LOCUS HSU14680 5711 bp mRNA linear HUM 10-JUN-2002 DEFINITION Homo sapiens breast and ovarian cancer susceptibility (BRCA1) mRNA, complete cds. ACCESSION U14680 VERSION U14680.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5711) AUTHORS Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K., Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W., Bell,R., Rosenthal,J., Hussey,C., Tran,T., McClure,M., Frye,C., Hattier,T., Phelps,R., Haugen-Strano,A., Katcher,H., Yakumo,K., Gholami,Z., Shaffer,D., Stone,S., Bayer,S., Wray,C., Bogden,R., Dayananth,P., Ward,J., Tonin,P., Narod,S., Bristow,P.K., Norris,F.H., Helvering,L., Morrison,P., Rosteck,P., Lai,M., Barrett,J.C., Lewis,C., Neuhausen,S., Cannon-Albright,L., Goldgar,D., Wiseman,R., Kamb,A. and Skolnick,M.H. TITLE A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 JOURNAL Science 266 (5182), 66-71 (1994) PUBMED 7545954 REFERENCE 2 (bases 1 to 5711) AUTHORS Skolnick,M.H. TITLE Direct Submission JOURNAL Submitted (14-SEP-1994) Mark H. Skolnick, Myriad Genetics Inc. and the University of Utah, 421 Wakara Way, Suite 201, Salt Lake City, UT 84108, USA FEATURES Location/Qualifiers source 1..5711 /db_xref="H-InvDB:HIT000218274" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="17" /map="17q21; spans D17S855" /note="For sequence of alternatively spliced exon 4, see GenBank Accession Number U15595" gene 1..5711 /gene="BRCA1" 5'UTR 1..119 /gene="BRCA1" exon 1..100 /gene="BRCA1" /number=1 exon 101..199 /gene="BRCA1" /number=2 CDS 120..5711 /gene="BRCA1" /note="influences susceptibility to breast and ovarian cancer" /codon_start=1 /product="breast and ovarian cancer susceptibility" /protein_id="AAA73985.1" /translation="MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFC KFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYA NSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLG TVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISL DSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGT NTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTP STEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDEL LGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSK SVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRP TSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEK NPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALE LVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSN KPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKV SNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEP NKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQY LQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNE SNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHG LLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNN IRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGV LQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVC SETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRR GAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLS LKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSV SEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDS SALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVE RSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSY LPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAES AQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKF ARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKER KMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMV QLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSV ALYQCQELDTYLIPQIPHSHY" exon 200..253 /gene="BRCA1" /number=3 exon 254..331 /gene="BRCA1" /number=5 exon 332..420 /gene="BRCA1" /number=6 exon 421..560 /gene="BRCA1" /number=7 exon 561..665 /gene="BRCA1" /number=8 exon 666..712 /gene="BRCA1" /number=9 exon 713..788 /gene="BRCA1" /number=10 exon 789..4215 /gene="BRCA1" /number=11 exon 4216..4302 /gene="BRCA1" /number=12 exon 4303..4476 /gene="BRCA1" /number=13 exon 4477..4603 /gene="BRCA1" /number=14 exon 4604..4794 /gene="BRCA1" /number=15 exon 4795..5105 /gene="BRCA1" /number=16 exon 5106..5193 /gene="BRCA1" /number=17 exon 5194..5273 /gene="BRCA1" /number=18 exon 5274..5310 /gene="BRCA1" /number=19 exon 5311..5396 /gene="BRCA1" /number=20 exon 5397..5451 /gene="BRCA1" /number=21 exon 5452..5526 /gene="BRCA1" /number=22 exon 5527..5586 /gene="BRCA1" /number=23 exon 5587..5711 /gene="BRCA1" /number=24 BASE COUNT 1956 a 1099 c 1274 g 1382 t ORIGIN 1 agctcgctga gacttcctgg accccgcacc aggctgtggg gtttctcaga taactgggcc 61 cctgcgctca ggaggccttc accctctgct ctgggtaaag ttcattggaa cagaaagaaa 121 tggatttatc tgctcttcgc gttgaagaag tacaaaatgt cattaatgct atgcagaaaa 181 tcttagagtg tcccatctgt ctggagttga tcaaggaacc tgtctccaca aagtgtgacc 241 acatattttg caaattttgc atgctgaaac ttctcaacca gaagaaaggg ccttcacagt 301 gtcctttatg taagaatgat ataaccaaaa ggagcctaca agaaagtacg agatttagtc 361 aacttgttga agagctattg aaaatcattt gtgcttttca gcttgacaca ggtttggagt 421 atgcaaacag ctataatttt gcaaaaaagg aaaataactc tcctgaacat ctaaaagatg 481 aagtttctat catccaaagt atgggctaca gaaaccgtgc caaaagactt ctacagagtg 541 aacccgaaaa tccttccttg caggaaacca gtctcagtgt ccaactctct aaccttggaa 601 ctgtgagaac tctgaggaca aagcagcgga tacaacctca aaagacgtct gtctacattg 661 aattgggatc tgattcttct gaagataccg ttaataaggc aacttattgc agtgtgggag 721 atcaagaatt gttacaaatc acccctcaag gaaccaggga tgaaatcagt ttggattctg 781 caaaaaaggc tgcttgtgaa ttttctgaga cggatgtaac aaatactgaa catcatcaac 841 ccagtaataa tgatttgaac accactgaga agcgtgcagc tgagaggcat ccagaaaagt 901 atcagggtag ttctgtttca aacttgcatg tggagccatg tggcacaaat actcatgcca 961 gctcattaca gcatgagaac agcagtttat tactcactaa agacagaatg aatgtagaaa 1021 aggctgaatt ctgtaataaa agcaaacagc ctggcttagc aaggagccaa cataacagat 1081 gggctggaag taaggaaaca tgtaatgata ggcggactcc cagcacagaa aaaaaggtag 1141 atctgaatgc tgatcccctg tgtgagagaa aagaatggaa taagcagaaa ctgccatgct 1201 cagagaatcc tagagatact gaagatgttc cttggataac actaaatagc agcattcaga 1261 aagttaatga gtggttttcc agaagtgatg aactgttagg ttctgatgac tcacatgatg 1321 gggagtctga atcaaatgcc aaagtagctg atgtattgga cgttctaaat gaggtagatg 1381 aatattctgg ttcttcagag aaaatagact tactggccag tgatcctcat gaggctttaa 1441 tatgtaaaag tgaaagagtt cactccaaat cagtagagag taatattgaa gacaaaatat 1501 ttgggaaaac ctatcggaag aaggcaagcc tccccaactt aagccatgta actgaaaatc 1561 taattatagg agcatttgtt actgagccac agataataca agagcgtccc ctcacaaata 1621 aattaaagcg taaaaggaga cctacatcag gccttcatcc tgaggatttt atcaagaaag 1681 cagatttggc agttcaaaag actcctgaaa tgataaatca gggaactaac caaacggagc 1741 agaatggtca agtgatgaat attactaata gtggtcatga gaataaaaca aaaggtgatt 1801 ctattcagaa tgagaaaaat cctaacccaa tagaatcact cgaaaaagaa tctgctttca 1861 aaacgaaagc tgaacctata agcagcagta taagcaatat ggaactcgaa ttaaatatcc 1921 acaattcaaa agcacctaaa aagaataggc tgaggaggaa gtcttctacc aggcatattc 1981 atgcgcttga actagtagtc agtagaaatc taagcccacc taattgtact gaattgcaaa 2041 ttgatagttg ttctagcagt gaagagataa agaaaaaaaa gtacaaccaa atgccagtca 2101 ggcacagcag aaacctacaa ctcatggaag gtaaagaacc tgcaactgga gccaagaaga 2161 gtaacaagcc aaatgaacag acaagtaaaa gacatgacag cgatactttc ccagagctga 2221 agttaacaaa tgcacctggt tcttttacta agtgttcaaa taccagtgaa cttaaagaat 2281 ttgtcaatcc tagccttcca agagaagaaa aagaagagaa actagaaaca gttaaagtgt 2341 ctaataatgc tgaagacccc aaagatctca tgttaagtgg agaaagggtt ttgcaaactg 2401 aaagatctgt agagagtagc agtatttcat tggtacctgg tactgattat ggcactcagg 2461 aaagtatctc gttactggaa gttagcactc tagggaaggc aaaaacagaa ccaaataaat 2521 gtgtgagtca gtgtgcagca tttgaaaacc ccaagggact aattcatggt tgttccaaag 2581 ataatagaaa tgacacagaa ggctttaagt atccattggg acatgaagtt aaccacagtc 2641 gggaaacaag catagaaatg gaagaaagtg aacttgatgc tcagtatttg cagaatacat 2701 tcaaggtttc aaagcgccag tcatttgctc cgttttcaaa tccaggaaat gcagaagagg 2761 aatgtgcaac attctctgcc cactctgggt ccttaaagaa acaaagtcca aaagtcactt 2821 ttgaatgtga acaaaaggaa gaaaatcaag gaaagaatga gtctaatatc aagcctgtac 2881 agacagttaa tatcactgca ggctttcctg tggttggtca gaaagataag ccagttgata 2941 atgccaaatg tagtatcaaa ggaggctcta ggttttgtct atcatctcag ttcagaggca 3001 acgaaactgg actcattact ccaaataaac atggactttt acaaaaccca tatcgtatac 3061 caccactttt tcccatcaag tcatttgtta aaactaaatg taagaaaaat ctgctagagg 3121 aaaactttga ggaacattca atgtcacctg aaagagaaat gggaaatgag aacattccaa 3181 gtacagtgag cacaattagc cgtaataaca ttagagaaaa tgtttttaaa gaagccagct 3241 caagcaatat taatgaagta ggttccagta ctaatgaagt gggctccagt attaatgaaa 3301 taggttccag tgatgaaaac attcaagcag aactaggtag aaacagaggg ccaaaattga 3361 atgctatgct tagattaggg gttttgcaac ctgaggtcta taaacaaagt cttcctggaa 3421 gtaattgtaa gcatcctgaa ataaaaaagc aagaatatga agaagtagtt cagactgtta 3481 atacagattt ctctccatat ctgatttcag ataacttaga acagcctatg ggaagtagtc 3541 atgcatctca ggtttgttct gagacacctg atgacctgtt agatgatggt gaaataaagg 3601 aagatactag ttttgctgaa aatgacatta aggaaagttc tgctgttttt agcaaaagcg 3661 tccagaaagg agagcttagc aggagtccta gccctttcac ccatacacat ttggctcagg 3721 gttaccgaag aggggccaag aaattagagt cctcagaaga gaacttatct agtgaggatg 3781 aagagcttcc ctgcttccaa cacttgttat ttggtaaagt aaacaatata ccttctcagt 3841 ctactaggca tagcaccgtt gctaccgagt gtctgtctaa gaacacagag gagaatttat 3901 tatcattgaa gaatagctta aatgactgca gtaaccaggt aatattggca aaggcatctc 3961 aggaacatca ccttagtgag gaaacaaaat gttctgctag cttgttttct tcacagtgca 4021 gtgaattgga agacttgact gcaaatacaa acacccagga tcctttcttg attggttctt 4081 ccaaacaaat gaggcatcag tctgaaagcc agggagttgg tctgagtgac aaggaattgg 4141 tttcagatga tgaagaaaga ggaacgggct tggaagaaaa taatcaagaa gagcaaagca 4201 tggattcaaa cttaggtgaa gcagcatctg ggtgtgagag tgaaacaagc gtctctgaag 4261 actgctcagg gctatcctct cagagtgaca ttttaaccac tcagcagagg gataccatgc 4321 aacataacct gataaagctc cagcaggaaa tggctgaact agaagctgtg ttagaacagc 4381 atgggagcca gccttctaac agctaccctt ccatcataag tgactcttct gcccttgagg 4441 acctgcgaaa tccagaacaa agcacatcag aaaaagcagt attaacttca cagaaaagta 4501 gtgaataccc tataagccag aatccagaag gcctttctgc tgacaagttt gaggtgtctg 4561 cagatagttc taccagtaaa aataaagaac caggagtgga aaggtcatcc ccttctaaat 4621 gcccatcatt agatgatagg tggtacatgc acagttgctc tgggagtctt cagaatagaa 4681 actacccatc tcaagaggag ctcattaagg ttgttgatgt ggaggagcaa cagctggaag 4741 agtctgggcc acacgatttg acggaaacat cttacttgcc aaggcaagat ctagagggaa 4801 ccccttacct ggaatctgga atcagcctct tctctgatga ccctgaatct gatccttctg 4861 aagacagagc cccagagtca gctcgtgttg gcaacatacc atcttcaacc tctgcattga 4921 aagttcccca attgaaagtt gcagaatctg cccagagtcc agctgctgct catactactg 4981 atactgctgg gtataatgca atggaagaaa gtgtgagcag ggagaagcca gaattgacag 5041 cttcaacaga aagggtcaac aaaagaatgt ccatggtggt gtctggcctg accccagaag 5101 aatttatgct cgtgtacaag tttgccagaa aacaccacat cactttaact aatctaatta 5161 ctgaagagac tactcatgtt gttatgaaaa cagatgctga gtttgtgtgt gaacggacac 5221 tgaaatattt tctaggaatt gcgggaggaa aatgggtagt tagctatttc tgggtgaccc 5281 agtctattaa agaaagaaaa atgctgaatg agcatgattt tgaagtcaga ggagatgtgg 5341 tcaatggaag aaaccaccaa ggtccaaagc gagcaagaga atcccaggac agaaagatct 5401 tcagggggct agaaatctgt tgctatgggc ccttcaccaa catgcccaca gatcaactgg 5461 aatggatggt acagctgtgt ggtgcttctg tggtgaagga gctttcatca ttcacccttg 5521 gcacaggtgt ccacccaatt gtggttgtgc agccagatgc ctggacagag gacaatggct 5581 tccatgcaat tgggcagatg tgtgaggcac ctgtggtgac ccgagagtgg gtgttggaca 5641 gtgtagcact ctaccagtgc caggagctgg acacctacct gataccccag atcccccaca 5701 gccactactg a //