LOCUS       HUMKER1A                1745 bp    mRNA    linear   HUM 27-APR-1993
DEFINITION  Human extracellular signal-regulated kinase 1 mRNA, 3' end.
ACCESSION   M84490
VERSION     M84490.1
KEYWORDS    kinase 1.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1745)
  AUTHORS   Owaki,H., Makar,R., Boulton,T.G., Cobb,M.H. and Geppert,T.D.
  TITLE     Extracellular signal-regulated kinases in T cells: characterization
            of human ERK1 and ERK2 cDNAs
  JOURNAL   Biochem. Biophys. Res. Commun. 182 (3), 1416-1422 (1992)
   PUBMED   1540184
COMMENT     Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1745
                     /db_xref="H-InvDB:HIT000196580"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /cell_line="T CELL"
                     /cell_type="CEM CELL LINE"
     gene            1..1745
                     /gene="ERK1"
     CDS             <1..1101
                     /gene="ERK1"
                     /codon_start=1
                     /product="kinase 1"
                     /protein_id="AAA36142.1"
                     /translation="PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVS
                     SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAM
                     RDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL
                     INTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSV
                     GCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTK
                     VAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFT
                     FAMELDDLPKERLKELIFQETARFQPGVLEAP"
BASE COUNT          357 a          570 c          476 g          342 t
ORIGIN      
        1 ccccgtagaa ccgagggggt gggcccgggg gtcccggggg aggtggagat ggtgaagggg
       61 cagccgttcg acgtgggccc gcgctacacg cagttgcagt acatcggcga gggcgcgtac
      121 ggcatggtca gctcggccta tgaccacgtg cgcaagactc gcgtggccat caagaagatc
      181 agccccttcg aacatcagac ctactgccag cgcacgctcc gggagatcca gatcctgctg
      241 cgcttccgcc atgagaatgt catcggcatc cgagacattc tgcgggcgtc caccctggaa
      301 gccatgagag atgtctacat tgtgcaggac ctgatggaga ctgacctgta caagttgctg
      361 aaaagccagc agctgagcaa tgaccatatc tgctacttcc tctaccagat cctgcggggc
      421 ctcaagtaca tccactccgc caacgtgctc caccgagatc taaagccctc caacctgctc
      481 atcaacacca cctgcgacct taagatttgt gatttcggcc tggcccggat tgccgatcct
      541 gagcatgacc acaccggctt cctgacggag tatgtggcta cgcgctggta ccgggcccca
      601 gagatcatgc tgaactccaa gggctatacc aagtccatcg acatctggtc tgtgggctgc
      661 attctggctg agatgctctc taaccggccc atcttccctg gcaagcacta cctggatcag
      721 ctcaaccaca ttctgggcat cctgggctcc ccatcccagg aggacctgaa ttgtatcatc
      781 aacatgaagg cccgaaacta cctacagtct ctgccctcca agaccaaggt ggcttgggcc
      841 aagcttttcc ccaagtcaga ctccaaagcc cttgacctgc tggaccggat gttaaccttt
      901 aaccccaata aacggatcac agtggaggaa gcgctggctc acccctacct ggagcagtac
      961 tatgacccga cggatgagcc agtggccgag gagcccttca ccttcgccat ggagctggat
     1021 gacctaccta aggagcggct gaaggagctc atcttccagg agacagcacg cttccagccc
     1081 ggagtgctgg aggcccccta gcccagacag acatctctgc accctggggc ctggacctgc
     1141 ctcctgcctg cccctctccc gccagactgt tagaaaatgg acactgtgcc cagcccggac
     1201 cttggcagcc caggccgggg tggagcatgg gcctggccac ctctctcctt tgctgaggcc
     1261 tccagcttca ggcaggccaa ggcttctcct ccccacccgc cctccccacg ggcctcggga
     1321 cctcaggtgg gcccagttca atctcccgct gctgctgctg cgcccttacc ttccccagcg
     1381 tcccagtctc tggcagtttt ggaatggaag ggttctggct gccccaacct gctgaagggc
     1441 agaggtggag ggtggggggc gctgagtagg gactcacggc catgcctgcc cccctcatct
     1501 cattcaaacc ccaccctagt ttccctgaag gaacattcct tagtctcaag ggctagcatc
     1561 cctgaggagc caggccgggc cgaatcccct ccctgtcaaa gctgtcactt cgcgtgccct
     1621 cgctgcttct gtgtgtggtg agcagaagtg gagctggggg gcgtggagag cccggctgcc
     1681 cctgccacct ccctgacccg tctaatatat aaatatagag atgtgtctat ggctgaaaaa
     1741 aaaaa
//