LOCUS       HUMNKIRX                1230 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human neurokinin 1 receptor (NKIR) mRNA, complete cds.
ACCESSION   M76675
VERSION     M76675.1
KEYWORDS    GTP-binding protein; neurokinin 1 receptor; neurotransmitter
            receptor; plasma membrane protein; protein coupled; substance P
            receptor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Gerard,N.P., Garraway,L.A., Eddy,R.L. Jr., Shows,T.B., Iijima,H.,
            Paquet,J.L. and Gerard,C.
  TITLE     Human substance P receptor (NK-1): organization of the gene,
            chromosome localization, and functional expression of cDNA clones
  JOURNAL   Biochemistry 30 (44), 10640-10646 (1991)
   PUBMED   1657150
COMMENT     Original source text: Homo sapiens lymphocyte cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1230
                     /db_xref="H-InvDB:HIT000196376"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="chromosome 2"
                     /cell_line="PCR IM9 lymphocyte"
                     /tissue_type="lymphocyte"
     gene            1..1230
                     /gene="NKIR"
     CDS             1..1224
                     /gene="NKIR"
                     /codon_start=1
                     /product="neurokinin 1 receptor"
                     /protein_id="AAA59936.1"
                     /translation="MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVV
                     TSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGL
                     FYCKFHNFFPIAACFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALL
                     LAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTI
                     VGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD
                     LYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGL
                     EMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDS
                     KTMTESFSFSSNVLS"
BASE COUNT          268 a          390 c          289 g          283 t
ORIGIN      chromosome 2.
        1 atggataacg tcctcccggt ggactcagac ctctccccaa acatctccac taacacctcg
       61 gaacccaatc agttcgtgca accagcctgg caaattgtcc tttgggcagc tgcttacacg
      121 gtcattgtgg tgacctctgt ggtgggcaac gtggtagtga tgtggatcat cttagcccac
      181 aaaagaatga ggacagtgac gaactatttt ctggtgaacc tggccttcgc ggaggcctcc
      241 atggctgcat tcaatacagt ggtgaacttc acctatgctg tccacaacga atggtactac
      301 ggcctgttct actgcaagtt ccacaacttc ttccccatcg ccgcttgctt cgccagtatc
      361 tactccatga cggctgtggc ctttgatagg tacatggcca tcatacatcc cctccagccc
      421 cggctgtcag ccacagccac caaagtggtc atctgtgtca tctgggtcct ggctctcctg
      481 ctggccttcc cccagggcta ctactcaacc acagagacca tgcccagcag agtcgtgtgc
      541 atgatcgaat ggccagagca tccgaacaag atttatgaga aagtgtacca catctgtgtg
      601 actgtgctga tctacttcct ccccctgctg gtgattggct atgcatacac catagtggga
      661 atcacactat gggccagtga gatccccggg gactcctctg accgctacca cgagcaagtc
      721 tctgccaagc gcaaggtggt caaaatgatg attgtcgtgg tgtgcacctt cgccatctgc
      781 tggctgccct tccacatctt cttcctcctg ccctacatca acccagatct ctacctgaag
      841 aagtttatcc agcaggtcta cctggccatc atgtggctgg ccatgagctc caccatgtac
      901 aaccccatca tctactgctg cctcaatgac aggttccgtc tgggcttcaa gcatgccttc
      961 cggtgctgcc ccttcatcag cgccggcgac tatgaggggc tggaaatgaa atccacccgg
     1021 tatctccaga cccagggcag tgtgtacaaa gtcagccgcc tggagaccac catctccaca
     1081 gtggtggggg cccacgagga ggagccagag gacggcccca aggccacacc ctcgtccctg
     1141 gacctgacct ccaactgctc ttcacgaagt gactccaaga ccatgacaga gagcttcagc
     1201 ttctcctcca atgtgctctc ctagggatcc
//