LOCUS       HSU44378                2680 bp    mRNA    linear   HUM 01-MAR-1996
DEFINITION  Human homozygous deletion target in pancreatic carcinoma (DPC4)
            mRNA, complete cds.
ACCESSION   U44378
VERSION     U44378.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2680)
  AUTHORS   Hahn,S.A., Hoque,A.T., Moskaluk,C.A., da Costa,L.T., Schutte,M.,
            Rozenblum,E., Seymour,A.B., Weinstein,C.L., Yeo,C.J., Hruban,R.H.
            and Kern,S.E.
  TITLE     Homozygous deletion map at 18q21.1 in pancreatic cancer
  JOURNAL   Cancer Res. 56 (3), 490-494 (1996)
   PUBMED   8564959
REFERENCE   2  (bases 1 to 2680)
  AUTHORS   Hahn,S.A., Schutte,M., Shamsul Hoque,A.T.M., Moskaluk,C.A., da
            Costa,L.T., Rozenblum,E., Weinstein,C.L., Fischer,A., Yeo,C.J.,
            Hruban,R.H. and Kern,S.E.
  TITLE     DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
  JOURNAL   Science 271 (5247), 350-353 (1996)
   PUBMED   8553070
REFERENCE   3  (bases 1 to 2680)
  AUTHORS   Hahn,S.A., Schutte,M. and Kern,S.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-1996) Scott E. Kern, Oncology, Johns Hopkins, 628
            Ross Bldg, 720 Rutland Ave., Baltimore, MD 21205-2196, USA
FEATURES             Location/Qualifiers
     source          1..2680
                     /db_xref="H-InvDB:HIT000219917"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..2680
                     /gene="DPC4"
     exon            1..377
                     /gene="DPC4"
                     /number=1
     5'UTR           1..128
                     /gene="DPC4"
                     /note="exon structure of untranslated region was not
                     determined"
     CDS             129..1787
                     /gene="DPC4"
                     /standard_name="homozygous deletion target in pancreatic
                     carcinoma"
                     /note="similar to Drosophila melanogaster Mothers against
                     dpp (Mad) gene, GenBank Accession Number U10328"
                     /codon_start=1
                     /product="Dpc4"
                     /protein_id="AAA91041.1"
                     /db_xref="GI:1163234"
                     /translation="MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLV
                     KKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWP
                     DLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKD
                     EYVHDFEGQPSLSTEGHSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIP
                     VASTSQPASILGGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPY
                     TPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQ
                     VGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECK
                     GEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQ
                     AATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKG
                     WGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD"
     exon            378..552
                     /gene="DPC4"
                     /number=2
     exon            553..582
                     /gene="DPC4"
                     /number=3
     exon            583..796
                     /gene="DPC4"
                     /number=4
     exon            797..915
                     /gene="DPC4"
                     /number=5
     exon            916..1032
                     /gene="DPC4"
                     /number=6
     exon            1033..1083
                     /gene="DPC4"
                     /number=7
     exon            1084..1267
                     /gene="DPC4"
                     /number=8
     exon            1268..1436
                     /gene="DPC4"
                     /number=9
     exon            1437..1575
                     /gene="DPC4"
                     /number=10
     exon            1576..>1787
                     /gene="DPC4"
                     /number=11
     3'UTR           1785..2680
                     /gene="DPC4"
                     /note="exon structure of untranslated region was not
                     determined"
BASE COUNT          775 a          548 c          567 g          790 t
ORIGIN      
        1 ggttatcctg aatacatgtc taacaatttt ccttgcaacg ttagctgttg tttttcactg
       61 tttccaaagg atcaaaattg cttcagaaat tggagacata tttgatttaa aaggaaaaac
      121 ttgaacaaat ggacaatatg tctattacga atacaccaac aagtaatgat gcctgtctga
      181 gcattgtgca tagtttgatg tgccatagac aaggtggaga gagtgaaaca tttgcaaaaa
      241 gagcaattga aagtttggta aagaagctga aggagaaaaa agatgaattg gattctttaa
      301 taacagctat aactacaaat ggagctcatc ctagtaaatg tgttaccata cagagaacat
      361 tggatgggag gcttcaggtg gctggtcgga aaggatttcc tcatgtgatc tatgcccgtc
      421 tctggaggtg gcctgatctt cacaaaaatg aactaaaaca tgttaaatat tgtcagtatg
      481 cgtttgactt aaaatgtgat agtgtctgtg tgaatccata tcactacgaa cgagttgtat
      541 cacctggaat tgatctctca ggattaacac tgcagagtaa tgctccatca agtatgatgg
      601 tgaaggatga atatgtgcat gactttgagg gacagccatc gttgtccact gaaggacatt
      661 caattcaaac catccagcat ccaccaagta atcgtgcatc gacagagaca tacagcaccc
      721 cagctctgtt agccccatct gagtctaatg ctaccagcac tgccaacttt cccaacattc
      781 ctgtggcttc cacaagtcag cctgccagta tactgggggg cagccatagt gaaggactgt
      841 tgcagatagc atcagggcct cagccaggac agcagcagaa tggatttact ggtcagccag
      901 ctacttacca tcataacagc actaccacct ggactggaag taggactgca ccatacacac
      961 ctaatttgcc tcaccaccaa aacggccatc ttcagcacca cccgcctatg ccgccccatc
     1021 ccggacatta ctggcctgtt cacaatgagc ttgcattcca gcctcccatt tccaatcatc
     1081 ctgctcctga gtattggtgt tccattgctt actttgaaat ggatgttcag gtaggagaga
     1141 catttaaggt tccttcaagc tgccctattg ttactgttga tggatacgtg gacccttctg
     1201 gaggagatcg cttttgtttg ggtcaactct ccaatgtcca caggacagaa gccattgaga
     1261 gagcaaggtt gcacataggc aaaggtgtgc agttggaatg taaaggtgaa ggtgatgttt
     1321 gggtcaggtg ccttagtgac cacgcggtct ttgtacagag ttactactta gacagagaag
     1381 ctgggcgtgc acctggagat gctgttcata agatctaccc aagtgcatat ataaaggtct
     1441 ttgatttgcg tcagtgtcat cgacagatgc agcagcaggc ggctactgca caagctgcag
     1501 cagctgccca ggcagcagcc gtggcaggaa acatccctgg cccaggatca gtaggtggaa
     1561 tagctccagc tatcagtctg tcagctgctg ctggaattgg tgttgatgac cttcgtcgct
     1621 tatgcatact caggatgagt tttgtgaaag gctggggacc ggattaccca agacagagca
     1681 tcaaagaaac accttgctgg attgaaattc acttacaccg ggccctccag ctcctagacg
     1741 aagtacttca taccatgccg attgcagacc cacaaccttt agactgaggt cttttaccgt
     1801 tggggccctt aaccttatca ggatggtgga ctacaaaata caatcctgtt tataatctga
     1861 agatatattt cacttttctt ctgctttatc ttttcataaa gggttgaaaa tgtgtttgct
     1921 gccttgctcc tagcagacag aaactggatt aaaacaattt ttttttcctc ttcagaactt
     1981 gtcaggcatg gctcagagct tgaagattag gagaaacaca ttcttattaa ttcttcacct
     2041 gttatgtatg aaggaatcat tccagtgcta gaaaatttag ccctttaaaa cgtcttagag
     2101 ccttttatct gcagaacatc gatatgtata tcattctaca gaataatcca gtattgctga
     2161 ttttaaaggc agagaagttc tcaaagttaa ttcacctatg ttattttgtg tacaagttgt
     2221 tattgttgaa catacttcaa aaataatgtg ccatgtgggt gagttaattt taccaagagt
     2281 aactttactc tgtgtttaaa aatgaagtta ataatgtatt gtaatctttc atccaaaata
     2341 ttttttgcaa gttatattag tgaagatggt ttcaattcag attgtcttgc aacttcagtt
     2401 ttatttttgc caaggcaaaa aactcttaat ctgtgtgtat attgagaatc ccttaaaatt
     2461 accagacaaa aaaatttaaa attacgtttg ttattcctag tggatgactg ttgatgaagt
     2521 atacttttcc cctgttaaac agtagttgta ttcttctgta tttctaggca caaggttggt
     2581 tgctaagaag cctataagag gaatttcttt tccttcattc atagggaaag gttttgtatt
     2641 ttttaaaaca ctaaaagcag cgtcactcta cctaatgtct
//