LOCUS       HSU02031                4249 bp    mRNA    linear   HUM 22-OCT-1994
DEFINITION  Human sterol regulatory element binding protein-2 mRNA, complete
            cds.
ACCESSION   U02031
VERSION     U02031.1
KEYWORDS    SREBP-2.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4249)
  AUTHORS   Hua,X., Yokoyama,C., Wu,J., Briggs,M.R., Brown,M.S., Goldstein,J.L.
            and Wang,X.
  TITLE     SREBP-2, a second basic-helix-loop-helix-leucine zipper protein
            that stimulates transcription by binding to a sterol regulatory
            element
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 90 (24), 11603-11607 (1993)
   PUBMED   7903453
REFERENCE   2  (bases 1 to 4249)
  AUTHORS   Hua,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-SEP-1993) Xianxin Hua, Department of Molecular
            Genetics, University of Texas, Southwestern Medical Center, 5323
            Harry Hines Blvd., Dallas, TX 75235 USA
FEATURES             Location/Qualifiers
     source          1..4249
                     /db_xref="H-InvDB:HIT000217436"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     CDS             118..3543
                     /standard_name="SREBP-2"
                     /codon_start=1
                     /product="sterol regulatory element binding protein-2"
                     /protein_id="AAA50746.1"
                     /db_xref="GI:451330"
                     /translation="MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPD
                     LFSEQLCSSFPGSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSP
                     SAASPQAPTLQVKVSPTSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTP
                     QTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANG
                     TLQTLAPATVQTVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTA
                     LTTPIQTAALQVPTLVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTT
                     HNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENM
                     VLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLLMSPPASDSGSQAGFSPYSID
                     SEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHD
                     SDQHPHSGSGRSVLSFESGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRP
                     HSRSSVTFWRHRKQADLDLARGDFAAAAANLQTCLAVLGRALPTSRLDLACSLSWNVI
                     RYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKL
                     PAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFL
                     SRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSAAKESLYCAQRNPADPIAQ
                     VHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSP
                     PLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVTES
                     PLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSGGTSDPALNHVVQ
                     LLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAYR
                     KVFLHEATVRLMAGGSPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRERATAILLAC
                     RHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS"
BASE COUNT          860 a         1315 c         1202 g          872 t
ORIGIN      
        1 ccgtcggtga ggcggtgccg ggcgggggtt gtcgggtgtc atgggcggtg gcgacggcac
       61 cgcccccgcg tctccctgag cgggacggca gggggggctt ctgcgctgag ccgggcgatg
      121 gacgacagcg gcgagctggg tggtctggag accatggaga ccctcacgga gctgggcgac
      181 gagctgaccc tgggagacat cgacgagatg ctgcaatttg tcagtaatca agtgggagag
      241 ttccctgact tgttttcaga acagctgtgt agctcctttc ctggcagtgg tggtagtggt
      301 agcagcagcg gcagcagtgg cagcagcagc agcagcagca atggcagggg cagcagcagc
      361 ggagctgtgg acccttcagt gcaacggtca ttcacccagg tcacattacc ttccttctct
      421 ccctcggcgg cctccccaca ggctccaact ctgcaagtca aggtttctcc cacctcagtt
      481 cccaccacac ccagggcaac tcctattctt cagccccgcc cccagcccca gcctcaacct
      541 caaactcagc tgcaacaaca gacggtaatg atcacgccaa cattcagcac cactccgcag
      601 acgaggatca tccagcagcc tttgatatac cagaatgcag ctactagctt tcaagtcctt
      661 cagcctcaag tccaaagcct ggtgacatcc tcccaggtac agccggtcac cattcagcag
      721 caggtgcaga cagtacaggc ccagcgggtg ctgacacaaa cggccaatgg cacgctgcag
      781 acccttgccc cggctacggt gcagacagtt gctgcgccac aggtgcagca ggtcccggtc
      841 ctggtccagc ctcagatcat caagacagat tcccttgttt tgaccacact gaagacagat
      901 ggcagccctg ttatggctgc ggtccagaac ccggccctca ccgccctcac cacccctatc
      961 cagacggctg cccttcaagt accaaccctg gtgggcagca gtgggaccat tctgaccaca
     1021 atgcctgtaa tgatggggca agagaaagtg cccattaagc aggtacctgg gggagtcaag
     1081 cagcttgagc cccccaaaga aggagaaagg cggacaaccc ataatatcat tgagaaacga
     1141 tatcgctcct ccatcaatga caaaatcatc gaattgaaag acctggtcat ggggacagac
     1201 gccaagatgc acaagtctgg cgttctgagg aaggccattg attacatcaa atacttgcag
     1261 caggtcaatc ataaactgcg ccaggagaac atggtgctga agctggcaaa tcaaaagaac
     1321 aagcttctaa agggcatcga cctaggcagt ctggtggaca atgaggtgga cctgaagatc
     1381 gaggacttta atcagaatgt ccttctgatg tcccccccag cctctgactc agggtcccag
     1441 gctggcttct ctccctactc cattgactct gagccaggaa gccctctatt ggatgatgca
     1501 aaggtcaaag atgagccaga ctctcctcct gtggcgctgg gcatggtaga ccgctcacgg
     1561 attcttctgt gtgtcctcac cttcctgtgc ctctccttta accccctgac ttccctgctg
     1621 cagtggggag gggcccacga ctctgaccag cacccacact caggctctgg ccgcagtgtc
     1681 ctgtcattcg agtcaggttc tgggggctgg tttgactgga tgatgcctac tcttctctta
     1741 tggctggtaa atggtgtgat tgtcctgagc gtctttgtga agctgctggt tcatggggag
     1801 ccagtgatcc ggccacactc gcgctcctcg gtcaccttct ggaggcaccg gaaacaggca
     1861 gatctggatc tcgccagagg agattttgca gctgctgccg ccaacctaca aacctgcctg
     1921 gcagttttgg gccgggcact gcccacctcc cgcctggacc tggcctgcag cctctcctgg
     1981 aacgtgatcc gctacagcct gcagaagcta cgcctggtgc gctggctgct caagaaagtc
     2041 ttccagtgcc ggcgggccac gccagccact gaggcaggct ttgaagacga agctaagacc
     2101 agcgcccggg atgcggctct ggcctatcac cggctgcacc agctgcacat cacagggaag
     2161 cttcctgcag gatccgcctg ttccgatgta cacatggcgt tgtgtgccgt gaacctggct
     2221 gaatgtgcag aggagaagat cccaccgagc acactggttg agatccatct gactgctgcc
     2281 atggggctca agacccggtg tggaggcaag ctgggcttcc tggccagcta cttcctcagc
     2341 cgagcccaga gcctgtgtgg ccccgagcac agtgctgttc ctgactccct gcgctggctc
     2401 tgccaccccc tgggccagaa gtttttcatg gagcggagct ggtctgtgaa gtcagctgcc
     2461 aaggagagtc tatactgtgc ccagaggaac ccagctgacc ccattgcgca ggtccaccag
     2521 gccttctgca agaacctgct ggagcgagct atagagtcct tggtgaaacc tcaggccaag
     2581 aagaaggctg gagaccagga agaagagagc tgtgaattct ccagtgctct ggagtacttg
     2641 aaattacttc attcttttgt ggactctgtg ggggttatga gccccccact ctccaggagc
     2701 tccgtgctca agtccgccct gggtccagac atcatctgtc ggtggtggac gtctgcaatc
     2761 actgtggcca tcagctggct ccagggagac gatgcagctg tgcgctctca ttttaccaaa
     2821 gtggaacgca tccccaaggc cctggaagtg acagagagcc ccctggtgaa ggccatcttc
     2881 catgcctgca gagccatgca tgcctcactc cctgggaaag cagatgggca gcagagttcc
     2941 ttctgccatt gcgagagggc cagtggccac ctatggagca gcctcaacgt cagtgggggc
     3001 acctctgacc ctgccctcaa ccacgtggtc cagctgctca cctgtgacct gctactgtcg
     3061 ctacggacag cgctctggca aaaacaggcc agtgccagcc aggctgtggg ggagacctac
     3121 cacgcgtcag gcgctgaact ggcgggcttc caacgggacc tgggcagcct gcgcaggctg
     3181 gcacacagct tccgcccagc ataccgcaag gtgttcctgc atgaagccac cgtgcgcctg
     3241 atggcaggag gcagccccac ccgcacccac cagctgctgg aacacagcct gcggcggcgc
     3301 accacgcaga gcaccaagca cggagaggtg gatgcctggc ccggccagcg agagcgggcc
     3361 accgccatcc tgctggcctg ccgccacctg cccctctcct tcctctcctc cccgggccag
     3421 cgggcagtgc tgctggccga agctgcccgc accctggaga aggtgggcga ccggcgctcc
     3481 tgcaacgact gccagcagat gattgttaag ctgggtggtg gcactgccat tgccgcctcc
     3541 tgaccaccag gctcagccca cccctccacc tctctctcga tttctctctc tccccctcag
     3601 catcttcccg ctgagagtgg tggggaagag ccttgtcttc ttagctgtca cctgccgagg
     3661 cttctgggcc actcaggcca gtgcacccct gggcagagcc ccttaaagct gctgtcacta
     3721 gatgcccatg gtccagggcc tggtgggcgt gagaggatag gtggcagggc agaaactggg
     3781 cagccctgac ttgatagcag cagggggagc tcccaagctg ccaagcccct gcctccagcc
     3841 ttcctgagtt tctctctcct gaaccctact ctctcctttt tgcttcctca gtttttatca
     3901 ggctttctct gggggacagc agtctctgag caccagggag cagttgccct caggcctgtg
     3961 cccagcatgc cctccccttt ttatacgaat gttttctacc agtgtgcttg ggtttgccat
     4021 gatgcgaggc tgagttgctg tagcgtcttg attctctccc tgggtctgcg ttccctcccc
     4081 tgggcctgac tgagcctgct cattgttttt ccctttatta cacaggacag ccaggggagg
     4141 aggggggccc agccctggga ggctggtggg aggcaggggg caggcctgcg gatgcatgaa
     4201 ataatgttgg cattattttt taatttttta aaaaataaat ggtatctta
//