LOCUS       HSU76833                2366 bp    mRNA    linear   HUM 14-AUG-1997
DEFINITION  Human integral membrane serine protease Seprase mRNA, complete cds.
ACCESSION   U76833
VERSION     U76833.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M.,
            Yeh,Y., Flessate,D. and Chen,W.T.
  TITLE     Molecular cloning of seprase: a serine integral membrane protease
            from human melanoma
  JOURNAL   Biochim. Biophys. Acta 1361 (1), 11-19 (1997)
   PUBMED   9247085
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Goldstein,L.A., Ghersi,G., Pineiro-Sanchez,M.L., Salamone,M.,
            Yeh,Y., Flessate,D. and Chen,W.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-OCT-1996) Cell Biology, Georgetown University Medical
            School, 3970 Reservoir Road N.W., Washington, DC 20007, USA
FEATURES             Location/Qualifiers
     source          1..2366
                     /db_xref="H-InvDB:HIT000221322"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="amelanotic melanoma; LOX"
     CDS             49..2331
                     /note="170 kDa homodimeric gelatinase; member of the
                     nonclassical serine hydrolase family; synthesized by
                     RT-PCR using Fibroblast Activation Protein alpha (FAP
                     alpha) primers"
                     /codon_start=1
                     /product="integral membrane serine protease Seprase"
                     /protein_id="AAC51668.1"
                     /translation="MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTL
                     KDILNGTFSYKTFFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASN
                     YGLSPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGS
                     KLAYVYQNNIYLKQRPGDPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNG
                     KFLAYAEFNDTDIPVIAYSYYGDEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVG
                     PQEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCPK
                     TQEHIEESRTGWAGGFFVSTPVFSYDAISYYKIFSDKDGYKHIHYIKDTVENAIQITS
                     GKWEAINIFRVTQDSLFYSSNEFEEYPGRRNIYRISIGSYPPSKKCVTCHLRKERCQY
                     YTASFSDYAKYYALVCYGPGIPISTLHDGRTDQEIKILEENKELENALKNIQLPKEEI
                     KKLEVDEITLWYKMILPPQFDRSKKYPLLIQVYGGPCSQSVRSVFAVNWISYLASKEG
                     MVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWS
                     YGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVYTERFMGLPTKDDNLEHYKNSTV
                     MARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLS
                     TNHLYTHMTHFLKQCFSLSD"
BASE COUNT          761 a          448 c          489 g          668 t
ORIGIN      
        1 ccacgctctg aagacagaat tagctaactt tcaaaaacat ctggaaaaat gaagacttgg
       61 gtaaaaatcg tatttggagt tgccacctct gctgtgcttg ccttattggt gatgtgcatt
      121 gtcttacgcc cttcaagagt tcataactct gaagaaaata caatgagagc actcacactg
      181 aaggatattt taaatggaac attttcttat aaaacatttt ttccaaactg gatttcagga
      241 caagaatatc ttcatcaatc tgcagataac aatatagtac tttataatat tgaaacaggg
      301 caatcatata ccattttgag taatagaacc atgaaaagtg tgaatgcttc aaattacggc
      361 ttatcacctg atcggcaatt tgtatatcta gaaagtgatt attcaaagct ttggagatac
      421 tcttacacag caacatatta catctatgac cttagcaatg gagaatttgt aagaggaaat
      481 gagcttcctc gtccaattca gtatttatgc tggtcgcctg ttgggagtaa attagcatat
      541 gtctatcaaa acaatatcta tttgaaacaa agaccaggag atccaccttt tcaaataaca
      601 tttaatggaa gagaaaataa aatatttaat ggaatcccag actgggttta tgaagaggaa
      661 atgcttgcta caaaatatgc tctctggtgg tctcctaatg gaaaattttt ggcatatgcg
      721 gaatttaatg atacggatat accagttatt gcctattcct attatggcga tgaacaatat
      781 cctagaacaa taaatattcc atacccaaag gctggagcta agaatcccgt tgttcggata
      841 tttattatcg ataccactta ccctgcgtat gtaggtcccc aggaagtgcc tgttccagca
      901 atgatagcct caagtgatta ttatttcagt tggctcacgt gggttactga tgaacgagta
      961 tgtttgcagt ggctaaaaag agtccagaat gtttcggtcc tgtctatatg tgacttcagg
     1021 gaagactggc agacatggga ttgtccaaag acccaggagc atatagaaga aagcagaact
     1081 ggatgggctg gtggattctt tgtttcaaca ccagttttca gctatgatgc catttcgtac
     1141 tacaaaatat ttagtgacaa ggatggctac aaacatattc actatatcaa agacactgtg
     1201 gaaaatgcta ttcaaattac aagtggcaag tgggaggcca taaatatatt cagagtaaca
     1261 caggattcac tgttttattc tagcaatgaa tttgaagaat accctggaag aagaaacatc
     1321 tacagaatta gcattggaag ctatcctcca agcaagaagt gtgttacttg ccatctaagg
     1381 aaagaaaggt gccaatatta cacagcaagt ttcagcgact acgccaagta ctatgcactt
     1441 gtctgctacg gcccaggcat ccccatttcc acccttcatg atggacgcac tgatcaagaa
     1501 attaaaatcc tggaagaaaa caaggaattg gaaaatgctt tgaaaaatat ccagctgcct
     1561 aaagaggaaa ttaagaaact tgaagtagat gaaattactt tatggtacaa gatgattctt
     1621 cctcctcaat ttgacagatc aaagaagtat cccttgctaa ttcaagtgta tggtggtccc
     1681 tgcagtcaga gtgtaaggtc tgtatttgct gttaattgga tatcttatct tgcaagtaag
     1741 gaagggatgg tcattgcctt ggtggatggt cgaggaacag ctttccaagg tgacaaactc
     1801 ctctatgcag tgtatcgaaa gctgggtgtt tatgaagttg aagaccagat tacagctgtc
     1861 agaaaattca tagaaatggg tttcattgat gaaaaaagaa tagccatatg gggctggtcc
     1921 tatggaggat acgtttcatc actggccctt gcatctggaa ctggtctttt caaatgtggt
     1981 atagcagtgg ctccagtctc cagctgggaa tattacgcgt ctgtctacac agagagattc
     2041 atgggtctcc caacaaagga tgataatctt gagcactata agaattcaac tgtgatggca
     2101 agagcagaat atttcagaaa tgtagactat cttctcatcc acggaacagc agatgataat
     2161 gtgcactttc agaactcagc acagattgct aaagctctgg ttaatgcaca agtggatttc
     2221 caggcaatgt ggtactctga ccagaaccac ggcttatccg gcctgtccac gaaccactta
     2281 tacacccaca tgacccactt cctaaagcag tgtttctctt tgtcagacta aaaacgatgc
     2341 agatgcaagc ctgtatcaga atctga
//