LOCUS       HSU62437                2448 bp    mRNA    linear   HUM 11-JAN-1997
DEFINITION  Human nicotinic acetylcholine receptor beta2 subunit precursor,
            mRNA, complete cds.
ACCESSION   U62437
VERSION     U62437.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J. Mol. Neurosci. 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Elliott,K.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUN-1996) Kathryn J. Elliott, SIBIA Neurosciences,
            Inc., 505 Coast Blvd. So., La Jolla, CA 92037, USA
FEATURES             Location/Qualifiers
     source          1..2448
                     /db_xref="H-InvDB:HIT000220721"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="Construct Hbeta2.1F (prefrontal cortex Hbeta2.1 +
                     thalamus Hbeta2.2, Hbeta2.7)"
                     /tissue_type="prefrontal cortex; thalamus"
                     /clone_lib="SIBIA lambda gt11 libraries (M. Williams, S.
                     Ellis)"
     5'UTR           1..264
     CDS             265..1773
                     /codon_start=1
                     /product="nicotinic acetylcholine receptor beta2 subunit
                     precursor"
                     /protein_id="AAB40115.1"
                     /translation="MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNK
                     LIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNM
                     KKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVK
                     HFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD
                     STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLAL
                     TVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPW
                     VKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVN
                     RASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSED
                     WKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK"
     sig_peptide     265..339
     mat_peptide     340..1770
                     /product="nicotinic acetylcholine receptor beta2 subunit"
     3'UTR           1774..2448
BASE COUNT          457 a          801 c          705 g          485 t
ORIGIN      
        1 ctcctccccc tcaccgtccc aattgtattc cctggaagag cagccggaaa agcctccgcc
       61 tgctcatacc aggataggca agaagctggt ttctcctcgc agccggctcc ctgaggccca
      121 ggaaccaccg cggcggccgg caccacctgg acccagctcc aggcgggcgc ggcttcagca
      181 ccacggacag cgccccaccc gcggccctcc ccccggcggc gcgctccagc cggtgtaggc
      241 gaggcagcga gctatgcccg cggcatggcc cggcgctgcg gccccgtggc gctgctcctt
      301 ggcttcggcc tcctccggct gtgctcaggg gtgtggggta cggatacaga ggagcggctg
      361 gtggagcatc tcctggatcc ttcccgctac aacaagctta tccgcccagc caccaatggc
      421 tctgagctgg tgacagtaca gcttatggtg tcactggccc agctcatcag tgtgcatgag
      481 cgggagcaga tcatgaccac caatgtctgg ctgacccagg agtgggaaga ttatcgcctc
      541 acctggaagc ctgaagagtt tgacaacatg aagaaagttc ggctcccttc caaacacatc
      601 tggctcccag atgtggtcct gtacaacaat gctgacggca tgtacgaggt gtccttctat
      661 tccaatgccg tggtctccta tgatggcagc atcttctggc tgccgcctgc catctacaag
      721 agcgcatgca agattgaagt aaagcacttc ccatttgacc agcagaactg caccatgaag
      781 ttccgttcgt ggacctacga ccgcacagag atcgacttgg tgctgaagag tgaggtggcc
      841 agcctggacg acttcacacc tagtggtgag tgggacatcg tggcgctgcc gggccggcgc
      901 aacgagaacc ccgacgactc tacgtacgtg gacatcacgt atgacttcat cattcgccgc
      961 aagccgctct tctacaccat caacctcatc atcccctgtg tgctcatcac ctcgctagcc
     1021 atccttgtct tctacctgcc atccgactgt ggcgagaaga tgacgttgtg catctcagtg
     1081 ctgctggcgc tcacggtctt cctgctgctc atctccaaga tcgtgcctcc cacctccctc
     1141 gacgtgccgc tcgtcggcaa gtacctcatg ttcaccatgg tgcttgtcac cttctccatc
     1201 gtcaccagcg tgtgcgtgct caacgtgcac caccgctcgc ccaccacgca caccatggcg
     1261 ccctgggtga aggtcgtctt cctggagaag ctgcccgcgc tgctcttcat gcagcagcca
     1321 cgccatcatt gcgcccgtca gcgcctgcgc ctgcggcgac gccagcgtga gcgcgagggc
     1381 gctggagccc tcttcttccg cgaagcccca ggggccgact cctgcacgtg cttcgtcaac
     1441 cgcgcgtcgg tgcaggggtt ggccggggcc ttcggggctg agcctgcacc agtggcgggc
     1501 cccgggcgct caggggagcc gtgtggctgt ggcctccggg aggcggtgga cggcgtgcgc
     1561 ttcatcgcag accacatgcg gagcgaggac gatgaccaga gcgtgagtga ggactggaag
     1621 tacgtcgcca tggtgatcga ccgcctcttc ctctggatct ttgtctttgt ctgtgtcttt
     1681 ggcaccatcg gcatgttcct gcagcctctc ttccagaact acaccaccac caccttcctc
     1741 cactcagacc actcagcccc cagctccaag tgaggccctt cctcatctcc atgctctttc
     1801 accctgccac cctctgctgc acagtagtgt tgggtggagg atggacgagt gagctaccag
     1861 gaagaggggc gctgccccca cagatccatc cttttgcttc atctggagtc cctcctcccc
     1921 cacgcctcca tccacacaca gcagctccaa cctggaggct ggaccaactg ctttgttttg
     1981 gctgctctcc atctcttgta ccagcccagg caatagtgtt gaggagggga gcaaggctgc
     2041 taagtggaag acagagatgg cagagccatc caccctgagg agtgacgggc aaggggccag
     2101 gaaggggaca ggattgtctg ctgcctccaa gtcatgggag aagaggggta taggacaagg
     2161 ggtggaaggg caggagctca caccgcaccg ggctggcctg acacaatggt agctctgaag
     2221 ggaggggaag agagaggcct gggtgtgacc tgacacctgc cgctgcttga gtggacagca
     2281 gctggactgg gtgggcccca cagtggtcag cgattcctgc caagtagggt ttagccgggc
     2341 cccatggtca cagacccctg ggggaggctt ccagctcagt cccacagccc cttgcttcta
     2401 agggatccag agacctgctc cagatcctct ttccccactg aagaattc
//