LOCUS       U48937                  3278 bp    DNA     linear   HUM 30-APR-2000
DEFINITION  Homo sapiens amiloride-sensitive epithelial sodium channel gamma
            subunit gene, promoter region and exon 1.
ACCESSION   U48937
VERSION     U48937.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 2479 to 3278)
  AUTHORS   Thomas,C.P., Doggett,N.A., Fisher,R. and Stokes,J.B.
  TITLE     Genomic organization and the 5' flanking region of the gamma
            subunit of the human amiloride-sensitive epithelial sodium channel
  JOURNAL   J. Biol. Chem. 271 (42), 26062-26066 (1996)
   PUBMED   8824247
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Auerbach,S.D., Loftus,R.W., Itani,O.A. and Thomas,C.P.
  TITLE     Human amiloride-sensitive epithelial Na+ channel gamma subunit
            promoter: functional analysis and identification of a
            polypurine-polypyrimidine tract with the potential for triplex DNA
            formation
  JOURNAL   Biochem. J. 347 (Pt 1), 105-114 (2000)
   PUBMED   10727408
REFERENCE   3  (bases 2479 to 3278)
  AUTHORS   Thomas,C.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-FEB-1996) Internal Medicine, University of Iowa, 200
            Hawkins Drive, Iowa City, IA 52242-1081, USA
REFERENCE   4  (bases 1 to 3278)
  AUTHORS   Thomas,C.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-OCT-1999) Internal Medicine, University of Iowa, 200
            Hawkins Drive, Iowa City, IA 52242-1081, USA
  REMARK    Sequence updated by submitter
COMMENT     On May 8, 2000 this sequence version replaced gi:1620566.
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12"
                     /clone="cosmid 320H2"
     repeat_region   340..630
                     /rpt_family="Alu-Jo"
                     /rpt_type=dispersed
     repeat_region   692..988
                     /rpt_family="Alu-Jb"
                     /rpt_type=dispersed
     repeat_region   1669..1799
                     /rpt_family="Alu-Jo"
                     /rpt_type=dispersed
     misc_feature    1792..2098
                     /note="polypurine-polypyrimidine tract"
     repeat_region   2102..2393
                     /rpt_family="Alu-Sx"
                     /rpt_type=dispersed
     misc_feature    <2588..>3230
                     /note="CpG island"
     GC_signal       2886..2896
     GC_signal       2916..2926
     mRNA            2938..>3034
                     /product="amiloride-sensitive epithelial sodium channel
                     gamma subunit"
                     /note="ENaC"
     exon            2938..3034
                     /number=1
BASE COUNT          972 a          682 c          993 g          631 t
ORIGIN      
        1 gatctaacct taattcaata agaatctctt tgactggctt attgacaaga ggctgtggag
       61 ggcagaatta gcaagattag tgaggagcct atggcaatga ttcgggtgag agacaatgat
      121 caattggagc atggtggtgg ccccagaggt ggggagaagt agattctagg tatattttat
      181 aaatctgaac actgatgctt caagaaggag aggacgttgc ctatggtctt atgatgacag
      241 gagtggttta gaggcaatac cactctgtac tgaagaatca gatggtgttg gtcataggag
      301 tgtacacatt taccaaaact ccttgacttg tacattttgg gccaggtgca gtggctcatg
      361 cctgcaatca taacactttg agaggccaag gcaggcaaat ttcttgaggc caggagttca
      421 agaccagcct gggcaacata gtgaaattcc atctccacaa aaataaaaaa ttagccaggc
      481 atggtggcac agacctctag tcctagctac tattttgtaa tctgaggcag gaggattgct
      541 tgagcccagg agttggaggc tgcagtgagc tatgatcaca ccactgcatt ccaccctggg
      601 tgacagagca aaaccttgcc tcaaaaacaa acaaacaaaa aaattgtgcg tttcactgta
      661 tataaatttt aacttgaatc tagcctaatt ccatgcctat aatgccagca ctttgggagg
      721 ctgagatggg tagatccctt gaactcggga gttcaagacc agccttgcaa acatggtgaa
      781 accccttctc taccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaatt atttgggtat
      841 cggtggcatg cacctggggt cccacctact tgggaggctg aggtgggagg atccttggag
      901 ccacaggaag ttgaaactgc aagtaagcca tgatcatgcc actacattcc agcctgggtg
      961 acaaagcaag accctgtctc aaaataaata aataaataaa taatttaaaa gacaaaaaga
     1021 agaaaaagct ggctttattt tgcagtgaaa atataactgt gtattgtcat tcaaaacaaa
     1081 cataaaattt gaacagtgtg tgtttcaaaa tcccattata tatgtatgtg tatatatata
     1141 aaactaatat gtgtgtgtgg acacacacac atacacacac accaaataat aaccaaactg
     1201 ttagccatgc ttatttgggg aggggggggc acagtttatt gttttaattc tttgcaatga
     1261 gcatatattg ttagaagaag cagctgagat ttttttagag gattttcttt aaatttctct
     1321 ccaataatgc tggacctgtt tccatccacc tgggcaaacc gcccttggac cagcaaccaa
     1381 ggcatctcct aggaatttgg aaattcggac tcttaagacc cactccaccc ctatcgagtc
     1441 agaatctgca ttttaacaac atccataggt gattgtaacc acattcaaat ctgagaagct
     1501 ctaggtaaga acagatcctt tcctctctct gggcttcagt ttctccccgg cacaaagggg
     1561 ctgtgtctct atggtccctc ccaattgcag ttttctaatc tccgtttctt gtagttatct
     1621 gagtccctat aaaaaggcag ctgaagctag gaaaggtggc ttaactctct gtaattccag
     1681 ctatttgaga cccctgaagt gggaggctcg cttgagccca gtagttggca gctacagtga
     1741 gctatgattg cagcactgca ctccagccaa ggtgacagag gcagaccctg ttaaaaaaag
     1801 aaagagagaa atagaggaaa gaaagaaaga aaaagaaaga aagaaagaaa gaaagaaagg
     1861 aagaaagaaa aaggagggag ggagggagga aggaaggaag ggagagagag aaagaagaaa
     1921 gagggaggaa ggaaggaagg aaggcaagca agcaagaaag agaaaggaag gaaggaagga
     1981 aggaaggaag gaaggaagga aggaaggaag gaaggaaggt gggcgggcgg gaaggcaggc
     2041 aggcaggcaa ggaaggaagg aggaaagaaa ggaaagaaag agagaaagag aaagaaggac
     2101 aggccaggcg cggtggctca acacctgtaa tcccagcact ttgggaggcc aagacgcgtg
     2161 gatcacctga ggtcagtagt ttgagaccag cctggccaac atggtgaaac cgcgtttcta
     2221 ctaaaaacac aaaaattaat ccgggcatgg tggcgcgcgc ctgtaacccc agctacttgg
     2281 gaggctgagg caggagaatt gcttgaaccc gggaggcgga ggttgtagtg agctgagata
     2341 gcgtcattgc actccagact gggcgacaga gcgagactcc gtcaaaaaaa aaaaaaaaga
     2401 aggaaagagg aaaagaaaga agaaggaagg aggaaataac gaaagaaaga gaaagaagca
     2461 gctgaaaagg tcaaaggatg agtggcctgg ctgaacagcc cctgctgcct acagccggac
     2521 gctggtgggc actgaagctg caggtctgga gggagtccga ggagcgaggc tgcgtgggat
     2581 tactgctggt gctagggcag gcacctgcca tctggacggg agtggaagga agtcgcgggg
     2641 cagtaatagg gggcagcagg cgctttgagg cgccttgggg taagtgccgc agagacccag
     2701 cgggaatgca ggatggcagg gcggcctcgg ggcggcagca ggcactgcgc ggtggcccag
     2761 gaaggcgcag cgcggccggg ctggggcgca gggcggcttc ggggcgccag ggggcgttgt
     2821 gaagtcgtgg cccgctccgg gcggtctcag gtgcctggcg gcctggggaa agcacctggg
     2881 caggtggggg cggggcctgg ggaggcgggt ccctaggggg cggggcctgg ccggcccaca
     2941 agagcccgcg gtggcgctgc caggggatgc taccccgaga gcgagcagag gagcagcgca
     3001 cccgcacgag ccttggaccc tttggaaccg aaaggtgagt tcagccgggt tgggtcggac
     3061 cagctcgggg gttctgggca ctggagcgga tgccgggcgc cagggcgtcg gacgccgtca
     3121 gcgcggtggg tggccgagcc agcatcagcc ggtggcggct tcccggtgcc cgggatgctg
     3181 ggacaccttg cccgggcggt agcggccagc tctcccgggt ctacccacgc cgtggcccgg
     3241 agcacgaagc cagtcgagag ccactcagag tccggggg
//