LOCUS HSU20536 1545 bp mRNA linear HUM 27-JUL-1995
DEFINITION Human cysteine protease Mch2 isoform alpha (Mch2) mRNA, complete
cds.
ACCESSION U20536
VERSION U20536.1
KEYWORDS Ced-3; ICE; Apoptosis.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1545)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease
gene family
JOURNAL Cancer Res. 55 (13), 2737-2742 (1995)
PUBMED 7796396
REFERENCE 2 (bases 1 to 1545)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE CPP32, a novel human apoptotic protein with homology to
Caenorhabditis elegans cell death protein Ced-3 and mammalian
interleukin-1 beta-converting enzyme
JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994)
PUBMED 7983002
REFERENCE 3 (bases 1 to 1545)
AUTHORS Alnemri,E.S.
TITLE Direct Submission
JOURNAL Submitted (01-FEB-1995) Emad S. Alnemri, Pharmacology, Thomas
Jefferson University, Jefferson Cancer Institute, 233 S. Tenth
Street, Philadelphia, PA 19107, USA
FEATURES Location/Qualifiers
source 1..1545
/db_xref="H-InvDB:HIT000218561"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/note="human"
source join(1..1488,1490..1537,1539..1545)
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="Mch5b3"
/cell_line="Jurkat"
/cell_type="T-lymphocyte"
gene 1..1545
/gene="Mch2"
CDS 79..960
/gene="Mch2"
/note="The gene product of this sequence is a new member
of the interleukin 1-beta converting enzyme gene family of
cysteine proteases; cysteine protease Mch2 isoform alpha"
/codon_start=1
/product="cysteine protease Mch2 isoform alpha"
/protein_id="AAC50168.1"
/translation="MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRR
GIALIFNHERFFWHLTLPERRRTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE
VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFII
QACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYS
HRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP
CFASMLTKKLHFFPKSN"
polyA_site 1545
/gene="Mch2"
/note="23 A nucleotides"
BASE COUNT 458 a 320 c 383 g 384 t
ORIGIN
1 ccgagggcgg ggccgggccc gggagcctgt ggcttcagga agaggagggc aaggtgtctg
61 gctgcgcgtt tggctgcaat gagctcggcc tcggggctcc gcagggggca cccggcaggt
121 ggggaagaaa acatgacaga aacagatgcc ttctataaaa gagaaatgtt tgatccggca
181 gaaaagtaca aaatggacca caggaggaga ggaattgctt taatcttcaa tcatgagagg
241 ttcttttggc acttaacact gccagaaagg cggcgcacct gcgcagatag agacaatctt
301 acccgcaggt tttcagatct aggatttgaa gtgaaatgct ttaatgatct taaagcagaa
361 gaactactgc tcaaaattca tgaggtgtca actgttagcc acgcagatgc cgattgcttt
421 gtgtgtgtct tcctgagcca tggcgaaggc aatcacattt atgcatatga tgctaaaatc
481 gaaattcaga cattaactgg cttgttcaaa ggagacaagt gtcacagcct ggttggaaaa
541 cccaagatat ttatcatcca ggcatgtcgg ggaaaccagc acgatgtgcc agtcattcct
601 ttggatgtag tagataatca gacagagaag ttggacacca acataactga ggtggatgca
661 gcctccgttt acacgctgcc tgctggagct gacttcctca tgtgttactc tgttgcagaa
721 ggatattatt ctcaccggga aactgtgaac ggctcatggt acattcaaga tttgtgtgag
781 atgttgggaa aatatggctc ctccttagag ttcacagaac tcctcacact ggtgaacagg
841 aaagtttctc agcgccgagt ggacttttgc aaagacccaa gtgcaattgg aaagaagcag
901 gttccctgtt ttgcctcaat gctaactaaa aagctgcatt tctttccaaa atctaattaa
961 ttaatagagg ctatctaatt tcacactctg tattgaaaat ggctttctca gccaggcgtg
1021 gttactcaca cctgtaatcc cagcactttg ggagtccaag gtgggcggat cacctgaggt
1081 cgggagttcg agaccagcct gaccaacatg gcagaagccc cgcctctact aaaaatgcaa
1141 aaaaaaattt agctaggcat ggcggcgcat gcctgcaatc ccagctactt ggaaggctga
1201 ggcaggagaa tcacttgaac ccaggaggtg gaggctgcgg tgagccgagc attgcgccat
1261 tgcactccag cctgggcaac gagtgaaact ccgtctcaaa aaaaaagaaa atgtctttct
1321 cttcctttta tataaatatc gttagggtga agcattatgg tctaatgatt caaatgtttt
1381 aaagtttaat gcctagcaga gaactgcctt aaaaaaaaaa agttcatgtt ggccatggtg
1441 aaagggtttg atatggagaa acaaaatcct caggaaatta gataaataaa aatttataag
1501 catttgtatt attttttaat aaactgcagg gttacacaaa aatct
//