LOCUS       HSU03864                1860 bp    mRNA    linear   HUM 29-MAR-1995
DEFINITION  Human adrenergic alpha-1a receptor protein mRNA, complete cds.
ACCESSION   U03864
VERSION     U03864.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1860)
  AUTHORS   Forray,C., Bard,J.A., Wetzel,J.M., Chiu,G., Shapiro,E., Tang,R.,
            Lepor,H., Hartig,P.R., Weinshank,R.L., Branchek,T.A. and
            Gluchowski,C.
  TITLE     The alpha 1-adrenergic receptor that mediates smooth muscle
            contraction in human prostate has the pharmacological properties of
            the cloned human alpha 1c subtype
  JOURNAL   Mol. Pharmacol. 45 (4), 703-708 (1994)
   PUBMED   8183249
REFERENCE   2  (bases 1 to 1860)
  AUTHORS   Bruno,J.F., Whittaker,J., Song,J.F. and Berelowitz,M.
  TITLE     Molecular cloning and sequencing of a cDNA encoding a human alpha
            1A adrenergic receptor
  JOURNAL   Biochem. Biophys. Res. Commun. 179 (3), 1485-1490 (1991)
   PUBMED   1656955
REFERENCE   3  (bases 1 to 1860)
  AUTHORS   Nawoschik,S.P. and Bard,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-1993) S.P. Nawoschik and Jonathan A. Bard,
            Synaptic Pharmaceutical Corporation, Molecular Biology, 215 College
            Rd., Paramus, NJ 07652 USA
FEATURES             Location/Qualifiers
     source          1..1860
                     /db_xref="H-InvDB:HIT000217525"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="hH14; hH22"
                     /tissue_type="hippocampus"
                     /clone_lib="human hippocampus cDNA library (Stratagene)"
     misc_difference 1..305
                     /note="conflict"
                     /citation=[2]
                     /replace="cccgtgcaggggccctacggacaccaccagggctacgacccagagcag
                     ggccaggatggcggccgccttgcgctcggtcatgatggctgggtacttgagtgagtgg
                     cgcacgcccacgtaccggtccacggagatggtgcagaggctgaggatggaggccgtgc
                     agcacagcacgtc"
     5'UTR           1..57
     CDS             58..1776
                     /citation=[1]
                     /codon_start=1
                     /product="adrenergic alpha-1a receptor protein"
                     /protein_id="AAB60351.1"
                     /translation="MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVG
                     GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVF
                     LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG
                     FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILA
                     LLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCR
                     VYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS
                     VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGY
                     FNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCA
                     PSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTT
                     QLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSN
                     LRETDI"
     misc_difference 1521
                     /note="conflict"
                     /citation=[2]
                     /replace=""
     misc_difference 1621..1622
                     /note="conflict"
                     /citation=[2]
                     /replace="gc"
     3'UTR           1777..1860
BASE COUNT          244 a          666 c          642 g          308 t
ORIGIN      
        1 tcctgccggc cgctcgttct gtgcccccgg cccggccacc gacggccgcg cgttgagatg
       61 actttccgcg atctcctgag cgtcagtttc gagggacccc gcccggacag cagcgcaggg
      121 ggctccagcg cgggcggcgg cgggggcagc gcgggcggcg cggccccctc ggagggcccg
      181 gcggtgggcg gcgtgccggg gggcgcgggc ggcggcggcg gcgtggtggg cgcaggcagc
      241 ggcgaggaca accggagctc cgcgggggag ccggggagcg cgggcgcggg cggcgacgtg
      301 aatggcacgg cggccgtcgg gggactggtg gtgagcgcgc agggcgtggg cgtgggcgtc
      361 ttcctggcag ccttcatcct tatggccgtg gcaggtaacc tgcttgtcat cctctcagtg
      421 gcctgcaacc gccacctgca gaccgtcacc aactatttca tcgtgaacct ggccgtggcc
      481 gacctgctgc tgagcgccac cgtactgccc ttctcggcca ccatggaggt tctgggcttc
      541 tgggcctttg gccgcgcctt ctgcgacgta tgggccgccg tggacgtgct gtgctgcacg
      601 gcctccatcc tcagcctctg caccatctcc gtggaccggt acgtgggcgt gcgccactca
      661 ctcaagtacc cagccatcat gaccgagcgc aaggcggccg ccatcctggc cctgctctgg
      721 gtcgtagccc tggtggtgtc cgtagggccc ctgctgggct ggaaggagcc cgtgccccct
      781 gacgagcgct tctgcggtat caccgaggag gcgggctacg ctgtcttctc ctccgtgtgc
      841 tccttctacc tgcccatggc ggtcatcgtg gtcatgtact gccgcgtgta cgtggtcgcg
      901 cgcagcacca cgcgcagcct cgaggcaggc gtcaagcgcg agcgaggcaa ggcctccgag
      961 gtggtgctgc gcatccactg tcgcggcgcg gccacgggcg ccgacggggc gcacggcatg
     1021 cgcagcgcca agggccacac cttccgcagc tcgctctccg tgcgcctgct caagttctcc
     1081 cgtgagaaga aagcggccaa gactctggcc atcgtcgtgg gtgtcttcgt gctctgctgg
     1141 ttccctttct tctttgtcct gccgctcggc tccttgttcc cgcagctgaa gccatcggag
     1201 ggcgtcttca aggtcatctt ctggctcggc tacttcaaca gctgcgtgaa cccgctcatc
     1261 tacccctgtt ccagccgcga gttcaagcgc gccttcctcc gtctcctgcg ctgccagtgc
     1321 cgtcgtcgcc ggcgccgccg ccctctctgg cgtgtctacg gccaccactg gcgggcctcc
     1381 accagcggcc tgcgccagga ctgcgccccg agttcgggcg acgcgccccc cggagcgccg
     1441 ctggccctca ccgcgctccc cgaccccgac cccgaacccc caggcacgcc cgagatgcag
     1501 gctccggtcg ccagccgtcg aaagccaccc agcgccttcc gcgagtggag gctgctgggg
     1561 ccgttccgga gacccacgac ccagctgcgc gccaaagtct ccagcctgtc gcacaagatc
     1621 cgcgccgggg gcgcgcagcg cgcagaggca gcgtgcgccc agcgctcaga ggtggaggct
     1681 gtgtccctag gcgtcccaca cgaggtggcc gagggcgcca cctgccaggc ctacgaattg
     1741 gccgactaca gcaacctacg ggagaccgat atttaaggac cccagagcta ggccgcggag
     1801 tgtgctgggc ttgggggtaa gggggaccag agaggcgggc tggtgttcta agagcccccg
//