LOCUS       HSU20770                1607 bp    mRNA    linear   HUM 16-MAY-1995
DEFINITION  Human metastasis suppressor (KAI1) mRNA, complete cds.
ACCESSION   U20770
VERSION     U20770.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 267)
  AUTHORS   Dong,J.T., Lamb,P.W., Rinker-Schaeffer,C.W., Vukanovic,J.,
            Ichikawa,T., Isaacs,J.T. and Barrett,J.C.
  TITLE     KAI1, a metastasis suppressor gene for prostate cancer on human
            chromosome 11p11.2
  JOURNAL   Science 268 (5212), 884-886 (1995)
   PUBMED   7754374
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Dong,J.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-1995) Jin-Tang Dong, The Johns Hopkins Oncology
            Center, The Johns Hopkins University School of Medicine, 422 North
            Bond Street, Baltimore, MD 21231, USA
FEATURES             Location/Qualifiers
     source          1..1607
                     /db_xref="H-InvDB:HIT000218572"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1607
                     /gene="KAI1"
     CDS             166..969
                     /gene="KAI1"
                     /note="metastasis suppressor"
                     /codon_start=1
                     /product="cell surface glycoprotein"
                     /protein_id="AAC50133.1"
                     /db_xref="GI:806806"
                     /translation="MGSACIKVTKYFLFLFNLIFFILGAVILGFGVWILADKSSFISV
                     LQTSSSSLRMGAYVFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTA
                     GALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTD
                     NAELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCME
                     KVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHSEDYSKVPKY"
BASE COUNT          311 a          467 c          496 g          333 t
ORIGIN      
        1 ccgactgagg cacgagcggg tgacgctggg cctgcagcgc ggagcagaaa gcagaacccg
       61 cagagtcctc cctgctgctg tgtggacgac acgtgggcac aggcagaagt gggccctgtg
      121 accagctgca ctggtttcgt ggaaggaagc tccaggactg gcgggatggg ctcagcctgt
      181 atcaaagtca ccaaatactt tctcttcctc ttcaacttga tcttctttat cctgggcgca
      241 gtgatcctgg gcttcggggt gtggatcctg gccgacaaga gcagtttcat ctctgtcctg
      301 caaacctcct ccagctcgct taggatgggg gcctatgtct tcatcggcgt gggggcagtc
      361 actatgctca tgggcttcct gggctgcatc ggcgccgtca acgaggtccg ctgcctgctg
      421 gggctgtact ttgctttcct gctcctgatc ctcattgccc aggtgacggc cggggccctc
      481 ttctacttca acatgggcaa gctgaagcag gagatgggcg gcatcgtgac tgagctcatt
      541 cgagactaca acagcagtcg cgaggacagc ctgcaggatg cctgggacta cgtgcaggct
      601 caggtgaagt gctgcggctg ggtcagcttc tacaactgga cagacaacgc tgagctcatg
      661 aatcgccctg aggtcaccta cccctgttcc tgcgaagtca agggggaaga ggacaacagc
      721 ctttctgtga ggaagggctt ctgcgaggcc cccggcaaca ggacccagag tggcaaccac
      781 cctgaggact ggcctgtgta ccaggagggc tgcatggaga aggtgcaggc gtggctgcag
      841 gagaacctgg gcatcatcct cggcgtgggc gtgggtgtgg ccatcatcga gctcctgggg
      901 atggtcctgt ccatctgctt gtgccggcac gtccattccg aagactacag caaggtcccc
      961 aagtactgag gcagctgcta tccccatctc cctgcctggc ccccaacctc agggctccca
     1021 ggggtctccc tggctccctc ctccaggcct gcctcccact tcactgcgaa gaccctcttg
     1081 cccaccctga ctgaaagtag ggggctttct ggggcctagc gatctctcct ggcctatccg
     1141 ctgccagcct tgagccctgg ctgttctgtg gttcctctgc tcaccgccca tcagggttct
     1201 cttatcaact cagagaaaaa tgctccccac agcgtccctg gcgcaggtgg gctggacttc
     1261 tacctgccct caagggtgtg tatattgtat aggggcaact gtatgaaaaa ttggggagga
     1321 gggggccggg cgcggtgctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg
     1381 gatcacgagg tcaggagatc gagaccatcc tggctaacat ggtgaaaccc cgtctctact
     1441 aaaaatacaa aaaaaattta gccgggcgcg gtggcgggca cctgtagtcc cagctacttg
     1501 ggaggctgag gcaggagaat ggtgtgaacc cgggagcgga ggttgcagtg agctgagatc
     1561 gtgctactgc actccagcct gggggacaga aagagactcc gtctcaa
//