LOCUS HSU10417 3779 bp mRNA linear HUM 02-OCT-2001
DEFINITION Homo sapiens ileal sodium-dependent bile acid transporter
(SLC10-A2) mRNA, complete cds.
ACCESSION U10417
VERSION U10417.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3779)
AUTHORS Wong,M.H., Oelkers,P. and Dawson,P.A.
TITLE Identification of a mutation in the ileal sodium-dependent bile
acid transporter gene that abolishes transport activity
JOURNAL J. Biol. Chem. 270 (45), 27228-27234 (1995)
PUBMED 7592981
REFERENCE 2 (bases 1 to 3779)
AUTHORS Craddock,A.L., Love,M.W., Daniel,R.W., Kirby,L.C., Walters,H.C.,
Wong,M.H. and Dawson,P.A.
TITLE Expression and transport properties of the human ileal and renal
sodium-dependent bile acid transporter
JOURNAL Am. J. Physiol. 274 (1 Pt 1), G157-G169 (1998)
PUBMED 9458785
REFERENCE 3 (bases 1 to 3779)
AUTHORS Dawson,P.A.
TITLE Direct Submission
JOURNAL Submitted (07-JUN-1994) Paul A. Dawson, Internal
Medicine/Gastroenterology, Bowman Gray School of Medicine, Wake
Forest University, Medical Center Boulevard, Winston-Salem, NC
27157, USA
REFERENCE 4 (bases 1 to 3779)
AUTHORS Dawson,P.A.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-1997) Paul A. Dawson, Internal
Medicine/Gastroenterology, Bowman Gray School of Medicine, Wake
Forest University, Medical Center Boulevard, Winston-Salem, NC
27157, USA
REMARK Sequence update by submitter
COMMENT On Nov 17, 1997 this sequence version replaced gi:595398.
FEATURES Location/Qualifiers
source 1..3779
/db_xref="H-InvDB:HIT000217996"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q33"
/clone="pHISBT"
/tissue_type="ileum"
/clone_lib="human ileal cDNA lambda gt10"
/dev_stage="adult"
gene 1..3779
/gene="SLC10-A2"
5'UTR 1..598
/gene="SLC10-A2"
CDS 599..1645
/gene="SLC10-A2"
/codon_start=1
/product="ileal sodium-dependent bile acid transporter"
/protein_id="AAC51870.1"
/translation="MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLAL
VMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLI
IGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVI
PYDNIGTSLVALVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQS
AWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQL
SFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPES
SFYKANGGFQPDEK"
BASE COUNT 1117 a 737 c 799 g 1126 t
ORIGIN
1 ttctattgaa agggaaatgg gagaacaata tgtgttccta tggctcagtc cctataagat
61 tctgtactat tcagagttga ttttaagtgt cacttaactg aaattatcca acaaaccttc
121 atggcatgaa acattaacac agctcttttt atatggcatg gttcctatgg ctcaatccct
181 ataagattct gtactagttc agagttgatt ttaaaagtca cttaactgaa attatccaac
241 aaaccctcga ggacattaaa cattaacgtg gctcttttta tatggcatgg ttcattatca
301 tgccaataaa tgattaatcg taactctctg tcttgaccaa taattttgct ggacttttgt
361 gattcacaac gtgctctgtg ttgtaatgct acctcttgaa actgacatcc tagctttatt
421 gttttttatt acttccctaa ggtggctttc aaaagagaca ccaagtgaca tatttttagg
481 aggggtttaa aagtttgatg gggtagaagt aaacgttgct taactcaacc agcagcagag
541 ccagggccca gggaccagcg cttctgtgga cttggccttt ccagcagcag acccagcaat
601 gaatgatccg aacagctgtg tggacaatgc aacagtttgc tctggtgcat cctgtgtggt
661 acctgagagc aatttcaata acatcctaag tgtggtccta agtacggtgc tgaccatcct
721 gttggccttg gtgatgttct ccatgggatg caacgtggaa atcaagaaat ttctagggca
781 cataaagcgg ccgtggggca tttgtgttgg cttcctctgt cagtttggaa tcatgcccct
841 cacaggattc atcctgtcgg tggcctttga catcctcccg ctccaggccg tagtggtgct
901 cattatagga tgctgccctg gaggaactgc ctccaatatc ttggcctatt gggtcgatgg
961 cgacatggac ctgagcgtca gcatgaccac atgctccaca ctgcttgccc tcggaatgat
1021 gccgctgtgc ctccttatct ataccaaaat gtgggtcgac tctgggagca tcgtaattcc
1081 ctatgataac ataggtacat ctctggttgc tctcgttgtt cctgtttcca ttggaatgtt
1141 tgttaatcac aaatggcccc aaaaagcaaa gatcatactt aaaattgggt ccatcgcggg
1201 cgccatcctc attgtgctca tagctgtggt tggaggaata ttgtaccaaa gcgcctggat
1261 cattgctccc aaactgtgga ttataggaac aatatttcct gtggcgggtt actccctggg
1321 gtttcttctg gctagaattg ctggtctacc ctggtacagg tgccgaacgg ttgcttttga
1381 aacggggatg cagaacacgc agctatgttc caccatcgtt cagctctcct tcactcctga
1441 ggagctcaat gtcgtattca ccttcccgct catctacagc attttccagc tcgcctttgc
1501 cgcaatattc ttaggatttt atgtggcata caagaaatgt catggaaaaa acaaggcaga
1561 aattccagag agcaaagaaa atggaacgga gccagagtca tcgttttata aggcaaatgg
1621 aggatttcaa cctgacgaaa agtagacatc aagtggacaa aacagacgag ttccaaatta
1681 cgttcttaaa ccgtaactat atttaattat ttgttttggt aggacagttg gcagaaaaga
1741 gttaaagtga aaattggaat ttcattggaa ttcatgtatt ggtttcagta ccaagtgact
1801 ggtggcccaa ttctttaatg ggacaaatat tgtttcctat atatatgtat atgttttata
1861 tatgtatgta tactcatata gatatattgt cattgaaata ttcccccaaa atattctcag
1921 actaaacctg acatagggaa caccgagaat gaaaacatcg ttaacaccaa aactgaattc
1981 ttatgcagaa tttcctagcc catagatgac aacctgagtt tctgtatgtt aaagtagatg
2041 taatgaatta ttattattac agtggtcacg attttcttca gtgtttatga ttataaaaat
2101 tgacatgaac atctttcact gacattttaa tcattatttt aaaagctttg caacctatat
2161 atttatataa ctttgtaata taacatgggc aaatatctga cttcagtatt tttaaaaagt
2221 tgccttctcc agtggcagtc caaaagcaga aatgagagga aattattaca aaatagaatt
2281 caataaccat attggatgca ggctcttaac tcagcaggga tatcgtacat ctattgctct
2341 acctcagggg tccagtgata cccactagat cttccaagga aaaacataat tctttcaaac
2401 ggtgtgtatt tggcaaagag ctcttcaaat ctgggagagg gacttcctca aggttttcct
2461 gtgtgcagtg gatccacata gctaatatga cagctagtca gttgacaggg accacccaca
2521 gtaagcacca tggtcaggga ggtggcagga ggtgcaaaga cagaagtatt gagagaaaca
2581 ccaagactct agtggaggaa ttaattcaat gggagatagt ataaaataca tagaaaacac
2641 aagtaacaga aacctggttg aaatgcttaa ctagagtcaa ttagatgtgc aggagtaagt
2701 agtataagaa gaatcaagtc cgagagtgat caggaaatga gtattaaaca gtatttgaaa
2761 cagagaacgt gtcccagggc ccaaaagtca gaagggcccc accagccagg aaagttgttt
2821 caatgctgta agtaggtgta gccaagggaa gccaggacta tctgatatac ggtagcaggg
2881 gtttacggct gccaggggaa aataactcat caagtgttgg actttcaatt ataagatcga
2941 atttaatttc ctttccctca ttctgcagca atcagaatac acaatcttaa ccactcggtc
3001 cttagtggtt ttgttccatt ttgcattggg tattttcact gcctcataga gtctatttca
3061 agtgtttggc tgaaagggct ttttgcattt gcatgttctg agttcagatt ctgctggtgc
3121 acccaagcat tatgggaaca ggaactcaac ttagctcttc cagtagaggg gtgagggatt
3181 ctgcttttca aattcataac attgatcttt ttatgcaaga tttccattta cagttgaata
3241 agtacttcat atttttccat cattagacaa atacaaaatg gactaaataa ttttaagaga
3301 tagtggaggc agcagggggt acagacttcc ttcttagaga gtgtcagaga atatgctccc
3361 aatggtggaa aggaagattt acagtctagc ggctaagtac ctcctacaca tttcccatca
3421 atcagaaaat agacaggtac actaaaggga cctgagaact cctcttgtaa tttcaacaca
3481 cccaaaatca agggcctgga tgccagcagc tgcagcaagc aggtttttcc tccctgttga
3541 gcaagacagg tgaggcaaga taggacttgg ctttcttaca tgatgcggta acttgtgact
3601 tgagtctttt tccctaattt gctagtggga agaaaaatag ctgagctttc taaaatgata
3661 gctctctatt tttaaatgaa tttgaaaagt cgattaaatt atgtatttta ttgcctctga
3721 gtatcatatt aaatgaatat tttattttaa aggcttaaat aaatgaaaat gatttttgt
//