LOCUS       HSU42625                 597 bp    DNA     linear   HUM 05-JUN-1996
DEFINITION  Human tumor necrosis factor alpha (TNFA) gene, allele TNFAp4,
            promoter region and partial cds.
ACCESSION   U42625
VERSION     U42625.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 597)
  AUTHORS   Nedwin,G.E., Naylor,S.L., Sakaguchi,A.Y., Smith,D.,
            Jarrett-Nedwin,J., Pennica,D., Goeddel,D.V. and Gray,P.W.
  TITLE     Human lymphotoxin and tumor necrosis factor genes: structure,
            homology and chromosomal localization
  JOURNAL   Nucleic Acids Res. 13 (17), 6361-6373 (1985)
   PUBMED   2995927
REFERENCE   2  (bases 1 to 597)
  AUTHORS   Wilson,A.G., di Giovine,F.S., Blakemore,A.I. and Duff,G.W.
  TITLE     Single base polymorphism in the human tumour necrosis factor alpha
            (TNF alpha) gene detectable by NcoI restriction of PCR product
  JOURNAL   Hum. Mol. Genet. 1 (5), 353 (1992)
   PUBMED   1363876
REFERENCE   3  (bases 1 to 597)
  AUTHORS   D'Alfonso,S. and Richiardi,P.M.
  TITLE     A polymorphic variation in a putative regulation box of the TNFA
            promoter region
  JOURNAL   Immunogenetics 39 (2), 150-154 (1994)
   PUBMED   7903959
REFERENCE   4  (bases 1 to 597)
  AUTHORS   Zimmerman,P.A., Tiffany,H.L., O'Brien,S.J., Guderian,R.H. and
            Nutman,T.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-DEC-1995) Peter A. Zimmerman, Laboratory of Parasitic
            Diseases, NIAID, Building 4, Room 126, 9000 Rockville Pike,
            Bethesda, MD 20892-0425, USA
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.3"
                     /note="allele TNFAp4"
     gene            89..597
                     /gene="TNFA"
     variation       89
                     /gene="TNFA"
                     /note="TNFAp2"
                     /citation=[2]
                     /replace="a"
     variation       153
                     /gene="TNFA"
                     /note="TNFAp1; most frequent allele"
                     /citation=[1]
                     /replace="g"
     variation       159
                     /gene="TNFA"
                     /note="TNFAp3"
                     /citation=[3]
                     /replace="a"
     regulatory      (396.397)..576
                     /regulatory_class="promoter"
                     /gene="TNFA"
     CDS             577..>597
                     /gene="TNFA"
                     /codon_start=1
                     /product="tumor necrosis factor alpha"
                     /protein_id="AAB01765.1"
                     /translation="MSTESMI"
BASE COUNT          154 a          185 c          151 g          107 t
ORIGIN      
        1 ttcctgcatc ctgtctggaa gttagaagga aacagaccac agacctggtc cccaaaagaa
       61 atggaggcaa taggttttga ggggcatggg gacggggttc agcctccagg gtcctacaca
      121 caaatcagtc agtggcccag aagacccccc tcagaatcgg agcagggagg atggggagtg
      181 tgaggggtat ccttgatgct tgtgtgtccc caactttcca aatccccgcc cccgcgatgg
      241 agaagaaacc gagacagaag gtgcagggcc cactaccgct tcctccagat gagctcatgg
      301 gtttctccac caaggaagtt ttccgctggt tgaatgattc tttccccgcc ctcctctcgc
      361 cccagggaca tataaaggca gttgttggca cacccagcca gcagacgctc cctcagcaag
      421 gacagcagag gaccagctaa gagggagaga agcaactaca gaccccccct gaaaacaacc
      481 ctcagacgcc acatcccctg acaagctgcc aggcaggttc tcttcctctc acatactgac
      541 ccacggctcc accctctctc ccctggaaag gacaccatga gcactgaaag catgatc
//