LOCUS HSU68068 355 bp mRNA linear HUM 24-JUL-2016 DEFINITION Human estrogen receptor mRNA, alternatively spliced transcript H, partial cds. ACCESSION U68068 VERSION U68068.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 335) AUTHORS Greene,G.L., Gilna,P., Waterfield,M., Baker,A., Hort,Y. and Shine,J. TITLE Sequence and expression of human estrogen receptor complementary DNA JOURNAL Science 231 (4742), 1150-1154 (1986) PUBMED 3753802 REFERENCE 2 (bases 1 to 335) AUTHORS Green,S., Walter,P., Kumar,V., Krust,A., Bornert,J.M., Argos,P. and Chambon,P. TITLE Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A JOURNAL Nature 320 (6058), 134-139 (1986) PUBMED 3754034 REFERENCE 3 (bases 1 to 335) AUTHORS Keaveney,M., Klug,J., Dawson,M.T., Nestor,P.V., Neilan,J.G., Forde,R.C. and Gannon,F. TITLE Evidence for a previously unidentified upstream exon in the human oestrogen receptor gene JOURNAL J. Mol. Endocrinol. 6 (1), 111-115 (1991) PUBMED 2015052 REFERENCE 4 (bases 1 to 335) AUTHORS Piva,R., Gambari,R., Zorzato,F., Kumar,L. and del Senno,L. TITLE Analysis of upstream sequences of the human estrogen receptor gene JOURNAL Biochem. Biophys. Res. Commun. 183 (3), 996-1002 (1992) PUBMED 1567414 REFERENCE 5 (bases 1 to 335) AUTHORS Keaveney,M., Klug,J. and Gannon,F. TITLE Sequence analysis of the 5' flanking region of the human estrogen receptor gene JOURNAL DNA Seq. 2 (6), 347-358 (1992) PUBMED 1476547 REFERENCE 6 (bases 1 to 335) AUTHORS Piva,R., Bianchi,N., Aguiari,G.L., Gambari,R. and del Senno,L. TITLE Sequencing of an RNA transcript of the human estrogen receptor gene: evidence for a new transcriptional event JOURNAL J. Steroid Biochem. Mol. Biol. 46 (5), 531-538 (1993) PUBMED 8240974 REFERENCE 7 (bases 1 to 335) AUTHORS Grandien,K. TITLE Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissue-specific, estrogen receptor-mRNA isoform JOURNAL Mol. Cell. Endocrinol. 116 (2), 207-212 (1996) PUBMED 8647321 REFERENCE 8 (bases 1 to 355) AUTHORS Thompson,D.A., McPherson,L.A., Carmeci,C., deConinck,E.C. and Weigel,R.J. TITLE Identification of two estrogen receptor transcripts with novel 5' exons isolated from a MCF7 cDNA library JOURNAL J. Steroid Biochem. Mol. Biol. 62 (2-3), 143-153 (1997) PUBMED 9393949 REFERENCE 9 (bases 1 to 355) AUTHORS Thompson,D.A. TITLE Direct Submission JOURNAL Submitted (27-AUG-1996) Deparment of Surgery, Stanford University, MSLS Building, Room P228, 1201 Welch Rd., Stanford, CA 94305, USA FEATURES Location/Qualifiers source 1..355 /db_xref="H-InvDB:HIT000221038" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /cell_line="MCF7" /tissue_type="breast adenocarcinoma" CDS 287..>355 /note="splice junction between nt 85/86, novel upstream exon Ha splices to the novel exon Hb (which is approximately 9 kb downstream from Ha in the genomic sequence); splice junction between nt 216/217; novel upstream exon Hb splices to nt 163; transcript H" /codon_start=1 /product="estrogen receptor" /protein_id="AAC51875.1" /translation="MTMTLHTKASGMALLHQIQGNEL" BASE COUNT 97 a 100 c 80 g 78 t ORIGIN 1 aacaggctcg aaaggtccat gctcctttct cctgcccatt ctatagcata agaagacagt 61 ctctgagtga taatcttctc ttcaagaaga agaaaactag gaaggagtaa gcacaaagat 121 ctcttcacat tctccgggac tgcggtacca aatatcagca cagcacttct tgaaaaagga 181 tgtagatttt aatctgaact ttgaaccatc actgaggtgg cccgccggtt tctgagcctt 241 ctgccctgcg gggacacggt ctgcaccctg cccgcggcca cggaccatga ccatgaccct 301 ccacaccaaa gcatctggga tggccctact gcatcagatc caagggaacg agctg //