LOCUS       HPU89349                5210 bp    DNA     linear   VRL 02-DEC-1999
DEFINITION  Human papillomavirus type 18 variant, partial sequence.
ACCESSION   U89349
VERSION     U89349.1
KEYWORDS    .
SOURCE      Human papillomavirus type 18
  ORGANISM  Human papillomavirus type 18
            Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
            Alphapapillomavirus.
REFERENCE   1  (bases 2216 to 2355; 2538 to 3127)
  AUTHORS   Schneider-Gadicke,A. and Schwarz,E.
  TITLE     Different human cervical carcinoma cell lines show similar
            transcription patterns of human papillomavirus type 18 early genes
  JOURNAL   EMBO J. 5 (9), 2285-2292 (1986)
   PUBMED   3023067
REFERENCE   2  (bases 1 to 5210)
  AUTHORS   Cole,S.T. and Danos,O.
  TITLE     Nucleotide sequence and comparative analysis of the human
            papillomavirus type 18 genome. Phylogeny of papillomaviruses and
            repeated structure of the E6 and E7 gene products
  JOURNAL   J. Mol. Biol. 193 (4), 599-608 (1987)
   PUBMED   3039146
REFERENCE   3  (bases 2146 to 4619)
  AUTHORS   Inagaki,Y., Tsunokawa,Y., Takebe,N., Nawa,H., Nakanishi,S.,
            Terada,M. and Sugimura,T.
  TITLE     Nucleotide sequences of cDNAs for human papillomavirus type 18
            transcripts in HeLa cells
  JOURNAL   J. Virol. 62 (5), 1640-1646 (1988)
   PUBMED   2833614
REFERENCE   4  (bases 1750 to 2070)
  AUTHORS   Ong,C.K., Chan,S.Y., Campo,M.S., Fujinaga,K., Mavromara-Nazos,P.,
            Labropoulou,V., Pfister,H., Tay,S.K., ter Meulen,J., Villa,L.L. and
            Bernard,H.-U.
  TITLE     Evolution of human papillomavirus type 18: an ancient phylogenetic
            root in Africa and intratype diversity reflect coevolution with
            human ethnic groups
  JOURNAL   J. Virol. 67 (11), 6424-6431 (1993)
   PUBMED   8411344
REFERENCE   5  (bases 1 to 5210)
  AUTHORS   Meissner,J.D.
  TITLE     Nucleotide sequences and further characterization of human
            papillomavirus DNA present in the CaSki, SiHa and HeLa cervical
            carcinoma cell lines
  JOURNAL   J. Gen. Virol. 80 (Pt 7), 1725-1733 (1999)
   PUBMED   10423141
REFERENCE   6  (bases 1 to 5210)
  AUTHORS   Meissner,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-FEB-1997) VEHB, Centers for Disease Control and
            Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
FEATURES             Location/Qualifiers
     source          1..5210
                     /organism="Human papillomavirus type 18"
                     /mol_type="genomic DNA"
                     /strain="type 18 variant"
                     /db_xref="taxon:333761"
                     /lab_host="HeLa cervical carcinoma cell line (ATCC CCL2)"
     variation       140
                     /replace="c"
     variation       666
                     /replace="a"
     misc_difference 725
                     /note="conflict; see reference HPV-18 sequence in GenBank
                     Accession Number X05015"
                     /citation=[2]
                     /replace="c"
     misc_difference 890
                     /note="conflict; see reference HPV-18 sequence in GenBank
                     Accession Number X05015"
                     /citation=[2]
                     /replace="c"
     misc_difference 1107
                     /note="conflict; see reference HPV-18 sequence in GenBank
                     Accession Number X05015"
                     /citation=[2]
                     /replace="c"
     variation       1523
                     /replace="t"
     variation       1751
                     /replace="c"
     variation       1794
                     /replace="c"
     variation       1832
                     /replace="a"
     variation       1857
                     /replace="t"
     variation       1935
                     /replace="a"
     variation       2226
                     /replace="t"
     misc_difference 2291
                     /note="conflict; see HPV-18 sequence in GenBank Accession
                     Number M26798"
                     /citation=[1]
                     /replace="g"
     misc_difference 2409
                     /note="conflict; see reference HPV-18 sequence in GenBank
                     Accession Number X05015"
                     /citation=[2]
                     /replace="c"
     variation       2607
                     /replace="t"
     variation       2671
                     /replace="c"
     variation       2873
                     /replace="c"
     variation       2928
                     /replace="g"
     variation       3134
                     /replace="a"
     variation       3316
                     /replace="c"
     variation       3475
                     /replace="t"
     variation       3929
                     /replace="t"
     variation       3965
                     /replace="t"
     variation       4391
                     /replace="c"
BASE COUNT         1655 a          921 c         1125 g         1509 t
ORIGIN      
        1 ttattaactg ttggtaatcc atattttagg gttcctgcag gtggtggcaa taagcaggat
       61 attcctaagg tttctgcata ccaatataga gtatttaggg tgcagttacc tgacccaaat
      121 aaatttggtt tacctgataa tagtatttat aatcctgaaa cacaacgttt agtgtgggcc
      181 tgtgctggag tggaaattgg ccgtggtcag cctttaggtg ttggccttag tgggcatcca
      241 ttttataata aattagatga cactgaaagt tcccatgccg ccacgtctaa tgtttctgag
      301 gacgttaggg acaatgtgtc tgtagattat aagcagacac agttatgtat tttgggctgt
      361 gcccctgcta ttggggaaca ctgggctaaa ggcactgctt gtaaatcgcg tcctttatca
      421 cagggcgatt gccccccttt agaacttaaa aacacagttt tggaagatgg tgatatggta
      481 gatactggat atggtgccat ggactttagt acattgcaag atactaaatg tgaggtacca
      541 ttggatattt gtcagtctat ttgtaaatat cctgattatt tacaaatgtc tgcagatcct
      601 tatggggatt ccatgttttt ttgcttacgg cgtgagcagc tttttgctag gcatttttgg
      661 aatagggcag gtactatggg tgacactgtg cctcaatcct tatatattaa aggcacaggt
      721 atgcgtgctt cacctggcag ctgtgtgtat tctccctctc caagtggctc tattgttacc
      781 tctgactccc agttgtttaa taaaccatat tggttacata aggcacaggg tcataacaat
      841 ggtgtttgct ggcataatca attatttgtt actgtggtag ataccactcg cagtaccaat
      901 ttaacaatat gtgcttctac acagtctcct gtacctgggc aatatgatgc taccaaattt
      961 aagcagtata gcagacatgt tgaggaatat gatttgcagt ttatttttca gttgtgtact
     1021 attactttaa ctgcagatgt tatgtcctat attcatagta tgaatagcag tattttagag
     1081 gattggaact ttggtgttcc ccccccgcca actactagtt tggtggatac atatcgtttt
     1141 gtacaatctg ttgctattac ctgtcaaaag gatgctgcac cggctgaaaa taaggatccc
     1201 tatgataagt taaagttttg gaatgtggat ttaaaggaaa agttttcttt agacttagat
     1261 caatatcccc ttggacgtaa atttttggtt caggctggat tgcgtcgcaa gcccaccata
     1321 ggccctcgca aacgttctgc tccatctgcc actacgtctt ctaaacctgc caagcgtgtg
     1381 cgtgtacgtg ccaggaagta atatgtgtgt gtgtatatat atatacatct attgttgtgt
     1441 ttgtatgtcc tgtgtttgtg tttgttgtat gattgcattg tatggtatgt atggttgttg
     1501 ttgtatgttg tatgttacta taattgttgg tatgtggcat taaataaaat atgttttgtg
     1561 gttctgtgtg ttatgtggtt gcgccctagt gagtaacaac tgtatttgtg tttgtggtat
     1621 gggtgttgct tgttgggcta tatattgtcc tgtatttcaa gttataaaac tgcacacctt
     1681 acagcatcca ttttatccta caatcctcca ttttgctgtg caaccgattt cggttgcctt
     1741 tggcttatgt ttgtggtttt ctgcacaata cagtacgctg gcactattgc aaaatttaat
     1801 cttttgggca ctgctcctac atattttgaa ccattggcgc gcctctttgg cgcatacaag
     1861 gcgcacctgg tattagtcat tttcctgtcc aggtgcgcta caacaattgc ttgcataact
     1921 atatccactc cctatgtaat aaaactgctt ttaggcacat attttagttt gtttttactt
     1981 aagctaattg catacttggc ttgtacaact actttcatgt ccaacattct gtctaccctt
     2041 aacatgaact ataatatgac taagctgtgc atacatagtt tatgcaaccg aaataggttg
     2101 ggcagcacat actatacttt tcattaatac ttttaacaat tgtagtatat aaaaaaggga
     2161 gtaaccgaaa acggtcggga ccgaaaacgg tgtatataaa agatgtgaga aacacaccac
     2221 aataccatgg cgcgctttga ggatccaaca cggcgaccct acaagctacc tgatctgtgc
     2281 acggaactga acacttcact gcaagacata gaaataacct gtgtatattg caagacagta
     2341 ttggaactta cagaggtatt tgaatttgca tttaaagatt tatttgtggt gtatagagac
     2401 agtataccgc atgctgcatg ccataaatgt atagattttt attctagaat tagagaatta
     2461 agacattatt cagactctgt gtatggagac acattggaaa aactaactaa cactgggtta
     2521 tacaatttat taataaggtg cctgcggtgc cagaaaccgt tgaatccagc agaaaaactt
     2581 agacacctta atgaaaaacg acgattccac aacatagctg ggcactatag aggccagtgc
     2641 cattcgtgct gcaaccgagc acgacaggaa agactccaac gacgcagaga aacacaagta
     2701 taatattaag tatgcatgga cctaaggcaa cattgcaaga cattgtattg catttagagc
     2761 cccaaaatga aattccggtt gaccttctat gtcacgagca attaagcgac tcagaggaag
     2821 aaaacgatga aatagatgga gttaatcatc aacatttacc agcccgacga gctgaaccac
     2881 aacgtcacac aatgttgtgt atgtgttgta agtgtgaagc cagaattaag ctagtagtag
     2941 aaagctcagc agacgacctt cgagcattcc agcagctgtt tctgaacacc ctgtcctttg
     3001 tgtgtccgtg gtgtgcatcc cagcagtaag caacaatggc tgatccagaa ggtacagacg
     3061 gggagggcac gggttgtaac ggctggtttt atgtacaagc tattgtagac aaaaaaacag
     3121 gagatgtaat atctgatgac gaggacgaaa atgcaacaga cacagggtcg gatatggtag
     3181 attttattga tacacaagga acattttgtg aacaggcaga gctagagaca gcacaggcat
     3241 tgttccatgc gcaggaggtc cacaatgatg cacaagtgtt gcatgtttta aaacgaaagt
     3301 ttgcaggagg cagcaaagaa aacagtccat taggggagcg gctggaggtg gatacagagt
     3361 taagtccacg gttacaagaa atatctttaa atagtgggca gaaaaaggca aaaaggcggc
     3421 tgtttacaat atcagatagt ggctatggct gttctgaagt ggaagcaaca cagaatcagg
     3481 taactacaaa tggcgaacat ggcggcaatg tatgtagtgg cggcagtacg gaggctatag
     3541 acaacggggg cacagagggc aacaacagca gtgtagacgg tacaagtgac aatagcaata
     3601 tagaaaatgt aaatccacaa tgtaccatag cacaattaaa agacttgtta aaagtaaaca
     3661 ataaacaagg agctatgtta gcagtattta aagacacata tgggctatca tttacagatt
     3721 tagttagaaa ttttaaaagt gataaaacca cgtgtacaga ttgggttaca gctatatttg
     3781 gagtaaaccc aacaatagca gaaggattta aaacactaat acagccattt atattatatg
     3841 cccatattca atgtctagac tgtaaatggg gagtattaat attagccctg ttgcgttaca
     3901 aatgtggtaa gagtagacta acagttgcca aaggtttaag tacgttgtta cacgtacctg
     3961 aaacgtgtat gttaattcaa ccaccaaaat tgcgaagtag tgttgcagca ctatattggt
     4021 atagaacagg aatatcaaat attagtgaag taatgggaga cacacctgag tggatacaaa
     4081 gacttactat tatacaacat ggaatagatg atagcaattt tgatttgtca gaaatggtac
     4141 aatgggcatt tgataatgag ctgacagatg aaagcgatat ggcatttgaa tatgccttat
     4201 tagcagacag caacagcaat gcagctgcct ttttaaaaag caattgccaa gctaaatatt
     4261 taaaagattg tgccacaatg tgcaaacatt ataggcgagc ccaaaaacga caaatgaata
     4321 tgtcacagtg gatacgattt agatgttcaa aaatagatga agggggagat tggagaccaa
     4381 tagtgcaatt tctgcgatac caacaaatag agtttataac atttttagga gccttaaaat
     4441 catttttaaa aggaaccccc aaaaaaaatt gtttagtatt ttgtggacca gcaaatacag
     4501 gaaaatcata ttttggaatg agttttatac actttataca aggagcagta atatcatttg
     4561 tgaattccac tagtcatttt tggttggaac cgttaacaga tactaaggtg gccatgttag
     4621 atgatgcaac gaccacgtgt tggacatact ttgataccta tatgagaaat gcgttagatg
     4681 gcaatccaat aagtattgat agaaagcaca aaccattaat acaactaaaa tgtcctccaa
     4741 tactactaac cacaaatata catccagcaa aggataatag atggccatat ttagaaagta
     4801 gaataacagt atttgaattt ccaaatgcat ttccatttga taaaaatggc aatccagtat
     4861 atgaaataaa tgacaaaaat tggaaatgtt tttttgaaag gacatggtcc agattagatt
     4921 tgcacgagga agaggaagat gcagacaccg aaggaaaccc tttcggaacg tttaagtgcg
     4981 ttgcaggaca aaatcataga ccactatgaa aatgacagta aagacataga cagccaaata
     5041 cagtattggc aactaatacg ttgggaaaat gcaatattct ttgcagcaag ggaacatggc
     5101 atacagacat taaaccacca ggtggtgcca gcctataaca tttcaaaaag taaagcacat
     5161 aaagctattg aactgcaaat ggccctacaa ggccttgcac aaagtgcata
//