcatga gagcatgaag ctattcgata gcatctgcaa caacaagtgg
901 ttcacagaca cgtccatcat cctcttcctc aacaagaagg acctgtttga ggagaagatc
961 acacacagtc ccctgaccat ctgcttccct gagtacacag gggccaacaa atatgatgag
1021 gcagccagct acatccagag taagtttgag gacctgaata agcgcaaaga caccaaggag
1081 atctacacgc acttcacgtg cgccaccgac accaagaacg tgcagttcgt gtttgacgcc
1141 gtcaccgatg tcatcatcaa gaacaacctg aaggactgcg gcctcttctg aggggcagcg
1201 gggcctggcg ggatgggcca ccgccgaatt tgtacccccc aacccctgag gaagatgggg
1261 gcaagaagat cacgctcccc gcctgttccc ccgccgcttt tctcctcttt cctctctttg
1321 ttctcagctc cccctgtccc ctcagctcca aacgtagggg aggggttcgc acaggcctcc
1381 ctgtttgaag cctgcccttg tctgagatgc tggtaatggc catggtaccc ccttctgggc
1441 atctgttctg gtttttaacc attgtcttgt tctgtgatga ggggaggggg gcacatgctg
1501 agtctcccaa ggctgcgtct ggaggggccc ctgcttctcc agcctggacc cccagctttg
1561 cccaacacca gcccctgccc cagcccaagt ccaaatgttt acgggagcct cctgcccagt
1621 cccccaaccc cagccgctcg gaggccccaa aggaaaaagc acaagaagcg tgagacgcca
1681 ccattcctgg aaaccacagt cc
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