LOCUS       HUMMHDRBKC               287 bp    DNA     linear   HUM 11-MAR-1996
DEFINITION  Human (WS 9004) MHC class II HLA-DR-beta-1 0101 gene, promoter
            region.
ACCESSION   M81172
VERSION     M81172.1
KEYWORDS    HLA-DRB1 gene; cell surface glycoprotein; class II gene; integral
            membrane protein; major histocompatibility complex; promoter.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 287)
  AUTHORS   Louis,P., Eliaou,J.-F., Pinet,V. and Clot,J.
  TITLE     Allelic polymorphism in promoter region of HLA-DRB genes
  JOURNAL   Unpublished
COMMENT     Original source text: Homo sapiens (individual_isolate WS 9004)
            DNA.
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /isolate="WS 9004"
                     /db_xref="taxon:9606"
                     /cell_line="AMAI"
                     /cell_type="cultured B lymphocytes, homozygous typing
                     cells"
     gene            1..287
                     /gene="HLA-DRB1"
     regulatory      1..141
                     /regulatory_class="promoter"
                     /gene="HLA-DRB1"
                     /note="proximal promoter; G00-120-642"
     regulatory      15..29
                     /regulatory_class="other"
                     /gene="HLA-DRB1"
                     /standard_name="X box"
                     /note="G00-120-642"
     regulatory      49..58
                     /regulatory_class="other"
                     /gene="HLA-DRB1"
                     /standard_name="Y box"
                     /note="G00-120-642"
     regulatory      75..80
                     /regulatory_class="CAAT_signal"
                     /gene="HLA-DRB1"
                     /note="CAAT box; G00-120-642"
     regulatory      112..117
                     /regulatory_class="TATA_box"
                     /gene="HLA-DRB1"
                     /note="TATA box; G00-120-642"
     exon            141..>287
                     /gene="HLA-DRB1"
                     /note="G00-120-642"
                     /number=1
     misc_feature    141
                     /gene="HLA-DRB1"
                     /note="cap site; G00-120-642"
     CDS             204..>287
                     /gene="HLA-DRB1"
                     /note="allele *0101"
                     /codon_start=1
                     /product="MHC HLA-DR-beta cell surface glycoprotein"
                     /protein_id="AAA91839.1"
                     /db_xref="GDB:G00-120-642"
                     /translation="MVCLKLPGGSCMTALTVTLMVLSSRLAL"
     sig_peptide     204..>287
                     /gene="HLA-DRB1"
                     /note="G00-120-642"
BASE COUNT           60 a           78 c           73 g           76 t
ORIGIN      
        1 catacagcat ctctgaccag caactgatga tgctattgaa ctcagatgct gattggttct
       61 ccaacacgag attacccaac ccaggagcaa ggaaatcagt aacttcctcc ctataacttg
      121 gaatgtgggt ggaggggttc atagttctcc ctgagtgaga cttgcctgct tctctggccc
      181 ctggtcctgt cctgttctcc agcatggtgt gtctgaagct ccctggaggc tcctgcatga
      241 cagcgctgac agtgacactg atggtgctga gctcccgact ggctttg
//