LOCUS HSU88880 3811 bp mRNA linear HUM 03-SEP-1998 DEFINITION Homo sapiens Toll-like receptor 4 (TLR4) mRNA, complete cds. ACCESSION U88880 VERSION U88880.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3811) AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F. TITLE A family of human receptors structurally related to Drosophila Toll JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998) PUBMED 9435236 REFERENCE 2 (bases 1 to 3811) AUTHORS Rock,F.L., Hardiman,G., Timans,J.C., Kastelein,R.A. and Bazan,J.F. TITLE Direct Submission JOURNAL Submitted (07-FEB-1997) Molecular Biology, DNAX Research Institute, 901 California Ave, Palo Alto, CA 94304, USA FEATURES Location/Qualifiers source 1..3811 /db_xref="H-InvDB:HIT000222104" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q32-33" /note="cloned using I.M.A.G.E. EST clone #202057 as a probe" gene 1..3811 /gene="TLR4" CDS 285..2684 /gene="TLR4" /function="signaling receptor" /note="type 1 transmembrane receptor; contains an extracellular domain largely composed of leucine-rich repeats and an intracellular segment similar to the signaling domains of interleukin-1-type receptors, the intracellular molecule Myd88 and several plant disease resistance gene products" /codon_start=1 /product="Toll-like receptor 4" /protein_id="AAC34135.1" /translation="MELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLD LSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLE NFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQ MPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRL VLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLV SVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPS LEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHS NLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPD IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQV LDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER MECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGC IKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANI IHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATS I" BASE COUNT 1070 a 820 c 784 g 1137 t ORIGIN 1 acagggccac tgctgctcac agaagcagtg aggatgatgc caggatgatg tctgcctcgc 61 gcctggctgg gactctgatc ccagccatgg ccttcctctc ctgcgtgaga ccagaaagct 121 gggagccctg cgtggagact tggccctaaa ccacacagaa gagctggcat gaaacccaga 181 gctttcagac tccggagcct cagcccttca ccccgattcc attgcttctt gctaaatgct 241 gccgttttat cacggaggtg gttcctaata ttacttatca atgcatggag ctgaatttct 301 acaaaatccc cgacaacctc cccttctcaa ccaagaacct ggacctgagc tttaatcccc 361 tgaggcattt aggcagctat agcttcttca gtttcccaga actgcaggtg ctggatttat 421 ccaggtgtga aatccagaca attgaagatg gggcatatca gagcctaagc cacctctcta 481 ccttaatatt gacaggaaac cccatccaga gtttagccct gggagccttt tctggactat 541 caagtttaca gaagctggtg gctgtggaga caaatctagc atctctagag aacttcccca 601 ttggacatct caaaactttg aaagaactta atgtggctca caatcttatc caatctttca 661 aattacctga gtatttttct aatctgacca atctagagca cttggacctt tccagcaaca 721 agattcaaag tatttattgc acagacttgc gggttctaca tcaaatgccc ctactcaatc 781 tctctttaga cctgtccctg aaccctatga actttatcca accaggtgca tttaaagaaa 841 ttaggcttca taagctgact ttaagaaata attttgatag tttaaatgta atgaaaactt 901 gtattcaagg tctggctggt ttagaagtcc atcgtttggt tctgggagaa tttagaaatg 961 aaggaaactt ggaaaagttt gacaaatctg ctctagaggg cctgtgcaat ttgaccattg 1021 aagaattccg attagcatac ttagactact acctcgatga tattattgac ttatttaatt 1081 gtttgacaaa tgtttcttca ttttccctgg tgagtgtgac tattgaaagg gtaaaagact 1141 tttcttataa tttcggatgg caacatttag aattagttaa ctgtaaattt ggacagtttc 1201 ccacattgaa actcaaatct ctcaaaaggc ttactttcac ttccaacaaa ggtgggaatg 1261 ctttttcaga agttgatcta ccaagccttg agtttctaga tctcagtaga aatggcttga 1321 gtttcaaagg ttgctgttct caaagtgatt ttgggacaac cagcctaaag tatttagatc 1381 tgagcttcaa tggtgttatt accatgagtt caaacttctt gggcttagaa caactagaac 1441 atctggattt ccagcattcc aatttgaaac aaatgagtga gttttcagta ttcctatcac 1501 tcagaaacct catttacctt gacatttctc atactcacac cagagttgct ttcaatggca 1561 tcttcaatgg cttgtccagt ctcgaagtct tgaaaatggc tggcaattct ttccaggaaa 1621 acttccttcc agatatcttc acagagctga gaaacttgac cttcctggac ctctctcagt 1681 gtcaactgga gcagttgtct ccaacagcat ttaactcact ctccagtctt caggtactaa 1741 atatgagcca caacaacttc ttttcattgg atacgtttcc ttataagtgt ctgaactccc 1801 tccaggttct tgattacagt ctcaatcaca taatgacttc caaaaaacag gaactacagc 1861 attttccaag tagtctagct ttcttaaatc ttactcagaa tgactttgct tgtacttgtg 1921 aacaccagag tttcctgcaa tggatcaagg accagaggca gctcttggtg gaagttgaac 1981 gaatggaatg tgcaacacct tcagataagc agggcatgcc tgtgctgagt ttgaatatca 2041 cctgtcagat gaataagacc atcattggtg tgtcggtcct cagtgtgctt gtagtatctg 2101 ttgtagcagt tctggtctat aagttctatt ttcacctgat gcttcttgct ggctgcataa 2161 agtatggtag aggtgaaaac atctatgatg cctttgttat ctactcaagc caggatgagg 2221 actgggtaag gaatgagcta gtaaagaatt tagaagaagg ggtgcctcca tttcagctct 2281 gccttcacta cagagacttt attcccggtg tggccattgc tgccaacatc atccatgaag 2341 gtttccataa aagccgaaag gtgattgttg tggtgtccca gcacttcatc cagagccgct 2401 ggtgtatctt tgaatatgag attgctcaga cctggcagtt tctgagcagt cgtgctggta 2461 tcatcttcat tgtcctgcag aaggtggaga agaccctgct caggcagcag gtggagctgt 2521 accgccttct cagcaggaac acttacctgg agtgggagga cagtgtcctg gggcggcaca 2581 tcttctggag acgactcaga aaagccctgc tggatggtaa atcatggaat ccagaaggaa 2641 cagtgggtac aggatgcaat tggcaggaag caacatctat ctgaagagga aaaataaaaa 2701 cctcctgagg catttcttgc ccagctgggt ccaacacttg ttcagttaat aagtattaaa 2761 tgctgccaca tgtcaggcct tatgctaagg gtgagtaatt ccatggtgca ctagatatgc 2821 agggctgcta atctcaagga gcttccagtg cagagggaat aaatgctaga ctaaaataca 2881 gagtcttcca ggtgggcatt tcaaccaact cagtcaagga acccatgaca aagaaagtca 2941 tttcaactct tacctcatca agttgaataa agacagagaa aacagaaaga gacattgttc 3001 ttttcctgag tcttttgaat ggaaattgta ttatgttata gccatcataa aaccattttg 3061 gtagttttga ctgaactggg tgttcacttt ttcctttttg attgaataca atttaaattc 3121 tacttgatga ctgcagtcgt caaggggctc ctgatgcaag atgccccttc cattttaagt 3181 ctgtctcctt acagaggtta aagtctaatg gctaattcct aaggaaacct gattaacaca 3241 tgctcacaac catcctggtc attctcgaac atgttctatt ttttaactaa tcacccctga 3301 tatattttta tttttatata tccagttttc atttttttac gtcttgccta taagctaata 3361 tcataaataa ggttgtttaa gacgtgcttc aaatatccat attaaccact atttttcaag 3421 gaagtatgga aaagtacact ctgtcacttt gtcactcgat gtcattccaa agttattgcc 3481 tactaagtaa tgactgtcat gaaagcagca ttgaaataat ttgtttaaag ggggcactct 3541 tttaaacggg aagaaaattt ccgcttcctg gtcttatcat ggacaatttg ggctataggc 3601 atgaaggaag tgggattacc tcaggaagtc accttttctt gattccagaa acatatgggc 3661 tgataaaccc ggggtgacct catgaaatga gttgcagcag atgtttattt ttttcagaac 3721 aagtgatgtt tgatggacct atgaatctat ttagggagac acagatggct gggatccctc 3781 ccctgtaccc ttctcactga caggagaact a //