LOCUS HSU62961 3337 bp mRNA linear HUM 04-SEP-1996
DEFINITION Human succinyl CoA:3-oxoacid CoA transferase precursor (OXCT) mRNA,
complete cds.
ACCESSION U62961
VERSION U62961.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3337)
AUTHORS Kassovska-Bratinova,S.G., Fukao,T., Song,X., Duncan,A., Chen,H.,
Robert,M., Chartrand,C., Vobecky,S., Perez-Cerda,C., Ugarte,M.,
Kondo,N. and Mitchell,G.A.
TITLE Succinyl CoA:3-oxoacid CoA transferase (SCOT): human cDNA cloning,
human chromosomal mapping to 5p13, and mutation detection in a
SCOT-deficient patient
JOURNAL Am. J. Hum. Genet. 59 59, 519-528 (1996)
REFERENCE 2 (bases 1 to 3337)
AUTHORS Mitchell,G.A.
TITLE Direct Submission
JOURNAL Submitted (04-JUL-1996) Genetique Medicale, Hopital Ste Justine,
3175, Cote Ste Catherine, Montreal, Quebec H3T 1C5, Canada
FEATURES Location/Qualifiers
source 1..3337
/db_xref="H-InvDB:HIT000220746"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="proximal 5p13"
/clone="SCOT-B, SCOT-C, SCOT-D, SCOT-F, SCOT-G"
/tissue_type="heart"
gene 1..3337
/gene="OXCT"
5'UTR 1..98
/gene="OXCT"
CDS 99..1661
/gene="OXCT"
/EC_number="2.8.3.5"
/function="key enzyme of ketolysis catalyses the transfer
of CoA from succinyl-CoA to 3-oxoacids such as acetoacetic
acid"
/codon_start=1
/product="succinyl CoA:3-oxoacid CoA transferase
precursor"
/protein_id="AAB07366.1"
/translation="MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYT
DPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLL
LRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTG
YGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRA
GNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYE
KRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFIS
PNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGG
HVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAH
KIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAV
SPKLMPMQQIAN"
sig_peptide 99..215
/gene="OXCT"
mat_peptide 216..1658
/gene="OXCT"
/product="succinyl CoA:3-oxoacid CoA transferase"
/experiment="experimental evidence, no additional details
recorded"
misc_feature 1128..1130
/gene="OXCT"
/note="encodes Glu-344 within the enzyme's active site"
3'UTR 1662..3320
/gene="OXCT"
regulatory 3300..3305
/regulatory_class="polyA_signal_sequence"
/gene="OXCT"
polyA_site 3321
/gene="OXCT"
BASE COUNT 994 a 620 c 770 g 953 t
ORIGIN
1 gtcgagcctc tagcccgccc gggtttcctt cgcagtcgcg caccgacgct caaacgcgcg
61 ctccaacccg cagcctcctc ctgcctcacc gcccgaagat ggcggctctc aaactcctct
121 cctccgggct tcggctctgc gcctctgccc gcggatctgg ggcaacctgg tacaagggat
181 gtgtttgttc cttttccacc agtgctcatc gccataccaa gttttataca gatccagtag
241 aagctgtaaa agacatccct gatggtgcca cggttttggt tggtggtttt gggctatgtg
301 gaattccaga gaatcttata gatgctttac tgaaaactgg agtaaaagga ctaactgcag
361 tcagcaacaa tgcaggggtt gacaattttg gtttggggct tttgcttcgg tcgaagcaga
421 taaaacgcat ggtctcttca tatgtgggag aaaatgcaga atttgaacga cagtacttat
481 ctggtgaatt agaagtggag ctgacaccac agggcacact tgcagagagg atccgtgcag
541 gcggggctgg agttcctgca ttttacaccc caacagggta tgggaccctg gtacaagaag
601 gaggatcgcc catcaaatac aacaaagatg gcagtgttgc cattgccagt aagccaagag
661 aggtgaggga gttcaatggt cagcacttta ttttggagga agcaattaca ggggattttg
721 ctttggtgaa agcctggaag gcggaccgag caggaaacgt gattttcagg aaaagtgcaa
781 ggaatttcaa cttgccaatg tgcaaagctg cagaaaccac agtggtagag gttgaagaaa
841 ttgtggatat tggagcattt gctccagaag acatccatat tcctcagatt tatgtacatc
901 gccttataaa gggagaaaaa tatgagaaaa gaattgagcg tttatcaatc cggaaagagg
961 gagatgggga agccaaatct gctaaacctg gagatgacgt aagggaacga atcatcaaga
1021 gggccgctct tgagtttgag gatggcatgt atgctaattt gggcatagga atccctctcc
1081 tggccagcaa ttttatcagc ccaaatataa ctgttcatct tcaaagtgaa aatggagttc
1141 tgggtttggg tccatatcca cgacaacatg aagctgatgc agatctcatc aatgcaggca
1201 aggaaacagt tactattctt ccaggagcct cttttttctc cagcgatgaa tcatttgcaa
1261 tgattagagg tggacacgtc gatctgacaa tgctaggagc gatgcaggtt tccaaatatg
1321 gtgacctggc taactggatg atacctggga agatggtgaa aggaatggga ggtgctatgg
1381 atttagtgtc cagtgcgaaa accaaagtgg tggtcaccat ggagcattct gcaaagggaa
1441 atgcacataa aatcatggag aaatgtacat taccattgac tggaaagcaa tgtgtcaacc
1501 gcattattac tgaaaaggct gtgtttgatg tggacaagaa gaaagggttg actctgattg
1561 agctctggga aggcctgaca gtggatgacg tacaaaagag tactgggtgt gattttgcag
1621 tttcaccaaa actcatgcca atgcagcaga tcgcaaattg aaatatggat atttgtacca
1681 ggctgcgtgt ttttcatttt aaacacacaa gatttaattg aaaggacatc aataatcata
1741 attgtgtatt taacaggtgg ttttttatta gttttcttgt gtttcagact ttatgcagcc
1801 atataaactg ttctctaggc atgctgtgac attttaataa aaagcaaaag gagcatttat
1861 aattatctca tttgttaagg ctgagaaggt tgtttttata ataggtaatt atattgaatg
1921 cattttcact gaatatggta tgtatgctaa attatatgaa cctttcccca agaagggccc
1981 tagaaattga tgtggctttc ctcttaaata ttaattatta gtcctgaaag aaagataaca
2041 tatgtgattt ttgtggttag gagagttgct gtcatgattg ttttttcttc agcctcctct
2101 gacttttctt ttggggcttc agattttatg attacatctt gtccccctag aacatccccc
2161 ttcctcccat actgctttta aacagatgcc caagaaggca agcaggaatg cctcttgtgg
2221 gggagggcag ggagaaataa ctagttcaaa ccaactatct atctatgctt tgcaaagact
2281 aaggcgtatt ataggaagag ggctagaaac ctaactgatt cttctcagtt ttctcatttt
2341 aaaacagccc agtattcctt tgtatcctca agggtccttg agaatacttc tgttattgaa
2401 accctgtggg ctacttgtac tgtacctcct ctcaagccaa gaagggctgt gggataattt
2461 accatgaatc cttagtagca atgacagcag agttaaaaaa taaaaggtgt tttactttca
2521 ggctcttgtt ttggttcaga ggagatttta aatattgaat gacacttcta cagaacaacg
2581 gtttttcttc tgccaaggct acttccttta acgaagtgcc tttaattcag ccttatccaa
2641 ctagggaaaa taatgttgga caagtctagg atttgaagag tcagtgaact tttagtgtca
2701 gggaataaac atggtgggta gattaggttt gaaaaaaact tccttagagg tatttattct
2761 caatacctga caggggccca tgggaatgac ttcagaagca tcccggataa tagatgggta
2821 aaaagtctag gcaccctgaa gaacaggtga gacagctggc ctctggacag aggtaggcat
2881 agtacagtac gatatatcat tcctctggtc ctaaatatac aaacttattc atgtttttag
2941 gtgatgatgg tcattgaaac tcacttcttt tcaggtgtag ctacaattgt gtaatgtaca
3001 atattagaga aaggacaggc tttttatgag taacacacac catatataaa acagcctttc
3061 tggctgacca catggttaaa tgcatacctt cccagtactg gggggaaaat gacccttctt
3121 agaatgtgca agttccatag agtaatatat tgatatgatt ttgaaaagaa ttgttgatag
3181 ttacatcttc aaacttatca ttccagtatg catctttaag ataatgtgat tctaagtaga
3241 tgactttata ttcttgatta aagagtgcta tacatgttaa gaaatgcatt aaggaataca
3301 ataaatattc taaactgatg aaaaaaaaaa aaaaaaa
//