LOCUS       HSU31120                5670 bp    DNA     linear   HUM 05-JUN-1996
DEFINITION  Human interleukin-13 (IL-13) precursor gene, complete cds.
ACCESSION   U31120
VERSION     U31120.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5670)
  AUTHORS   Dolganov,G., Bort,S., Lovett,M., Burr,J., Schubert,L., Short,D.,
            McGurn,M., Gibson,C. and Lewis,D.B.
  TITLE     Coexpression of the interleukin-13 and interleukin-4 genes
            correlates with their physical linkage in the cytokine gene cluster
            on human chromosome 5q23-31
  JOURNAL   Blood 87 (8), 3316-3326 (1996)
   PUBMED   8605348
REFERENCE   2  (bases 1 to 5670)
  AUTHORS   Dolganov,G.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-1995) Gregory M. Dolganov, Human Genetics,
            Genelabs, Inc., 505 Penobscot, Redwood City, CA 94063, USA
FEATURES             Location/Qualifiers
     source          1..5670
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23-31"
                     /clone="58D9"
     repeat_region   1360..1490
                     /rpt_family="Alu-repeat, left monomer"
                     /rpt_type=other
     gene            2158..5095
                     /gene="IL-13"
     mRNA            join(2158..2345,3403..3456,3709..3813,4160..5095)
                     /gene="IL-13"
                     /product="interleukin-13 precursor"
     exon            2158..2345
                     /gene="IL-13"
     CDS             join(2214..2345,3403..3456,3709..3813,4160..4267)
                     /gene="IL-13"
                     /codon_start=1
                     /product="interleukin-13 precursor"
                     /protein_id="AAB01681.1"
                     /db_xref="GI:1045452"
                     /translation="MALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQK
                     APLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSL
                     HVRDTKIEVAQFVKDLLLHLKKLFREGRFN"
     sig_peptide     2214..2273
                     /gene="IL-13"
     mat_peptide     join(2274..2345,3403..3456,3709..3813,4160..4264)
                     /gene="IL-13"
                     /product="interleukin-13"
                     /function="cytokine"
                     /experiment="experimental evidence, no additional details
                     recorded"
     intron          2346..3402
                     /gene="IL-13"
     exon            3403..3456
                     /gene="IL-13"
     intron          3457..3708
                     /gene="IL-13"
     exon            3709..3813
                     /gene="IL-13"
     intron          3814..4159
                     /gene="IL-13"
     exon            4160..5095
                     /gene="IL-13"
     repeat_region   4831..4878
                     /rpt_type=direct
     polyA_site      5076..5081
                     /gene="IL-13"
     repeat_region   5522..5567
BASE COUNT         1243 a         1676 c         1582 g         1169 t
ORIGIN      
        1 ggatccccgc tgacaatcta gaaacaagca acagaccctc tgatgtagcc atctgtgccg
       61 cgcctctccg caccgcccgc cacgccttgg tccctggaga ccaccctcca gggcaggggc
      121 tgccgctcgg ccgggcccgc ggggtccctc ggcctgacat ggccggtgct ggagcggcac
      181 gtgcgcgcct cggcccctcg gccgctcccg cccctcgccg gtgcgcaccg gcgctcgggg
      241 agccgctggc ccgggtgtcc agccggccct tgccctgcct ggcgctcgga ccgccacctt
      301 tgccgccccc tcgccagcct ccgcagcttc cagactggcc ggtctgcgcg cccacccctg
      361 cctcccggac cggccaccgc cggaggccgc ggaggagggc ccggccgcgc agatcccgct
      421 tatcgggccc catctcccgt tacataaggc caccccccta tctccgcggg ccatcgccgc
      481 cgcaaccgcc gcgccagcgc cttctcccac gcgcgggggc gcccctgccc accgctcccg
      541 gcagggcttt tggtggccat gggggataag gggcgttgac tcacccgggc ggggctccgg
      601 gagttgcaca gaccaaggta gttccccgct ccttccccca tcacggagac cctgtgggag
      661 atgccgtggg ccctctacta cagattagga aacaggcccg tagaggggtc gcgcggccaa
      721 gtagcggcac tccaggcact gggggccctc gagggaaggg gcagacttct gggagtcaga
      781 gccagcagct gggctgggaa gcttcgagtg tggacagaga gggtgggaat gacgttccct
      841 gtgggaagag agggtgggca agcctgggat gcctctgagc gggaatccag catgccttgt
      901 gaggagggtc acaagcacac ccttgtgagg aggttgagcc ccatcgagga caggacggag
      961 ggagcctgag caggcagaga gggggcctgg ggaggcgctg gttcggggag gaagtgggta
     1021 ggggagaaat cttgacatca acacccaaca ggcaaatgcc gtggcctctg ctgtgggggt
     1081 ttctggagga cttctaggaa aacgagggaa gagcaggaaa aggcgacatg gctgtagggc
     1141 caagcccagg agccgccctc cacagcactc attctgcaga agggaaattt gaggccccca
     1201 gacggcaggg gttgatcctg cagagactgg tgagcaaagg ggatcacccc aagccccagt
     1261 ggcactagga acacttacaa tctctgacct ggactaaggc tgccagcctg gcccagttaa
     1321 gagtttccca gaaggatggc ccatacactt taaattaaag gggccagaca cgtgcacact
     1381 acttccagcc actctggaag ctgaggtggg gggatcgctt gagtctggga gttggaggcc
     1441 agcctaggca ggcaacatag tgagacccca tctccaaaaa aacaaaacaa aacaaaacaa
     1501 aaaaacacca aaaaagctcc cagaaagacc tctgaatctt tctggatctc tcagtggaga
     1561 cctggaaatc tgaactttga caatccctct cacagtgggg ccaaggagga attaggcaag
     1621 ccaaaagaag tgaactttac tcttctattg cctgtttgaa ttttgtatcc aagcaagtgt
     1681 tacttaagta atttaagaga ctggttcatc gaaaaaataa aactccccaa attcccatag
     1741 ctggtagact gtggtcacag ccacagtgca ctaagactat ctgctcagca cttctggtga
     1801 cccaaaaggg tctgaggaca ggagctcaga gttgggtcag ctgtccaggt actcagggtt
     1861 gtcacaggca aaactgctgg aactcagggc agcattgcaa atgccacgcc gctctcaggg
     1921 ccccttgcct gccgctggaa ttaaacccac ccagatcttg gaaactctgc cctggaccct
     1981 tctcaataag tccatgagaa atcaaactct ttcctttatg cgacactgga ttttccacaa
     2041 agtaaaatca agatgagtaa agatgtggtt tctagatagt gcctgaaaaa gcagagacca
     2101 tggtgtcagg cgtcaccact tgggcctata aaagctgcca caagacgcca aggccacaag
     2161 ccacccagcc tatgcatccg ctcctcaatc ctctcctgtt ggcactgggc ctcatggcgc
     2221 ttttgttgac cacggtcatt gctctcactt gccttggcgg ctttgcctcc ccaggccctg
     2281 tgcctccctc tacagccctc agggagctca ttgaggagct ggtcaacatc acccagaacc
     2341 agaaggtgag tgtcggctag ccagggtcct agctatgagg gctccagggt gggtgattcc
     2401 caagatgagg tcatgagcag gctgggcctg gtcctaagat gcctgtaggt caggaaaaat
     2461 ctccatggac caaggcccgg cccagccatg agggagagag gagctgggct ggggggctca
     2521 gcactgtgga tggacctatg gaggtgtctg gcagactccc cagggactac ctgctctcct
     2581 ggcctggcct tgtctgccac tgccagctcc tactcagcca ttcctgaaca gaggacagca
     2641 gagaagggcc agcaccctcc cagaaccatg tggcatttgc caactggatt ttgaccataa
     2701 caatgcagcc attctcccca gcaccatcat aggcccgccc ttacaggagg attcgttagt
     2761 agagtccgct ccttgcccca ctagtaacag ctcacatgtc tgagcactgc ttacaccagg
     2821 cctggtgcac gtgctttatg tgtcatttca tcactgccag ccacctcaag aggcaggtac
     2881 gatgaaccca ttctgctaag gttcagtgag gttaagtgac agaggctgga ttcaagccag
     2941 gcctggccaa caccagagtg tccatgctcc taactgcagt gttccctcac catcagaagg
     3001 cagggcattt aatacaccag atccccaccg cctcccatct gatttgtctt ggtcaacagt
     3061 ggcccaggcc actcctactt cactcgtccc caccctggcc cttcccgcag gcccctgtcc
     3121 tcctgccctg actatggcaa gccttgcatg cagcttgtcc cttactagtg gtgtcaattt
     3181 ttttctctca gctccaagac cctaaacagt gggacctcac ccctatgcct gctgttcaaa
     3241 gcagaaaacg aagctcagga atgctgaggg gctgccaggc ctgcctctgt gccacaccag
     3301 ggatgcttgt ggggcctgtg ctggggcaga cctggcctgg gctgccaggg caggcccaca
     3361 acccctgcca gcactctgct cactgtcact ttgctcccac aggctccgct ctgcaatggc
     3421 agcatggtat ggagcatcaa cctgacagct ggcatggtaa ggacctttgg gtgcagggag
     3481 gatggggcag aggctccagg ccttgggctt atcttctctg agcctccctt ccatggctgg
     3541 ggttccaagc aagcttcaag tgctctcctc cctcccgcca taatctggcc ccttcccgcc
     3601 caccacccag actcacctgc gccaggcatc tcagccccat cttcctgcag actcacaaaa
     3661 ggcagctgcc caagcagggc ctgacccctc ggtgtcccct ccccacagta ctgtgcagcc
     3721 ctggaatccc tgatcaacgt gtcaggctgc agtgccatcg agaagaccca gaggatgctg
     3781 agcggattct gcccgcacaa ggtctcagct ggggtaaggc atcccccacc ctctcacacc
     3841 caccctgcac cccctcctgc caaccctggg ctcgctgaag ggaagctggc tgaatatcca
     3901 tggtgtgtgt ccacccaggg gtggggccat tgtggcagca gggacgtggc cttcgggatt
     3961 tacaggatct gggctcaagg gctcctaact cctacctggg cctcaatttc cacatctgta
     4021 cagtagaggt actaacagta cccacctcat ggggacttcc gtgaggactg aatgagacag
     4081 tccctggaaa gcccctggtt tgtgcgagtc gtcccggcct ctggcgttct actcacgtgc
     4141 tgacctcttt gtcctgcagc agttttccag cttgcatgtc cgagacacca aaatcgaggt
     4201 ggcccagttt gtaaaggacc tgctcttaca tttaaagaaa ctttttcgcg agggacggtt
     4261 caactgaaac ttcgaaagca tcattatttg cagagacagg acctgactat tgaagttgca
     4321 gattcatttt tctttctgat gtcaaaaatg tcttgggtag gcgggaagga gggttaggga
     4381 ggggtaaaat tccttagctt agacctcagc ctgtgctgcc cgtcttcagc ctagccgacc
     4441 tcagccttcc ccttgcccag ggctcagcct ggtgggcctc ctctgtccag ggccctgagc
     4501 tcggtggacc cagggatgac atgtccctac acccctcccc tgccctagag cacactgtag
     4561 cattacagtg ggtgcccccc ttgccagaca tgtggtggga cagggaccca cttcacacac
     4621 aggcaactga ggcagacagc agctcaggca cacttcttct tggtcttatt tattattgtg
     4681 tgttatttaa atgagtgtgt ttgtcaccgt tggggattgg ggaagactgt ggctgctggc
     4741 acttggagcc aagggttcag agactcaggg ccccagcact aaagcagtgg accccaggag
     4801 tccctggtaa taagtactgt gtacagaatt ctgctacctc actggggtcc tggggcctcg
     4861 gagcctcatc cgaggcaggg tcaggagagg ggcagaacag ccgctcctgt ctgccagcca
     4921 gcagccagct ctcagccaac gagtaattta ttgtttttcc tcgtatttaa atattaaata
     4981 tgttagcaaa gagttaatat atagaagggt accttgaaca ctgggggagg ggacattgaa
     5041 caagttgttt cattgactat caaactgaag ccagaaataa agttggtgac agataggcct
     5101 gattgtattt gtctttcatt ttggcctttg gggacactgg tctgtggtct gaagactctg
     5161 aggagctctt cgggaggctg gtgggttgga ggaggggact gggatggatt acagcgaggg
     5221 tagggtgcag tgacctgggc tgaatgcaag ctagctcccg agggtgggga catggcctga
     5281 aggaagcccc accttctgtc tgctgcacca gcaaggacgg agaggcttgg gccagactgt
     5341 cagggttcaa ggagggcatc aggagcagac ggagacccag gaagtctcac aatcacatct
     5401 cctgaggact ggccagctgt gtctggcacc acccacacat ccatgtctcc ctcacaaccc
     5461 aggaggccga tgagaactgt gaggctcaga aagcgtgggc ggtttgccta aggtcacgta
     5521 gctacttcct cactggggtc ctggggcctc agagcctcat ctgaggtaaa ggagcaaagt
     5581 tgggattggg gtccaaaatt cactttaact ccaaagccca cacacttaac caccctgcct
     5641 atttctgtcc aaatgtcacc tgtcctgaat
//