LOCUS X02910 3634 bp DNA linear HUM 14-NOV-2006 DEFINITION Human gene for tumor necrosis factor (TNF-alpha). ACCESSION X02910 X02159 VERSION X02910.1 KEYWORDS signal peptide; tumor necrosis factor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3634) AUTHORS Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W. TITLE Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization JOURNAL Nucleic Acids Res. 13(17), 6361-6373(1985). PUBMED 2995927 REFERENCE 2 (bases 329 to 3634) AUTHORS Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B. TITLE Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor JOURNAL Nature 313(6005), 803-806(1985). PUBMED 3883195 REFERENCE 3 AUTHORS Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R., Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V. TITLE Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin JOURNAL Nature 312(5996), 724-729(1984). PUBMED 6392892 COMMENT In the cDNA sequence from ref [3] the mature protein site starts also with Val at pos 1631 Data kindly reviewed (18-FEB-1986) by A. Sakaguchi FEATURES Location/Qualifiers source 1..3634 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" regulatory 590..595 /regulatory_class="TATA_box" prim_transcript 615..3381 /note="put. primary transcript" exon 615..981 /number=1 misc_difference 768 /replace="c" /note="conflict" /citation=[3] CDS join(796..981,1589..1634,1822..1869,2171..2592) /product="TNF-alpha" /db_xref="GOA:P01375" /db_xref="HGNC:HGNC:11892" /db_xref="InterPro:IPR002959" /db_xref="InterPro:IPR006052" /db_xref="InterPro:IPR006053" /db_xref="InterPro:IPR008983" /db_xref="InterPro:IPR021184" /db_xref="PDB:1A8M" /db_xref="PDB:1TNF" /db_xref="PDB:2AZ5" /db_xref="PDB:2E7A" /db_xref="PDB:2TUN" /db_xref="PDB:2ZJC" /db_xref="PDB:2ZPX" /db_xref="PDB:3ALQ" /db_xref="PDB:3IT8" /db_xref="PDB:3L9J" /db_xref="PDB:3WD5" /db_xref="PDB:4G3Y" /db_xref="PDB:4TSV" /db_xref="PDB:4TWT" /db_xref="PDB:4Y6O" /db_xref="PDB:5M2I" /db_xref="PDB:5M2J" /db_xref="PDB:5M2M" /db_xref="PDB:5MU8" /db_xref="PDB:5TSW" /db_xref="PDB:5UUI" /db_xref="PDB:5WUX" /db_xref="PDB:5YOY" /db_xref="UniProtKB/Swiss-Prot:P01375" /protein_id="CAA26669.1" /translation="MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGA TTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQL QWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIA VSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYL DFAESGQVYFGIIAL" sig_peptide join(796..981,1589..1630) /note="put. signal peptide (aa -76 to -1; aa -78 to -3 in ref.[2])" intron 982..1588 /number=1 misc_difference 1092 /replace="" /note="conflict" /citation=[2] /citation=[3] exon 1589..1634 /number=2 mat_peptide join(1631..1634,1822..1869,2171..2589) /product="TNF-alpha" intron 1635..1821 /number=2 exon 1822..1869 /number=3 misc_feature 1822..1823 /note="put. signal peptide (aa -1, ref. [2])" misc_feature 1824..1869 /note="TNF-alpha (aa 1-15, ref. 2)" intron 1870..2170 /number=3 exon 2171..3381 /number=4 misc_feature 2171..2589 /note="TNF-alpha (aa 18-157; aa 16-155 in ref. [2])" misc_difference 2791 /replace="t" /note="conflict" /citation=[3] misc_difference 2882 /replace="a" /note="conflict" /citation=[2] misc_difference 3326 /replace="a" /note="conflict" /citation=[2] regulatory 3368..3373 /regulatory_class="polyA_signal_sequence" polyA_site 3381 BASE COUNT 906 a 959 c 975 g 794 t ORIGIN 1 gaattccggg tgatttcact cccggctgtc caggcttgtc ctgctacccc acccagcctt 61 tcctgaggcc tcaagcctgc caccaagccc ccagctcctt ctccccgcag gacccaaaca 121 caggcctcag gactcaacac agcttttccc tccaacccgt tttctctccc tcaacggact 181 cagctttctg aagcccctcc cagttctagt tctatctttt tcctgcatcc tgtctggaag 241 ttagaaggaa acagaccaca gacctggtcc ccaaaagaaa tggaggcaat aggttttgag 301 gggcatgggg acggggttca gcctccaggg tcctacacac aaatcagtca gtggcccaga 361 agacccccct cggaatcgga gcagggagga tggggagtgt gaggggtatc cttgatgctt 421 gtgtgtcccc aactttccaa atccccgccc ccgcgatgga gaagaaaccg agacagaagg 481 tgcagggccc actaccgctt cctccagatg agctcatggg tttctccacc aaggaagttt 541 tccgctggtt gaatgattct ttccccgccc tcctctcgcc ccagggacat ataaaggcag 601 ttgttggcac acccagccag cagacgctcc ctcagcaagg acagcagagg accagctaag 661 agggagagaa gcaactacag accccccctg aaaacaaccc tcagacgcca catcccctga 721 caagctgcca ggcaggttct cttcctctca catactgacc cacggcttca ccctctctcc 781 cctggaaagg acaccatgag cactgaaagc atgatccggg acgtggagct ggccgaggag 841 gcgctcccca agaagacagg ggggccccag ggctccaggc ggtgcttgtt cctcagcctc 901 ttctccttcc tgatcgtggc aggcgccacc acgctcttct gcctgctgca ctttggagtg 961 atcggccccc agagggaaga ggtgagtgcc tggccagcct tcatccactc tcccacccaa 1021 ggggaaatga gagacgcaag agagggagag agatgggatg ggtgaaagat gtgcgctgat 1081 agggagggat gagagagaaa aaaacatgga gaaagacggg gatgcagaaa gagatgtggc 1141 aagagatggg gaagagagag agagaaagat ggagagacag gatgtctggc acatggaagg 1201 tgctcactaa gtgtgtatgg agtgaatgaa tgaatgaatg aatgaacaag cagatatata 1261 aataagatat ggagacagat gtggggtgtg agaagagaga tgggggaaga aacaagtgat 1321 atgaataaag atggtgagac agaaagagcg ggaaatatga cagctaagga gagagatggg 1381 ggagataagg agagaagaag atagggtgtc tggcacacag aagacactca gggaaagagc 1441 tgttgaatgc tggaaggtga atacacagat gaatggagag agaaaaccag acacctcagg 1501 gctaagagcg caggccagac aggcagccag ctgttcctcc tttaagggtg actccctcga 1561 tgttaaccat tctccttctc cccaacagtt ccccagggac ctctctctaa tcagccctct 1621 ggcccaggca gtcagtaagt gtctccaaac ctctttccta attctgggtt tgggtttggg 1681 ggtagggtta gtaccggtat ggaagcagtg ggggaaattt aaagttttgg tcttggggga 1741 ggatggatgg aggtgaaagt aggggggtat tttctaggaa gtttaagggt ctcagctttt 1801 tcttttctct ctcctcttca ggatcatctt ctcgaacccc gagtgacaag cctgtagccc 1861 atgttgtagg taagagctct gaggatgtgt cttggaactt ggagggctag gatttgggga 1921 ttgaagcccg gctgatggta ggcagaactt ggagacaatg tgagaaggac tcgctgagct 1981 caagggaagg gtggaggaac agcacaggcc ttagtgggat actcagaacg tcatggccag 2041 gtgggatgtg ggatgacaga cagagaggac aggaaccgga tgtggggtgg gcagagctcg 2101 agggccagga tgtggagagt gaaccgacat ggccacactg actctcctct ccctctctcc 2161 ctccctccag caaaccctca agctgagggg cagctccagt ggctgaaccg ccgggccaat 2221 gccctcctgg ccaatggcgt ggagctgaga gataaccagc tggtggtgcc atcagagggc 2281 ctgtacctca tctactccca ggtcctcttc aagggccaag gctgcccctc cacccatgtg 2341 ctcctcaccc acaccatcag ccgcatcgcc gtctcctacc agaccaaggt caacctcctc 2401 tctgccatca agagcccctg ccagagggag accccagagg gggctgaggc caagccctgg 2461 tatgagccca tctatctggg aggggtcttc cagctggaga agggtgaccg actcagcgct 2521 gagatcaatc ggcccgacta tctcgacttt gccgagtctg ggcaggtcta ctttgggatc 2581 attgccctgt gaggaggacg aacatccaac cttcccaaac gcctcccctg ccccaatccc 2641 tttattaccc cctccttcag acaccctcaa cctcttctgg ctcaaaaaga gaattggggg 2701 cttagggtcg gaacccaagc ttagaacttt aagcaacaag accaccactt cgaaacctgg 2761 gattcaggaa tgtgtggcct gcacagtgaa gtgctggcaa ccactaagaa ttcaaactgg 2821 ggcctccaga actcactggg gcctacagct ttgatccctg acatctggaa tctggagacc 2881 agggagcctt tggttctggc cagaatgctg caggacttga gaagacctca cctagaaatt 2941 gacacaagtg gaccttaggc cttcctctct ccagatgttt ccagacttcc ttgagacacg 3001 gagcccagcc ctccccatgg agccagctcc ctctatttat gtttgcactt gtgattattt 3061 attatttatt tattatttat ttatttacag atgaatgtat ttatttggga gaccggggta 3121 tcctggggga cccaatgtag gagctgcctt ggctcagaca tgttttccgt gaaaacggag 3181 ctgaacaata ggctgttccc atgtagcccc ctggcctctg tgccttcttt tgattatgtt 3241 ttttaaaata tttatctgat taagttgtct aaacaatgct gatttggtga ccaactgtca 3301 ctcattgctg agcctctgct ccccagggga gttgtgtctg taatcgccct actattcagt 3361 ggcgagaaat aaagtttgct tagaaaagaa acatggtctc cttcttggaa ttaattctgc 3421 atctgcctct tcttgtgggt gggaagaagc tccctaagtc ctctctccac aggctttaag 3481 atccctcgga cccagtccca tccttagact cctagggccc tggagaccct acataaacaa 3541 agcccaacag aatattcccc atcccccagg aaacaagagc ctgaacctaa ttacctctcc 3601 ctcagggcat gggaatttcc aactctggga attc //