LOCUS HUMAPE 1279 bp mRNA linear HUM 31-DEC-1994
DEFINITION Human apurinic endonuclease (APE) mRNA, complete cds.
ACCESSION M80261
VERSION M80261.1
KEYWORDS apurinic endonuclease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1279)
AUTHORS Demple,B., Herman,T. and Chen,D.S.
TITLE Cloning and expression of APE, the cDNA encoding the major human
apurinic endonuclease: definition of a family of DNA repair enzymes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (24), 11450-11454 (1991)
PUBMED 1722334
COMMENT Original source text: Homo sapiens placenta cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1279
/db_xref="H-InvDB:HIT000196426"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HeLa"
/tissue_type="placenta"
gene 1..1279
/gene="APE"
CDS 123..1079
/gene="APE"
/codon_start=1
/product="apurinic endonuclease"
/protein_id="AAA58371.1"
/translation="MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPAL
YEDPPDQKTSPSAKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSEN
KLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVA
EFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEI
DLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSK
NVGWRLDYFLLSHSLLPALCDSKIRSKALASDHCPITLYLAL"
BASE COUNT 334 a 315 c 334 g 296 t
ORIGIN
1 gaattcgggg gttgctcttt tgctcataag aggggcttcg ctggcagtct gaacggcaag
61 ccggtaaaaa tattgcttcg gtgggtgacg cggtacagct gcccaagggg ttcgtaacgg
121 gaatgccgaa gcgtgggaaa aagggagcgg tggcggaaga cggggatgag ctcaggacag
181 agccagaggc caagaagagt aagacggccg caaagaaaaa tgacaaagag gcagcaggag
241 agggcccagc cctgtatgag gaccccccag atcagaaaac ctcacccagt gcgaaacctg
301 ccacactcaa gatctgctct tggaatgtgg atgggcttcg agcctggatt aagaagaaag
361 gattagattg ggtaaaggaa gaagccccag atatactgtg ccttcaagag accaaatgtt
421 cagagaacaa actaccagct gaacttcagg agctgcctgg actctctcat caatactggt
481 cagctccttc ggacaaggaa gggtacagtg gcgtgggcct gctttcccgc cagtgcccac
541 tcaaagtttc ttacggcata ggcgatgagg agcatgatca ggaaggccgg gtgattgtgg
601 ctgaatttga ctcgtttgtg ctggtaacag catatgtacc taatgcaggc cgaggtctgg
661 tacgactgga gtaccggcag cgctgggatg aagcctttcg caagttcctg aagggcctgg
721 cttcccgaaa gccccttgtg ctgtgtggag acctcaatgt ggcacatgaa gaaattgacc
781 ttcgcaaccc caaggggaac aaaaagaatg ctggcttcac gccacaagag cgccaaggct
841 tcggggaatt actgcaggct gtgccactgg ctgacagctt taggcacctc taccccaaca
901 caccctatgc ctacaccttt tggacttata tgatgaatgc tcgatccaag aatgttggtt
961 ggcgccttga ttactttttg ttgtcccact ctctgttacc tgcattgtgt gacagcaaga
1021 tccgttccaa ggccctcgcg agtgatcact gtcctatcac cctataccta gcactgtgac
1081 accaccccta aatcactttg agcctgggaa ataagccccc tcaactacca ttccttcttt
1141 aaacactctt cagagaaatc tgcattctat ttctcatgta taaaacgagg aatcctccaa
1201 ccaggctcct gtgatagagt tcttttaagc ccaagatttt ttatttgagg gttttttgtt
1261 ttttaaaaaa cccgaattc
//